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Body Weight-Based Interval Training in Sedentary Overweight and Obese Adults

Sponsor
Mayo Clinic (Other)
Overall Status
Completed
CT.gov ID
NCT03524521
Collaborator
(none)
22
Enrollment
1
Location
2
Arms
26.1
Actual Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Body-weight based interval training (IT) performed 3 times per week will lead to reductions in abdominal adiposity and reduce overall body fat percentage in overweight and obese sedentary adults more effectively than moderate intensity continuous training (MICT). Body-weight interval training will improve exercise capacity (peak VO2) in overweight/obese adults.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Interval Training
  • Behavioral: Standard of Care
 N/A

Detailed Description

Participants will be randomly assigned to one of the two home-based exercise groups.

The MICT group is the standard care group and will be instructed to walk for 30 minutes, 5 days per week at a moderate intensity. The goal is to accumulate 150 minutes of continuous aerobic exercise each week. Participants will be instructed on the use of the Rating of Perceived Exertion (RPE) scale during baseline testing and will be instructed to reach an RPE of 12-16. A heart rate monitor will be worn to monitor exercise intensity. Heart rate should reach ~70% of maximal heart rate.

The IT group will perform 5 body-weight exercises in three progressive phases. During the first 2 weeks the circuit will be completed twice, 30 second intervals, 90 seconds of rest. The exercises will be performed on 3 days of the week with at least one day of rest between exercise days (ideally Monday, Wednesday, Friday). The number of repetitions will increase to a maximum of 4 while the interval and rest periods increase to a maximum of 45 seconds each. The total time spent performing intervals by week 8 will be 15 minutes. A 2 minute warm up and 3 minute cool down will be performed, such as jumping jacks or simply walking. A heart rate monitor will be used to measure exercise intensity. Heart rate should reach approximately 90% of heart rate max during the intervals. Participants will be instructed on the use of the Rating of Perceived Exertion scale during baseline testing and will be instructed to reach an RPE of ≥17 during the high intensity intervals.

Study Design

Study Type:
Interventional
Actual Enrollment :
22 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
The Effect of Interval Training Using Body Weight on Body Composition in Sedentary Overweight and Obese Adults
Actual Study Start Date :
Nov 6, 2018
Actual Primary Completion Date :
Jan 8, 2021
Actual Study Completion Date :
Jan 8, 2021

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Standard Walking

This arm is prescribed standard of care exercise prescription; 30 minutes of moderate intensity walking, 5 days/week.

Behavioral: Standard of Care
Walking prescribed to meet current exercise guidelines; 150 minutes per week.
Experimental: Interval Training

This arm is prescribed body-weight based interval training 3 days per week with progressive increase in exercise intervals and sets.

Behavioral: Interval Training
Interval training is prescribed 3 days per week using 5 body weight exercises in a progressive fashion.

Outcome Measures

Primary Outcome Measures

  1. Change in Body fat percent [12 weeks]

    DEXA derived body fat %

Secondary Outcome Measures

  1. Change in Weight [12 weeks]

    Weight in kilograms

  2. Change in peak VO2 [12 weeks]

    Peak VO2 in ml/kg/min

  3. Visceral adipose tissue area [12 weeks]

    cm^2

  4. Thigh adipose tissue area [12 weeks]

    cm^2

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Adults 18-65 years of age

  • Willing and able to provide informed consent

  • Sedentary, overweight and obese adults (<90 minutes of moderate intensity exercise)

  • BMI 25≤35

  • Able to safely begin an exercise program

  • Have a smartphone, and willing and able to download and use the Fitbit app

Exclusion Criteria:

  • Unable to provide informed consent.

  • Known cardiovascular disease, or uncontrolled hypertension,

  • Diagnosed type 1 or 2 diabetes

  • Women who are pregnant or plan to become pregnant in the next 3-4 months

  • Orthopedic injury/limitation or any other contraindications to exercise.

  • Medications that cause weight gain (steroids, HIV-related medications, etc.), or glucose lowering medications

Contacts and Locations

Locations

Site City State Country Postal Code
1 Mayo Clinic in Rochester Rochester Minnesota United States 55905

Sponsors and Collaborators

  • Mayo Clinic

Investigators

  • Principal Investigator: Amanda R Bonikowske, Mayo Clinic

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
Amanda R. Bonikowske, Senior Associate Consultant, Mayo Clinic
ClinicalTrials.gov Identifier:
NCT03524521
Other Study ID Numbers:
  • 17-010163
First Posted:
May 14, 2018
Last Update Posted:
Jan 11, 2021
Last Verified:
Jan 1, 2021
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Body Weight
Overweight
Body Weight Changes

Study Results

No Results Posted as of Jan 11, 2021