Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder

• Sponsor: University Hospital, Basel, Switzerland (Other)
• Overall Status: Completed
• CT.gov ID: NCT01311193
• Collaborator: Velux Fonden (Other), Lumie UK (Other)
• Location: 1
• Arm: 1

Study Details

Study Description

Brief Summary

Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. The investigators examined circadian rhythms, sleep and well-being in women with BPD under their habitual life conditions with and without light treatment.

Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. Saliva samples were collected weekly to determine the diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. Ten matched healthy women followed the same 6-week protocol without light treatment.

Condition or Disease	Intervention/Treatment	Phase
Borderline Personality Disorder; Sleep Disturbances; Depression	Other: light therapy	N/A

Study Design

• Study Type: Interventional
• Official Title: Circadian Sleep-wake Cycles, Well-being and Light Therapy in Borderline Personality Disorder

Arms and Interventions

Arm	Intervention/Treatment
Experimental: light therapy Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)	Other: light therapy; early morning exposures to bright light, 8000lux for 40min, daily during 3 weeks

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years to 45 Years
• Sexes Eligible for Study: Female

Inclusion Criteria:

• Borderline Personality Disorder (DSM IV-criteria)

• German-speaking

• normal ocular function

Exclusion Criteria:

• lack of compliance

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Centre for Chronobiology, Psychiatric Hospital, University of Basel	Basel	BS	Switzerland	4012

Sponsors and Collaborators

• University Hospital, Basel, Switzerland
• Velux Fonden
• Lumie UK

Investigators

• Principal Investigator: Christian Cajochen, PhD, Centre for Chronobiology, Psychiatric Hospital, University of Basel

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• Related Info

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT01311193
• Other Study ID Numbers: Velux-425
• First Posted: Mar 9, 2011
• Last Update Posted: Mar 9, 2011
• Last Verified: Mar 1, 2011

• Keywords provided by , ,: Circadian rhythms; Sleep-wake cycles; Melatonin; Borderline Personality Disorder; Light therapy
• Additional relevant MeSH terms: Dyssomnias; Parasomnias; Disease; Personality Disorders; Borderline Personality Disorder

Study Results

No Results Posted as of Mar 9, 2011