Bowel Function and Associated Risk Factors for Bowel Dysfunciton in Patients With Anorectal Malformation
Study Details
Study Description
Brief Summary
The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with anorectal Malformation and to identify the associated risk factors for bowel dysfunction.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Anorectal malformation (ARM) is a type of congenital malformation resulting from post-embryonic intestinal dysgenesis, occurring in about 1 in 5000 cases.Surgery is an effective means of treating ARM,which includes reconstruction of the anus and treatment of associated deformities. However, even with reconstruction of the anus, most children still have serious complications, such as constipation, fecal incontinence, urinary incontinence, and sexual dysfunction, in the mid-to-long postoperative period.A lot of studies have been designed to explore the trend toward normal bowel habits from preschool and early childhood age to adolescence or adult; however, no apparent improvement in bowel habits was completely confirmed. In contrast, many reports have shown that poor bowel function in preschool and early childhood may lead to social problems and depression in adolescence and adult.The reasons for bowel dysfunction of ARM in preschool and early childhood were complicated and undefined,including associated malformations, the type of ARM, and the development of the perianal sphincter,etc.The bowel function score (BFS) is currently used to assess mid- and long-term anal function in patients with ARM, and comprises seven major categories (e.g., self-perception, fecal control, stool collection, and social problems) with a total of 20 points, or less than 17 points, for the presence of anal weakness (11-17 points, for the general weakness, or less than 11 points, for the severe weakness) .Therefore,bowel function at preschool and early childhood should be evaluated in a large number of patients with ARM and the associated risk factors for bowel dysfunction should also be assessed. The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with ARM and to identify the associated risk factors for bowel dysfunction using BFS.
Study Design
Outcome Measures
Primary Outcome Measures
- bowel function score in partipants with ARM [through study completion, an average of 6 year]
approved by Rintala in 1995, and patients with a score ≥ 17 were considered to have normal bowel habits
Secondary Outcome Measures
- Sacral ratio in partipants with ARM [through study completion, an average of 6 year]
test by X ray
Other Outcome Measures
- Number of partipants with every type of ARM [through study completion, an average of 6 year]
confirmed in surgery
- age at surgery of partipants with ARM [through study completion, an average of 6 year]
age at surger
- Number of partipants performed with every surgical method [through study completion, an average of 6 year]
Posterior sagittal approach to anoplasty or Anterior sagittal approach to anoplasty or Laparoscopic assisted anoplasty
- Number of partipants with abnormal spinal cord [through study completion, an average of 6 year]
tethered cord or other
- Number of partipants with reoperation [through study completion, an average of 6 year]
re-anoplasty
Eligibility Criteria
Criteria
Inclusion Criteria:
Anorectal malformation >4 years old
Exclusion Criteria:
Down syndrome patients <4 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Nanjing Medical University | Nanjing | Jiangsu | China | 210008 |
Sponsors and Collaborators
- Nanjing Children's Hospital
Investigators
- Study Director: Weibing Tang, Dr, Children's Hospital of Nanjing Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- NanjingCH0109