Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor
Study Details
Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy or radiation therapy and kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of chemotherapy with topotecan, cyclophosphamide, cisplatin, and vincristine plus radiation therapy and peripheral stem cell transplantation in treating children with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 2 |
Detailed Description
OBJECTIVES:
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Estimate the response rate to topotecan in children with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumors who have measurable residual disease after surgery. (Topotecan window closed to accrual 9/10/2001)
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Determine the feasibility of four courses of high-dose chemotherapy (vincristine, cisplatin, and cyclophosphamide) with peripheral blood stem cell support after craniospinal irradiation (CSI) in these patients.
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Estimate the 5-year overall survival and progression-free survival in patients treated with risk-adapted CSI and high-dose chemotherapy.
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Compare changes in intellectual functioning in patients treated with reduced-dose vs standard-dose CSI.
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Estimate the incidence of ototoxicity associated with risk-adapted CSI and posterior fossa boost(s) given by 3-D conformal radiotherapy technique combined with amifostine and cisplatin.
OUTLINE: This is a multicenter study. Patients are assigned to 1 of 2 treatment groups based on risk status.
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Group 1 (average-risk): Patients receive filgrastim (G-CSF) subcutaneously (SC) or IV daily until peripheral blood stem cells (PBSC) are harvested. PBSC are harvested when blood counts recover. Patients then receive craniospinal irradiation (CSI) 5 days a week for 6 weeks. Beginning 6 weeks after completion of CSI, patients receive high-dose chemotherapy comprising vincristine IV followed by cisplatin IV over 6 hours on day -4 and cyclophosphamide IV over 1 hour on days -3 and -2. Patients receive amifostine IV over 1 minute a maximum of 5 minutes prior to cisplatin infusion and then 3 hours into cisplatin infusion. PBSC are reinfused on day 0. Patients receive G-CSF SC beginning on day 1 and continuing for a minimum of 7 days or until blood counts recover. Vincristine IV is administered on day 6. G-CSF is stopped 48 hours prior to beginning subsequent courses of chemotherapy. High-dose chemotherapy repeats every 4 weeks for 4 courses.
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Group 2 (high-risk): Patients receive topotecan IV over 4 hours on days 1-5 and G-CSF SC or IV beginning 24 hours after completion of the first course of topotecan and continuing until PBSC are harvested. Treatment repeats every 3 weeks for 2 courses. If an adequate number of PBSC are not harvested, the patient undergoes a second harvest of PBSC after the second course of topotecan. Patients then receive CSI, high-dose chemotherapy, amifostine, and PBSC support as in group 1. (Topotecan window closed to accrual 9/10/2001) Patients undergo neuropsychological testing prior to radiotherapy and chemotherapy and then at 1, 2, and 5 years.
Patients are followed at 1, 2, 4, 6, 9, 12, 15, 18, and 24 months and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 12-36 patients will be accrued for this study within 5 years.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Average-risk Participants meeting the eligibility requirements for assignment to the average-risk arm. Interventions: filgrastim, amifostine trihydrate, cisplatin, cyclophosphamide, vincristine sulfate, peripheral blood stem cell transplantation, radiation therapy. |
Biological: filgrastim
Drug: amifostine trihydrate
Drug: cisplatin
Drug: cyclophosphamide
Drug: vincristine sulfate
Procedure: peripheral blood stem cell transplantation
Other Names:
Radiation: radiation therapy
|
| Experimental: High-risk Participants meeting the eligibility requirements for assignment to the high-risk arm. Interventions: filgrastim, amifostine trihydrate, cisplatin, cyclophosphamide, vincristine sulfate, peripheral blood stem cell transplantation, radiation therapy. |
Biological: filgrastim
Drug: amifostine trihydrate
Drug: cisplatin
Drug: cyclophosphamide
Drug: vincristine sulfate
Procedure: peripheral blood stem cell transplantation
Other Names:
Radiation: radiation therapy
|
Outcome Measures
Primary Outcome Measures
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
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Histologically proven medulloblastoma or supratentorial primitive neuroectodermal tumor
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Average-risk group:
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Localized tumor with no overt evidence of invasion beyond the posterior fossa
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Less than 1.5 cm2 residual tumor/imaging abnormality
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No CNS or extraneural metastasis (confirmed by bone scan)
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Brain stem invasion allowed if above criteria met
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High-risk group:
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Metastatic disease within the neuraxis (subarachnoid dissemination) OR greater than 1.5 cm^2 residual disease at the primary site after surgery
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No bone involvement by bone scan
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Must begin study within 28 days of definitive surgery
PATIENT CHARACTERISTICS:
Age
- 3 to 20 at diagnosis
Performance status
- ECOG 0-3 (except patients with posterior fossa syndrome)
Life expectancy
- Not specified
Hematopoietic
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WBC greater than 3,000/mm^3
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Absolute neutrophil count greater than 1,500/mm^3
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Platelet count greater than 100,000/mm^3
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Hemoglobin greater than 10 g/dL
Hepatic
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Bilirubin less than 1.5 mg/dL
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SGPT less than 1.5 times normal
Renal
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Creatinine less than 1.2 mg/dL OR
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Creatinine clearance greater than 70 mL/min
Other
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Not pregnant or nursing
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Negative pregnancy test
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HIV negative
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- No prior chemotherapy
Endocrine therapy
- Prior corticosteroids allowed
Radiotherapy
- No prior radiotherapy
Surgery
- See Disease Characteristics
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | St. Jude Children's Research Hospital | Memphis | Tennessee | United States | 38105 |
| 2 | Texas Children's Cancer Center | Houston | Texas | United States | 77030-2399 |
| 3 | Children's Hospital at Westmead | Westmead | New South Wales | Australia | 2145 |
| 4 | Royal Children's Hospital | Parkville | Victoria | Australia | 3052 |
Sponsors and Collaborators
- St. Jude Children's Research Hospital
- National Cancer Institute (NCI)
Investigators
- Study Chair: Amar Gajjar, MD, St. Jude Children's Research Hospital
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- CDR0000066069
- SJCRH-MB-96
- SJMB-96
- NCI-G98-1387