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Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients

Sponsor
Shandong University (Other)
Overall Status
Unknown status
CT.gov ID
NCT00925223
Collaborator
(none)
30
Enrollment
5
Duration (Months)

Study Details

Study Description

Brief Summary

Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently. Visceral hypersensitivity is recognized as a clinical hallmark in IBS patients. So in this study, the investigators will focus on the role of BDNF in colonic hyperalgesia in IBS patients.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    30 participants
    Observational Model:
    Case-Control
    Official Title:
    Study of Brain-derived Neurotrophic Factor in Visceral Hyperalgesia in IBS Patients
    Study Start Date :
    Jun 1, 2009
    Anticipated Primary Completion Date :
    Aug 1, 2009
    Anticipated Study Completion Date :
    Nov 1, 2009

    Arms and Interventions

    Arm Intervention/Treatment
    irritable bowel syndrome

    patients with diarrhea-predominant IBS will be enrolled in this group.
    control group

    patients with colon cancer or colon polyp will be enrolled as control group.

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Patients diagnosed with irritable bowel syndrome.
      Exclusion Criteria:
      • Patients have similar clinical symptoms as IBS, yet there is morphologic changes in the intestine.

      Contacts and Locations

      Locations

      No locations specified.

      Sponsors and Collaborators

      • Shandong University

      Investigators

      • Study Director: Yanqing Li, PhD. MD., Department of Gastroenterology, Qilu Hospital, Shandong University

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00925223
      Other Study ID Numbers:
      • 2009SDU-QILU-G02
      • NSFC30570831
      First Posted:
      Jun 22, 2009
      Last Update Posted:
      Oct 14, 2009
      Last Verified:
      Oct 1, 2009
      Keywords provided by , ,
      IBS
      BDNf
      visceral hypersensitivity
      Additional relevant MeSH terms:
      Irritable Bowel Syndrome
      Hyperalgesia
      Syndrome

      Study Results

      No Results Posted as of Oct 14, 2009