Aerovent-: Influence of Respiratory Gases Conditioning on Aerosol Delivery During Invasive Ventilation
Study Details
Study Description
Brief Summary
The intention is to enroll a specific sample of intubated patients. To compare the effect of respiratory gas conditioning on lung deposition and considering the well-known influences of lung pathology on lung deposition, intubated patients with healthy lungs will be included. Postoperative neurosurgery ventilated patients respond perfectly to this criteria. A previous study including 17 postoperative neurosurgery patients was performed in 2013 with a perfect collaboration between the ICU and the Department of Neurosurgery and Anesthesiology.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Heated-humidifier left on during nebulization
|
Device: Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Device: Heated-humidified circuit
It will be left on during the transfer and the nebulization in group 1
|
| Active Comparator: Heated-humidifier turned off 30 minutes before nebulization
|
Device: Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Device: Heated-humidified circuit
It will be turned off 15 minutes before the transfer in the Nuclear Medicine Department in group 2 (nebulization performed 30 minutes after turning off the heated-humidifier).
|
| Active Comparator: Use of a heat and moisture exchanger (HME) filter
|
Device: Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Device: Conventional dry ventilator circuit with HME filter
The nebulizer is placed between the filter and the endotracheal tube.
|
| Active Comparator: Use of a dry ventilator circuit specific for aerosol therapy
|
Device: Aerogen Solo®
Aerosol particles are generated by a vibrating-mesh nebulizer specifically designed for mechanical ventilation
Device: Dry ventilator circuit specific for aerosol therapy
Streamlined components, integrated T-piece for the nebulizer at 15 cm of the Y piece
|
Outcome Measures
Primary Outcome Measures
- Quantity of aerosol deposition from the nebulizer reservoir to the subject. Measured by Planar scintigraphy. [45 minutes]
% of the nominal dose.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Aged 18 years or older
-
Postoperative neurosurgery intubated patients admitted for brain neurosurgery in the ICU (Intensive care neuro-traumatologic and Toxicologic)- With a healthy lung function.
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Signed and dated informed consent should be obtained in accordance of local regulations.
Exclusion Criteria:
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Spine neurosurgery
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History of cardiovascular and pulmonary disease
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Extubation immediately after surgery
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Modification of the allocated humidification technique before or during the nebulization (heated-humidifier deficiency or safety concern)
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Inaccurate quantification of aerosol deposition (i.e., artifacts or overlap of tracheal and pulmonary deposition).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Cliniques Universiataires Saint-Luc | Bruxelles | Belgium | 1200 |
Sponsors and Collaborators
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Investigators
- Principal Investigator: Pierre-François Laterre, MD, PhD, Cliniques universitaires Saint-Luc
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 2017/08NOV/508