BCN: Brain and Cognitive Reserve

Sponsor

Hospices Civils de Lyon (Other)

Overall Status

Completed

CT.gov ID

NCT02819167

Collaborator

(none)

Enrollment

Location

Arm

2.2

Actual Duration (Months)

9.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Ischemic strokes are one of the leading causes of handicap and death in elderly people in France.

Cognitive reserve (CR) is an active model, defined as a function of lifetime intellectual activities and other environmental factors that explain differential susceptibility to functional impairment in the presence of pathology or other neurological insult. CR is estimated using variables for cognitive activity: years of education, professional status, socioeconomic status… Furthermore, brain reverse (BR) is a passive and quantitative model that depend on brain size and other quantitative aspects of the brain that explain differential susceptibility to functional impairment in the presence of pathology.

Firstly, volume and localization of ischemic strokes have a great impact on CR and BR due to brain injury. On the other hand, CR influences the severity and the expression of cognitive diseases.

The investigators realize a prospective study in order to assess the impact of CR and BR on cognitive prognosis after a right middle cerebral artery ischemic stroke in elderly patients.

Condition or Disease	Intervention/Treatment	Phase
Brain Ischemia	Other: neurologic and neuropsychological evaluation	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

20 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Basic Science

Official Title:

Neuro-anatomical Correlates on Volumetric MRI on the Impact of Brain Reserve and Cognitive Reserve on Ischemic Strokes in Elderly

Actual Study Start Date :

May 26, 2016

Actual Primary Completion Date :

Aug 1, 2016

Actual Study Completion Date :

Aug 1, 2016

Arms and Interventions

Arm	Intervention/Treatment
Other: neurologic and neuropsychological evaluation	Other: neurologic and neuropsychological evaluation cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging

Arm

Intervention/Treatment

Other: neurologic and neuropsychological evaluation

Other: neurologic and neuropsychological evaluation

cognitive prognosis, cognitive reserve, brain volume will be studied on patients with scale, questionnaire, magnetic resonance imaging

Outcome Measures

Primary Outcome Measures

evaluation of cognitive prognosis [one year post Ischemic stroke]
measure will be performed with the Mattis dementia rating scale

Secondary Outcome Measures

Volume of leucoencephalopathy [one year post Ischemic stroke]
measure will be performed with a MRI
volume of hippocampic [one year post Ischemic stroke]
measure will be performed with a MRI
brain injury [one year post Ischemic stroke]
measure will be performed with a MRI
volume of ischemic stroke [one year post Ischemic stroke]
measure will be performed with a MRI
evaluation of cognitive reserve [one year post Ischemic stroke]
measure will be performed with the Cognitive reserve index questionnaire

Eligibility Criteria

Criteria

Ages Eligible for Study:

70 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

≥70 years old
right middle cerebral artery ischemic stroke
hospitalized in neurovascular unit of Pierre Wertheimer hospital between January 2015 to January 2016