BRAHMS: Brain Representation of Acquisition in Humans of Motor-Sensory Skills

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05688683

Collaborator

(none)

Enrollment

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Interactions between the perceptual and motor systems are fundamental to the performance of complex motor tasks and are at the heart of the fine motor control required for the production of complex sounds such as speech production or playing a musical instrument. In such situations, the brain must learn to generate relevant motor commands to a sound-producing system with fixed physical characteristics, such as the vocal tract or a musical instrument.

No study has yet been able to directly test the dynamic aspect of this sensorimotor learning in an acoustic production task with fine motor control.

The Adolphe de Rothschild Foundation Hospital takes care of patients requiring awake surgery. During these procedures, a direct cortical recording, called electro-corticography, is performed in order to better delineate the tumor or epileptogenic resection area. Reference recordings are made in healthy areas at a distance from the lesion site making it possible to record normal brain activity.

In this case, we would propose to the patient to use a tool similar to the theremin (a musical instrument the size of a golf ball whose displacement in space modulates the frequency and the harmonics of a sound). The patient should therefore learn in order to create relevant motor patterns.

Condition or Disease	Intervention/Treatment	Phase
Epilepsy Cerebral Tumor	Other: use of a theremin-type musical instrument

Study Design

Study Type:

Observational

Anticipated Enrollment :

50 participants

Observational Model:

Other

Time Perspective:

Prospective

Official Title:

Brain Representation of Acquisition in Humans of Motor-Sensory Skills

Anticipated Study Start Date :

Mar 1, 2023

Anticipated Primary Completion Date :

Mar 1, 2028

Anticipated Study Completion Date :

Mar 1, 2028

Outcome Measures

Primary Outcome Measures

intracranial electroencephalography recording [Day 0]
intracranial electroencephalography recording

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Benefiting from an intracranial brain recording during a programmed surgery in awake condition.

Exclusion Criteria:

Patient with complete deafness
Patient with a disorder or impairment that does not allow him/her to perform the experimental task according to the investigator's judgment

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Fondation Ophtalmologique Adolphe de Rothschild

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Fondation Ophtalmologique Adolphe de Rothschild

ClinicalTrials.gov Identifier:

NCT05688683

Other Study ID Numbers:

PBN_2022_9

First Posted:

Jan 18, 2023

Last Update Posted:

Jan 20, 2023

Last Verified:

Jan 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Epilepsy

Study Results

No Results Posted as of Jan 20, 2023