Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma
Study Details
Study Description
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells.
PURPOSE: Phase I trial to study the effectiveness of temozolomide plus lomustine followed by radiation therapy in treating patients who have high-grade malignant glioma.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
Phase 1 |
Detailed Description
OBJECTIVES:
-
Determine the maximum tolerated dose of temozolomide when administered with lomustine in patients with high-grade malignant gliomas.
-
Determine the dose-limiting toxic effects of this regimen in these patients.
-
Evaluate the feasibility of radiotherapy after this treatment regimen in this patient population.
-
Evaluate the radiographic responses in patients treated with this regimen.
OUTLINE: This is a multicenter, dose-escalation study of temozolomide.
Patients receive oral temozolomide on days 1-5 and oral lomustine on day 1. Treatment continues every 28 days, if blood counts have recovered, for 2 courses in the absence of disease progression or unacceptable toxicity. Patients then undergo radiotherapy on days 1-5 weekly for 6 weeks. Patients continue the same chemotherapy regimen for up to 6 more courses beginning 4 weeks after completion of radiotherapy.
Cohorts of 3-6 patients receive escalating doses of temozolomide until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
Patients are followed for survival.
PROJECTED ACCRUAL: A total of 3-30 patients will be accrued for this study.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Pre and Post radiation Chemotherapy
|
Drug: lomustine
Drug: temozolomide
|
Outcome Measures
Primary Outcome Measures
- Progression Free Survival [Length of study]
This trial is a phase I evaluation of temozolomide in combination with a fixed dose of CCNU with the starting dose for temozolomide
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
-
Histologically confirmed high-grade malignant glioma of one of the following subtypes:
-
Glioblastoma
-
Anaplastic astrocytoma
-
Anaplastic oligoastrocytoma
-
Gliomatosis cerebri
-
No disseminated disease or primary spinal cord malignancies
-
Measurable intracranial residual disease by MRI
PATIENT CHARACTERISTICS:
Age:
-
3 and over
-
Under 22 at time of diagnosis
Performance status:
-
Karnofsky 50-100% if over 10 years of age
-
Lansky 50-100% if 10 years of age or under
Life expectancy:
- At least 8 weeks
Hematopoietic:
-
Absolute neutrophil count at least 1,000/mm^3
-
Platelet count at least 100,000/mm^3 (transfusion independent)
-
Hemoglobin at least 8.0 g/dL (RBC transfusions allowed)
Hepatic:
-
Bilirubin no greater than 1.5 times normal for age
-
SGPT no greater than 2.5 times normal for age
-
Albumin at least 2 g/dL
Renal:
-
Creatinine no greater than 1.5 times normal for age OR
-
Creatinine clearance or radioisotope glomerular filtration rate at least lower limit of normal for age
Pulmonary:
-
No dyspnea at rest
-
No exercise intolerance
-
Pulse oximetry at least 94%
Other:
-
Not pregnant or nursing
-
Negative pregnancy test
-
Fertile patients must use effective contraception
-
No uncontrolled infection
PRIOR CONCURRENT THERAPY:
Biologic therapy:
-
No prior biologic therapy
-
No concurrent prophylactic hematopoietic growth factors
Chemotherapy:
- No prior chemotherapy
Endocrine therapy:
-
Prior corticosteroid therapy allowed
-
No concurrent corticosteroids as antiemetic
Radiotherapy:
- No prior radiotherapy
Surgery:
- No more than 31 days since prior maximal neurosurgical procedure
Other:
- No concurrent phenobarbital or cimetidine
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | University of Alabama at Birmingham Comprehensive Cancer Center | Birmingham | Alabama | United States | 35233 |
2 | University of South Alabama Medical Center | Mobile | Alabama | United States | 36604 |
3 | Phoenix Children's Hospital | Phoenix | Arizona | United States | 85016-7710 |
4 | Arizona Cancer Center | Tucson | Arizona | United States | 85724 |
5 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
6 | Southern California Permanente Medical Group | Downey | California | United States | 90242 |
7 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
8 | Rebecca and John Moores UCSD Cancer Center | La Jolla | California | United States | 92093-0658 |
9 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
10 | Jonathan Jaques Children's Cancer Center | Long Beach | California | United States | 90801-1428 |
11 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027-0700 |
12 | Cedars-Sinai Medical Center | Los Angeles | California | United States | 90048 |
13 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
14 | Children's Hospital Central California | Madera | California | United States | 93638-8762 |
15 | Children's Hospital of Oakland | Oakland | California | United States | 94609-1809 |
16 | Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
17 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
18 | Lucile Packard Children's Hospital at Stanford | Palo Alto | California | United States | 94304 |
19 | Sutter Cancer Center | Sacramento | California | United States | 95816 |
20 | University of California Davis Medical Center | Sacramento | California | United States | 95817 |
21 | Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
22 | Children's Hospital San Diego | San Diego | California | United States | 92123-4282 |
23 | Kaiser Permanente Medical Center - San Francisco Geary Campus | San Francisco | California | United States | 94115 |
24 | UCSF Comprehensive Cancer Center | San Francisco | California | United States | 94143-0128 |
25 | Santa Barbara Cottage Hospital | Santa Barbara | California | United States | 93102 |
26 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051-5386 |
27 | David Grant Medical Center | Travis Air Force Base | California | United States | 94535 |
28 | Children's Hospital of Denver | Denver | Colorado | United States | 80218-1088 |
29 | Childhood Hematology/Oncology Associates | Denver | Colorado | United States | 80218 |
30 | Presbyterian-St Luke's Medical Center | Denver | Colorado | United States | 80218 |
31 | University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-7106 |
32 | Yale Comprehensive Cancer Center | New Haven | Connecticut | United States | 06520-8028 |
33 | Alfred I. Dupont Institute | Wilmington | Delaware | United States | 19899 |
34 | Lombardi Cancer Center | Washington | District of Columbia | United States | 20007 |
35 | Children's National Medical Center | Washington | District of Columbia | United States | 20010-2970 |
36 | Walter Reed Army Medical Center | Washington | District of Columbia | United States | 20307-5000 |
37 | Broward General Medical Center | Fort Lauderdale | Florida | United States | 33316 |
38 | Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
39 | Shands Hospital and Clinics, University of Florida | Gainesville | Florida | United States | 32610-100277 |
40 | Joe DiMaggio Children's Hospital at Memorial | Hollywood | Florida | United States | 33021 |
41 | Nemours Children's Clinic | Jacksonville | Florida | United States | 32207 |
42 | University of Miami-Jackson Memorial Hospital | Miami | Florida | United States | 33136 |
43 | Miami Children's Hospital | Miami | Florida | United States | 33155-4069 |
44 | Baptist Hospital of Miami | Miami | Florida | United States | 33176-2197 |
45 | Florida Hospital Cancer Institute | Orlando | Florida | United States | 32803 |
46 | Nemours Children's Clinic-Orlando | Orlando | Florida | United States | 32806 |
47 | Sacred Heart Children's Hospital | Pensacola | Florida | United States | 32504 |
48 | All Children's Hospital | St. Petersburg | Florida | United States | 33701 |
49 | Tampa Children's Hospital | Tampa | Florida | United States | 33677-4227 |
50 | St. Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
51 | Emory University Hospital - Atlanta | Atlanta | Georgia | United States | 30322 |
52 | Children's Healthcare of Atlanta - Scottish Rite | Atlanta | Georgia | United States | 30342 |
53 | Medical College of Georgia Comprehensive Cancer Center | Augusta | Georgia | United States | 30912-4000 |
54 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
55 | Memorial Health University Medical Center, Inc. | Savannah | Georgia | United States | 31403-3089 |
56 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
57 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
58 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859-5000 |
59 | Mountain States Tumor Institute | Boise | Idaho | United States | 83712 |
60 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60601 |
61 | Rush-Presbyterian-St. Luke's Medical Center | Chicago | Illinois | United States | 60612 |
62 | University of Illinois at Chicago | Chicago | Illinois | United States | 60612 |
63 | Children's Memorial Hospital - Chicago | Chicago | Illinois | United States | 60614 |
64 | Hope Children's Hospital | Oak Lawn | Illinois | United States | 60453 |
65 | Lutheran General Hospital | Park Ridge | Illinois | United States | 60068-1174 |
66 | Saint Jude Midwest Affiliate | Peoria | Illinois | United States | 61637 |
67 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62794-9658 |
68 | Indiana University Cancer Center | Indianapolis | Indiana | United States | 46202-5289 |
69 | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
70 | Raymond Blank Memorial Hospital for Children | Des Moines | Iowa | United States | 50308 |
71 | John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
72 | Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242-1009 |
73 | Wesley Medical Center | Wichita | Kansas | United States | 67214 |
74 | Albert B. Chandler Medical Center, University of Kentucky | Lexington | Kentucky | United States | 40536-0284 |
75 | Kosair Children's Hospital | Louisville | Kentucky | United States | 40202-3830 |
76 | Tulane University School of Medicine | New Orleans | Louisiana | United States | 70112 |
77 | Children's Hospital of New Orleans | New Orleans | Louisiana | United States | 70118 |
78 | Ochsner Clinic | New Orleans | Louisiana | United States | 70121 |
79 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
80 | Maine Children's Cancer Program | Scarborough | Maine | United States | 04074 |
81 | Marlene and Stewart Greenebaum Cancer Center, University of Maryland | Baltimore | Maryland | United States | 21201-1595 |
82 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21225 |
83 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
84 | Floating Hospital for Children | Boston | Massachusetts | United States | 02111 |
85 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
86 | Baystate Medical Center | Springfield | Massachusetts | United States | 01107 |
87 | University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
88 | Mott Children's Hospital | Ann Arbor | Michigan | United States | 48109-0914 |
89 | Children's Hospital of Michigan | Detroit | Michigan | United States | 48201 |
90 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
91 | St. John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
92 | Michigan State University | East Lansing | Michigan | United States | 48824 |
93 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
94 | Spectrum Health and DeVos Children's Hospital | Grand Rapids | Michigan | United States | 49503 |
95 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
96 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
97 | William Beaumont Hospital | Royal Oak | Michigan | United States | 48073-6769 |
98 | St. Mary's/Duluth Clinic Cancer Center | Duluth | Minnesota | United States | 55805-1983 |
99 | Children's Hospitals and Clinics - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
100 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
101 | Children's Hospitals and Clinics of Minnesota | Saint Paul | Minnesota | United States | 55102 |
102 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216-4505 |
103 | Children's Mercy Hospital | Kansas City | Missouri | United States | 64108 |
104 | Cardinal Glennon Children's Hospital | Saint Louis | Missouri | United States | 63104 |
105 | St. Louis Children's Hospital | Saint Louis | Missouri | United States | 63110 |
106 | Children's Hospital of Omaha | Omaha | Nebraska | United States | 68114 |
107 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198-2168 |
108 | Sunrise Hospital and Medical Center | Las Vegas | Nevada | United States | 89109-2306 |
109 | Norris Cotton Cancer Center | Lebanon | New Hampshire | United States | 03756-0002 |
110 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
111 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
112 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112-2094 |
113 | St. Joseph's Hospital and Medical Center | Paterson | New Jersey | United States | 07503 |
114 | Atlantic Health System | Summit | New Jersey | United States | 07901 |
115 | University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | United States | 87131 |
116 | Cancer Center of Albany Medical Center | Albany | New York | United States | 12208 |
117 | Albert Einstein Clinical Cancer Center | Bronx | New York | United States | 10461 |
118 | Brooklyn Hospital Center | Brooklyn | New York | United States | 11201 |
119 | State University of New York Health Science Center at Brooklyn College of Medicine | Brooklyn | New York | United States | 11203 |
120 | Brookdale University Hospital and Medical Center | Brooklyn | New York | United States | 11212 |
121 | Maimonides Medical Center | Brooklyn | New York | United States | 11219 |
122 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
123 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
124 | Schneider Children's Hospital | New Hyde Park | New York | United States | 11042 |
125 | New York Presbyterian Hospital - Cornell Campus | New York | New York | United States | 10021-4885 |
126 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
127 | Mount Sinai School of Medicine | New York | New York | United States | 10029 |
128 | Columbia Presbyterian Hospital | New York | New York | United States | 10032 |
129 | James P. Wilmot Cancer Center | Rochester | New York | United States | 14642 |
130 | State University of New York Health Sciences Center - Stony Brook | Stony Brook | New York | United States | 11790-7775 |
131 | State University of New York - Upstate Medical University | Syracuse | New York | United States | 13210 |
132 | New York Medical College | Valhalla | New York | United States | 10595 |
133 | Mission Saint Joseph's Health System | Asheville | North Carolina | United States | 28801 |
134 | Lineberger Comprehensive Cancer Center, UNC | Chapel Hill | North Carolina | United States | 27599-7295 |
135 | Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
136 | Presbyterian Healthcare | Charlotte | North Carolina | United States | 28233-3549 |
137 | Duke Comprehensive Cancer Center | Durham | North Carolina | United States | 27710 |
138 | East Carolina University School of Medicine | Greenville | North Carolina | United States | 27858-4354 |
139 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1081 |
140 | Dakota Cancer Institute | Fargo | North Dakota | United States | 58103-4940 |
141 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
142 | Children's Hospital Medical Center - Cincinnati | Cincinnati | Ohio | United States | 45229-3039 |
143 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
144 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
145 | Children's Hospital of Columbus | Columbus | Ohio | United States | 43205-2696 |
146 | Children's Medical Center - Dayton | Dayton | Ohio | United States | 45404 |
147 | Toledo Children's Hospital | Toledo | Ohio | United States | 43601 |
148 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
149 | Forum Health-Tod Childrens Hospital | Youngstown | Ohio | United States | 44501 |
150 | Children's Hospital of Oklahoma | Oklahoma City | Oklahoma | United States | 73104 |
151 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
152 | Natalie Warren Bryant Cancer Center | Tulsa | Oklahoma | United States | 74136 |
153 | Doernbecher Children's Hospital | Portland | Oregon | United States | 97201-3098 |
154 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
155 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-1320 |
156 | Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
157 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
158 | St. Christopher's Hospital for Children | Philadelphia | Pennsylvania | United States | 19134-1095 |
159 | Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | United States | 15213 |
160 | Rhode Island Hospital | Providence | Rhode Island | United States | 02818 |
161 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425-0721 |
162 | Palmetto Health South Carolina Cancer Center | Columbia | South Carolina | United States | 29203 |
163 | Children's Hospital of Greenville Hospital System | Greenville | South Carolina | United States | 29605 |
164 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105-1080 |
165 | Sioux Valley Hospital | Sioux Falls | South Dakota | United States | 57117 |
166 | East Tennessee State University Cancer Center at JCMC | Johnson City | Tennessee | United States | 37604 |
167 | East Tennessee Children's Hospital | Knoxville | Tennessee | United States | 37901 |
168 | Saint Jude Children's Research Hospital | Memphis | Tennessee | United States | 38105-2794 |
169 | Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | United States | 37232-6838 |
170 | Texas Tech University Health Sciences Center School of Medicine | Amarillo | Texas | United States | 79106 |
171 | Children's Hospital of Austin | Austin | Texas | United States | 78701 |
172 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
173 | Simmons Cancer Center - Dallas | Dallas | Texas | United States | 75235-9154 |
174 | Cook Children's Medical Center - Fort Worth | Fort Worth | Texas | United States | 76104 |
175 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0361 |
176 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
177 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
178 | San Antonio Military Pediatric Cancer and Blood Disorders Center | Lackland Air Force Base | Texas | United States | 78236-5300 |
179 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
180 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78207 |
181 | Methodist Health Care System | San Antonio | Texas | United States | 78229-3902 |
182 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
183 | Huntsman Cancer Institute | Salt Lake City | Utah | United States | 84112 |
184 | Vermont Cancer Center | Burlington | Vermont | United States | 05401-3498 |
185 | Cancer Center at the University of Virginia | Charlottesville | Virginia | United States | 22908 |
186 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042-3300 |
187 | Children's Hospital of the King's Daughters | Norfolk | Virginia | United States | 23507 |
188 | Naval Medical Center, Portsmouth | Portsmouth | Virginia | United States | 23708-5100 |
189 | Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
190 | Carilion Medical Center for Children | Roanoke | Virginia | United States | 24013 |
191 | Children's Hospital and Regional Medical Center - Seattle | Seattle | Washington | United States | 98105 |
192 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109-1024 |
193 | Group Health Cooperative | Seattle | Washington | United States | 98112 |
194 | Deaconess Medical Center | Spokane | Washington | United States | 99210-0248 |
195 | Mary Bridge Children's Health Center | Tacoma | Washington | United States | 98415-0299 |
196 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431-5000 |
197 | West Virginia University - Charleston | Charleston | West Virginia | United States | 25302 |
198 | Cabell-Huntington Hospital, Inc | Huntington | West Virginia | United States | 25701 |
199 | West Virginia University Hospitals | Morgantown | West Virginia | United States | 26506-9300 |
200 | Bellin Memorial Hospital | Green Bay | Wisconsin | United States | 54301 |
201 | CCOP - St. Vincent Hospital Cancer Center, Green Bay | Green Bay | Wisconsin | United States | 54301 |
202 | St. Vincent Hospital | Green Bay | Wisconsin | United States | 54307-9070 |
203 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
204 | University of Wisconsin Hospital and Clinics | Madison | Wisconsin | United States | 53792-0001 |
205 | Marshfield Clinic | Marshfield | Wisconsin | United States | 54449-5772 |
206 | Midwest Children's Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
207 | Sydney Children's Hospital | Randwick | New South Wales | Australia | 2031 |
208 | Children's Hospital at Westmead | Westmead | New South Wales | Australia | 2145 |
209 | Royal Children's Hospital | Brisbane | Queensland | Australia | 4029 |
210 | Women's and Children's Hospital | North Adelaide | South Australia | Australia | 5006 |
211 | Royal Children's Hospital | Parkville | Victoria | Australia | 3052 |
212 | Princess Margaret Hospital for Children | Perth | Western Australia | Australia | 6001 |
213 | Alberta Children's Hospital | Calgary | Alberta | Canada | T2T 5C7 |
214 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
215 | British Columbia Children's Hospital | Vancouver | British Columbia | Canada | V6H 3V4 |
216 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
217 | Janeway Children's Health and Rehabilitation Centre | St. John's | Newfoundland and Labrador | Canada | A1B 3V6 |
218 | IWK Health Centre | Halifax | Nova Scotia | Canada | B3J 3G9 |
219 | Children's Hospital | Hamilton | Ontario | Canada | L8N 3Z5 |
220 | Children's Hospital of Western Ontario | London | Ontario | Canada | N6C 2V5 |
221 | Children's Hospital of Eastern Ontario | Ottawa | Ontario | Canada | K1H 8L1 |
222 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
223 | McGill University Health Center - Montreal Children's Hospital | Montreal | Quebec | Canada | H3H 1P3 |
224 | Hopital Sainte Justine | Montreal | Quebec | Canada | H3T 1C5 |
225 | Centre Hospitalier de L'Universite Laval | Sainte Foy | Quebec | Canada | GIV 4G2 |
226 | Laval University Medical Center | Sainte-Foy | Quebec | Canada | G1V 4G2 |
227 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
228 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
229 | Academisch Ziekenhuis Groningen | Groningen | Netherlands | 9700 RB | |
230 | Starship Children's Hospital | Auckland | New Zealand | ||
231 | University of Puerto Rico School of Medicine Medical Sciences Campus | San Juan | Puerto Rico | 00936-5067 | |
232 | San Jorge Childrens Hospital | Santurce | Puerto Rico | 00912 | |
233 | Swiss Pediatric Oncology Group Bern | Bern | Switzerland | CH 3010 | |
234 | Swiss Pediatric Oncology Group Geneva | Geneva | Switzerland | CH 1211 | |
235 | Swiss Pediatric Oncology Group Lausanne | Lausanne | Switzerland | CH 1011 |
Sponsors and Collaborators
- Children's Oncology Group
- National Cancer Institute (NCI)
Investigators
- Study Chair: Regina Jakacki, MD, University of Pittsburgh
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ADVL0011
- COG-ADVL0011
- CCG-ADVL0011
- CCG-A0993
- CDR0000068036