Cognitive Rehabilitation in Brain Tumor Patients After Neurosurgery
Study Details
Study Description
Brief Summary
Many patients with primary brain tumors experience cognitive deficits and cognitive rehabilitation programs aim to alleviate these deficits.The cognitive rehabilitation program developed by the investigators proved effective in a large randomized controlled trial (RCT). To increase its accessibility, it was converted into the iPad-based cognitive rehabilitation program ReMind, which incorporates psychoeducation, strategy training and retraining. A pilot study and a randomized controlled trial are conducted, to evaluate the feasibility of the use of the program and the efficacy of the program in brain tumor patients after resective surgery.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Detailed Description
OBJECTIVE: To evaluate the immediate and longer-term effects of early cognitive telerehabilitation on cognitive performance and self-reported symptoms/functioning in patients with low-grade gliomas and meningiomas, in a prospective randomized trial.
HYPOTHESIS: Cognitive telerehabilitation after brain tumor surgery has both immediate and longer-term beneficiary effects on cognitive functioning and patient-reported outcomes.
STUDY DESIGN: In the first 6 months of the project a feasibility study will be conducted to ensure that adherence, patient experience, and potential attrition are acceptable.
Subsequently, a prospective randomized (waiting-list) controlled trial (RCT) will be performed. Information from the feasibility study will be used to modify the RCT when necessary. In the RCT, patients are randomized to early cognitive rehabilitation (3 months after surgery) or to a waiting-list control condition. The waiting-list control group will be offered the same cognitive rehabilitation program after they have undergone all study assessments. Assessment of cognitive performance and self-reported symptoms will be performed prior to surgery (T0), before cognitive rehabilitation (3 months after surgery, T3), immediately after cognitive rehabilitation (6 months after surgery, T6), and at half-year follow up (12 months after surgery, T12).
STUDY POPULATION/SAMPLE SIZE: Patients with presumed low-grade glioma or meningioma, who are scheduled for resective surgery, will be included in the study. Fifteen patients will be invited in feasibility study. Based on the yearly numbers of meningioma and low-grade glioma patients that are operated in the Elisabeth-TweeSteden Hospital Tilburg, it is expected that 60 patients will be randomized in the RCT per year for 2.5 years. With a maximum attrition rate of 33%, a minimum of 100 patients (50 per group) will be evaluated.
INTERVENTION: An evidence-based cognitive rehabilitation program that is provided via a tablet app. The program consists of retraining, and teaching and practicing of compensational strategies of attention, memory and executive functioning. Patients spend 3 hours per week during 2.5 month in this home-based program. They are monitored and supervised by a trainer.
OUTCOME MEASURES: Feasibility (accrual, attrition, adherence, patient experience) will be monitored in the feasibility study.
At several time points during the RCT, patients will be tested with the computerized test battery (for cognition; CNS VS), two additional cognitive tests and several self-report questionnaires. Testing is done prior to surgery, prior to cognitive rehabilitation (3 months), immediately after cognitive rehabilitation (6 months) and at half-year follow up (12 months post-surgery). Questionnaires on self-reported cognitive functioning, psychological symptoms (anxiety and depression), and fatigue will be administered on all assessments; the questionnaires on work status, professional functioning and community integration are administered at baseline and one-year follow-up only.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Early-intervention group Patients follow the evidence-based cognitive rehabilitation program ReMind, which is provided via an iPad. It incorporates psychoeducation, strategy training and retraining. The intervention commenced 3 months after surgery and patients were advised to spend 3 hours per week on the program for 10 weeks. |
Behavioral: The cognitive rehabilitation program ReMind
Cognitive rehabilitation, i.e. psychoeducation, strategy training & retraining
Other Names:
|
| Other: Waiting-list control group The waiting-list control group will be offered the same cognitive rehabilitation program after they have undergone all study assessments one year after surgery. |
Behavioral: The cognitive rehabilitation program ReMind
Cognitive rehabilitation, i.e. psychoeducation, strategy training & retraining
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Change in objective cognitive functioning [3, 6, and 12 months after surgery]
Objective cognitive functioning is measured with the computerized test battery CNS Vital Signs
- Change in working memory [3, 6, and 12 months after surgery]
Working memory is measured with the subtest Digit Span of the the Wechsler Adult Intelligence Scale (WAIS-III)
- Change in word fluency [3, 6, and 12 months after surgery]
Word fluency is measured with the Letter Fluency test
Secondary Outcome Measures
- Change in subjective cognitive functioning [3, 6, and 12 months after surgery]
Subjective cognitive functioning is measured with the Cognitive Failures Questionnaire (CFQ)
- Change in symptoms of fatigue [3, 6, and 12 months after surgery]
Fatigue is measured with the Multidimensional Fatigue Inventory (MFI)
- Change in symptoms of anxiety [3, 6, and 12 months after surgery]
Anxiety is measured with the Hospital Anxiety and Depression Scale (HADS)
- Change in symptoms of depression [3, 6, and 12 months after surgery]
Depression is measured with the Hospital Anxiety and Depression Scale (HADS)
- Change in subjective executive functioning [3, 6, and 12 months after surgery]
Subjective executive functioning is measured with the Behavior Rating Inventory of Executive Function
- Change in professional functioning (1) [One day before surgery vs. 12 months after surgery]
Professional functioning is measured with the Work Ability Index (WAI)
- Change in professional functioning (2) [One day before surgery vs. 12 months after surgery]
Professional functioning is measured with the Work Limitation Questionnaire (WLQ)
- Change in (social) participation [One day before surgery vs. 12 months after surgery]
Participation is measured with the Community Integration Questionnaire (CIQ)
Eligibility Criteria
Criteria
Inclusion Criteria:
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The adult patient has a (supratentorial or infratentorial) brain tumor that is radiologically suspect for either a meningioma or low grade glioma
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The patient will undergo resective surgery for the brain tumor
Exclusion Criteria:
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tumor resection in the last year
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progressive neurological disease
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diagnose of (acute) psychiatric or neurological disorders in the last 2 years
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chemotherapy in the last 2 years
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Karnovsky Performance Scale under 70
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Surgery-related complication (morbidity or mortality e.g., thrombosis or heart attack)
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Lack of basic proficiency in Dutch
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IQ below 85, or (very) low cognitive skills
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Insufficient reading skills/visual impairment (limiting the ability to follow the cognitive rehabilitation program).
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Clinical referral to cognitive rehabilitation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Erasmus Medical Center | Rotterdam | Netherlands | ||
| 2 | Medical Center Haaglanden | The Hague | Netherlands | ||
| 3 | Elisabeth-TweeSteden Hospital | Tilburg | Netherlands | 5022 GC |
Sponsors and Collaborators
- Elisabeth-TweeSteden Ziekenhuis
- Tilburg University
- ZonMw: The Netherlands Organisation for Health Research and Development
- Erasmus Medical Center
- Medical Center Haaglanden
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 842003009