Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)
Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Active, not recruiting
CT.gov ID
NCT00310180
Collaborator
American College of Surgeons (Other), Cancer and Leukemia Group B (Other), NSABP Foundation Inc (Other), NCIC Clinical Trials Group (Other), North Central Cancer Treatment Group (Other), Southwest Oncology Group (Other)
10,273
1231
4
293.8
8.3
0
Study Details
Study Description
Brief Summary
This randomized phase III trial studies the best individual therapy for women who have node-negative, estrogen-receptor positive breast cancer by using a special test (Oncotype DX), and whether hormone therapy alone or hormone therapy together with combination chemotherapy is better for women who have an Oncotype DX recurrence score of 11-25. Estrogen can cause the growth of breast cancer cells. Hormone therapy may fight breast cancer by blocking the use of estrogen by the tumor cells or by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving hormone therapy together with more than one chemotherapy drug (combination chemotherapy) has been shown to reduce the chance of breast cancer recurrence, but the benefit of adding chemotherapy to hormone therapy for women with node-negative, estrogen-receptor positive breast cancer is small. New tests may provide information about which patients are more likely to benefit from chemotherapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVES:
-
To determine whether adjuvant hormonal therapy is not inferior to adjuvant chemohormonal in women whose tumors meet established clinical guidelines for adjuvant chemotherapy and fall in the "primary study group" category (Oncotype DX Recurrence Score 11-25).
-
To create a tissue and specimen bank for patients enrolled in this trial, including formalin fixed paraffin embedded tumor specimens, tissue microarrays, plasma, and deoxyribonucleic acid (DNA) obtained from peripheral blood.
SECONDARY OBJECTIVES:
-
To determine whether adjuvant hormonal therapy is sufficient treatment (i.e. 10 year distant disease-free survival of at least 95%) for women whose tumors meet established clinical guidelines for adjuvant chemotherapy and who fall into the "Secondary Study Group-1" category (Oncotype DX Recurrence Score =< 10).
-
To compare the outcomes projected at 10 years by Adjuvant (with outcomes projected using classical pathologic information including tumor size, hormone receptor status, and histologic grade) with those made by the Genomic Health Oncotype DX test. Classical pathologic information and outcome results will also be used to create and refine models that would use classical information instead of or in combination with genomic tests.
-
To estimate failure rates as a function of recurrence score (RS) separately in the chemotherapy (arms C, D) and no chemotherapy (arms A, B) groups. The purpose of the analysis is to develop more precise estimates of the relationship between recurrence score and chemotherapy treatment effect, if any, at the upper range of the RS 11 - 25 group.
-
To determine the prognostic significance of the Oncotype DX recurrence score and of the individual RS gene groups (proliferation gene group, human epidermal growth factor receptor [HER]2 gene group, estrogen receptor [ER] gene group, invasion gene group, and other genes).
TERTIARY OBJECTIVES:
-
To evaluate the effects of chemotherapy and hormonal therapy vs hormonal therapy alone on perceived cognitive impairment, fatigue, fear of recurrence among pre-menopausal patients, endocrine symptoms and sexual dysfunction, and overall health-related quality of life (HRQL).
-
To determine whether perceived cognitive impairment, fatigue, fear of recurrence, endocrine symptoms, and overall HRQL are similar for patients receiving chemotherapy plus hormonal therapy in secondary study group 2 as for those in the primary study group (arm D vs C).
-
To determine whether perceived cognitive impairment, fatigue, fear of recurrence, endocrine symptoms, and overall HRQL are similar for patients receiving hormonal therapy alone in secondary study group 1 as for those in the primary study group (arms A vs B).
-
To determine whether age will be inversely associated with a fear of recurrence, independent of treatment assignment.
-
Among participants receiving hormonal treatment alone on arm A and arm B, to determine whether Oncotype DX Recurrence score will be inversely correlated with fear of recurrence.
-
To create a biospecimen repository including plasma, serum and CellSearch cassettes containing circulating tumor cells (CTC) for evaluating determinants of late relapse, including candidate biomarkers reflecting occult tumor burden (e.g., CTCs and plasma tumor DNA) and host factors (e.g., estrogen, insulin growth factor-[IGF] axis, inflammation, etc).
-
To create a biorepository of metastatic tumor samples in patients who have had a late relapse.
-
To determine body mass index (BMI) and comorbidity burden in patients with operable breast cancer five or more years after diagnosis.
-
To determine whether there is a relationship between late relapse and BMI at diagnosis and at 5 years after diagnosis, and whether BMI-associated inflammatory and/or metabolic biomarkers are associated with early and late recurrence.
OUTLINE: This is a partially randomized study. Patients are assigned to 1 of 3 treatment groups.
GROUP 1 (SECONDARY STUDY GROUP 1; ONCOTYPE DX RECURRENCE SCORE [ODRS] =< 10): Patients receive standard hormonal therapy (e.g., tamoxifen alone orally (PO), aromatase inhibitor [e.g., anastrozole, letrozole, or exemestane] alone PO, or tamoxifen PO followed by aromatase inhibitor PO) at the discretion of the treating physician for 5 or 10 years.
GROUP 2 (PRIMARY STUDY GROUP; ODRS 11-25): Patients are randomized to receive either hormonal therapy alone or combination chemotherapy and hormonal therapy.
ARM I (EXPERIMENTAL): Patients receive hormonal therapy as in Group 1 at the discretion of the treating physician.
ARM II (STANDARD): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician.
GROUP 3 (SECONDARY STUDY GROUP 2; ODRS >= 26): Patients receive combination chemotherapy as in Group 2, Arm II followed by hormonal therapy as in Group 1.
Patients in all groups who have had breast-conservation surgery are also treated with radiotherapy. Radiotherapy should begin within 4 weeks of registration for patients receiving hormonal therapy alone or within 8 weeks after completion of chemotherapy. Patients participating in National Surgical Adjuvant Breast and Bowel Project (NSABP) and/or Radiation Therapy Oncology Group (RTOG) partial irradiation trial(s) may receive partial breast radiation.
After completion of study treatment, patients are followed up every 3-6 months for 5 years and then annually for 15 years.
Study Design
Study Type:
Interventional
Actual Enrollment
:
10273 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Program for the Assessment of Clinical Cancer Tests (PACCT-1): Trial Assigning Individualized Options for Treatment:The TAILORx Trial
Actual Study Start Date
:
Apr 7, 2006
Actual Primary Completion Date
:
Mar 2, 2018
Anticipated Study Completion Date
:
Sep 30, 2030
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Group 1 (Oncotype DX recurrence score =< 10) Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. |
Drug: Anastrozole
Given PO
Other Names:
Drug: Exemestane
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Letrozole
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Radiation: Radiation Therapy
Undergo radiation therapy or partial breast irradiation
Other Names:
Drug: Tamoxifen Citrate
Given PO
Other Names:
|
| Experimental: Group 2, Arm I (experimental) Patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. |
Drug: Anastrozole
Given PO
Other Names:
Drug: Exemestane
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Letrozole
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Drug: Tamoxifen Citrate
Given PO
Other Names:
|
| Active Comparator: Group 2, Arm II (standard) Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. |
Drug: Anastrozole
Given PO
Other Names:
Drug: Exemestane
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Letrozole
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Radiation: Radiation Therapy
Undergo radiation therapy or partial breast irradiation
Other Names:
Drug: Tamoxifen Citrate
Given PO
Other Names:
|
| Experimental: Group 3 (Oncotype DX recurrence score >= 26) Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in group two who are assigned to receive both types of treatment. |
Drug: Anastrozole
Given PO
Other Names:
Drug: Exemestane
Given PO
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Letrozole
Given PO
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Radiation: Radiation Therapy
Undergo radiation therapy or partial breast irradiation
Other Names:
Drug: Tamoxifen Citrate
Given PO
Other Names:
|
Outcome Measures
Primary Outcome Measures
- 5-year Disease-free Survival [Assessed every 6 months within 5 years from registration and then annually up to 20 years, DFS rate estimated at 5 years]
Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method, and compared between the two randomized arms (arm B vs. arm C) using stratified log rank test and stratified Cox proportional hazard model.
Secondary Outcome Measures
- 5-year Distant Recurrence-free Interval [Assessed every 6 months within 5 years from registration and then annually up to 20 years, DRFI rate estimated at 5 years]
Distant recurrence-free interval (DRFI) is defined as time from date of randomization or registration to the date of distant recurrence of breast cancer, or of death with distant recurrence, if death is the first manifestation of distant recurrence. The distribution of DRFI (eg, 5-year DRFI rate) is estimated using Kaplan-Meier method.
- 5-year Recurrence-free Interval [Assessed every 6 months within 5 years from registration and then annually up to 20 years, RFS rate estimated at 5 years]
Recurrence-free interval (RFS) is defined as time from date of randomization or registration to the date of first recurrence of breast cancer (ipsilateral breast tumor recurrence, local/regional recurrence, distant recurrence) or to the date of death with recurrence, if death is the first manifestation of recurrence. The distribution of RFS (eg, 5-year RFS rate) is estimated using Kaplan-Meier method.
- 5-year Overall Survival [Assessed every 6 months within 5 years from registration and then annually up to 20 years, OS rate estimated at 5 years]
Overall survival (OS) is defined as time from date of randomization or registration to date of death from any cause. The distribution of OS (eg, 5-year OS rate) is estimated using Kaplan-Meier method.
- 5-year Disease-free Survival by Age and Recurrence Score Groups [Assessed every 6 months within 5 years from registration and then annually up to 20 years, DFS rate estimated at 5 years]
Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. DFS is evaluated by recurrence score (0-10 vs. 11-15 vs. 16-20 vs. 21-25 vs. >25) and age groups (<=50 vs. 51-65 vs. 65-75). The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method.
- To Compare the Outcomes Projected at 10 Years by Adjuvant! With Those Made by the Genomic Health Oncotype DX Test [Assessed at 10 years after study entry]
Adjuvant! is not currently available; additional work combining classical information with genomic tests will be reported separately.
- 5-year Disease-free Survival by Individual RS Gene Groups [Assessed every 6 months within 5 years from registration and then annually up to 20 years]
Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method. 5-year DFS by individual RS gene groups (Proliferation Gene Group, HER2 Gene Group, ER Gene Group, Invasion Gene Group, and Other Genes) will be estimated in each arm.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 75 Years
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Patients with operable histologically confirmed adenocarcinoma of the female breast who have completed primary surgical treatment and meet the following criteria:
-
ER and/or progesterone receptor (PR)-positive: Estrogen and/or progesterone receptor positive disease (as defined by local pathology laboratory)
-
Negative axillary nodes: As assessed by a sentinel lymph node biopsy, an axillary dissection, or both, and as defined by the Sixth Edition of the American Joint Committee on Cancer (AJCC) staging criteria
-
Tumor size 1.1-5.0 cm (or 5 mm-1.0 cm plus unfavorable histological features):
-
Unfavorable features defined as intermediate or poor nuclear and/or histologic grade, or lymphovascular invasion
-
NOTE: Definition of tumor size: The tumor size used for determination of eligibility is the pathologic tumor size, which is usually determined by the size of the tumor as measured by inspection of the gross specimen; if the tumor size is measured microscopically and the tumor includes ductal carcinoma in-situ, the measurement should include only the invasive component of the tumor
-
The tumor must be human epidermal growth factor receptor 2 (Her2)/neu negative by either fluorescent in-situ hybridization (FISH) or immunohistochemistry (e.g. 0 or 1+ by DAKO Herceptest)
-
The patient and physician must be agreeable to initiate standard chemotherapy and hormonal therapy as adjuvant therapy
-
A tissue specimen from the primary breast cancer has been located and is ready to be shipped to the appropriate laboratory after consent is obtained and within 3 days following pre-registration; NOTE: For determination of the Oncotype Recurrence Score, tissue must be shipped to Genomic Health; if the Oncotype DX Recurrence Score was previously performed by Genomic Health (prior to pre-registration), tissue must be submitted to the Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility upon randomization
-
Leukocyte count >= 3500/mm^3
-
Platelets >= 100,000/mm^3
-
Serum creatinine =< 1.5 mg/dL
-
Serum aspartate transaminase (AST) that is =< 3-fold the upper institutional limits of normal
-
Patients must be disease-free of prior invasive malignancies for >= 5 years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix; patients with a previous ipsilateral or contralateral invasive breast cancer, or with bilateral synchronous cancers, are not eligible; patients with previous ipsilateral or contralateral ductal in situ carcinoma (DCIS) are not eligible
-
Prior treatment
-
Mandatory prior surgery criteria:
-
Patient must pre-register within 84 days from the final surgical procedure required to adequately treat the primary tumor (please note that if margins are not clear and a resection has to be conducted after pre-registration but before randomization, the patient will be deemed to be within the 84 day window allowed by protocol and therefore eligible)
-
All tumors should be removed by either a mastectomy or local excision plus an acceptable axillary procedure (i.e., sentinel lymph node biopsy, axillary dissection, or both); there must be adequate (at least 1 mm if margin width specified) tumor-free margins of resection (for invasive and ductal carcinoma in-situ) in order for the patients to be eligible; patients with lobular carcinoma in-situ involving the resection margins are eligible
-
Criteria re: other prior treatments:
-
No prior chemotherapy for this malignancy
-
No prior radiation therapy for this malignancy; this includes no prior MammoSite Brachytherapy radiation therapy (RT)
-
Hormonal therapy: Patients who develop breast cancer while receiving a selective estrogen-receptor modulator (SERM; e.g., tamoxifen, toremifene, raloxifene) or an aromatase inhibitor (e.g., anastrazole, letrozole, exemestane) for breast cancer prevention or a SERM for other indications (e.g., raloxifene for osteoporosis) are not eligible; however, patients may have received up to 8 weeks of a SERM or aromatase inhibitor for this malignancy and still be eligible for study entry
-
Patients must have an anticipated life expectancy of at least 10 years
-
Patients with the following medical conditions should not be enrolled on the study:
-
Chronic obstructive pulmonary disease requiring treatment
-
Chronic liver disease (e.g., cirrhosis, chronic active hepatitis)
-
Previous history of a cerebrovascular accident
-
History of congestive heart failure or other cardiac disease that would represent a contraindication to the use of an anthracycline (e.g., doxorubicin or epirubicin)
-
Chronic psychiatric condition or other condition that would impair compliance with the treatment regimen
-
Women must not be pregnant or breast-feeding; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to pre-registration to rule out pregnancy
-
Women of childbearing potential must be strongly advised to utilize an accepted and effective form of non-hormonal contraception (e.g. intrauterine device, condoms, diaphragm, abstinence)
-
Patients must not have previously had the Oncotype DX Assay performed, with the exception of patients who have had the assay performed and have a recurrence score of 11-25
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Northeast Alabama Regional Medical Center | Anniston | Alabama | United States | 36202 |
| 2 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 3 | Mobile Infirmary Medical Center | Mobile | Alabama | United States | 36607 |
| 4 | Providence Hospital | Mobile | Alabama | United States | 36608 |
| 5 | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | United States | 36688 |
| 6 | Alaska Regional Hospital | Anchorage | Alaska | United States | 99508 |
| 7 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 8 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 9 | Banner Thunderbird Medical Center | Glendale | Arizona | United States | 85306 |
| 10 | Banner Desert Medical Center | Mesa | Arizona | United States | 85202 |
| 11 | Banner Baywood Medical Center | Mesa | Arizona | United States | 85206 |
| 12 | Banner-University Medical Center Phoenix | Phoenix | Arizona | United States | 85006 |
| 13 | Western Regional CCOP | Phoenix | Arizona | United States | 85006 |
| 14 | Virginia G Piper Cancer Care-Del Camino | Scottsdale | Arizona | United States | 85258 |
| 15 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 16 | Sparks Regional Medical Center | Fort Smith | Arkansas | United States | 72901 |
| 17 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 18 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 19 | NEA Baptist Memorial Hospital | Jonesboro | Arkansas | United States | 72401 |
| 20 | Saint Bernards Regional Medical Center | Jonesboro | Arkansas | United States | 72401 |
| 21 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 22 | Arroyo Grande Community | Arroyo Grande | California | United States | 93420 |
| 23 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 24 | Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | United States | 94704 |
| 25 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 26 | Mills-Peninsula Medical Center | Burlingame | California | United States | 94010 |
| 27 | East Bay Radiation Oncology Center | Castro Valley | California | United States | 94546 |
| 28 | Eden Hospital Medical Center | Castro Valley | California | United States | 94546 |
| 29 | Valley Medical Oncology Consultants-Castro Valley | Castro Valley | California | United States | 94546 |
| 30 | Enloe Medical Center | Chico | California | United States | 95926 |
| 31 | Community Cancer Institute | Clovis | California | United States | 93611 |
| 32 | John Muir Medical Center-Concord Campus | Concord | California | United States | 94520 |
| 33 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 34 | Bay Area Breast Surgeons Inc | Emeryville | California | United States | 94608 |
| 35 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 36 | Valley Medical Oncology Consultants-Fremont | Fremont | California | United States | 94538 |
| 37 | Washington Hospital | Fremont | California | United States | 94538 |
| 38 | California Cancer Associates for Research and Excellence (cCare) | Fresno | California | United States | 93720 |
| 39 | Saint Jude Medical Center | Fullerton | California | United States | 92835 |
| 40 | Glendale Memorial Hospital and Health Center | Glendale | California | United States | 91204 |
| 41 | Marin Cancer Care Inc | Greenbrae | California | United States | 94904 |
| 42 | Marin General Hospital | Greenbrae | California | United States | 94904 |
| 43 | Saint Rose Hospital | Hayward | California | United States | 94545 |
| 44 | Scripps Green Hospital | La Jolla | California | United States | 92037 |
| 45 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 46 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 47 | Long Beach Memorial Medical Center-Todd Cancer Institute | Long Beach | California | United States | 90806 |
| 48 | USC / Norris Comprehensive Cancer Center | Los Angeles | California | United States | 90033 |
| 49 | UCLA / Jonsson Comprehensive Cancer Center | Los Angeles | California | United States | 90095 |
| 50 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 51 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 52 | Providence Holy Cross Medical Center | Mission Hills | California | United States | 91346-9600 |
| 53 | Memorial Medical Center | Modesto | California | United States | 95355 |
| 54 | Community Hospital of Monterey Peninsula | Monterey | California | United States | 93940 |
| 55 | Palo Alto Medical Foundation-Camino Division | Mountain View | California | United States | 94040 |
| 56 | Northridge Hospital Medical Center | Northridge | California | United States | 91325 |
| 57 | Sutter Cancer Research Consortium | Novato | California | United States | 94945 |
| 58 | Highland General Hospital | Oakland | California | United States | 94602 |
| 59 | Alta Bates Summit Medical Center - Summit Campus | Oakland | California | United States | 94609 |
| 60 | Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 61 | Hematology and Oncology Associates-Oakland | Oakland | California | United States | 94609 |
| 62 | Tom K Lee Inc | Oakland | California | United States | 94609 |
| 63 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 64 | Saint Joseph Hospital - Orange | Orange | California | United States | 92868 |
| 65 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 66 | Desert Regional Medical Center | Palm Springs | California | United States | 92262 |
| 67 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
| 68 | Valley Care Health System - Pleasanton | Pleasanton | California | United States | 94588 |
| 69 | Valley Medical Oncology Consultants | Pleasanton | California | United States | 94588 |
| 70 | Pomona Valley Hospital Medical Center | Pomona | California | United States | 91767 |
| 71 | Mercy Regional Cancer Center | Redding | California | United States | 96001 |
| 72 | Kaiser Permanente-Redwood City | Redwood City | California | United States | 94063 |
| 73 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 74 | Kaiser Permanente-Roseville | Roseville | California | United States | 95661 |
| 75 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 76 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 77 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 78 | Mercy General Hospital | Sacramento | California | United States | 95819 |
| 79 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 80 | Kaiser Permanente - Sacramento | Sacramento | California | United States | 95825 |
| 81 | Salinas Valley Memorial | Salinas | California | United States | 93901 |
| 82 | UC San Diego Medical Center - Hillcrest | San Diego | California | United States | 92103 |
| 83 | Kaiser Permanente-San Diego Mission | San Diego | California | United States | 92108 |
| 84 | Sharp Memorial Hospital | San Diego | California | United States | 92123 |
| 85 | Naval Medical Center -San Diego | San Diego | California | United States | 92134 |
| 86 | San Diego VA Medical Center | San Diego | California | United States | 92161 |
| 87 | Zuckerberg San Francisco General Hospital | San Francisco | California | United States | 94110 |
| 88 | California Pacific Medical Center-Pacific Campus | San Francisco | California | United States | 94115 |
| 89 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 90 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 91 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 92 | Doctors Medical Center- JC Robinson Regional Cancer Center | San Pablo | California | United States | 94806 |
| 93 | Kaiser Permanente-San Rafael | San Rafael | California | United States | 94903 |
| 94 | Breastlink Medical Group Inc | Santa Ana | California | United States | 92705 |
| 95 | Cancer Center of Santa Barbara | Santa Barbara | California | United States | 93105 |
| 96 | Ridley-Tree Cancer Center | Santa Barbara | California | United States | 93105 |
| 97 | Sansum Clinic Inc | Santa Barbara | California | United States | 93105 |
| 98 | Ray, Margaret, Savage. M.D. (UIA Investigator) | Santa Barbara | California | United States | 93111 |
| 99 | Kaiser Permanente Medical Center - Santa Clara | Santa Clara | California | United States | 95051 |
| 100 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 101 | Providence Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95405 |
| 102 | Ridley-Tree Cancer Center-Solvang | Solvang | California | United States | 93463 |
| 103 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 104 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 105 | Olive View-University of California Los Angeles Medical Center | Sylmar | California | United States | 91342 |
| 106 | Torrance Memorial Medical Center | Torrance | California | United States | 90509 |
| 107 | Emanuel Medical Center | Turlock | California | United States | 95382 |
| 108 | Northbay Cancer Center | Vacaville | California | United States | 95687 |
| 109 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 110 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 111 | Sutter Solano Medical Center/Cancer Center | Vallejo | California | United States | 94589 |
| 112 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 113 | John Muir Medical Center-Walnut Creek | Walnut Creek | California | United States | 94598 |
| 114 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
| 115 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 116 | Rocky Mountain Regional VA Medical Center | Aurora | Colorado | United States | 80045 |
| 117 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 118 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 119 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 120 | UCHealth Memorial Hospital Central | Colorado Springs | Colorado | United States | 80909 |
| 121 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 122 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 123 | University of Colorado | Denver | Colorado | United States | 80217-3364 |
| 124 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 125 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 126 | Rose Medical Center | Denver | Colorado | United States | 80220 |
| 127 | Western States Cancer Research NCORP | Denver | Colorado | United States | 80222 |
| 128 | Shaw Cancer Center | Edwards | Colorado | United States | 81632 |
| 129 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 130 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 131 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 132 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 133 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 134 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 135 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 136 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 137 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 138 | Montrose Memorial Hospital | Montrose | Colorado | United States | 81401 |
| 139 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 140 | North Suburban Medical Center | Thornton | Colorado | United States | 80229 |
| 141 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 142 | Hartford HealthCare - Saint Vincent's Medical Center | Bridgeport | Connecticut | United States | 06606 |
| 143 | Bridgeport Hospital | Bridgeport | Connecticut | United States | 06610 |
| 144 | Danbury Hospital | Danbury | Connecticut | United States | 06810 |
| 145 | University of Connecticut | Farmington | Connecticut | United States | 06030 |
| 146 | Greenwich Hospital | Greenwich | Connecticut | United States | 06830 |
| 147 | Hartford Hospital | Hartford | Connecticut | United States | 06102 |
| 148 | Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | United States | 06105 |
| 149 | Manchester Memorial Hospital | Manchester | Connecticut | United States | 06040 |
| 150 | Middlesex Hospital | Middletown | Connecticut | United States | 06457 |
| 151 | The Hospital of Central Connecticut | New Britain | Connecticut | United States | 06050 |
| 152 | Yale-New Haven Hospital Saint Raphael Campus | New Haven | Connecticut | United States | 06511 |
| 153 | Yale University | New Haven | Connecticut | United States | 06520 |
| 154 | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | United States | 06360 |
| 155 | Stamford Hospital/Bennett Cancer Center | Stamford | Connecticut | United States | 06904 |
| 156 | Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | United States | 06790 |
| 157 | Harold Leever Regional Cancer Center | Waterbury | Connecticut | United States | 06708 |
| 158 | Bayhealth Hospital Kent Campus | Dover | Delaware | United States | 19901 |
| 159 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 160 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 161 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 162 | MedStar Washington Hospital Center | Washington | District of Columbia | United States | 20010 |
| 163 | Sibley Memorial Hospital | Washington | District of Columbia | United States | 20016 |
| 164 | George Washington University Medical Center | Washington | District of Columbia | United States | 20037 |
| 165 | Lynn Regional Cancer Center - West | Boca Raton | Florida | United States | 33428 |
| 166 | Boca Raton Comprehensive Cancer Center | Boca Raton | Florida | United States | 33486 |
| 167 | Boca Raton Regional Hospital | Boca Raton | Florida | United States | 33486 |
| 168 | Halifax Health Medical Center-Centers for Oncology | Daytona Beach | Florida | United States | 32114 |
| 169 | Broward Health North | Deerfield Beach | Florida | United States | 33064 |
| 170 | Holy Cross Hospital | Fort Lauderdale | Florida | United States | 33308 |
| 171 | Broward Health Medical Center | Fort Lauderdale | Florida | United States | 33316 |
| 172 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 173 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 174 | Saint Vincent's Medical Center | Jacksonville | Florida | United States | 32204 |
| 175 | Baptist MD Anderson Cancer Center | Jacksonville | Florida | United States | 32207 |
| 176 | Mayo Clinic in Florida | Jacksonville | Florida | United States | 32224-9980 |
| 177 | Jupiter Medical Center | Jupiter | Florida | United States | 33458 |
| 178 | Lakeland Regional Health Hollis Cancer Center | Lakeland | Florida | United States | 33805 |
| 179 | The Watson Clinic | Lakeland | Florida | United States | 33805 |
| 180 | Cancer Centers of Central Florida PA | Leesburg | Florida | United States | 34788 |
| 181 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 182 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 183 | Miami Cancer Institute | Miami | Florida | United States | 33176 |
| 184 | 21st Century Oncology-Orange Park | Orange Park | Florida | United States | 32073 |
| 185 | AdventHealth Orlando | Orlando | Florida | United States | 32803 |
| 186 | Orlando Health Cancer Institute | Orlando | Florida | United States | 32806 |
| 187 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 188 | Florida Cancer Specialists - Sarasota Downtown | Sarasota | Florida | United States | 34236 |
| 189 | Martin Medical Center | Stuart | Florida | United States | 34994 |
| 190 | Robert and Carol Weissman Cancer Center at Martin Health | Stuart | Florida | United States | 34994 |
| 191 | Martin Hospital South | Stuart | Florida | United States | 34997 |
| 192 | Space Coast Cancer Centers-Titusville | Titusville | Florida | United States | 32796 |
| 193 | Cleveland Clinic-Weston | Weston | Florida | United States | 33331 |
| 194 | Phoebe Putney Memorial Hospital | Albany | Georgia | United States | 31701 |
| 195 | University Cancer and Blood Center LLC | Athens | Georgia | United States | 30607 |
| 196 | Grady Health System | Atlanta | Georgia | United States | 30303 |
| 197 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 198 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 199 | Atlanta Regional CCOP | Atlanta | Georgia | United States | 30342 |
| 200 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 201 | Northside Hospital | Atlanta | Georgia | United States | 30342 |
| 202 | Augusta Oncology Associates PC-D'Antignac | Augusta | Georgia | United States | 30901 |
| 203 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 204 | WellStar Cobb Hospital | Austell | Georgia | United States | 30106 |
| 205 | John B Amos Cancer Center | Columbus | Georgia | United States | 31904 |
| 206 | Dekalb Medical Center | Decatur | Georgia | United States | 30033 |
| 207 | Northeast Georgia Medical Center-Gainesville | Gainesville | Georgia | United States | 30501 |
| 208 | Northside Hospital - Gwinnett | Lawrenceville | Georgia | United States | 30046 |
| 209 | Medical Center of Central Georgia | Macon | Georgia | United States | 31201 |
| 210 | Wellstar Kennestone Hospital | Marietta | Georgia | United States | 30060 |
| 211 | Southern Regional Medical Center | Riverdale | Georgia | United States | 30274 |
| 212 | Harbin Clinic Medical Oncology and Clinical Research | Rome | Georgia | United States | 30165 |
| 213 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 214 | Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 215 | South Georgia Medical Center/Pearlman Cancer Center | Valdosta | Georgia | United States | 31602 |
| 216 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 217 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 218 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 219 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 220 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 221 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 222 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 223 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 224 | Tripler Army Medical Center | Honolulu | Hawaii | United States | 96859 |
| 225 | Maui Memorial Medical Center | Wailuku | Hawaii | United States | 96793 |
| 226 | Pacific Cancer Institute of Maui | Wailuku | Hawaii | United States | 96793 |
| 227 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 228 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 229 | Portneuf Medical Center | Pocatello | Idaho | United States | 83201 |
| 230 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 231 | Saint Anthony's Health | Alton | Illinois | United States | 62002 |
| 232 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 233 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 234 | Saint Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 235 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 236 | Graham Hospital Association | Canton | Illinois | United States | 61520 |
| 237 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 238 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 239 | Memorial Hospital | Carthage | Illinois | United States | 62321 |
| 240 | Mount Sinai Hospital Medical Center | Chicago | Illinois | United States | 60608 |
| 241 | Hematology and Oncology Associates | Chicago | Illinois | United States | 60611 |
| 242 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 243 | John H Stroger Jr Hospital of Cook County | Chicago | Illinois | United States | 60612 |
| 244 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 245 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 246 | Mercy Hospital and Medical Center | Chicago | Illinois | United States | 60616 |
| 247 | Swedish Covenant Hospital | Chicago | Illinois | United States | 60625 |
| 248 | Presence Resurrection Medical Center | Chicago | Illinois | United States | 60631 |
| 249 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 250 | Weiss Memorial Hospital | Chicago | Illinois | United States | 60640 |
| 251 | Advocate Illinois Masonic Medical Center | Chicago | Illinois | United States | 60657 |
| 252 | UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital | Chicago | Illinois | United States | 60657 |
| 253 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 254 | Heartland Cancer Research NCORP | Decatur | Illinois | United States | 62526 |
| 255 | AMITA Health Alexian Brothers Medical Center | Elk Grove Village | Illinois | United States | 60007 |
| 256 | Elmhurst Memorial Hospital | Elmhurst | Illinois | United States | 60126 |
| 257 | Eureka Hospital | Eureka | Illinois | United States | 61530 |
| 258 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 259 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 260 | Saint Francis Hospital | Evanston | Illinois | United States | 60202 |
| 261 | Galesburg Cottage Hospital | Galesburg | Illinois | United States | 61401 |
| 262 | Illinois CancerCare-Cottage | Galesburg | Illinois | United States | 61401 |
| 263 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 264 | LaGrange Oncology Associates | Geneva | Illinois | United States | 60134 |
| 265 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 266 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 267 | Illinois CancerCare-Havana | Havana | Illinois | United States | 62644 |
| 268 | Mason District Hospital | Havana | Illinois | United States | 62644 |
| 269 | Hinsdale Hematology Oncology Associates Incorporated | Hinsdale | Illinois | United States | 60521 |
| 270 | Hopedale Medical Complex - Hospital | Hopedale | Illinois | United States | 61747 |
| 271 | Midwest Center for Hematology Oncology | Joliet | Illinois | United States | 60432 |
| 272 | Duly Health and Care Joliet | Joliet | Illinois | United States | 60435 |
| 273 | Presence Saint Mary's Hospital | Kankakee | Illinois | United States | 60901 |
| 274 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 275 | Kewanee Hospital | Kewanee | Illinois | United States | 61443 |
| 276 | AMITA Health Adventist Medical Center | La Grange | Illinois | United States | 60525 |
| 277 | AMG Libertyville - Oncology | Libertyville | Illinois | United States | 60048 |
| 278 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 279 | Mcdonough District Hospital | Macomb | Illinois | United States | 61455 |
| 280 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 281 | Garneau, Stewart C MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 282 | Porubcin, Michael MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 283 | Sharis, Christine M MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 284 | Stoffel, Thomas J MD (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 285 | Trinity Medical Center | Moline | Illinois | United States | 61265 |
| 286 | Vigliotti, Antonio, P.G. M.D. (UIA Investigator) | Moline | Illinois | United States | 61265 |
| 287 | Holy Family Medical Center | Monmouth | Illinois | United States | 61462 |
| 288 | Illinois CancerCare-Monmouth | Monmouth | Illinois | United States | 61462 |
| 289 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 290 | Edward Hospital/Cancer Center | Naperville | Illinois | United States | 60540 |
| 291 | Illinois Cancer Specialists-Niles | Niles | Illinois | United States | 60714 |
| 292 | Bromenn Regional Medical Center | Normal | Illinois | United States | 61761 |
| 293 | Carle Cancer Institute Normal | Normal | Illinois | United States | 61761 |
| 294 | Illinois CancerCare-Community Cancer Center | Normal | Illinois | United States | 61761 |
| 295 | Mid-Illinois Hematology Oncology Associates Limited | Normal | Illinois | United States | 61761 |
| 296 | Advocate Christ Medical Center | Oak Lawn | Illinois | United States | 60453-2699 |
| 297 | Franciscan St. James Health-Olympia Fields Campus | Olympia Fields | Illinois | United States | 60461 |
| 298 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 299 | Ottawa Regional Hospital and Healthcare Center | Ottawa | Illinois | United States | 61350 |
| 300 | Advocate Lutheran General Hospital | Park Ridge | Illinois | United States | 60068 |
| 301 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 302 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 303 | Pekin Hospital | Pekin | Illinois | United States | 61554 |
| 304 | Proctor Hospital | Peoria | Illinois | United States | 61614 |
| 305 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 306 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 307 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 308 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 309 | Illinois Valley Hospital | Peru | Illinois | United States | 61354 |
| 310 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 311 | Perry Memorial Hospital | Princeton | Illinois | United States | 61356 |
| 312 | West Suburban Medical Center | River Forest | Illinois | United States | 60305 |
| 313 | Swedish American Hospital | Rockford | Illinois | United States | 61104 |
| 314 | OSF Saint Anthony Medical Center | Rockford | Illinois | United States | 61108 |
| 315 | Edward H Kaplan MD and Associates | Skokie | Illinois | United States | 60076 |
| 316 | Hematology Oncology Associates of Illinois - Skokie | Skokie | Illinois | United States | 60076 |
| 317 | Midwest Cancer Research Group Incorporated | Skokie | Illinois | United States | 60077 |
| 318 | Illinois CancerCare-Spring Valley | Spring Valley | Illinois | United States | 61362 |
| 319 | Saint Margaret's Hospital | Spring Valley | Illinois | United States | 61362 |
| 320 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 321 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 322 | Northwestern Medicine Central DuPage Hospital | Winfield | Illinois | United States | 60190 |
| 323 | Saint Vincent Anderson Regional Hospital/Cancer Center | Anderson | Indiana | United States | 46016 |
| 324 | Franciscan Saint Francis Health-Beech Grove | Beech Grove | Indiana | United States | 46107 |
| 325 | IU Health Bloomington | Bloomington | Indiana | United States | 47403 |
| 326 | Elkhart Clinic | Elkhart | Indiana | United States | 46514-2098 |
| 327 | Elkhart General Hospital | Elkhart | Indiana | United States | 46515 |
| 328 | Fort Wayne Medical Oncology and Hematology Inc-Parkview | Fort Wayne | Indiana | United States | 46845 |
| 329 | Goshen Center for Cancer Care | Goshen | Indiana | United States | 46526 |
| 330 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 331 | Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | United States | 46202 |
| 332 | Community Cancer Center East | Indianapolis | Indiana | United States | 46219 |
| 333 | Franciscan Health Indianapolis | Indianapolis | Indiana | United States | 46237 |
| 334 | Community Cancer Center North | Indianapolis | Indiana | United States | 46256 |
| 335 | Saint Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
| 336 | Community Howard Regional Health | Kokomo | Indiana | United States | 46904 |
| 337 | IU Health La Porte Hospital | La Porte | Indiana | United States | 46350 |
| 338 | IU Health Arnett Cancer Care | Lafayette | Indiana | United States | 47904 |
| 339 | Horizon Oncology Research LLC | Lafayette | Indiana | United States | 47905 |
| 340 | Premier Oncology Hematology Associates | Merrillville | Indiana | United States | 46410 |
| 341 | Franciscan Saint Anthony Health-Michigan City | Michigan City | Indiana | United States | 46360 |
| 342 | Saint Joseph Regional Medical Center-Mishawaka | Mishawaka | Indiana | United States | 46545 |
| 343 | IU Health Ball Memorial Hospital | Muncie | Indiana | United States | 47303 |
| 344 | The Community Hospital | Munster | Indiana | United States | 46321 |
| 345 | Reid Health | Richmond | Indiana | United States | 47374 |
| 346 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 347 | Michiana Hematology Oncology PC-South Bend | South Bend | Indiana | United States | 46601 |
| 348 | South Bend Clinic | South Bend | Indiana | United States | 46617 |
| 349 | Northern Indiana Cancer Research Consortium | South Bend | Indiana | United States | 46628 |
| 350 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 351 | Constantinou, Costas L MD (UIA Investigator) | Bettendorf | Iowa | United States | 52722 |
| 352 | University of Iowa Healthcare Cancer Services Quad Cities | Bettendorf | Iowa | United States | 52722 |
| 353 | Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa | United States | 52402 |
| 354 | Saint Luke's Hospital | Cedar Rapids | Iowa | United States | 52402 |
| 355 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 356 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 357 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 358 | Heartland Oncology and Hematology LLP | Council Bluffs | Iowa | United States | 51503 |
| 359 | Genesis Medical Center - East Campus | Davenport | Iowa | United States | 52803 |
| 360 | Genesis Cancer Care Institute | Davenport | Iowa | United States | 52804 |
| 361 | Mercy Capitol | Des Moines | Iowa | United States | 50307 |
| 362 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 363 | Iowa-Wide Oncology Research Coalition NCORP | Des Moines | Iowa | United States | 50309 |
| 364 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 365 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 366 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 367 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 368 | Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 369 | Medical Associates Clinic PC | Dubuque | Iowa | United States | 52001 |
| 370 | Mercy Medical Center - North Iowa | Mason City | Iowa | United States | 50401 |
| 371 | Ottumwa Regional Health Center | Ottumwa | Iowa | United States | 52501 |
| 372 | Siouxland Regional Cancer Center | Sioux City | Iowa | United States | 51101 |
| 373 | Mercy Medical Center-Sioux City | Sioux City | Iowa | United States | 51102 |
| 374 | Saint Luke's Regional Medical Center | Sioux City | Iowa | United States | 51104 |
| 375 | Cedar Valley Medical Specialists | Waterloo | Iowa | United States | 50701 |
| 376 | MercyOne Waterloo Medical Center | Waterloo | Iowa | United States | 50702 |
| 377 | Cancer Center of Kansas - Chanute | Chanute | Kansas | United States | 66720 |
| 378 | Cancer Center of Kansas - Dodge City | Dodge City | Kansas | United States | 67801 |
| 379 | Cancer Center of Kansas - El Dorado | El Dorado | Kansas | United States | 67042 |
| 380 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 381 | Providence Medical Center | Kansas City | Kansas | United States | 66112 |
| 382 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 383 | Cancer Center of Kansas-Kingman | Kingman | Kansas | United States | 67068 |
| 384 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 385 | Southwest Medical Center | Liberal | Kansas | United States | 67901 |
| 386 | Cancer Center of Kansas-Liberal | Liberal | Kansas | United States | 67905 |
| 387 | Cancer Center of Kansas - Newton | Newton | Kansas | United States | 67114 |
| 388 | Olathe Cancer Center | Olathe | Kansas | United States | 66061 |
| 389 | Olathe Health Cancer Center | Olathe | Kansas | United States | 66061 |
| 390 | Menorah Medical Center | Overland Park | Kansas | United States | 66209 |
| 391 | Radiation Oncology Practice Corporation Southwest | Overland Park | Kansas | United States | 66210 |
| 392 | Saint Luke's South Hospital | Overland Park | Kansas | United States | 66213 |
| 393 | Cancer Center of Kansas - Parsons | Parsons | Kansas | United States | 67357 |
| 394 | Kansas City NCI Community Oncology Research Program | Prairie Village | Kansas | United States | 66208 |
| 395 | Cancer Center of Kansas - Pratt | Pratt | Kansas | United States | 67124 |
| 396 | Cancer Center of Kansas - Salina | Salina | Kansas | United States | 67401 |
| 397 | Salina Regional Health Center | Salina | Kansas | United States | 67401 |
| 398 | Advent Health - Shawnee Mission Medical Center | Shawnee Mission | Kansas | United States | 66204 |
| 399 | Cotton O'Neil Cancer Center / Stormont Vail Health | Topeka | Kansas | United States | 66606 |
| 400 | University of Kansas Health System Saint Francis Campus | Topeka | Kansas | United States | 66606 |
| 401 | Cancer Center of Kansas - Wellington | Wellington | Kansas | United States | 67152 |
| 402 | Associates In Womens Health | Wichita | Kansas | United States | 67208 |
| 403 | Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 404 | Ascension Via Christi Hospitals Wichita | Wichita | Kansas | United States | 67214 |
| 405 | Cancer Center of Kansas - Wichita | Wichita | Kansas | United States | 67214 |
| 406 | Wichita NCI Community Oncology Research Program | Wichita | Kansas | United States | 67214 |
| 407 | Cancer Center of Kansas - Winfield | Winfield | Kansas | United States | 67156 |
| 408 | King's Daughter's Medical Center | Ashland | Kentucky | United States | 41101 |
| 409 | Our Lady Bellefonte Hospital | Ashland | Kentucky | United States | 41101 |
| 410 | Baptist Health Lexington | Lexington | Kentucky | United States | 40503 |
| 411 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 412 | The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 413 | Baptist Health Louisville | Louisville | Kentucky | United States | 40207 |
| 414 | Baptist Health Madisonville/Merle Mahr Cancer Center | Madisonville | Kentucky | United States | 42431 |
| 415 | Owensboro Health Mitchell Memorial Cancer Center | Owensboro | Kentucky | United States | 42303 |
| 416 | Christus Saint Frances Cabrini Hospital | Alexandria | Louisiana | United States | 71301 |
| 417 | Baton Rouge General Medical Center | Baton Rouge | Louisiana | United States | 70806 |
| 418 | Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | United States | 70809 |
| 419 | Ochsner Health Center-Summa | Baton Rouge | Louisiana | United States | 70809 |
| 420 | Ochsner Health Center-Covington | Covington | Louisiana | United States | 70433 |
| 421 | Metairie Oncologists | Metairie | Louisiana | United States | 70006 |
| 422 | Ochsner LSU Health Monroe Medical Center | Monroe | Louisiana | United States | 71202 |
| 423 | Louisiana State University Health Science Center | New Orleans | Louisiana | United States | 70112 |
| 424 | Tulane University Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 425 | University Medical Center New Orleans | New Orleans | Louisiana | United States | 70112 |
| 426 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 427 | Overton Brooks Veteran's Administration Medical Center | Shreveport | Louisiana | United States | 71101 |
| 428 | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States | 71103 |
| 429 | CHRISTUS Highland Medical Center | Shreveport | Louisiana | United States | 71105 |
| 430 | Highland Clinic | Shreveport | Louisiana | United States | 71105 |
| 431 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 432 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 433 | Central Maine Medical Center | Lewiston | Maine | United States | 04240 |
| 434 | Saint Mary's Regional Medical Center | Lewiston | Maine | United States | 04240 |
| 435 | Mercy Hospital | Portland | Maine | United States | 04101 |
| 436 | Maine Center for Cancer Medicine-Scarborough | Scarborough | Maine | United States | 04074 |
| 437 | Maine Medical Center- Scarborough Campus | Scarborough | Maine | United States | 04074 |
| 438 | Maine General Medical Center-Thayer | Waterville | Maine | United States | 04901 |
| 439 | York Hospital | York | Maine | United States | 03909 |
| 440 | Anne Arundel Medical Center | Annapolis | Maryland | United States | 21401 |
| 441 | Mercy Medical Center | Baltimore | Maryland | United States | 21202 |
| 442 | Greater Baltimore Medical Center | Baltimore | Maryland | United States | 21204 |
| 443 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 444 | MedStar Union Memorial Hospital | Baltimore | Maryland | United States | 21218 |
| 445 | Saint Agnes Hospital | Baltimore | Maryland | United States | 21229 |
| 446 | MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | United States | 21237 |
| 447 | MedStar Good Samaritan Hospital | Baltimore | Maryland | United States | 21239 |
| 448 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 449 | Suburban Hospital | Bethesda | Maryland | United States | 20814 |
| 450 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 451 | Western Maryland Regional Medical Center | Cumberland | Maryland | United States | 21502 |
| 452 | University of Maryland Shore Medical Center at Easton | Easton | Maryland | United States | 21601 |
| 453 | Christiana Care - Union Hospital | Elkton | Maryland | United States | 21921 |
| 454 | Frederick Memorial Hospital | Frederick | Maryland | United States | 21701 |
| 455 | Associates in Oncology Hematology PC -Kensington | Kensington | Maryland | United States | 20895 |
| 456 | Maryland Oncology Hematology PA-Aquilino Cancer Center | Rockville | Maryland | United States | 20850 |
| 457 | TidalHealth Peninsula Regional | Salisbury | Maryland | United States | 21801 |
| 458 | Holy Cross Hospital | Silver Spring | Maryland | United States | 20910 |
| 459 | UM Saint Joseph Medical Center | Towson | Maryland | United States | 21204 |
| 460 | Sturdy Memorial Hospital | Attleboro | Massachusetts | United States | 02703 |
| 461 | Tufts Medical Center | Boston | Massachusetts | United States | 02111 |
| 462 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 463 | Brigham and Women's Hospital | Boston | Massachusetts | United States | 02115 |
| 464 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 465 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 466 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 467 | Steward Saint Elizabeth's Medical Center | Brighton | Massachusetts | United States | 02135 |
| 468 | Lahey Hospital and Medical Center | Burlington | Massachusetts | United States | 01805 |
| 469 | Commonwealth Hematology Oncology PC-Concord | Concord | Massachusetts | United States | 01742 |
| 470 | Mass General/North Shore Cancer Center | Danvers | Massachusetts | United States | 01923 |
| 471 | Dana Farber Community Cancer Care-Dorchester | Dorchester | Massachusetts | United States | 02124 |
| 472 | Saint Anne's Hospital | Fall River | Massachusetts | United States | 02721 |
| 473 | Simonds-Sinon Regional Cancer Center | Fitchburg | Massachusetts | United States | 01420 |
| 474 | MetroWest Medical Center-Framingham Union Hospital | Framingham | Massachusetts | United States | 01702 |
| 475 | Addison Gilbert Hospital | Gloucester | Massachusetts | United States | 01930 |
| 476 | Dana Farber Community Cancer Care-Haverhill | Haverhill | Massachusetts | United States | 01830 |
| 477 | Cape Cod Hospital | Hyannis | Massachusetts | United States | 02601 |
| 478 | HealthAlliance Hospital - Leominster | Leominster | Massachusetts | United States | 01453 |
| 479 | Saints Memorial Medical Center | Lowell | Massachusetts | United States | 01852 |
| 480 | Lowell General Hospital | Lowell | Massachusetts | United States | 01854 |
| 481 | Dana Farber-Merrimack Valley | Methuen | Massachusetts | United States | 01844 |
| 482 | Holy Family Hospital | Methuen | Massachusetts | United States | 01844 |
| 483 | Norwood Hospital | Norwood | Massachusetts | United States | 02062 |
| 484 | Berkshire Medical Center - Cancer Center | Pittsfield | Massachusetts | United States | 01201 |
| 485 | Dana Farber Community Cancer Care-Quincy | Quincy | Massachusetts | United States | 02169 |
| 486 | South Shore Hospital | South Weymouth | Massachusetts | United States | 02190 |
| 487 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 488 | Dana Farber Community Cancer Care-Stoneham | Stoneham | Massachusetts | United States | 02180 |
| 489 | Morton Hospital and Medical Center | Taunton | Massachusetts | United States | 02780 |
| 490 | Dana Farber Community Cancer Care-Weymouth | Weymouth | Massachusetts | United States | 02189 |
| 491 | Commonwealth Hematology Oncology PC-Worcester | Worcester | Massachusetts | United States | 01605 |
| 492 | Reliant Medical Group Inc | Worcester | Massachusetts | United States | 01606 |
| 493 | UMass Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
| 494 | Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 495 | Hickman Cancer Center | Adrian | Michigan | United States | 49221 |
| 496 | Michigan Cancer Research Consortium NCORP | Ann Arbor | Michigan | United States | 48106 |
| 497 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 498 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109 |
| 499 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 500 | McLaren Cancer Institute-Bay City | Bay City | Michigan | United States | 48706 |
| 501 | Spectrum Health Big Rapids Hospital | Big Rapids | Michigan | United States | 49307 |
| 502 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 503 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 504 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 505 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 506 | Michigan State University Clinical Center | East Lansing | Michigan | United States | 48824-7016 |
| 507 | Green Bay Oncology - Escanaba | Escanaba | Michigan | United States | 49829 |
| 508 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 509 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 510 | Genesys Regional Medical Center-West Flint Campus | Flint | Michigan | United States | 48532 |
| 511 | McLaren Cancer Institute-Flint | Flint | Michigan | United States | 48532 |
| 512 | Cancer Research Consortium of West Michigan NCORP | Grand Rapids | Michigan | United States | 49503 |
| 513 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 514 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 515 | Holland Community Hospital | Holland | Michigan | United States | 49423 |
| 516 | Green Bay Oncology - Iron Mountain | Iron Mountain | Michigan | United States | 49801 |
| 517 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 518 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 519 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 520 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 521 | Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | United States | 48910 |
| 522 | Sparrow Hospital | Lansing | Michigan | United States | 48912 |
| 523 | Lapeer Regional Hospital | Lapeer | Michigan | United States | 48446 |
| 524 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 525 | UP Health System Marquette | Marquette | Michigan | United States | 49855 |
| 526 | MyMichigan Medical Center Midland | Midland | Michigan | United States | 48670 |
| 527 | Mercy Memorial Hospital | Monroe | Michigan | United States | 48162 |
| 528 | Toledo Clinic Cancer Centers-Monroe | Monroe | Michigan | United States | 48162 |
| 529 | McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | United States | 48043 |
| 530 | Mercy Health Partners-Hackley Campus | Muskegon | Michigan | United States | 49442 |
| 531 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 532 | McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | United States | 49770 |
| 533 | Saint Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341 |
| 534 | Lake Huron Medical Center | Port Huron | Michigan | United States | 48060 |
| 535 | Crittenton Hospital | Rochester | Michigan | United States | 48307 |
| 536 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 537 | Ascension Saint Mary's Hospital | Saginaw | Michigan | United States | 48601 |
| 538 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 539 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 540 | Oncology Care Associates PLLC | Saint Joseph | Michigan | United States | 49085 |
| 541 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 542 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 543 | Saint John Macomb-Oakland Hospital | Warren | Michigan | United States | 48093 |
| 544 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 545 | Medini, Eitan MD (UIA Investigator) | Alexandria | Minnesota | United States | 56308 |
| 546 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 547 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 548 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 549 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 550 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 551 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 552 | Saint Luke's Hospital of Duluth | Duluth | Minnesota | United States | 55805 |
| 553 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 554 | Etzell, Paul S MD (UIA Investigator) | Fergus Falls | Minnesota | United States | 56537 |
| 555 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 556 | Swenson, Wade II, MD (UIA Investigator) | Fergus Falls | Minnesota | United States | 56537 |
| 557 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 558 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 559 | Meeker County Memorial Hospital | Litchfield | Minnesota | United States | 55355 |
| 560 | Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | United States | 56001 |
| 561 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 562 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 563 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 564 | Virginia Piper Cancer Institute | Minneapolis | Minnesota | United States | 55407 |
| 565 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 566 | University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | United States | 55455 |
| 567 | Chippewa County - Montevideo Hospital | Montevideo | Minnesota | United States | 56265 |
| 568 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 569 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 570 | Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 571 | Saint Cloud Hospital | Saint Cloud | Minnesota | United States | 56303 |
| 572 | Metro Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | United States | 55416 |
| 573 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 574 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 575 | Saint Joseph's Hospital - Healtheast | Saint Paul | Minnesota | United States | 55102 |
| 576 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 577 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 578 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 579 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 580 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 581 | Woodwinds Health Campus | Woodbury | Minnesota | United States | 55125 |
| 582 | Hattiesburg Clinic - Hematology/Oncology Clinic | Hattiesburg | Mississippi | United States | 39401 |
| 583 | Hematology and Oncology Clinic | Hattiesburg | Mississippi | United States | 39402 |
| 584 | Jackson Oncology Associates PLLC | Jackson | Mississippi | United States | 39202 |
| 585 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 586 | Keesler Medical Center | Keesler Air Force Base | Mississippi | United States | 39534 |
| 587 | Singing River Hospital | Pascagoula | Mississippi | United States | 39581 |
| 588 | Southeast Missouri Hospital | Cape Girardeau | Missouri | United States | 63701 |
| 589 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 590 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 591 | Missouri Cancer Associates | Columbia | Missouri | United States | 65201 |
| 592 | Veterans Administration | Columbia | Missouri | United States | 65201 |
| 593 | University of Missouri - Ellis Fischel | Columbia | Missouri | United States | 65212 |
| 594 | Centerpoint Medical Center LLC | Independence | Missouri | United States | 64057 |
| 595 | Capital Region Medical Center | Jefferson City | Missouri | United States | 65101 |
| 596 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 597 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 598 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 599 | Truman Medical Centers | Kansas City | Missouri | United States | 64108 |
| 600 | Saint Luke's Hospital of Kansas City | Kansas City | Missouri | United States | 64111 |
| 601 | Radiation Oncology Practice Corporation South | Kansas City | Missouri | United States | 64114 |
| 602 | Saint Joseph Health Center | Kansas City | Missouri | United States | 64114 |
| 603 | North Kansas City Hospital | Kansas City | Missouri | United States | 64116 |
| 604 | Heartland Hematology and Oncology Associates Incorporated | Kansas City | Missouri | United States | 64118 |
| 605 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 606 | Radiation Oncology Practice Corporation - North | Kansas City | Missouri | United States | 64154 |
| 607 | Saint Luke's East - Lee's Summit | Lee's Summit | Missouri | United States | 64086 |
| 608 | Liberty Radiation Oncology Center | Liberty | Missouri | United States | 64068 |
| 609 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 610 | SSM Health Saint Louis University Hospital | Saint Louis | Missouri | United States | 63104 |
| 611 | Saint Louis Cancer and Breast Institute-South City | Saint Louis | Missouri | United States | 63109 |
| 612 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 613 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 614 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 615 | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri | United States | 63136 |
| 616 | Center for Cancer Care and Research | Saint Louis | Missouri | United States | 63141 |
| 617 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 618 | Saint Louis-Cape Girardeau CCOP | Saint Louis | Missouri | United States | 63141 |
| 619 | Cancer Research for the Ozarks NCORP | Springfield | Missouri | United States | 65804 |
| 620 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 621 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 622 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 623 | Northern Rockies Radiation Oncology Center | Billings | Montana | United States | 59101 |
| 624 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 625 | Montana Cancer Consortium NCORP | Billings | Montana | United States | 59102 |
| 626 | Saint Vincent Frontier Cancer Center | Billings | Montana | United States | 59102 |
| 627 | Deaconess Medical Center | Billings | Montana | United States | 59107 |
| 628 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 629 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 630 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 631 | Berdeaux, Donald MD (UIA Investigator) | Great Falls | Montana | United States | 59405 |
| 632 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 633 | Northern Montana Hospital | Havre | Montana | United States | 59501 |
| 634 | Saint Peter's Community Hospital | Helena | Montana | United States | 59601 |
| 635 | Glacier Oncology PLLC | Kalispell | Montana | United States | 59901 |
| 636 | Kalispell Medical Oncology | Kalispell | Montana | United States | 59901 |
| 637 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 638 | Montana Cancer Specialists | Missoula | Montana | United States | 59802 |
| 639 | Saint Patrick Hospital - Community Hospital | Missoula | Montana | United States | 59802 |
| 640 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 641 | Guardian Oncology and Center for Wellness | Missoula | Montana | United States | 59804 |
| 642 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 643 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 644 | Nebraska Cancer Research Center | Lincoln | Nebraska | United States | 68510 |
| 645 | Cancer Alliance of Nebraska | Omaha | Nebraska | United States | 68106 |
| 646 | Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 647 | Nebraska Methodist Hospital | Omaha | Nebraska | United States | 68114 |
| 648 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 649 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 650 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 651 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 652 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 653 | Midlands Community Hospital | Papillion | Nebraska | United States | 68046 |
| 654 | Carson-Tahoe Specialty Medical Center | Carson City | Nevada | United States | 89703 |
| 655 | University Medical Center of Southern Nevada | Las Vegas | Nevada | United States | 89102 |
| 656 | Nevada Cancer Research Foundation NCORP | Las Vegas | Nevada | United States | 89169 |
| 657 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 658 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 659 | New Hampshire Oncology Hematology PA-Concord | Concord | New Hampshire | United States | 03301 |
| 660 | Exeter Hospital | Exeter | New Hampshire | United States | 03833 |
| 661 | Cheshire Medical Center-Dartmouth-Hitchcock Keene | Keene | New Hampshire | United States | 03431 |
| 662 | LRGHealthcare-Lakes Region General Hospital | Laconia | New Hampshire | United States | 03246 |
| 663 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 664 | Elliot Hospital | Manchester | New Hampshire | United States | 03103 |
| 665 | Solinsky Center for Cancer Care | Manchester | New Hampshire | United States | 03103 |
| 666 | Foundation Medical Partners | Nashua | New Hampshire | United States | 03060 |
| 667 | Saint Joseph Hospital | Nashua | New Hampshire | United States | 03060 |
| 668 | Portsmouth Regional Hospital | Portsmouth | New Hampshire | United States | 03802 |
| 669 | Ocean Medical Center | Brick | New Jersey | United States | 08724 |
| 670 | Cooper Hospital University Medical Center | Camden | New Jersey | United States | 08103 |
| 671 | John F Kennedy Medical Center | Edison | New Jersey | United States | 08818 |
| 672 | Englewood Hospital and Medical Center | Englewood | New Jersey | United States | 07631 |
| 673 | Hunterdon Medical Center | Flemington | New Jersey | United States | 08822 |
| 674 | CentraState Medical Center | Freehold | New Jersey | United States | 07728 |
| 675 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 676 | The Cancer Institute of New Jersey Hamilton | Hamilton | New Jersey | United States | 08690 |
| 677 | Saint Barnabas Medical Center | Livingston | New Jersey | United States | 07039 |
| 678 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740 |
| 679 | Mountainside Hospital | Montclair | New Jersey | United States | 07042 |
| 680 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 681 | Virtua Memorial | Mount Holly | New Jersey | United States | 08060 |
| 682 | Jersey Shore Medical Center | Neptune | New Jersey | United States | 07753 |
| 683 | Saint Peter's University Hospital | New Brunswick | New Jersey | United States | 08901 |
| 684 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 685 | Rutgers New Jersey Medical School | Newark | New Jersey | United States | 07101 |
| 686 | Saint Michael's Medical Center | Newark | New Jersey | United States | 07102 |
| 687 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 688 | Saint Joseph's Regional Medical Center | Paterson | New Jersey | United States | 07503 |
| 689 | Capital Health Medical Center-Hopewell | Pennington | New Jersey | United States | 08534 |
| 690 | Saint Luke's Hospital-Warren Campus | Phillipsburg | New Jersey | United States | 08865 |
| 691 | Penn Medicine Princeton Health | Plainsboro | New Jersey | United States | 08536 |
| 692 | AtlantiCare Regional Medical Center -Main Campus | Pomona | New Jersey | United States | 08240 |
| 693 | Riverview Medical Center/Booker Cancer Center | Red Bank | New Jersey | United States | 07701 |
| 694 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 695 | Shore Memorial Hospital | Somers Point | New Jersey | United States | 08244 |
| 696 | Robert Wood Johnson University Hospital Somerset | Somerville | New Jersey | United States | 08876 |
| 697 | Sparta Cancer Treatment Center | Sparta | New Jersey | United States | 07871 |
| 698 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 699 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 700 | Inspira Medical Center Vineland | Vineland | New Jersey | United States | 08360 |
| 701 | Virtua Voorhees | Voorhees | New Jersey | United States | 08043 |
| 702 | Lovelace Medical Center-Downtown | Albuquerque | New Mexico | United States | 87102 |
| 703 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 704 | Hematology Oncology Associates | Albuquerque | New Mexico | United States | 87106 |
| 705 | Presbyterian Kaseman Hospital | Albuquerque | New Mexico | United States | 87110 |
| 706 | Memorial Medical Center - Las Cruces | Las Cruces | New Mexico | United States | 88011 |
| 707 | San Juan Regional Medical Center | San Juan | New Mexico | United States | 87401 |
| 708 | Christus Saint Vincent Regional Cancer Center | Santa Fe | New Mexico | United States | 87505 |
| 709 | New York Oncology Hematology PC - Albany | Albany | New York | United States | 12206 |
| 710 | New York Oncology Hematology PC - Albany Medical Center | Albany | New York | United States | 12208 |
| 711 | New York Oncology Hematology PC - Amsterdam | Amsterdam | New York | United States | 12010 |
| 712 | Lincoln Medical and Mental Health Center | Bronx | New York | United States | 10451 |
| 713 | Bronx-Lebanon Hospital Center | Bronx | New York | United States | 10456 |
| 714 | Montefiore Medical Center-Weiler Hospital | Bronx | New York | United States | 10461 |
| 715 | Montefiore Medical Center-Wakefield Campus | Bronx | New York | United States | 10466 |
| 716 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 717 | Coney Island Hospital | Brooklyn | New York | United States | 11235 |
| 718 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 719 | New York Oncology Hematology PC - Clifton Park | Clifton Park | New York | United States | 12065 |
| 720 | Finger Lakes Hematology and Oncology | Clifton Springs | New York | United States | 14432 |
| 721 | Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 722 | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | United States | 13057 |
| 723 | Adirondack Cancer Center | Glens Falls | New York | United States | 12801 |
| 724 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 725 | Catskill Regional Medical Center | Harris | New York | United States | 12742 |
| 726 | New York Oncology Hematology PC-Hudson | Hudson | New York | United States | 12534 |
| 727 | Queens Hospital Center | Jamaica | New York | United States | 11432 |
| 728 | Benedictine Hospital | Kingston | New York | United States | 12401 |
| 729 | Northwell Health NCORP | Lake Success | New York | United States | 11042 |
| 730 | Northwell Health/Center for Advanced Medicine | Lake Success | New York | United States | 11042 |
| 731 | North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 732 | Garnet Health Medical Center | Middletown | New York | United States | 10940 |
| 733 | NYU Winthrop Hospital | Mineola | New York | United States | 11501 |
| 734 | Long Island Jewish Medical Center | New Hyde Park | New York | United States | 11040 |
| 735 | Mount Sinai Union Square | New York | New York | United States | 10003 |
| 736 | Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | United States | 10016 |
| 737 | Mount Sinai West | New York | New York | United States | 10019 |
| 738 | Mount Sinai Hospital | New York | New York | United States | 10029 |
| 739 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 740 | Ralph Lauren Center for Cancer Care and Prevention | New York | New York | United States | 10035 |
| 741 | Memorial Sloan Kettering Cancer Center | New York | New York | United States | 10065 |
| 742 | NYP/Weill Cornell Medical Center | New York | New York | United States | 10065 |
| 743 | Nyack Hospital | Nyack | New York | United States | 10960 |
| 744 | Champlain Valley Physicians Hospital Medical Center | Plattsburgh | New York | United States | 12901 |
| 745 | Hudson Valley Hematology Oncology Associates | Poughkeepsie | New York | United States | 12601 |
| 746 | MidHudson Regional Hospital of Westchester Medical Center | Poughkeepsie | New York | United States | 12601 |
| 747 | The Dyson Center for Cancer Care | Poughkeepsie | New York | United States | 12601 |
| 748 | Vassar Brothers Medical Center | Poughkeepsie | New York | United States | 12601 |
| 749 | Highland Hospital | Rochester | New York | United States | 14620 |
| 750 | Rochester General Hospital | Rochester | New York | United States | 14621 |
| 751 | Interlakes Foundation Inc-Rochester | Rochester | New York | United States | 14623 |
| 752 | University of Rochester | Rochester | New York | United States | 14642 |
| 753 | Staten Island University Hospital | Staten Island | New York | United States | 10305 |
| 754 | Richmond University Medical Center | Staten Island | New York | United States | 10310 |
| 755 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 756 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 757 | New York Oncology Hematology PC - Troy | Troy | New York | United States | 12180 |
| 758 | Faxton-Saint Luke's Healthcare | Utica | New York | United States | 13502 |
| 759 | Randolph Hospital | Asheboro | North Carolina | United States | 27203 |
| 760 | Mission Hospital | Asheville | North Carolina | United States | 28801 |
| 761 | Hope Women's Cancer Centers-Asheville | Asheville | North Carolina | United States | 28816 |
| 762 | Waverly Hematology Oncology | Cary | North Carolina | United States | 27518 |
| 763 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
| 764 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 765 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 766 | Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | United States | 28025 |
| 767 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 768 | Moorehead Memorial Hospital | Eden | North Carolina | United States | 27288 |
| 769 | Cape Fear Valley Health System | Fayetteville | North Carolina | United States | 28304 |
| 770 | CaroMont Regional Medical Center | Gastonia | North Carolina | United States | 28054 |
| 771 | Wayne Memorial Hospital | Goldsboro | North Carolina | United States | 27534 |
| 772 | Wayne Radiation Oncology | Goldsboro | North Carolina | United States | 27534 |
| 773 | Cone Health Cancer Center | Greensboro | North Carolina | United States | 27403 |
| 774 | East Carolina University | Greenville | North Carolina | United States | 27834 |
| 775 | AdventHealth Hendersonville | Hendersonville | North Carolina | United States | 28792 |
| 776 | Maria Parham Hospital | Henderson | North Carolina | United States | 27536 |
| 777 | High Point Regional Hospital | High Point | North Carolina | United States | 27262 |
| 778 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 779 | Southeastern Regional Medical Center | Lumberton | North Carolina | United States | 28358 |
| 780 | Granville Medical Center | Oxford | North Carolina | United States | 27565 |
| 781 | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | United States | 28374 |
| 782 | UNC Rex Cancer Center | Raleigh | North Carolina | United States | 27607 |
| 783 | Duke Raleigh Hospital | Raleigh | North Carolina | United States | 27609 |
| 784 | Annie Penn Memorial Hospital | Reidsville | North Carolina | United States | 27320 |
| 785 | Person Memorial Hospital | Roxboro | North Carolina | United States | 27573 |
| 786 | Rutherford Hospital | Rutherfordton | North Carolina | United States | 28139 |
| 787 | Iredell Memorial Hospital | Statesville | North Carolina | United States | 28677 |
| 788 | Marion L Shepard Cancer Center at Vidant Beaufort Hospital | Washington | North Carolina | United States | 27889 |
| 789 | New Hanover Regional Medical Center/Zimmer Cancer Center | Wilmington | North Carolina | United States | 28401 |
| 790 | Wilson Medical Center | Wilson | North Carolina | United States | 27893 |
| 791 | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
| 792 | Southeast Clinical Oncology Research Consortium NCORP | Winston-Salem | North Carolina | United States | 27104 |
| 793 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 794 | Mid Dakota Clinic | Bismarck | North Dakota | United States | 58501 |
| 795 | Saint Alexius Medical Center | Bismarck | North Dakota | United States | 58501 |
| 796 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 797 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 798 | Sanford Clinic North-Fargo | Fargo | North Dakota | United States | 58122 |
| 799 | Altru Cancer Center | Grand Forks | North Dakota | United States | 58201 |
| 800 | Trinity Cancer Care Center | Minot | North Dakota | United States | 58701 |
| 801 | Summa Health System - Akron Campus | Akron | Ohio | United States | 44304 |
| 802 | Cleveland Clinic Akron General | Akron | Ohio | United States | 44307 |
| 803 | Summa Health System - Barberton Campus | Barberton | Ohio | United States | 44203 |
| 804 | Mary Rutan Hospital | Bellefontaine | Ohio | United States | 43311 |
| 805 | Toledo Clinic Cancer Centers-Bowling Green | Bowling Green | Ohio | United States | 43402 |
| 806 | Community Hospital and Wellness Centers | Bryan | Ohio | United States | 43506 |
| 807 | Cleveland Clinic Mercy Hospital | Canton | Ohio | United States | 44708 |
| 808 | Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 809 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 810 | The Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 811 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 812 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 813 | Oncology Hematology Care Inc-Blue Ash | Cincinnati | Ohio | United States | 45242 |
| 814 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 815 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 816 | Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 817 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 818 | North Coast Cancer Care-Clyde | Clyde | Ohio | United States | 43410 |
| 819 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 820 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 821 | Columbus NCI Community Oncology Research Program | Columbus | Ohio | United States | 43215 |
| 822 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 823 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 824 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 825 | Grandview Hospital | Dayton | Ohio | United States | 45405 |
| 826 | Good Samaritan Hospital - Dayton | Dayton | Ohio | United States | 45406 |
| 827 | Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 828 | Miami Valley Hospital North | Dayton | Ohio | United States | 45415 |
| 829 | Dayton Veterans Affairs Medical Center | Dayton | Ohio | United States | 45428 |
| 830 | Dayton NCI Community Oncology Research Program | Dayton | Ohio | United States | 45459 |
| 831 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 832 | Hematology Oncology Center Incorporated | Elyria | Ohio | United States | 44035 |
| 833 | Blanchard Valley Hospital | Findlay | Ohio | United States | 45840 |
| 834 | Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 835 | Fremont Memorial Hospital | Fremont | Ohio | United States | 43420 |
| 836 | Wayne Hospital | Greenville | Ohio | United States | 45331 |
| 837 | Cleveland Clinic Cancer Center Independence | Independence | Ohio | United States | 44131 |
| 838 | Cole, Sharon, K. M.D. (UIA Investigator) | Kenton | Ohio | United States | 43326 |
| 839 | Kettering Medical Center | Kettering | Ohio | United States | 45429 |
| 840 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 841 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 842 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 843 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 844 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 845 | Saint Luke's Hospital | Maumee | Ohio | United States | 43537 |
| 846 | Toledo Clinic Cancer Centers-Maumee | Maumee | Ohio | United States | 43537 |
| 847 | Toledo Radiation Oncology at Northwest Ohio Onocolgy Center | Maumee | Ohio | United States | 43537 |
| 848 | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | United States | 44124 |
| 849 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 850 | Fisher-Titus Medical Center | Norwalk | Ohio | United States | 44857 |
| 851 | Saint Charles Hospital | Oregon | Ohio | United States | 43616 |
| 852 | Toledo Clinic Cancer Centers-Oregon | Oregon | Ohio | United States | 43616 |
| 853 | UH Seidman Cancer Center at Salem Regional Medical Center | Salem | Ohio | United States | 44460 |
| 854 | Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 855 | North Coast Cancer Care | Sandusky | Ohio | United States | 44870 |
| 856 | Springfield Regional Medical Center | Springfield | Ohio | United States | 45505 |
| 857 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 858 | Mercy Hospital of Tiffin | Tiffin | Ohio | United States | 44883 |
| 859 | ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | United States | 43606 |
| 860 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 861 | University of Toledo | Toledo | Ohio | United States | 43614 |
| 862 | Toledo Community Hospital Oncology Program CCOP | Toledo | Ohio | United States | 43617 |
| 863 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 864 | Stark, Michael, Edward. M.D. (UIA Investigator) | Toledo | Ohio | United States | 43623 |
| 865 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 866 | Upper Valley Medical Center | Troy | Ohio | United States | 45373 |
| 867 | Saint Joseph Warren Hospital | Warren | Ohio | United States | 44484 |
| 868 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 869 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 870 | Clinton Memorial Hospital | Wilmington | Ohio | United States | 45177 |
| 871 | Cancer Treatment Center | Wooster | Ohio | United States | 44691 |
| 872 | Cleveland Clinic Wooster Family Health and Surgery Center | Wooster | Ohio | United States | 44691 |
| 873 | Wright-Patterson Medical Center | Wright-Patterson Air Force Base | Ohio | United States | 45433 |
| 874 | Greene Memorial Hospital | Xenia | Ohio | United States | 45385 |
| 875 | Tod Children's Hospital - Forum Health | Youngstown | Ohio | United States | 44501 |
| 876 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 877 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 878 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 879 | Cancer Care Associates | Oklahoma City | Oklahoma | United States | 73120 |
| 880 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 881 | Saint John Medical Center | Tulsa | Oklahoma | United States | 74104 |
| 882 | Natalie Warren Bryant Cancer Center at Saint Francis | Tulsa | Oklahoma | United States | 74136 |
| 883 | Bend Memorial Clinic | Bend | Oregon | United States | 97701 |
| 884 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 885 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 886 | Three Rivers Community Hospital | Grants Pass | Oregon | United States | 97527 |
| 887 | Legacy Mount Hood Medical Center | Gresham | Oregon | United States | 97030 |
| 888 | Sky Lakes Medical Center - Cancer Treatment Center | Klamath Falls | Oregon | United States | 97601 |
| 889 | Asante Health System | Medford | Oregon | United States | 97504 |
| 890 | Providence Medford Medical Center | Medford | Oregon | United States | 97504 |
| 891 | Rogue Valley Medical Center | Medford | Oregon | United States | 97504 |
| 892 | Providence Milwaukie Hospital | Milwaukie | Oregon | United States | 97222 |
| 893 | Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | United States | 97210 |
| 894 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 895 | Adventist Medical Center | Portland | Oregon | United States | 97216 |
| 896 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 897 | Compass Oncology Rose Quarter | Portland | Oregon | United States | 97227 |
| 898 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 899 | Legacy Emanuel Hospital and Health Center | Portland | Oregon | United States | 97227 |
| 900 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 901 | Salem Hospital | Salem | Oregon | United States | 97301 |
| 902 | Legacy Meridian Park Hospital | Tualatin | Oregon | United States | 97062 |
| 903 | Jefferson Abington Hospital | Abington | Pennsylvania | United States | 19001 |
| 904 | Sacred Heart Hospital | Allentown | Pennsylvania | United States | 18102 |
| 905 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 906 | Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | United States | 18015 |
| 907 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 908 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 909 | Mercy Fitzgerald Hospital | Darby | Pennsylvania | United States | 19023-1291 |
| 910 | Doylestown Hospital | Doylestown | Pennsylvania | United States | 18901 |
| 911 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 912 | Oncology Hematology Associates of Northern Pennsylvania | DuBois | Pennsylvania | United States | 15801 |
| 913 | Pocono Medical Center | East Stroudsburg | Pennsylvania | United States | 18301 |
| 914 | Easton Hospital | Easton | Pennsylvania | United States | 18042 |
| 915 | Ephrata Cancer Center | Ephrata | Pennsylvania | United States | 17522 |
| 916 | UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | United States | 16505 |
| 917 | Saint Vincent Hospital | Erie | Pennsylvania | United States | 16544 |
| 918 | UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | United States | 17109 |
| 919 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 920 | Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 921 | Conemaugh Memorial Medical Center | Johnstown | Pennsylvania | United States | 15905-4398 |
| 922 | Lancaster General Hospital | Lancaster | Pennsylvania | United States | 17602 |
| 923 | Saint Mary Medical and Regional Cancer Center | Langhorne | Pennsylvania | United States | 19047 |
| 924 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 925 | Holy Redeemer Hospital and Medical Center | Meadowbrook | Pennsylvania | United States | 19046 |
| 926 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 927 | Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301 |
| 928 | Drexel University School of Medicine | Philadelphia | Pennsylvania | United States | 19102 |
| 929 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 930 | Pennsylvania Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 931 | Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | United States | 19107 |
| 932 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 933 | Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | United States | 19114 |
| 934 | Chestnut Hill Health System | Philadelphia | Pennsylvania | United States | 19118 |
| 935 | Einstein Medical Center Philadelphia | Philadelphia | Pennsylvania | United States | 19141 |
| 936 | Phoenixville Hospital | Phoenixville | Pennsylvania | United States | 19460 |
| 937 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212 |
| 938 | UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | United States | 15213 |
| 939 | West Penn Hospital | Pittsburgh | Pennsylvania | United States | 15224 |
| 940 | University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | United States | 15232 |
| 941 | Pottstown Hospital | Pottstown | Pennsylvania | United States | 19464 |
| 942 | Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | United States | 19605 |
| 943 | Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | United States | 18840 |
| 944 | Mercy Hospital | Scranton | Pennsylvania | United States | 18501 |
| 945 | Hematology and Oncology Associates of North East Pennsylvania | Scranton | Pennsylvania | United States | 18508 |
| 946 | Scranton Hematology Oncology | Scranton | Pennsylvania | United States | 18510 |
| 947 | Grand View Hospital | Sellersville | Pennsylvania | United States | 18960 |
| 948 | Geisinger Medical Group | State College | Pennsylvania | United States | 16801 |
| 949 | Mount Nittany Medical Center | State College | Pennsylvania | United States | 16803 |
| 950 | Associates In Hematology Oncology PC-Upland | Upland | Pennsylvania | United States | 19013 |
| 951 | Chester County Hospital | West Chester | Pennsylvania | United States | 19380 |
| 952 | Jennersville Regional Hospital | West Grove | Pennsylvania | United States | 19390 |
| 953 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 954 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 955 | UPMC Susquehanna | Williamsport | Pennsylvania | United States | 17701 |
| 956 | Lankenau Medical Center | Wynnewood | Pennsylvania | United States | 19096 |
| 957 | Main Line Health NCORP | Wynnewood | Pennsylvania | United States | 19096 |
| 958 | WellSpan Health-York Hospital | York | Pennsylvania | United States | 17403 |
| 959 | Hematology and Oncology Associates of Rhode Island Inc | Cranston | Rhode Island | United States | 02920 |
| 960 | Memorial Hospital of Rhode Island | Pawtucket | Rhode Island | United States | 02860 |
| 961 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 962 | Women and Infants Hospital | Providence | Rhode Island | United States | 02905 |
| 963 | Miriam Hospital | Providence | Rhode Island | United States | 02906 |
| 964 | Roger Williams Medical Center | Providence | Rhode Island | United States | 02908 |
| 965 | Kent Hospital | Warwick | Rhode Island | United States | 02886 |
| 966 | AnMed Health Hospital | Anderson | South Carolina | United States | 29621 |
| 967 | Beaufort Memorial Hospital | Beaufort | South Carolina | United States | 29902 |
| 968 | Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 969 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 970 | South Carolina Oncology Associates PA | Columbia | South Carolina | United States | 29210 |
| 971 | McLeod Regional Medical Center | Florence | South Carolina | United States | 29506 |
| 972 | Tidelands Georgetown Memorial Hospital | Georgetown | South Carolina | United States | 29440 |
| 973 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 974 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 975 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 976 | Avera Cancer Institute-Aberdeen | Aberdeen | South Dakota | United States | 57401 |
| 977 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 978 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 979 | Medical X-Ray Center | Sioux Falls | South Dakota | United States | 57105 |
| 980 | Avera McKennan Hospital and University Health Center | Sioux Falls | South Dakota | United States | 57117-5045 |
| 981 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 982 | Wellmont Medical Associates Oncology and Hematology-Bristol | Bristol | Tennessee | United States | 37620 |
| 983 | Erlanger Medical Center | Chattanooga | Tennessee | United States | 37403 |
| 984 | Cookeville Regional Medical Center | Cookeville | Tennessee | United States | 38501 |
| 985 | Vanderbilt-Ingram Cancer Center Cool Springs | Franklin | Tennessee | United States | 37067 |
| 986 | Jones Clinic | Germantown | Tennessee | United States | 38138 |
| 987 | Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301 |
| 988 | The Jackson Clinic PA | Jackson | Tennessee | United States | 38301 |
| 989 | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | United States | 37660 |
| 990 | Tennessee Cancer Specialists-Dowell Springs | Knoxville | Tennessee | United States | 37909 |
| 991 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 992 | East Tennessee Baptist Hospital-Mercy Health Partners | Knoxville | Tennessee | United States | 37920 |
| 993 | University of Tennessee - Knoxville | Knoxville | Tennessee | United States | 37920 |
| 994 | University of Tennessee Health Science Center | Memphis | Tennessee | United States | 38163 |
| 995 | Nashville Breast Center | Nashville | Tennessee | United States | 37203 |
| 996 | Nashville Oncology Associates PC | Nashville | Tennessee | United States | 37203 |
| 997 | Tennessee Oncology PLLC- Centennial Medical Center | Nashville | Tennessee | United States | 37203 |
| 998 | Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | United States | 37204 |
| 999 | Saint Thomas Hospital | Nashville | Tennessee | United States | 37205 |
| 1000 | Meharry Medical College | Nashville | Tennessee | United States | 37208 |
| 1001 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 1002 | Saint Thomas Midtown Hospital | Nashville | Tennessee | United States | 37236 |
| 1003 | Saint Mary's North Cancer Center | Powell | Tennessee | United States | 37849 |
| 1004 | The Don and Sybil Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 1005 | Dell Seton Medical Center at The University of Texas | Austin | Texas | United States | 78701 |
| 1006 | Texas Oncology-Austin Midtown | Austin | Texas | United States | 78705 |
| 1007 | Texas Oncology - Central Austin Cancer Center | Austin | Texas | United States | 78731 |
| 1008 | Texas Oncology - South Austin Cancer Center | Austin | Texas | United States | 78745 |
| 1009 | Texas Oncology-Austin North | Austin | Texas | United States | 78758 |
| 1010 | Texas Oncology Seton Northwest | Austin | Texas | United States | 78759 |
| 1011 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 1012 | The Center for Cancer and Blood Disorders-Burleson | Burleson | Texas | United States | 76115 |
| 1013 | Texas Oncology-Cedar Park | Cedar Park | Texas | United States | 78613 |
| 1014 | The Center for Cancer and Blood Disorders-Cleburne | Cleburne | Texas | United States | 76033 |
| 1015 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
| 1016 | Parkland Memorial Hospital | Dallas | Texas | United States | 75235 |
| 1017 | Clements University Hospital | Dallas | Texas | United States | 75390 |
| 1018 | UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | United States | 75390 |
| 1019 | Dallas Oncology Consultants PA | Duncanville | Texas | United States | 75137 |
| 1020 | The Center for Integrative Cancer Medicine | El Paso | Texas | United States | 79902 |
| 1021 | Brooke Army Medical Center | Fort Sam Houston | Texas | United States | 78234 |
| 1022 | The Center for Cancer and Blood Disorders-Fort Worth | Fort Worth | Texas | United States | 76104 |
| 1023 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 1024 | Ben Taub General Hospital | Houston | Texas | United States | 77030 |
| 1025 | Houston Methodist Hospital | Houston | Texas | United States | 77030 |
| 1026 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 1027 | Wilford Hall Medical Center | Lackland Air Force Base | Texas | United States | 78236 |
| 1028 | Doctor's Hospital of Laredo | Laredo | Texas | United States | 78041 |
| 1029 | Covenant Medical Center-Lakeside | Lubbock | Texas | United States | 79410 |
| 1030 | Texas Tech University Health Sciences Center-Lubbock | Lubbock | Texas | United States | 79430 |
| 1031 | The Center for Cancer and Blood Disorders-Mineral Wells | Mineral Wells | Texas | United States | 76067 |
| 1032 | Texas Oncology-Seton Williamson | Round Rock | Texas | United States | 78665 |
| 1033 | Texas Oncology - Round Rock Cancer Center | Round Rock | Texas | United States | 78681 |
| 1034 | Cancer Therapy and Research Center at The UT Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 1035 | University Hospital | San Antonio | Texas | United States | 78229 |
| 1036 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 1037 | Texas Oncology- San Marcos | San Marcos | Texas | United States | 78666 |
| 1038 | Scott and White Memorial Hospital | Temple | Texas | United States | 76508 |
| 1039 | The Center for Cancer and Blood Disorders-Weatherford | Weatherford | Texas | United States | 76086 |
| 1040 | American Fork Hospital / Huntsman Intermountain Cancer Center | American Fork | Utah | United States | 84003 |
| 1041 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 1042 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 1043 | Cottonwood Hospital Medical Center | Murray | Utah | United States | 84107 |
| 1044 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 1045 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 1046 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 1047 | Saint George Regional Medical Center | Saint George | Utah | United States | 84770 |
| 1048 | Intermountain Health Care | Salt Lake City | Utah | United States | 84103 |
| 1049 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 1050 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 1051 | Southwestern Vermont Medical Center | Bennington | Vermont | United States | 05201 |
| 1052 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 1053 | Rutland Regional Medical Center | Rutland | Vermont | United States | 05701 |
| 1054 | Mount Ascutney Hospital and Health Center | Windsor | Vermont | United States | 05089 |
| 1055 | Sentara Martha Jefferson Hospital | Charlottesville | Virginia | United States | 22901 |
| 1056 | University of Virginia Cancer Center | Charlottesville | Virginia | United States | 22908 |
| 1057 | Danville Regional Medical Center | Danville | Virginia | United States | 24541 |
| 1058 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042 |
| 1059 | Fredericksburg Oncology Inc | Fredericksburg | Virginia | United States | 22401 |
| 1060 | Peninsula Cancer Institute-Gloucester | Gloucester | Virginia | United States | 23061 |
| 1061 | Virginia Oncology Associates-Hampton | Hampton | Virginia | United States | 23666 |
| 1062 | Centra Lynchburg Hematology-Oncology Clinic Inc | Lynchburg | Virginia | United States | 24501 |
| 1063 | Peninsula Cancer Institute-Newport News | Newport News | Virginia | United States | 23601 |
| 1064 | Sentara Port Warwick | Newport News | Virginia | United States | 23606 |
| 1065 | Eastern Virginia Medical School | Norfolk | Virginia | United States | 23507 |
| 1066 | Southwest VA Regional Cancer Center | Norton | Virginia | United States | 24273 |
| 1067 | Virginia Cancer Institute | Richmond | Virginia | United States | 23229 |
| 1068 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 1069 | Peninsula Cancer Institute-Williamsburg | Williamsburg | Virginia | United States | 23185 |
| 1070 | MultiCare Auburn Medical Center | Auburn | Washington | United States | 98001 |
| 1071 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 1072 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 1073 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 1074 | Saint Francis Hospital | Federal Way | Washington | United States | 98003 |
| 1075 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 1076 | EvergreenHealth Medical Center | Kirkland | Washington | United States | 98033 |
| 1077 | Saint Clare Hospital | Lakewood | Washington | United States | 98499 |
| 1078 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 1079 | Providence - Saint Peter Hospital | Olympia | Washington | United States | 98506-5166 |
| 1080 | Capital Medical Center | Olympia | Washington | United States | 98507 |
| 1081 | Olympic Medical Center | Port Angeles | Washington | United States | 98362 |
| 1082 | Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo | Washington | United States | 98370 |
| 1083 | MultiCare Good Samaritan Hospital | Puyallup | Washington | United States | 98372 |
| 1084 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 1085 | Virginia Mason Medical Center | Seattle | Washington | United States | 98101 |
| 1086 | Minor and James Medical PLLC | Seattle | Washington | United States | 98104 |
| 1087 | Pacific Medical Center-First Hill | Seattle | Washington | United States | 98104 |
| 1088 | Kaiser Permanente Washington | Seattle | Washington | United States | 98112 |
| 1089 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 1090 | University of Washington Medical Center - Montlake | Seattle | Washington | United States | 98195 |
| 1091 | Cancer Care Northwest - Spokane South | Spokane | Washington | United States | 99202 |
| 1092 | Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | United States | 99204 |
| 1093 | Providence Holy Family Hospital | Spokane | Washington | United States | 99208 |
| 1094 | Evergreen Hematology and Oncology PS | Spokane | Washington | United States | 99218 |
| 1095 | Rockwood Clinic | Spokane | Washington | United States | 99220 |
| 1096 | MultiCare Allenmore Hospital | Tacoma | Washington | United States | 98405 |
| 1097 | MultiCare Tacoma General Hospital | Tacoma | Washington | United States | 98405 |
| 1098 | Northwest NCI Community Oncology Research Program | Tacoma | Washington | United States | 98405 |
| 1099 | Saint Joseph Medical Center | Tacoma | Washington | United States | 98405 |
| 1100 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431 |
| 1101 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 1102 | Compass Oncology Vancouver | Vancouver | Washington | United States | 98684 |
| 1103 | Cancer Institutes of Washington PLLC | Yakima | Washington | United States | 98902 |
| 1104 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 1105 | United Hospital Center | Bridgeport | West Virginia | United States | 26330 |
| 1106 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 1107 | Edwards Comprehensive Cancer Center | Huntington | West Virginia | United States | 25701 |
| 1108 | Marshall University Medical Center | Huntington | West Virginia | United States | 25701 |
| 1109 | Saint Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 1110 | West Virginia University Healthcare | Morgantown | West Virginia | United States | 26506 |
| 1111 | Camden Clark Medical Center | Parkersburg | West Virginia | United States | 26101 |
| 1112 | Princeton Community Hospital | Princeton | West Virginia | United States | 24740 |
| 1113 | Wheeling Hospital/Schiffler Cancer Center | Wheeling | West Virginia | United States | 26003 |
| 1114 | Langlade Hospital and Cancer Center | Antigo | Wisconsin | United States | 54409 |
| 1115 | Fox Valley Surgical Associates Limited | Appleton | Wisconsin | United States | 54911 |
| 1116 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
| 1117 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 1118 | Marshfield Clinic-Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 1119 | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 1120 | Marshfield Clinic Cancer Center at Sacred Heart | Eau Claire | Wisconsin | United States | 54701 |
| 1121 | Saint Agnes Hospital/Agnesian Cancer Center | Fond Du Lac | Wisconsin | United States | 54935 |
| 1122 | Aurora Cancer Care-Franklin | Franklin | Wisconsin | United States | 53132 |
| 1123 | Aurora Cancer Care-Glendale | Glendale | Wisconsin | United States | 53212 |
| 1124 | Green Bay Oncology at Saint Vincent Hospital | Green Bay | Wisconsin | United States | 54301-3526 |
| 1125 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 1126 | Green Bay Oncology Limited at Saint Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 1127 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 1128 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 1129 | Mercyhealth Hospital and Cancer Center - Janesville | Janesville | Wisconsin | United States | 53548 |
| 1130 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 1131 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 1132 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 1133 | Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | United States | 54601 |
| 1134 | Dean Hematology and Oncology Clinic | Madison | Wisconsin | United States | 53717 |
| 1135 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 1136 | Holy Family Memorial Hospital | Manitowoc | Wisconsin | United States | 54221 |
| 1137 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 1138 | Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 1139 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 1140 | Marshfield Medical Center | Marshfield | Wisconsin | United States | 54449 |
| 1141 | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin | United States | 53097 |
| 1142 | Ascension Southeast Wisconsin Hospital - Saint Joseph Campus | Milwaukee | Wisconsin | United States | 53210 |
| 1143 | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin | United States | 53211 |
| 1144 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 1145 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 1146 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 1147 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 1148 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 1149 | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 1150 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 1151 | Ascension All Saints Hospital | Racine | Wisconsin | United States | 53405 |
| 1152 | Ascension Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 1153 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 1154 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 1155 | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 1156 | Green Bay Oncology - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 1157 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 1158 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 1159 | ProHealth Waukesha Memorial Hospital | Waukesha | Wisconsin | United States | 53188 |
| 1160 | Aspirus Regional Cancer Center | Wausau | Wisconsin | United States | 54401 |
| 1161 | Marshfield Clinic-Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 1162 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 1163 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 1164 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 1165 | Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 1166 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 1167 | Rocky Mountain Oncology | Casper | Wyoming | United States | 82609 |
| 1168 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 1169 | Border Medical Oncology | Albury | New South Wales | Australia | 2640 |
| 1170 | Coffs Harbour Health Campus-North Coast Cancer Institute | Coffs Harbour | New South Wales | Australia | 2450 |
| 1171 | Concord Repatriation General Hospital | Concord | New South Wales | Australia | 2139 |
| 1172 | Lismore Base Hospital | Lismore | New South Wales | Australia | 2480 |
| 1173 | Lingard Private Hospital | Merewether | New South Wales | Australia | 2191 |
| 1174 | Royal Newcastle Hospital | New Castle | New South Wales | Australia | 2300 |
| 1175 | Calvary Mater Newcastle Hospital | Waratah | New South Wales | Australia | 2310 |
| 1176 | Royal Brisbane and Women's Hospital | Herston | Queensland | Australia | 4029 |
| 1177 | Nambour Hospital | Nambour | Queensland | Australia | 4560 |
| 1178 | Royal Hobart Hospital | Saint Hobart | Tasmania | Australia | 7000 |
| 1179 | Breast Unit-Mercy Private | East Melbourne | Victoria | Australia | 3002 |
| 1180 | Epworth Hospital | Richmond | Victoria | Australia | 3121 |
| 1181 | Saint John of God Hospital - Bunbury | Bunbury | Western Australia | Australia | 6230 |
| 1182 | Sir Charles Gairdner Hospital | Nedlands | Western Australia | Australia | 6009 |
| 1183 | Tom Baker Cancer Centre | Calgary | Alberta | Canada | T2N 4N2 |
| 1184 | BCCA-Cancer Centre for the Southern Interior | Kelowna | British Columbia | Canada | V1Y 5L3 |
| 1185 | Penticton Regional Hospital | Penticton | British Columbia | Canada | V2A 3G6 |
| 1186 | BCCA-Fraser Valley Cancer Centre | Surrey | British Columbia | Canada | V3V 1Z2 |
| 1187 | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia | Canada | V5Z 4E6 |
| 1188 | BCCA-Vancouver Island Cancer Centre | Victoria | British Columbia | Canada | V8R 6V5 |
| 1189 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
| 1190 | The Moncton Hospital | Moncton | New Brunswick | Canada | E1C 6Z8 |
| 1191 | Atlantic Health Sciences Corporation-Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 1192 | Trillium Health Partners - Credit Valley Hospital | Mississauga | Ontario | Canada | L5M 2N1 |
| 1193 | Health Sciences North | Sudbury | Ontario | Canada | P3E 5J1 |
| 1194 | Thunder Bay Regional Health Science Centre | Thunder Bay | Ontario | Canada | P7B 6V4 |
| 1195 | Michael Garron Hospital | Toronto | Ontario | Canada | M4C 3E7 |
| 1196 | Odette Cancer Centre- Sunnybrook Health Sciences Centre | Toronto | Ontario | Canada | M4N 3M5 |
| 1197 | Saint Michael's Hospital | Toronto | Ontario | Canada | M5B 1W8 |
| 1198 | Trillium Health Partners - Queensway Health Centre | Toronto | Ontario | Canada | M9C 1A5 |
| 1199 | Windsor Regional Cancer Centre | Windsor | Ontario | Canada | N8W 2X3 |
| 1200 | CSSS Champlain-Charles Le Moyne | Greenfield Park | Quebec | Canada | J4V 2H1 |
| 1201 | CIUSSSEMTL-Hopital Maisonneuve-Rosemont | Montreal | Quebec | Canada | H1T 2M4 |
| 1202 | CHUM - Hopital Notre-Dame | Montreal | Quebec | Canada | H2L 4M1 |
| 1203 | McGill University Department of Oncology | Montreal | Quebec | Canada | H2W 1S6 |
| 1204 | CHUM-Hotel Dieu de Montreal | Montreal | Quebec | Canada | H2W 1T8 |
| 1205 | CHUM - Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2X 3E4 |
| 1206 | The Research Institute of the McGill University Health Centre (MUHC) | Montreal | Quebec | Canada | H3H 2R9 |
| 1207 | Jewish General Hospital | Montreal | Quebec | Canada | H3T 1E2 |
| 1208 | CHU de Quebec-Hopital du Saint-Sacrement (HSS) | Quebec City | Quebec | Canada | G1S 4L8 |
| 1209 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 1210 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
| 1211 | Bon Secours Hospital | Cork | Co Cork | Ireland | |
| 1212 | South Infirmary Victoria Hospital | Cork | Co Cork | Ireland | |
| 1213 | Tallaght University Hospital | Dublin | Co Dublin | Ireland | 24 |
| 1214 | Saint Vincent's University Hospital | Dublin | Co Dublin | Ireland | 4 |
| 1215 | Mater Misericordiae University Hospital | Dublin | Co Dublin | Ireland | 7 |
| 1216 | Mater Private Hospital | Dublin | Co Dublin | Ireland | 7 |
| 1217 | Beaumont Hospital | Dublin | Co Dublin | Ireland | 9 |
| 1218 | Saint Vincent's Private Hospital | Merrion | Co Dublin | Ireland | 4 |
| 1219 | University College Hospital Galway | Galway | Co Galway | Ireland | |
| 1220 | Mid-Western Regional Hospital | Limerick | Co Limerick | Ireland | 9 |
| 1221 | Sligo University Hospital | Sligo | Co Sligo | Ireland | |
| 1222 | University Hospital Waterford | Waterford | Co Waterford | Ireland | 9 |
| 1223 | Cork University Hospital | Cork | Ireland | ||
| 1224 | Saint James Hospital | Dublin | Ireland | 8 | |
| 1225 | Letterkenny General Hospital | Letterkenny | Ireland | Co Donegal | |
| 1226 | Auckland City Hospital | Grafton | Auckland | New Zealand | 1010 |
| 1227 | Waikato Hospital | Hamilton | New Zealand | 3204 | |
| 1228 | Wellington Hospital | Wellington | New Zealand | 6021 | |
| 1229 | Instituto Nacional de Enfermedades Neoplasicas | Lima | Peru | Lima 34 | |
| 1230 | San Juan City Hospital | San Juan | Puerto Rico | 00936 | |
| 1231 | Belfast City Hospital | Belfast | Northern Ireland | United Kingdom | BT9 7AB |
Sponsors and Collaborators
- National Cancer Institute (NCI)
- American College of Surgeons
- Cancer and Leukemia Group B
- NSABP Foundation Inc
- NCIC Clinical Trials Group
- North Central Cancer Treatment Group
- Southwest Oncology Group
Investigators
- Principal Investigator: Joseph A Sparano, ECOG-ACRIN Cancer Research Group
Study Documents (Full-Text)
More Information
Additional Information:
Publications
None provided.Responsible Party:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00310180
Other Study ID Numbers:
- NCI-2009-00707
- NCI-2009-00707
- ECOG-PACCT-1
- 06-482
- CDR0000472066
- PACCT-1
- PACCT-1
- PACCT-1
- U10CA180820
- U10CA021115
- NCT00554931
First Posted:
Apr 3, 2006
Last Update Posted:
Jul 28, 2022
Last Verified:
Mar 1, 2022
Study Results
Participant Flow
| Recruitment Details | This study was activated on April 7, 2006 and closed to registrations on October 6, 2010. A total of 11,232 patients were preregistered for Recurrence Score evaluation and 10,273 proceeded to register on the study. |
|---|---|
| Pre-assignment Detail | Patients needed to be preregistered to the trial for ONCOTYPE recurrence score test, patients then were assigned or randomized to one of the four arms based on the recurrence score. |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Period Title: Overall Study | ||||
| STARTED | 1629 | 3458 | 3449 | 1737 |
| No On-study Data | 0 | 2 | 10 | 172 |
| Ineligible | 3 | 4 | 6 | 7 |
| No Follow-up Data | 7 | 55 | 131 | 245 |
| COMPLETED | 1619 | 3399 | 3312 | 1389 |
| NOT COMPLETED | 10 | 59 | 137 | 348 |
Baseline Characteristics
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D | Total |
|---|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Total of all reporting groups |
| Overall Participants | 1619 | 3399 | 3312 | 1389 | 9719 |
| Age, Customized (Count of Participants) | |||||
| <=40 years |
58
3.6%
|
154
4.5%
|
157
4.7%
|
79
5.7%
|
448
4.6%
|
| 41-50 years |
371
22.9%
|
985
29%
|
920
27.8%
|
330
23.8%
|
2606
26.8%
|
| 51-60 years |
563
34.8%
|
1235
36.3%
|
1206
36.4%
|
512
36.9%
|
3516
36.2%
|
| 61-70 years |
518
32%
|
868
25.5%
|
895
27%
|
395
28.4%
|
2676
27.5%
|
| 71-75 years |
109
6.7%
|
157
4.6%
|
134
4%
|
73
5.3%
|
473
4.9%
|
| Sex: Female, Male (Count of Participants) | |||||
| Female |
1619
100%
|
3399
100%
|
3312
100%
|
1389
100%
|
9719
100%
|
| Male |
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
| Race (NIH/OMB) (Count of Participants) | |||||
| American Indian or Alaska Native |
8
0.5%
|
11
0.3%
|
16
0.5%
|
4
0.3%
|
39
0.4%
|
| Asian |
82
5.1%
|
140
4.1%
|
132
4%
|
51
3.7%
|
405
4.2%
|
| Native Hawaiian or Other Pacific Islander |
8
0.5%
|
7
0.2%
|
14
0.4%
|
1
0.1%
|
30
0.3%
|
| Black or African American |
107
6.6%
|
236
6.9%
|
235
7.1%
|
115
8.3%
|
693
7.1%
|
| White |
1361
84.1%
|
2883
84.8%
|
2783
84%
|
1162
83.7%
|
8189
84.3%
|
| More than one race |
2
0.1%
|
5
0.1%
|
2
0.1%
|
1
0.1%
|
10
0.1%
|
| Unknown or Not Reported |
51
3.2%
|
117
3.4%
|
130
3.9%
|
55
4%
|
353
3.6%
|
| Recurrence score (Count of Participants) | |||||
| 0-5 |
432
26.7%
|
0
0%
|
0
0%
|
0
0%
|
432
4.4%
|
| 6-10 |
1187
73.3%
|
0
0%
|
0
0%
|
0
0%
|
1187
12.2%
|
| 11-15 |
0
0%
|
1214
35.7%
|
1159
35%
|
0
0%
|
2373
24.4%
|
| 16-20 |
0
0%
|
1368
40.2%
|
1344
40.6%
|
0
0%
|
2712
27.9%
|
| 21-25 |
0
0%
|
817
24%
|
809
24.4%
|
0
0%
|
1626
16.7%
|
| 26-30 |
0
0%
|
0
0%
|
0
0%
|
598
43.1%
|
598
6.2%
|
| 31-35 |
0
0%
|
0
0%
|
0
0%
|
315
22.7%
|
315
3.2%
|
| 36-40 |
0
0%
|
0
0%
|
0
0%
|
158
11.4%
|
158
1.6%
|
| 41-50 |
0
0%
|
0
0%
|
0
0%
|
202
14.5%
|
202
2.1%
|
| >50 |
0
0%
|
0
0%
|
0
0%
|
116
8.4%
|
116
1.2%
|
Outcome Measures
| Title | 5-year Disease-free Survival |
|---|---|
| Description | Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method, and compared between the two randomized arms (arm B vs. arm C) using stratified log rank test and stratified Cox proportional hazard model. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years, DFS rate estimated at 5 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| All eligible patients who had on-study data and follow-up data were included in the analysis |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 1619 | 3399 | 3312 | 1389 |
| Number (95% Confidence Interval) [percentage of participants] |
94.0
5.8%
|
92.8
2.7%
|
93.1
2.8%
|
87.6
6.3%
|
Statistical Analysis 1
| Statistical Analysis Overview | Comparison Group Selection | Arm B, Arm C |
|---|---|---|
| Comments | This study uses a noninferiority design, but the noninferiority question is formulated using the conventional superiority null hypothesis of equal DFS on the two arms (that is, the null hypothesis is that Arm B is not inferior to Arm C). The alternative hypothesis is that Arm B has substantially worse DFS than Arm C, specified by a hazard ratio for B vs. C of 1.322. | |
| Type of Statistical Test | Superiority | |
| Comments | Since the noninferiority comparison is formulated using a conventional superiority null hypothesis described as above, a type II error corresponds to concluding that Arm B is not inferior when in fact it is. The design therefore uses a one-sided type I error of 10% and is planned to have 95% power (5% type II error). If the null hypothesis is rejected (at the one-sided 10% level), then it will be concluded that endocrine therapy alone is inferior to chemoendocrine therapy. | |
| Statistical Test of Hypothesis | p-Value | 0.13 |
| Comments | One-sided p value for stratified Cox proportional hazard analysis, stratified on recurrence score, tumor size and menopausal status. | |
| Method | Regression, Cox | |
| Comments | ||
| Method of Estimation | Estimation Parameter | Hazard Ratio (HR) |
| Estimated Value | 1.08 | |
| Confidence Interval |
(2-Sided) 95% 0.94 to 1.24 |
|
| Parameter Dispersion |
Type: Value: |
|
| Estimation Comments | ||
| Title | 5-year Distant Recurrence-free Interval |
|---|---|
| Description | Distant recurrence-free interval (DRFI) is defined as time from date of randomization or registration to the date of distant recurrence of breast cancer, or of death with distant recurrence, if death is the first manifestation of distant recurrence. The distribution of DRFI (eg, 5-year DRFI rate) is estimated using Kaplan-Meier method. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years, DRFI rate estimated at 5 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| All eligible patients who had on-study data and follow-up data |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 1619 | 3399 | 3312 | 1389 |
| Number (95% Confidence Interval) [percentage of participants] |
99.3
6.1%
|
98.0
2.9%
|
98.2
3%
|
93.0
6.7%
|
| Title | 5-year Recurrence-free Interval |
|---|---|
| Description | Recurrence-free interval (RFS) is defined as time from date of randomization or registration to the date of first recurrence of breast cancer (ipsilateral breast tumor recurrence, local/regional recurrence, distant recurrence) or to the date of death with recurrence, if death is the first manifestation of recurrence. The distribution of RFS (eg, 5-year RFS rate) is estimated using Kaplan-Meier method. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years, RFS rate estimated at 5 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| All eligible patients who had on-study data and follow-up data were included in the analysis |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 1619 | 3399 | 3312 | 1389 |
| Number (95% Confidence Interval) [percentage of participants] |
98.8
6.1%
|
96.9
2.9%
|
97.0
2.9%
|
91.0
6.6%
|
| Title | 5-year Overall Survival |
|---|---|
| Description | Overall survival (OS) is defined as time from date of randomization or registration to date of death from any cause. The distribution of OS (eg, 5-year OS rate) is estimated using Kaplan-Meier method. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years, OS rate estimated at 5 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| All eligible patients who had on-study data and follow-up data were included in the analysis |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 1619 | 3399 | 3312 | 1389 |
| Number (95% Confidence Interval) [percentage of participants] |
98.0
6.1%
|
98.0
2.9%
|
98.1
3%
|
95.9
6.9%
|
| Title | 5-year Disease-free Survival by Age and Recurrence Score Groups |
|---|---|
| Description | Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. DFS is evaluated by recurrence score (0-10 vs. 11-15 vs. 16-20 vs. 21-25 vs. >25) and age groups (<=50 vs. 51-65 vs. 65-75). The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years, DFS rate estimated at 5 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| All eligible patients who had on-study data and follow-up data were included in the analysis |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 1619 | 3399 | 3312 | 1389 |
| RS 0-10 & Age<=50 |
95.1
5.9%
|
NA
NaN
|
NA
NaN
|
NA
NaN
|
| RS 0-10 & Age 51-65 |
94.7
5.8%
|
NA
NaN
|
NA
NaN
|
NA
NaN
|
| RS 0-10 & Age 66-75 |
90.5
5.6%
|
NA
NaN
|
NA
NaN
|
NA
NaN
|
| RS 11-15 & Age <=50 |
NA
NaN
|
95.1
2.8%
|
94.3
2.8%
|
NA
NaN
|
| RS 11-15 & Age 51-65 |
NA
NaN
|
95.5
2.8%
|
93.9
2.8%
|
NA
NaN
|
| RS 11-15 & Age 66-75 |
NA
NaN
|
87.1
2.6%
|
91.4
2.8%
|
NA
NaN
|
| RS 16-20 & Age <=50 |
NA
NaN
|
92.0
2.7%
|
94.7
2.9%
|
NA
NaN
|
| RS 16-20 & Age 51-65 |
NA
NaN
|
94.3
2.8%
|
92.2
2.8%
|
NA
NaN
|
| RS 16-20 & Age 66-75 |
NA
NaN
|
90.1
2.7%
|
90.2
2.7%
|
NA
NaN
|
| RS 21-25 & Age <=50 |
NA
NaN
|
86.3
2.5%
|
92.1
2.8%
|
NA
NaN
|
| RS 21-25 & Age 51-65 |
NA
NaN
|
91.6
2.7%
|
93.4
2.8%
|
NA
NaN
|
| RS 21-25 & Age 66-75 |
NA
NaN
|
93.8
2.8%
|
90.9
2.7%
|
NA
NaN
|
| RS >25 & Age <=50 |
NA
NaN
|
NA
NaN
|
NA
NaN
|
86.4
6.2%
|
| RS >25 & Age 51-65 |
NA
NaN
|
NA
NaN
|
NA
NaN
|
87.5
6.3%
|
| RS >25 & Age 66-75 |
NA
NaN
|
NA
NaN
|
NA
NaN
|
89.8
6.5%
|
Statistical Analysis 1
| Statistical Analysis Overview | Comparison Group Selection | Arm B, Arm C |
|---|---|---|
| Comments | Treatment interaction test was performed for the 9 age by RS subsets (3 groups for each, age groups <=50 vs. 51-65 vs. 66-75; RS groups 0-10 vs. 11-25 vs. >25) in patients randomized to arms B and C | |
| Type of Statistical Test | Other | |
| Comments | Treatment-by-Age and RS subset was performed via Cox proportional hazard analysis | |
| Statistical Test of Hypothesis | p-Value | 0.004 |
| Comments | ||
| Method | Regression, Cox | |
| Comments | ||
| Title | To Compare the Outcomes Projected at 10 Years by Adjuvant! With Those Made by the Genomic Health Oncotype DX Test |
|---|---|
| Description | Adjuvant! is not currently available; additional work combining classical information with genomic tests will be reported separately. |
| Time Frame | Assessed at 10 years after study entry |
Outcome Measure Data
| Analysis Population Description |
|---|
| Outcome will never be analyzed. |
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D |
|---|---|---|---|---|
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials |
| Measure Participants | 0 | 0 | 0 | 0 |
| Title | 5-year Disease-free Survival by Individual RS Gene Groups |
|---|---|
| Description | Disease-free survival (DFS) is defined to be time from randomization to first event, where the first event is any of ipsilateral breast tumor recurrence, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary non-breast invasive cancer (excluding non-melanoma skin cancers), or death without evidence of recurrence. The distribution of DFS (eg, 5-year DFS rate) is estimated using Kaplan-Meier method. 5-year DFS by individual RS gene groups (Proliferation Gene Group, HER2 Gene Group, ER Gene Group, Invasion Gene Group, and Other Genes) will be estimated in each arm. |
| Time Frame | Assessed every 6 months within 5 years from registration and then annually up to 20 years |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title |
|---|
| Arm/Group Description |
Adverse Events
| Time Frame | Both the chemotherapy and endocrine therapy given on this study were standard therapies for this population. To simplify the effort required for participating sites, adverse event data were not collected. | |||||||
|---|---|---|---|---|---|---|---|---|
| Adverse Event Reporting Description | Both the chemotherapy and endocrine therapy given on this study were standard therapies for this population. To simplify the effort required for participating sites, adverse event data were not collected. | |||||||
| Arm/Group Title | Arm A | Arm B | Arm C | Arm D | ||||
| Arm/Group Description | Group 1 (Oncotype DX recurrence score =< 10): Patients in this group receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive hormone therapy with tamoxifen, anastrozole, letrozole, or exemestane PO for up to 5 years. Some patients then continue to receive hormone therapy for an additional 5 years. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO | Group 2 (Oncotype DX recurrence score 11-25): Patients receive standard combination chemotherapy at the discretion of the treating physician. Within 4 weeks after the last dose of chemotherapy, patients receive hormonal therapy as in Group 1 at the discretion of the treating physician. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | Group 3 (Oncotype DX recurrence score >= 26): Patients in this group receive combination chemotherapy followed by hormone therapy similar to the patients in Group 2 who are assigned to receive both types of treatment. Anastrozole: Given PO Exemestane: Given PO Letrozole: Given PO Tamoxifen: Given PO Combination chemotherapy: including oral CMF, IV CMF, standard AC, dose dense AC, standard AC-T, dose dense AC-T, FEC, TAC, TC, other protocol-specified regimens if participating in other CTSU trials including chemotherapy, and other regimens not protocol-specified if not participating in CTSU trials | ||||
All Cause Mortality |
||||||||
| Arm A | Arm B | Arm C | Arm D | |||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | ||||
Serious Adverse Events |
||||||||
| Arm A | Arm B | Arm C | Arm D | |||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | ||||
Other (Not Including Serious) Adverse Events |
||||||||
| Arm A | Arm B | Arm C | Arm D | |||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | 0/0 (NaN) | ||||
Limitations/Caveats
[Not Specified]
More Information
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is less than or equal to 60 days. The sponsor cannot require changes to the communication and cannot extend the embargo.
Results Point of Contact
| Name/Title | ECOG-ACRIN statistician |
|---|---|
| Organization | ECOG-ACRIN Cancer Research Group |
| Phone | 617-632-3000 |
| eatrials@jimmy.harvard.edu |
Responsible Party:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00310180
Other Study ID Numbers:
- NCI-2009-00707
- NCI-2009-00707
- ECOG-PACCT-1
- 06-482
- CDR0000472066
- PACCT-1
- PACCT-1
- PACCT-1
- U10CA180820
- U10CA021115
- NCT00554931
First Posted:
Apr 3, 2006
Last Update Posted:
Jul 28, 2022
Last Verified:
Mar 1, 2022