Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer in Postmenopausal Women
Sponsor
NSABP Foundation Inc (Other)
Overall Status
Completed
CT.gov ID
NCT00003906
Collaborator
National Cancer Institute (NCI) (NIH), Eli Lilly and Company (Industry), AstraZeneca (Industry)
19,747
516
2
159
38.3
0.2
Study Details
Study Description
Brief Summary
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using raloxifene and tamoxifen may fight breast cancer by blocking the uptake of estrogen by the tumor cells.
PURPOSE: Randomized double-blinded clinical trial to compare the effectiveness of raloxifene with that of tamoxifen in preventing breast cancer in postmenopausal women.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 3 |
Detailed Description
OBJECTIVES:
-
Determine whether raloxifene is more or less effective than tamoxifen in significantly reducing the incidence rate of invasive breast cancer in postmenopausal women.
-
Evaluate the effects of tamoxifen and raloxifene on the incidence of intraductal carcinoma in situ, lobular carcinoma in situ, endometrial cancer, ischemic heart disease, fractures of the hip and spine, or Colles' fractures of the wrist in these participants.
-
Evaluate the toxic effects of these regimens in these participants.
-
Determine the effect of these regimens on the quality of life of these participants (at selected centers). (Quality of life evaluation closed to accrual effective 5/31/01.)
OUTLINE: This is a randomized, double-blind study. Participants are stratified by age (35 to 49 vs 50 to 59 vs over 59), race (black vs white vs other), history of lobular carcinoma in situ (yes vs no), prior hysterectomy (yes vs no), and estimated absolute risk of invasive breast cancer within 5 years (using the Gail model)(less than 2.0 vs 2.0-2.9 vs 3.0-4.9 vs 5.0 or greater). Participants are randomized to 1 of 2 arms.
-
Arm I: Participants receive oral tamoxifen plus placebo daily for 5 years.
-
Arm II: Participants receive oral raloxifene plus placebo daily for 5 years. Quality of life is assessed (at selected centers) at baseline and at 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, and 72 months. (Quality of life evaluation closed to accrual effective 5/31/01.)
Participants are followed annually after 5 years.
PROJECTED ACCRUAL: Approximately 19,000 participants will be accrued for this study within 5 years.
Study Design
Study Type:
Interventional
Actual Enrollment
:
19747 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Prevention
Official Title:
Study of Tamoxifen and Raloxifene (STAR) for the Prevention of Breast Cancer
Study Start Date
:
May 1, 1999
Actual Primary Completion Date
:
Dec 1, 2005
Actual Study Completion Date
:
Aug 1, 2012
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Group 1 Tamoxifen and placebo |
Drug: Tamoxifen
20 mg/day plus placebo for 5 years
|
| Experimental: Group 2 Raloxifene and Placebo |
Drug: Raloxifene
60 mg/day plus placebo for 5 years
|
Outcome Measures
Primary Outcome Measures
- Incidence of invasive breast cancer; superiority of one of the therapies. [Time from randomization to the occurance of invasive breast cancer.]
Determine which of the following is true: compared to tamoxifen, raloxifene significantly reduces the incidence rate of invasive breast cancer; compared to raloxifene, tamoxifen significantly reduces the incidence rate of invasive breast cancer; or the statistical superiority of one of the treatments cannot be demonstrated and the choice of therapy should be based on benefit/risk considerations.
Secondary Outcome Measures
- Effect of the study therapies on the incidence of intraductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). [Time from randomization to the occurance of DCIS or LCIS.]
- Effect of the study therapies on the incidence of endometrial cancer. [Time from randomization to the occurance of endometrial cancer.]
- Effect of the study therapies on the incidence of ischemic heart disease. [Time from randomization to the occurance of ischimic heart disease.]
- Effect of the study therapies on the incidence of fractures of the hip, spine, or Colles' fractures of the wrist. [Time from randomization to the occurance of fractures of the hip, spine, or Colles' fractures of the wrist.]
- Effect of the study therapies on the toxicity and side effects of each therapy. [Incidences of protocol defined toxicities and side effects.]
- Effect of the study therapies on participants' quality of life. [pre-entry, every 6 months for 5 years, and then annual after 5 years following randomization.]
Eligibility Criteria
Criteria
Ages Eligible for Study:
35 Years
and Older
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
-
Postmenopausal women at increased risk for developing invasive breast cancer, who meet one of the following criteria:
-
At least 12 months since spontaneous menstrual bleeding
-
Prior documented hysterectomy and bilateral salpingo-oophorectomy
-
At least 55 years of age with prior hysterectomy with or without oophorectomy
-
Age 35 to 54 with a prior hysterectomy without oophorectomy OR with a status of ovaries unknown with documented follicle-stimulating hormone level demonstrating elevation in postmenopausal range
-
Histologically confirmed lobular carcinoma in situ treated by local excision only OR a minimum projected 5 year probability of invasive breast cancer of at least 1.66%, using Breast Cancer Risk Assessment Profile
-
No clinical evidence of malignancy on physical exam within the past 180 days
-
No evidence of suspicious or malignant disease on bilateral mammogram within the past year
-
No bilateral or unilateral prophylactic mastectomy
-
No prior invasive breast cancer or intraductal carcinoma in situ
-
Hormone receptor status:
-
Not specified
PATIENT CHARACTERISTICS:
Age:
- 35 and over
Sex:
- Female
Menopausal status:
- See Disease Characteristics
Performance status:
- No restricted normal activity for a significant portion of each day
Life expectancy:
- At least 10 years
Hematopoietic:
-
Granulocyte count at least 1,500/mm^3
-
Complete blood count and differential normal
-
Platelet count normal
Hepatic:
-
SGOT or SGPT normal
-
Bilirubin normal
-
Alkaline phosphatase normal
Renal:
- Creatinine normal
Cardiovascular:
-
No cerebral vascular accident, transient ischemic attack, atrial fibrillation, or uncontrolled hypertension
-
No deep vein thrombosis
Pulmonary:
- No pulmonary embolus
Other:
-
No other prior malignancy within the past 5 years except basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
-
No concurrent nonmalignant disease that would preclude administration of tamoxifen or raloxifene
-
No clinical depression, psychiatric condition, or addictive disorder
-
No uncontrolled diabetes
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- Not specified
Endocrine therapy:
-
At least 3 months since prior estrogen or progesterone replacement therapy, oral contraceptives, androgens, luteinizing hormone-releasing hormone analogs, prolactin inhibitors, or antiandrogens
-
At least 3 months since prior tamoxifen, raloxifene, or other selective estrogen-receptor modulators of less than 3 months duration
-
Concurrent Estring allowed
Radiotherapy:
- No prior breast radiotherapy
Surgery:
- See Disease Characteristics
Other:
-
No prior systemic adjuvant therapy for breast cancer
-
No other participation in a cancer prevention or osteoporosis prevention study involving pharmacologic intervention(s)
-
NSABP-P-1 patients who received placebo are eligible
-
No concurrent warfarin or cholestyramine
-
Concurrent calcitonin or nonhormonal medication (e.g., cholecalciferol, fluoride, or bisphosphonates) allowed
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Comprehensive Cancer Institute | Huntsville | Alabama | United States | 35801 |
| 2 | MBCCOP - Gulf Coast | Mobile | Alabama | United States | 36688 |
| 3 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99519-6604 |
| 4 | CCOP - Western Regional, Arizona | Phoenix | Arizona | United States | 85006-2726 |
| 5 | CCOP - Mayo Clinic Scottsdale Oncology Program | Scottsdale | Arizona | United States | 85259-5404 |
| 6 | Arizona Cancer Center at University of Arizona Health Sciences Center | Tucson | Arizona | United States | 85724 |
| 7 | Breast Associates | Fayetteville | Arkansas | United States | 72703 |
| 8 | Surgical Associates | Fort Smith | Arkansas | United States | 72917 |
| 9 | Northeast Arkansas Clinic | Jonesboro | Arkansas | United States | 72401 |
| 10 | Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 11 | Kaiser Permanente Medical Center - Anaheim/Orange County | Anaheim | California | United States | 92805 |
| 12 | Kaiser Permanente Medical Center - Baldwin Park | Baldwin Park | California | United States | 91706 |
| 13 | Kaiser Permanente Medical Center - Bellflower | Bellflower | California | United States | 90706 |
| 14 | Alta Bates Comprehensive Cancer Center | Berkeley | California | United States | 94704 |
| 15 | Providence Saint Joseph Medical Center - Burbank | Burbank | California | United States | 91505 |
| 16 | Mills-Peninsula Health Services | Burlingame | California | United States | 94010 |
| 17 | Enloe Cancer Center at Enloe Medical Center | Chico | California | United States | 95926 |
| 18 | Mount Diablo Medical Center | Concord | California | United States | 94524-4110 |
| 19 | Corona Regional Medical Center | Corona | California | United States | 92882-3400 |
| 20 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010-3000 |
| 21 | Scripps Memorial Hospitals-Stevens Cancer Center - Encinitas | Encinitas | California | United States | 92024 |
| 22 | North Bay Cancer Center | Fairfield | California | United States | 94533 |
| 23 | Kaiser Permanente Medical Center - Fontana | Fontana | California | United States | 92335 |
| 24 | Crosson Cancer Center at St. Jude Medical Center | Fullerton | California | United States | 92835 |
| 25 | Glendale Memorial Hospital Comprehensive Cancer Center | Glendale | California | United States | 91204 |
| 26 | Oncology/Hematology Associates | Granada Hills | California | United States | 91344 |
| 27 | Marin General Hospital Cancer Institute | Greenbrae | California | United States | 94904 |
| 28 | Kaiser Permanente Medical Center - Harbor City | Harbor City | California | United States | 90710 |
| 29 | Hemet Valley Medical Center | Hemet | California | United States | 92543 |
| 30 | Rebecca and John Moores UCSD Cancer Center | La Jolla | California | United States | 92093-0658 |
| 31 | Valley Tumor Medical Group | Lancaster | California | United States | 93534 |
| 32 | Loma Linda University Cancer Institute at Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 33 | Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach | California | United States | 90801-1428 |
| 34 | Pacific Shores Medical Group Comprehensive Hematology-Oncology Services - Long Beach | Long Beach | California | United States | 90813 |
| 35 | Kaiser Permanente Medical Center - Los Angeles | Los Angeles | California | United States | 90027 |
| 36 | USC/Norris Comprehensive Cancer Center and Hospital | Los Angeles | California | United States | 90033-0804 |
| 37 | Cecilia Gonzalez De La Hoya Cancer Center at White Memorial Medical Center | Los Angeles | California | United States | 90033 |
| 38 | Kaiser Foundation Hospital - West Los Angeles | Los Angeles | California | United States | 90034 |
| 39 | St. Vincent Medical Center - Los Angeles | Los Angeles | California | United States | 90057-1901 |
| 40 | Jonsson Comprehensive Cancer Center, UCLA | Los Angeles | California | United States | 90095-1781 |
| 41 | Mission Cancer Center at Mission Hospital | Mission Viejo | California | United States | 92691 |
| 42 | Sutter Gould Medical Foundation | Modesto | California | United States | 95353 |
| 43 | Leavey Cancer Center at Northridge Hospital Medical Center | Northridge | California | United States | 91328 |
| 44 | Breast Health Center | Oceanside | California | United States | 92056 |
| 45 | St. Joseph Hospital Regional Cancer Center - Orange | Orange | California | United States | 92868-3849 |
| 46 | Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center | Orange | California | United States | 92868 |
| 47 | Ventura Hematology - Oncology Specialists - Oxnard | Oxnard | California | United States | 93030 |
| 48 | Comprehensive Cancer Centers of the Desert | Palm Springs | California | United States | 92262 |
| 49 | Palo Alto Medical Foundation | Palo Alto | California | United States | 95819-5156 |
| 50 | Kaiser Permanente Medical Group | Panorama City | California | United States | 91402 |
| 51 | Huntington Cancer Center at Huntington Hospital | Pasadena | California | United States | 91109-7013 |
| 52 | Wilshire Oncology Medical Group, Incorporated - Pomona | Pomona | California | United States | 91767-3021 |
| 53 | North Valley Breast Clinic | Redding | California | United States | 96001 |
| 54 | Kaiser Permanente Medical Center - Riverside | Riverside | California | United States | 92505 |
| 55 | Sutter Roseville Medical Center | Roseville | California | United States | 95661 |
| 56 | Sutter Breast Cancer Group | Sacramento | California | United States | 95819-5156 |
| 57 | Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego | San Diego | California | United States | 92120 |
| 58 | Naval Medical Center - San Diego | San Diego | California | United States | 92134-3202 |
| 59 | California Pacific Medical Center - California Campus | San Francisco | California | United States | 94118-1618 |
| 60 | UCSF Comprehensive Cancer Center | San Francisco | California | United States | 94143-0128 |
| 61 | Cancer Center of Santa Barbara | Santa Barbara | California | United States | 93105 |
| 62 | CCOP - Santa Rosa Memorial Hospital | Santa Rosa | California | United States | 95403 |
| 63 | Stanford Cancer Center at Stanford University Medical Center | Stanford | California | United States | 94305-5408 |
| 64 | Torrance Memorial Medical Center | Torrance | California | United States | 90505 |
| 65 | Santa Clarita Valley Cancer Center - UCLA | Valencia | California | United States | 91355 |
| 66 | Kaiser Permanente Medical Center - Vallejo | Vallejo | California | United States | 94589 |
| 67 | Kaiser Permanente Medical Cener - Woodland Hills | Woodland Hills | California | United States | 91365-4084 |
| 68 | Penrose Cancer Center | Colorado Springs | Colorado | United States | 80933 |
| 69 | CCOP - Colorado Cancer Research Program, Incorporated | Denver | Colorado | United States | 80209-5031 |
| 70 | Poudre Valley Hospital | Fort Collins | Colorado | United States | 80524 |
| 71 | St. Mary-Corwin Regional Medical Center | Pueblo | Colorado | United States | 81004 |
| 72 | University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center | Farmington | Connecticut | United States | 06360-7106 |
| 73 | Hartford Hospital | Hartford | Connecticut | United States | 06102-5037 |
| 74 | St. Francis Hospital and Medical Center | Hartford | Connecticut | United States | 06105 |
| 75 | Manchester Memorial Hospital | Manchester | Connecticut | United States | 06040-4188 |
| 76 | Midstate Medical Center | Meriden | Connecticut | United States | 06451 |
| 77 | New Britain General Hospital | New Britain | Connecticut | United States | 06050 |
| 78 | Hospital of St. Raphael | New Haven | Connecticut | United States | 06511 |
| 79 | Yale Comprehensive Cancer Center | New Haven | Connecticut | United States | 06520-8028 |
| 80 | Lawrence and Memorial Hospital | New London | Connecticut | United States | 06320 |
| 81 | Eastern Connecticut Hematology and Oncology Associates | Norwich, | Connecticut | United States | 06360 |
| 82 | Hematology Oncology, P.C. | Stamford | Connecticut | United States | 06902 |
| 83 | Northwestern Connecticut Oncology-Hematology Associates | Torrington | Connecticut | United States | 06790 |
| 84 | Windham Community Memorial Hospital | Williamantic | Connecticut | United States | 06226 |
| 85 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 86 | Nanticoke Memorial Hospital | Seaford | Delaware | United States | 19973 |
| 87 | CCOP - Christiana Care Health Services | Wilmington | Delaware | United States | 19899 |
| 88 | Lombardi Cancer Center at Georgetown University Medical Center | Washington | District of Columbia | United States | 20007 |
| 89 | Washington Hospital Center | Washington | District of Columbia | United States | 20010 |
| 90 | Providence Hospital | Washington | District of Columbia | United States | 20017 |
| 91 | JFK Medical Center | Atlantis | Florida | United States | 33462 |
| 92 | St. Vincent's Medical Center | Jacksonville | Florida | United States | 32203 |
| 93 | Baptist Regional Cancer Institute - Jacksonville | Jacksonville | Florida | United States | 32207 |
| 94 | Mayo Clinic - Jacksonville | Jacksonville | Florida | United States | 32224 |
| 95 | Ella Milbank Foshay Cancer Center at Jupiter Medical Center | Jupiter | Florida | United States | 33458 |
| 96 | Watson Clinic | Lakeland | Florida | United States | 33804-5000 |
| 97 | Lakeland Regional Cancer Center at Lakeland Regional Medical Center | Lakeland | Florida | United States | 33804 |
| 98 | CCOP - Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 99 | University of Miami Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 100 | Florida Hospital Medical Center | Orlando | Florida | United States | 32803-1273 |
| 101 | MD Anderson Cancer Center Orlando | Orlando | Florida | United States | 32806 |
| 102 | West Florida Regional Medical Center | Pensacola | Florida | United States | 32514-6088 |
| 103 | Cancer Research Network Inc. | Plantation | Florida | United States | 33324 |
| 104 | Clinical Research Center of South Florida | Stuart | Florida | United States | 34996 |
| 105 | H. Lee Moffitt Cancer Center and Research Institute | Tampa | Florida | United States | 33612-9497 |
| 106 | Palm Beach Cancer Institute | West Palm Beach | Florida | United States | 33401 |
| 107 | CCOP - Atlanta Regional | Atlanta | Georgia | United States | 30342-1701 |
| 108 | Medical College of Georgia | Augusta | Georgia | United States | 30912 |
| 109 | Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center | Savannah | Georgia | United States | 31403-3089 |
| 110 | Cancer Care and Research Pavilion at St. Joseph's/Candler | Savannah | Georgia | United States | 31405-6013 |
| 111 | MBCCOP - Hawaii | Honolulu | Hawaii | United States | 96813 |
| 112 | North Idaho Cancer Center | Coeur d'Alene | Idaho | United States | 83814 |
| 113 | Northwest Community Hospital | Arlington Heights | Illinois | United States | 60005 |
| 114 | Rush Copley Medical Center | Aurora | Illinois | United States | 60504-4206 |
| 115 | Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | United States | 60611-3013 |
| 116 | Northwestern Memorial Hospital | Chicago | Illinois | United States | 60611 |
| 117 | MBCCOP - University of Illinois at Chicago | Chicago | Illinois | United States | 60612-7323 |
| 118 | John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | United States | 60612-9985 |
| 119 | Rush Cancer Institute at Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 120 | Resurrection Medical Center | Chicago | Illinois | United States | 60631 |
| 121 | Our Lady of the Resurrection Medical Center | Chicago | Illinois | United States | 60634 |
| 122 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60637-1470 |
| 123 | Creticos Cancer Center at Advocate Illinois Masonic Medical Center | Chicago | Illinois | United States | 60657 |
| 124 | CCOP - Central Illinois | Decatur | Illinois | United States | 62526 |
| 125 | Sherman Hospital | Elgin | Illinois | United States | 60120-2198 |
| 126 | CCOP - Evanston | Evanston | Illinois | United States | 60201 |
| 127 | St. Francis Hospital | Evanston | Illinois | United States | 60202 |
| 128 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 129 | Advocate South Suburban Hospital | Hazel Crest | Illinois | United States | 60429 |
| 130 | Evanston Northwestern Health Care - Highland Park Hospital | Highland Park | Illinois | United States | 60035-2497 |
| 131 | Hinsdale Hematology Oncology Associates | Hinsdale | Illinois | United States | 60521 |
| 132 | Joliet Oncology Hematology Associates, Limited - Joliet | Joliet | Illinois | United States | 60435 |
| 133 | Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 134 | Edward Hospital Cancer Center | Naperville | Illinois | United States | 60540-7499 |
| 135 | Mid-Illinois Hematology-Oncology Associates | Normal | Illinois | United States | 61761 |
| 136 | Advocate Christ Medical Center | Oak Lawn | Illinois | United States | 60453 |
| 137 | Saint James Hospital and Health Centers Comprehensive Cancer Institute | Olympia Fields | Illinois | United States | 60461 |
| 138 | Lutheran General Cancer Care Center | Park Ridge | Illinois | United States | 60068 |
| 139 | CCOP - Illinois Oncology Research Association | Peoria | Illinois | United States | 61602 |
| 140 | Trinity Medical Center - West | Rock Island | Illinois | United States | 61201 |
| 141 | Rockford Clinic | Rockford | Illinois | United States | 61103 |
| 142 | Swedish-American Regional Cancer Center | Rockford | Illinois | United States | 61104-2315 |
| 143 | Saint Anthony Medical Center | Rockford | Illinois | United States | 61108 |
| 144 | Edward H. Kaplan MD and Associates | Skokie | Illinois | United States | 60076 |
| 145 | St. John's Hospital | Springfield | Illinois | United States | 62769 |
| 146 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 147 | CCOP - Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 148 | Center for Cancer Care at Goshen Health System | Goshen | Indiana | United States | 46526 |
| 149 | Indiana Community Cancer Care, Incorporated | Indianapolis | Indiana | United States | 46202 |
| 150 | Methodist Cancer Center at Methodist Hospital | Indianapolis | Indiana | United States | 46206-1367 |
| 151 | Indiana Regional Cancer Center | Indianapolis | Indiana | United States | 46256 |
| 152 | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
| 153 | Oncology Institute of Greater Lafayette | Lafayette | Indiana | United States | 47904 |
| 154 | Saint Anthony Memorial Health Centers | Michigan City | Indiana | United States | 46360 |
| 155 | Ball Memorial Hospital Cancer Center | Muncie | Indiana | United States | 47303-3499 |
| 156 | Community Hospital | Munster | Indiana | United States | 46321 |
| 157 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 158 | McFarland Clinic, P.C. | Ames | Iowa | United States | 50010 |
| 159 | CCOP - Cedar Rapids Oncology Project | Cedar Rapids | Iowa | United States | 52403-1206 |
| 160 | Medical Associates | Clinton | Iowa | United States | 52732-5031 |
| 161 | Jennie Edmundson Memorial Hospital | Council Bluffs | Iowa | United States | 51503 |
| 162 | Genesis Regional Cancer Center at Genesis Medical Center | Davenport | Iowa | United States | 52803 |
| 163 | CCOP - Iowa Oncology Research Association | Des Moines | Iowa | United States | 50309-1016 |
| 164 | Wendt Regional Cancer Center of Finley Hospital | Dubuque | Iowa | United States | 52001 |
| 165 | Holden Comprehensive Cancer Center at University of Iowa | Iowa City | Iowa | United States | 52242-1009 |
| 166 | Mercy Cancer Center at Mercy Medical Center - North Iowa | Mason City | Iowa | United States | 50401 |
| 167 | Ottumwa Regional Health Center | Ottumwa | Iowa | United States | 52501 |
| 168 | Siouxland Hematology-Oncology | Sioux City | Iowa | United States | 51101-1733 |
| 169 | Cedar Valley Medical Specialists, P.C. | Waterloo | Iowa | United States | 50701 |
| 170 | Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | Kansas City | Kansas | United States | 66160-7357 |
| 171 | CCOP - Wichita | Wichita | Kansas | United States | 67214-3882 |
| 172 | King's Daughters Medical Center | Ashland | Kentucky | United States | 41101 |
| 173 | St. Elizabeth Medical Center | Edgewood | Kentucky | United States | 41017 |
| 174 | HCA Kings Daughters Memorial Hospital | Frankfort | Kentucky | United States | 40601 |
| 175 | Central Baptist Hospital | Lexington | Kentucky | United States | 40503 |
| 176 | Markey Cancer Center at University of Kentucky Chandler Medical Center | Lexington | Kentucky | United States | 40536-0093 |
| 177 | Norton Healthcare Cancer Center | Louisville | Kentucky | United States | 40202-5070 |
| 178 | James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | United States | 40202 |
| 179 | Baptist Hospital East - Louisville | Louisville | Kentucky | United States | 40207 |
| 180 | Ochsner Clinic of Baton Rouge | Baton Rouge | Louisiana | United States | 70809 |
| 181 | Baton Rouge General Medical Center | Baton Rouge | Louisiana | United States | 70821-2511 |
| 182 | Cancer Care Specialists | Houma | Louisiana | United States | 70360 |
| 183 | MBCCOP - LSU Health Sciences Center | New Orleans | Louisiana | United States | 70112 |
| 184 | Tulane Cancer Center at Tulane University Hospital and Clinic | New Orleans | Louisiana | United States | 70112 |
| 185 | CCOP - Ochsner | New Orleans | Louisiana | United States | 70121 |
| 186 | Cancer Treatment Center at Christus Schumpert St. Mary Place | Shreveport | Louisiana | United States | 71101 |
| 187 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 188 | Goodall Hospital | Sanford | Maine | United States | 04073 |
| 189 | Maine Center for Cancer Medicine and Blood Disorders - Scarborough | Scarborough | Maine | United States | 04074 |
| 190 | Anne Arundel Medical Center | Annapolis | Maryland | United States | 21401 |
| 191 | Greenebaum Cancer Center at University of Maryland Medical Center | Baltimore | Maryland | United States | 21201 |
| 192 | Greater Baltimore Medical Center and Cancer Center | Baltimore | Maryland | United States | 21204 |
| 193 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
| 194 | Franklin Square Hospital Center | Baltimore | Maryland | United States | 21237 |
| 195 | Suburban Hospital | Bethesda | Maryland | United States | 20814 |
| 196 | Frederick Memorial Hospital Regional Cancer Therapy Center | Frederick | Maryland | United States | 21701 |
| 197 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 198 | Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute | Boston | Massachusetts | United States | 02115 |
| 199 | Cancer Research Center at Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 200 | Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States | 02215 |
| 201 | Harvard Vanguard Medical Associates - Kenmore | Boston | Massachusetts | United States | 02215 |
| 202 | Lahey Clinic Medical Center - Burlington | Burlington | Massachusetts | United States | 01805 |
| 203 | Saint Anne's Hospital | Fall River | Massachusetts | United States | 02721 |
| 204 | Caritas Norwood Hospital | Norfolk | Massachusetts | United States | 02062 |
| 205 | NSMC Cancer Center | Peabody | Massachusetts | United States | 01960 |
| 206 | Berkshire Physicians and Surgeons, P.C. | Pittsfield | Massachusetts | United States | 01201 |
| 207 | Jordan Hospital Club Cancer Center | Plymouth | Massachusetts | United States | 02360 |
| 208 | Baystate Regional Cancer Program at Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 209 | University of Massachusetts Memorial Medical Center - University Campus | Worcester | Massachusetts | United States | 01655 |
| 210 | Hickman Cancer Center at Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 211 | CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | United States | 48106 |
| 212 | University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | United States | 48109-0752 |
| 213 | Battle Creek Health System | Battle Creek | Michigan | United States | 49016 |
| 214 | Bay Diagnostic Center for Women | Bay City | Michigan | United States | 48708 |
| 215 | Community Health Center of Branch County | Coldwater | Michigan | United States | 49036 |
| 216 | Oakwood Hospital and Medical Center | Dearborn | Michigan | United States | 48123-2500 |
| 217 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201-1379 |
| 218 | Josephine Ford Cancer Center at Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 219 | St. John Hospital and Medical Center | Detroit | Michigan | United States | 48236 |
| 220 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 221 | Flint Hematology Oncology | Flint | Michigan | United States | 48532 |
| 222 | Genesys Regional Medical Center | Grand Blanc | Michigan | United States | 48439-8066 |
| 223 | CCOP - Grand Rapids | Grand Rapids | Michigan | United States | 49503 |
| 224 | Holland Community Hospital | Holland | Michigan | United States | 49423 |
| 225 | Center for Hematology/Oncology | Jackson | Michigan | United States | 49201 |
| 226 | CCOP - Kalamazoo | Kalamazoo | Michigan | United States | 49007-3731 |
| 227 | Michigan State University Department of Surgery | Lansing | Michigan | United States | 48912 |
| 228 | Lapeer Regional Hospital | Lapeer | Michigan | United States | 48446 |
| 229 | Marquette General Hospital | Marquette | Michigan | United States | 49855 |
| 230 | Mercy Memorial Hospital, Corporation | Monroe | Michigan | United States | 48161-0067 |
| 231 | Community Cancer Care Specialist | Mount Clemens | Michigan | United States | 48043 |
| 232 | Memorial Healthcare | Owosso | Michigan | United States | 48867 |
| 233 | Blue Water Oncology PC, Port Huron | Port Huron | Michigan | United States | 48060 |
| 234 | CCOP - Beaumont | Royal Oak | Michigan | United States | 48073-6769 |
| 235 | Saint Mary's Seton Cancer Institute | Saginaw | Michigan | United States | 48601 |
| 236 | Providence Cancer Institute at Providence Hospital | Southfield | Michigan | United States | 48075-9975 |
| 237 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 238 | St. John Macomb Hospital | Warren | Michigan | United States | 48093-3494 |
| 239 | CCOP - Duluth | Duluth | Minnesota | United States | 55805 |
| 240 | St. Luke's Medical Clinic | Duluth | Minnesota | United States | 55805 |
| 241 | Minnesota Cooperative Group Program | Minneapolis | Minnesota | United States | 55407 |
| 242 | Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | United States | 55415 |
| 243 | University of Minnesota | Minneapolis | Minnesota | United States | 55455 |
| 244 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 245 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 246 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 247 | Coast Oncology/Hematology, P.L.L.C. | Biloxi | Mississippi | United States | 39530-4239 |
| 248 | Mid Delta Family Practice | Cleveland | Mississippi | United States | 38732 |
| 249 | Hattiesburg Clinic, P.A. | Hattiesburg | Mississippi | United States | 39401 |
| 250 | Jackson Oncology Associates, PLLC | Jackson | Mississippi | United States | 39202 |
| 251 | Keesler Medical Center - Keesler Air Force Base | Keesler AFB | Mississippi | United States | 39534-2576 |
| 252 | North Mississippi Hematology and Oncology Associates, Limited | Tupelo | Mississippi | United States | 38801 |
| 253 | Saint Luke's Hospital | Chesterfield | Missouri | United States | 63017 |
| 254 | Ellis Fischel Cancer Center at University of Missouri - Columbia | Columbia | Missouri | United States | 65203 |
| 255 | Freeman Cancer Institute at Freeman Health System | Joplin | Missouri | United States | 64803-2644 |
| 256 | St. John's Regional Medical Center | Joplin | Missouri | United States | 64804 |
| 257 | CCOP - Kansas City | Kansas City | Missouri | United States | 64131 |
| 258 | Phelps County Regional Medical Center | Rolla | Missouri | United States | 65401 |
| 259 | Midwest Hematology Oncology Group, Inc. | Saint Louis | Missouri | United States | 63109 |
| 260 | Siteman Cancer Center | Saint Louis | Missouri | United States | 63110 |
| 261 | Missouri Baptist Cancer Center | Saint Louis | Missouri | United States | 63131 |
| 262 | CCOP - St. Louis-Cape Girardeau | Saint Louis | Missouri | United States | 63141 |
| 263 | St. John's Regional Health Center | Springfield | Missouri | United States | 65804 |
| 264 | CCOP - Cancer Research for the Ozarks | Springfield | Missouri | United States | 65807 |
| 265 | Missouri Cancer Care, P.C. - St. Charles | St. Charles | Missouri | United States | 63301 |
| 266 | Ozarks Medical Center | West Plains | Missouri | United States | 65775 |
| 267 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 268 | Montana Cancer Institute - Benefis Healthcare | Great Falls | Montana | United States | 59405 |
| 269 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 270 | Saint Francis Medical Center | Grand Island | Nebraska | United States | 68802 |
| 271 | Cancer Center at the Good Samaritan Health Systems | Kearney | Nebraska | United States | 68848-1990 |
| 272 | Cancer Resource Center - Lincoln | Lincoln | Nebraska | United States | 68510-4844 |
| 273 | Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha | Omaha | Nebraska | United States | 68114 |
| 274 | Alegent Health - Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 275 | Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 276 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131-2197 |
| 277 | CCOP - Southern Nevada Cancer Research Foundation | Las Vegas | Nevada | United States | 89106 |
| 278 | New Hampshire Oncology-Hematology, PA - Hooksett | Hooksett | New Hampshire | United States | 03106 |
| 279 | Southern New Hampshire Medical Center | Nashua | New Hampshire | United States | 03061 |
| 280 | Cooper Cancer Institute | Camden | New Jersey | United States | 08103 |
| 281 | Englewood Hospital and Medical Center | Englewood | New Jersey | United States | 07631 |
| 282 | Hunterdon Regional Cancer Center | Flemington | New Jersey | United States | 08822 |
| 283 | CCOP - Northern New Jersey | Hackensack | New Jersey | United States | 07601 |
| 284 | St. Barnabas Medical Center | Livingston | New Jersey | United States | 07039 |
| 285 | Monmouth Medical Center | Long Branch | New Jersey | United States | 07740-6395 |
| 286 | South Jersey Regional Cancer Center | Millville | New Jersey | United States | 08332 |
| 287 | Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital | Mount Holly | New Jersey | United States | 08060 |
| 288 | Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 289 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 290 | Warren Hospital | Phillipsburg | New Jersey | United States | 08865 |
| 291 | Atlantic City Medical Center | Pomona | New Jersey | United States | 08240 |
| 292 | Booker Cancer Center at Riverview Medical Center | Red Bank | New Jersey | United States | 07701 |
| 293 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 294 | Somerset Medical Center | Somerville | New Jersey | United States | 08876 |
| 295 | Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 296 | Capital Health System at Mercer | Trenton | New Jersey | United States | 08607 |
| 297 | Underwood Memorial Hospital | Woodbury | New Jersey | United States | 08096 |
| 298 | Hematology-Oncology Associates, PC | Albuquerque | New Mexico | United States | 87102 |
| 299 | Lovelace Medical Center at Lovelace Sandia Health System | Albuquerque | New Mexico | United States | 87108 |
| 300 | New Mexico Oncology-Hematology Consultants, Limited | Albuquerque | New Mexico | United States | 87109 |
| 301 | University of New Mexico Cancer Research and Treatment Center | Albuquerque | New Mexico | United States | 87131 |
| 302 | New Mexico Cancer Care Associates | Santa Fe | New Mexico | United States | 87505-7670 |
| 303 | New York Oncology Hematology, P.C. - Albany Regional Cancer Center | Albany | New York | United States | 12208 |
| 304 | Albert Einstein Clinical Cancer Center | Bronx | New York | United States | 10461 |
| 305 | Comprehensive Cancer Center at Our Lady of Mercy Medical Center | Bronx | New York | United States | 10466 |
| 306 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 307 | Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326-1394 |
| 308 | Charles R. Wood Foundation Cancer Center at Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 309 | Queens Cancer Center of Queens Hospital | Jamaica | New York | United States | 11432 |
| 310 | New York Oncology Hematology, P.C. - Latham | Latham | New York | United States | 12110-0610 |
| 311 | CCOP - North Shore University Hospital | Manhasset | New York | United States | 11030 |
| 312 | Saint Vincent Catholic Medical Center of New York | New York | New York | United States | 10011 |
| 313 | NYU School of Medicine's Kaplan Comprehensive Cancer Center | New York | New York | United States | 10016 |
| 314 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10021 |
| 315 | Herbert Irving Comprehensive Cancer Center at Columbia University | New York | New York | United States | 10032 |
| 316 | St. Francis Hospital and Health Centers | Poughkeepsie | New York | United States | 12601 |
| 317 | Vassar Brothers Medical Center | Poughkeepsie | New York | United States | 12601 |
| 318 | Genesee Surgical Associates | Rochester | New York | United States | 14607 |
| 319 | Gynecologic Oncology Associates | Rochester | New York | United States | 14620 |
| 320 | James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | United States | 14642 |
| 321 | University Hospital - Stony Brook | Stony Brook | New York | United States | 11794-8174 |
| 322 | University Hospital at State University of New York - Upstate Medical University | Syracuse | New York | United States | 13210 |
| 323 | CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse | New York | United States | 13217 |
| 324 | Mission Hospitals | Asheville | North Carolina | United States | 28801 |
| 325 | Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | United States | 27599-7295 |
| 326 | Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
| 327 | Presbyterian Healthcare | Charlotte | North Carolina | United States | 28233-3549 |
| 328 | Duke Comprehensive Cancer Center | Durham | North Carolina | United States | 27710 |
| 329 | Cape Fear Valley Health System | Fayetteville | North Carolina | United States | 28302-2000 |
| 330 | Gaston Hematology and Oncology | Gastonia | North Carolina | United States | 28054 |
| 331 | Southeastern Medical Oncology Center | Goldsboro | North Carolina | United States | 27534 |
| 332 | Moses Cone Regional Cancer Center at Wesley Long Community Hospital | Greensboro | North Carolina | United States | 27403-1199 |
| 333 | Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina | Greenville | North Carolina | United States | 27858-4354 |
| 334 | Pardee Memorial Hospital | Hendersonville | North Carolina | United States | 28791 |
| 335 | Cornerstone Surgery | High Point | North Carolina | United States | 27262 |
| 336 | Raleigh Hematology/Oncology Associates, P.A. - Rex Cancer Center | Raleigh | North Carolina | United States | 27607 |
| 337 | Cancer Center at Iredell Memorial Hospital | Statesville | North Carolina | United States | 28687-1828 |
| 338 | New Hanover Regional Medical Center | Wilmington | North Carolina | United States | 28402-9000 |
| 339 | Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
| 340 | CCOP - Southeast Cancer Control Consortium | Winston-Salem | North Carolina | United States | 27104-4241 |
| 341 | Comprehensive Cancer Center at Wake Forest University | Winston-Salem | North Carolina | United States | 27157-1082 |
| 342 | Quain & Ramstad Clinic | Bismarck | North Dakota | United States | 58501 |
| 343 | CCOP - Merit Care Hospital | Fargo | North Dakota | United States | 58122 |
| 344 | Akron General Medical Center | Akron | Ohio | United States | 44302 |
| 345 | Mercy Medical Center | Canton | Ohio | United States | 44708 |
| 346 | Aultman Hospital Cancer Center at Aultman Health Foundation | Canton | Ohio | United States | 44710 |
| 347 | Cancer Center at Christ Hospital | Cincinnati | Ohio | United States | 45219 |
| 348 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 349 | Charles M. Barrett Cancer Center at University Hospital | Cincinnati | Ohio | United States | 45267-0502 |
| 350 | Ireland Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 351 | Fairview Hospital | Cleveland | Ohio | United States | 44111 |
| 352 | Kaiser Permanente | Cleveland | Ohio | United States | 44120 |
| 353 | Cleveland Clinic Taussig Cancer Center | Cleveland | Ohio | United States | 44195 |
| 354 | CCOP - Columbus | Columbus | Ohio | United States | 43206 |
| 355 | Arthur G. James Cancer Hospital - Ohio State University | Columbus | Ohio | United States | 43210-1240 |
| 356 | Blanchard Valley Medical Associates | Findlay | Ohio | United States | 45840 |
| 357 | Fremont Memorial Hospital | Fremont | Ohio | United States | 43420 |
| 358 | Cleveland Clinic Cancer Center | Independence | Ohio | United States | 44131 |
| 359 | CCOP - Dayton | Kettering | Ohio | United States | 45429 |
| 360 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 361 | St. Luke's Hospital | Maumee | Ohio | United States | 43537 |
| 362 | Parma Community General Hospital | Parma | Ohio | United States | 44129 |
| 363 | Firelands Regional Medical Center | Sandusky | Ohio | United States | 44870 |
| 364 | Flower Hospital - ProMedica Health System | Sylvania | Ohio | United States | 43560 |
| 365 | Toledo Hospital | Toledo | Ohio | United States | 43606 |
| 366 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 367 | Medical College of Ohio Cancer Institute | Toledo | Ohio | United States | 43614-0008 |
| 368 | St. Charles Hospital | Toledo | Ohio | United States | 43616 |
| 369 | CCOP - Toledo Community Hospital | Toledo | Ohio | United States | 43623 |
| 370 | Toledo Clinic, Incorporated | Toledo | Ohio | United States | 43623 |
| 371 | Cleveland Clinic Health System STAR BCPT | Warrensville Heights | Ohio | United States | 44122 |
| 372 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 373 | Muskogee Regional Medical Center | Muskogee | Oklahoma | United States | 74401 |
| 374 | Frank C. Love Cancer Institute at St. Anthony Hospital | Oklahoma City | Oklahoma | United States | 73101 |
| 375 | Central Oklahoma Cancer Center at INTEGRIS Southwest Medical Center | Oklahoma City | Oklahoma | United States | 73109 |
| 376 | Mercy Health Center | Oklahoma City | Oklahoma | United States | 73120 |
| 377 | Oklahoma University Medical Center at University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73190 |
| 378 | St. John Health System | Tulsa | Oklahoma | United States | 74104 |
| 379 | CCOP - Oklahoma | Tulsa | Oklahoma | United States | 74136 |
| 380 | St. Charles Medical Center | Bend | Oregon | United States | 97701 |
| 381 | Cancer Institute at Oregon Health and Science University | Portland | Oregon | United States | 97201-3098 |
| 382 | CCOP - Columbia River Oncology Program | Portland | Oregon | United States | 97213 |
| 383 | Kaiser Permanente Center for Health Research | Portland | Oregon | United States | 97227-1098 |
| 384 | Abington Memorial Hospital | Abington | Pennsylvania | United States | 19001 |
| 385 | Sacred Heart Hospital | Allentown | Pennsylvania | United States | 18102 |
| 386 | John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital | Allentown | Pennsylvania | United States | 18103 |
| 387 | Bon Secours-Holy Family Health System | Altoona | Pennsylvania | United States | 16602 |
| 388 | St. Luke's Hospital Cancer Center | Bethlehem | Pennsylvania | United States | 18015 |
| 389 | Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | United States | 19010 |
| 390 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822-2001 |
| 391 | Mercy Fitzgerald Hospital | Darby | Pennsylvania | United States | 19023 |
| 392 | Doylestown Hospital | Doylestown | Pennsylvania | United States | 18901 |
| 393 | Delaware County Memorial Hospital | Drexel Hill | Pennsylvania | United States | 19026 |
| 394 | Easton Hospital | Easton | Pennsylvania | United States | 18042 |
| 395 | Ephrata Community Hopital | Ephrata | Pennsylvania | United States | 17522-1002 |
| 396 | Regional Cancer Center - Erie | Erie | Pennsylvania | United States | 16505 |
| 397 | Pinnacle Health Regional Cancer Center at Pinnacle Health System | Harrisburg | Pennsylvania | United States | 17105-8700 |
| 398 | Mercy Community Hospital | Havertown | Pennsylvania | United States | 19083 |
| 399 | Penn State Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 400 | Lancaster General Hospital | Lancaster | Pennsylvania | United States | 17604-3555 |
| 401 | Saint Mary Regional Cancer Center | Langhorne | Pennsylvania | United States | 19047 |
| 402 | Riddle Memorial Hospital | Media | Pennsylvania | United States | 19063 |
| 403 | Cancer Center at Paoli Memorial Hospital | Paoli | Pennsylvania | United States | 19301-1792 |
| 404 | Abramson Cancer Center at University of Pennsylvania Medical Center | Philadelphia | Pennsylvania | United States | 19104-4283 |
| 405 | Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107-5541 |
| 406 | Pennsylvania Oncology Hematology Associates | Philadelphia | Pennsylvania | United States | 19107 |
| 407 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 408 | Frankford Hospital | Philadelphia | Pennsylvania | United States | 19114 |
| 409 | Chestnut Hill Healthcare | Philadelphia | Pennsylvania | United States | 19118 |
| 410 | Fox Chase - Temple Cancer Center | Philadelphia | Pennsylvania | United States | 19140 |
| 411 | Albert Einstein Cancer Center | Philadelphia | Pennsylvania | United States | 19141 |
| 412 | Mercy Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19143 |
| 413 | Allegheny General Hospital | Pittsburgh | Pennsylvania | United States | 15212-4772 |
| 414 | Hillman Cancer Center at University of Pittsburgh Cancer Institute | Pittsburgh | Pennsylvania | United States | 15213-3489 |
| 415 | Pottstown Memorial Regional Cancer Center | Pottstown | Pennsylvania | United States | 19464 |
| 416 | Reading Hospital and Medical Center | Reading | Pennsylvania | United States | 19612-6052 |
| 417 | Grand View Hospital | Sellersville | Pennsylvania | United States | 18960 |
| 418 | Crozer-Chester Medical Center | Upland | Pennsylvania | United States | 19013 |
| 419 | Chester County Hospital | West Chester | Pennsylvania | United States | 19380 |
| 420 | Lankenau Cancer Center at Lankenau Hospital | Wynnewood | Pennsylvania | United States | 19096 |
| 421 | Wellspan Health - York Cancer Center | York | Pennsylvania | United States | 17403 |
| 422 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 423 | AnMed Health | Anderson | South Carolina | United States | 29621 |
| 424 | Roper St. Francis Healthcare - Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 425 | Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 426 | Palmetto Richland Memorial Hospital | Columbia | South Carolina | United States | 29203 |
| 427 | McLeod Regional Medical Center | Florence | South Carolina | United States | 29501 |
| 428 | Cancer Centers of the Carolinas - Eastside | Greenville | South Carolina | United States | 29601 |
| 429 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 430 | Rapid City Regional Hospital | Rapid City | South Dakota | United States | 57701 |
| 431 | CCOP - Sioux Community Cancer Consortium | Sioux Falls | South Dakota | United States | 57104 |
| 432 | Wellmont Holston Valley Hospital and Medical Center | Kingsport | Tennessee | United States | 37662 |
| 433 | Thompson Cancer Survival Center | Knoxville | Tennessee | United States | 37916 |
| 434 | U.T. Cancer Institute at University of Tennessee Medical Center | Knoxville | Tennessee | United States | 37920-2911 |
| 435 | Baptist Cancer Institute - Memphis at Baptist Memorial Hospital - Memphis | Memphis | Tennessee | United States | 38117 |
| 436 | MBCCOP - Meharry Medical College - Nashville | Nashville | Tennessee | United States | 37208-3599 |
| 437 | Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center | Nashville | Tennessee | United States | 37232-6838 |
| 438 | Hendrick Cancer Center | Abilene | Texas | United States | 79601-2316 |
| 439 | Harrington Cancer Center | Amarillo | Texas | United States | 79106 |
| 440 | Julie and Ben Rogers Cancer Center | Beaumont | Texas | United States | 77701 |
| 441 | Presbyterian Hospital of Dallas | Dallas | Texas | United States | 75231 |
| 442 | Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas | Dallas | Texas | United States | 75235-9154 |
| 443 | Charles A. Sammons Cancer Center | Dallas | Texas | United States | 75246 |
| 444 | Methodist Dallas Medical Center | Dallas | Texas | United States | 75265-5999 |
| 445 | Providence Memorial Hospital | El Paso | Texas | United States | 79902 |
| 446 | Harris Methodist Fort Worth | Fort Worth | Texas | United States | 76104 |
| 447 | University of Texas - MD Anderson Cancer Center | Houston | Texas | United States | 77030-4009 |
| 448 | Baylor College of Medicine | Houston | Texas | United States | 77030 |
| 449 | Texas Cancer Institute at St. Luke's Episcopal Hospital | Houston | Texas | United States | 77030 |
| 450 | Baylor Medical Center at Garland | Irving | Texas | United States | 75061 |
| 451 | Wilford Hall Medical Center | Lackland Air Force Base | Texas | United States | 78236-5300 |
| 452 | Sanchez Cancer Center | Laredo | Texas | United States | 78041 |
| 453 | Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | United States | 79410-1894 |
| 454 | Southwest Cancer and Research Center at University Medical Center | Lubbock | Texas | United States | 79415 |
| 455 | Memorial Health System of East Texas | Lufkin | Texas | United States | 75902 |
| 456 | Baylor/Richardson Cancer Center | Richardson | Texas | United States | 75080 |
| 457 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78284-7811 |
| 458 | CCOP - Scott and White Hospital | Temple | Texas | United States | 76508 |
| 459 | University of Texas Health Center at Tyler | Tyler | Texas | United States | 75708 |
| 460 | Huntsman Cancer Institute | Salt Lake City | Utah | United States | 84112 |
| 461 | Green Mountain Oncology Group | Bennington | Vermont | United States | 05201 |
| 462 | Southwestern Vermont Regional Cancer Center | Bennington | Vermont | United States | 05201 |
| 463 | Mountainview Medical | Berlin | Vermont | United States | 05602 |
| 464 | Vermont Cancer Center at University of Vermont | Burlington | Vermont | United States | 05401-3498 |
| 465 | Community Cancer Center at Rutland Regional Medical Center | Rutland | Vermont | United States | 05701 |
| 466 | Martha Jefferson Hospital | Charlottesville | Virginia | United States | 22901 |
| 467 | Cancer Center of the Piedmont, Inc. | Danville | Virginia | United States | 24541 |
| 468 | Danville Hematology and Oncology, Incorporated | Danville | Virginia | United States | 24541 |
| 469 | Virginia Oncology Associates - Newport News | Newport News | Virginia | United States | 23606 |
| 470 | Henrico Doctors' Hospital - Parham Campus | Richmond | Virginia | United States | 23229 |
| 471 | MBCCOP - Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 472 | Oncology and Hematology Associates of Southwest Virginia, Inc. | Roanoke | Virginia | United States | 24014 |
| 473 | St. Joseph Hospital Community Cancer Center | Bellingham | Washington | United States | 98225 |
| 474 | Olympic Hematology and Oncology | Bremerton | Washington | United States | 98310 |
| 475 | Flynn Cancer Center at Providence Everett Medical Center - Pacific Campus | Everett | Washington | United States | 98258-0000 |
| 476 | CCOP - Virginia Mason Research Center | Seattle | Washington | United States | 98101 |
| 477 | Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle | Washington | United States | 98104 |
| 478 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109-1024 |
| 479 | Cancer Care Northwest - Spokane North | Spokane | Washington | United States | 99207 |
| 480 | Rockwood Clinic P.S. | Spokane | Washington | United States | 99220 |
| 481 | CCOP - Northwest | Tacoma | Washington | United States | 98405-0986 |
| 482 | Yakima Regional Cancer Care Center | Yakima | Washington | United States | 89802 |
| 483 | David Lee Cancer Center at Charleston Area Medical Center | Charleston | West Virginia | United States | 25304-1297 |
| 484 | Camden-Clark Memorial Hospital | Parkersburg | West Virginia | United States | 26102 |
| 485 | Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 486 | University of Wisconsin Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792-6164 |
| 487 | CCOP - Marshfield Clinic Research Foundation | Marshfield | Wisconsin | United States | 54449 |
| 488 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53201-0342 |
| 489 | Oncology Alliance, S.C. | Milwaukee | Wisconsin | United States | 53215 |
| 490 | Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
| 491 | Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | United States | 53188 |
| 492 | UW Cancer Center Wausau Hospital | Wausau | Wisconsin | United States | 54401 |
| 493 | Tom Baker Cancer Center - Calgary | Calgary | Alberta | Canada | T2N 4N2 |
| 494 | Cross Cancer Institute | Edmonton | Alberta | Canada | T6G 1Z2 |
| 495 | University Hospital - U.B.C. Site | Vancouver | British Columbia | Canada | V6T 2B5 |
| 496 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
| 497 | Familial Oncology Program | Kingston | Ontario | Canada | K7L 5P9 |
| 498 | Credit Valley Hospital | Mississauga | Ontario | Canada | L5M 2N1 |
| 499 | North York General Hospital, Ontario | North York | Ontario | Canada | M2E 1K1 |
| 500 | Ottawa Regional Cancer Centre | Ottawa | Ontario | Canada | K1H 1C4 |
| 501 | Northwestern Ontario Regional Cancer Care | Thunder Bay | Ontario | Canada | P7A 7T1 |
| 502 | Toronto Sunnybrook Regional Cancer Centre | Toronto | Ontario | Canada | M4N 3M5 |
| 503 | St. Michael's Hospital - Toronto | Toronto | Ontario | Canada | M5B 1W8 |
| 504 | Toronto General Hospital | Toronto | Ontario | Canada | M5G 2C4 |
| 505 | Women's College Ambulatory Care Center, Sunnybrook and Women's College Health Science Center | Toronto | Ontario | Canada | M5S 1B6 |
| 506 | CHUS-Hopital Fleurimont | Fleurimont | Quebec | Canada | J1H 5N4 |
| 507 | Hopital Charles Lemoyne | Greenfield Park | Quebec | Canada | J4V 2H1 |
| 508 | Centre Hospitalier de l'Universite de Montreal | Montreal | Quebec | Canada | H2L-4M1 |
| 509 | Royal Victoria Hospital - Montreal | Montreal | Quebec | Canada | H3A 1A1 |
| 510 | Montreal General Hospital | Montreal | Quebec | Canada | H3G 1A4 |
| 511 | Ville Marie Breast Center | Montreal | Quebec | Canada | H3G 1L5 |
| 512 | Jewish General Hospital - Montreal | Montreal | Quebec | Canada | H3T 1E2 |
| 513 | Hopital du Saint-Sacrement, Quebec | Quebec City | Quebec | Canada | G1S 4L8 |
| 514 | Centre Universitaire de Sante de L'Estrie | Sherbrooke | Quebec | Canada | J1H 5N4 |
| 515 | Saskatoon Cancer Centre | Saskatoon | Saskatchewan | Canada | S7N 4H4 |
| 516 | MBCCOP - San Juan | San Juan | Puerto Rico | 00927-5800 |
Sponsors and Collaborators
- NSABP Foundation Inc
- National Cancer Institute (NCI)
- Eli Lilly and Company
- AstraZeneca
Investigators
- Study Chair: Norman Wolmark, MD, NSABP Foundation Inc
Study Documents (Full-Text)
None provided.More Information
Publications
- Cronin WM, Cecchini RS, Wickerham DL, et al.: Factors associated with participant adherence in the NSABP Study of Tamoxifen and Raloxifene (STAR). [Abstract] J Clin Oncol 26 (Suppl 15): A-6518, 2008.
- Gradishar WJ, Cella D. Selective estrogen receptor modulators and prevention of invasive breast cancer. JAMA. 2006 Jun 21;295(23):2784-6. Epub 2006 Jun 5.
- Land SR, Ritter MW, Costantino JP, Julian TB, Cronin WM, Haile SR, Wolmark N, Ganz PA. Compliance with patient-reported outcomes in multicenter clinical trials: methodologic and practical approaches. J Clin Oncol. 2007 Nov 10;25(32):5113-20. Review.
Responsible Party:
NSABP Foundation Inc
ClinicalTrials.gov Identifier:
NCT00003906
Other Study ID Numbers:
- NSABP P-2
- CDR0000067081
First Posted:
Jan 27, 2003
Last Update Posted:
Oct 6, 2015
Last Verified:
Oct 1, 2015
Keywords provided by NSABP Foundation Inc
Additional relevant MeSH terms: