Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer
Sponsor
Eastern Cooperative Oncology Group (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT01242800
Collaborator
National Cancer Institute (NCI) (NIH)
391
377
2
136.7
1
0
Study Details
Study Description
Brief Summary
RATIONALE: Early surgery may have fewer side effects and improve recovery. Palliative surgery or radiation therapy may help patients with advanced breast cancer live more comfortably. It is not yet known whether early surgery is more effective than palliative therapy for advanced breast cancer.
PURPOSE: This randomized phase III trial is studying early surgery to see how well it works compared to standard palliative therapy in treating patients with stage IV breast cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
OBJECTIVES:
Primary
- To evaluate whether early local therapy comprising surgery of intact primary disease compared to local palliative therapy only in patients with stage IV breast cancer, whose disease does not progress during initial optimal systemic therapy, will result in prolonged survival.
Secondary
-
To compare the time to uncontrolled chest wall disease between patients treated with these regimens.
-
To determine whether there is a difference in health-related quality-of-life (HRQOL) between patients treated with these regimens.
-
To determine whether the absolute value of circulating tumor cells (CTC) burden at 6 months following randomization (time +6) will be lower in the palliative therapy arm than in early local therapy arm, and whether this value is inversely related to survival (lower CTC, longer survival).
-
To collect tumor and blood specimens for future exploration of the biological interactions between the primary tumor and metastatic lesions and the effect of primary tumor resection.
OUTLINE: This is a multicenter study. Patients are stratified according to hormone receptor and treatment plan (ER+ or PR+, HER2-, endocrine therapy alone vs ER+ or PR+, and HER2-, chemotherapy and/or endocrine therapy vs ER- or PR-, and HER2- vs HER2+), and number of involved organ systems with distant disease (regional nodes in the axillary, supraclavicular, and internal mammary locations are not considered distant sites) (1 vs > 1). Patients are randomized to 1 of 2 treatment arms.
-
Arm I: Patients receive standard palliative therapy, if needed, to address symptoms such as tumor ulceration, pain, bulky adenopathy causing arm symptoms, and other similar situations. Therapy may consist of radiotherapy alone, surgery alone, or a combination of both.
-
Arm II: Patients undergo surgery comprising breast-conserving therapy (BCT) or total mastectomy according to patient and treating physician preference. Surgery is to occur no later than 10 weeks after completion of 32 weeks of systemic therapy. Free surgical margins must be achieved with re-excision or mastectomy for patients undergoing BCT. After completion of BCT, patients undergo radiotherapy once a day, 5 days per week. Patients who had mastectomy undergo radiotherapy at the discretion of treating physician.
Patients may undergo blood and tumor tissue sample collection for circulating tumor cells (CTC) burden and future studies.
Patients complete the Functional Assessment of Cancer Therapy - Breast Trial Outcome Index (FACT- TOI) and FACT - General (22) and the Breast Cancer Subscale (FACT-B) quality-of-life questionnaires at baseline and periodically during study.
After completion of study therapy, patients are followed up periodically for 5 years.
Study Design
Study Type:
Interventional
Actual Enrollment
:
391 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer
Actual Study Start Date
:
Feb 8, 2011
Actual Primary Completion Date
:
Apr 30, 2021
Anticipated Study Completion Date
:
Jun 30, 2022
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Arm I Patients receive standard palliative therapy, if needed, to address symptoms such as tumor ulceration, pain, bulky adenopathy causing arm symptoms, and other similar situations. Therapy may consist of radiotherapy alone, surgery alone, or a combination of both. |
Procedure: palliative surgery
Undergo standard palliative surgery
Radiation: palliative radiation therapy
Undergo standard palliative radiotherapy
|
| Experimental: Arm II Patients undergo surgery comprising breast-conserving therapy (BCT) or total mastectomy according to patient and treating physician preference. Free surgical margins must be achieved with re-excision or mastectomy for patients undergoing BCT. After completion of BCT, patients undergo radiotherapy once a day, 5 days per week. Patients who had mastectomy undergo radiotherapy at the discretion of treating physician. |
Procedure: therapeutic conventional surgery
Undergo early surgery
Radiation: radiation therapy
Undergo radiotherapy
|
Outcome Measures
Primary Outcome Measures
- Overall survival [Assessed at baseline, then every 3 months within 2 years and every 6 months between 2-5 years, up to 5 years]
Overall survival, defined as time from randomization to death from any cause. All patients will be followed for survival through 5 years. Cases with incomplete follow-up or without record of vital status will be censored at the date of last contact.
Secondary Outcome Measures
- Uncontrolled chest wall disease [Assessed at baseline, then every 3 months within 2 years and every 6 months between 2-5 years, up to 5 years]
The chest wall/breast will be called "controlled" if there is no clinical or radiological evidence of the local tumor; or if there is evidence of the primary tumor but no skin nodules, ulceration, or chest wall fixation. Time to uncontrolled chest wall disease is defined as time from randomization to the development of uncontrolled chest wall disease. Patients with controlled chest wall will be censored at the last date of evaluation.
- Health-related quality of life [Assessed at baseline, randomization, 6, 18 and 30 months after randomization]
The FACT-Breast Trial Outcome Index will be used as the primary HRQL endpoint. FACT-B TOI scores at baseline, randomization, 6, 18 and 30 months after randomization will be calculated and compared for participants randomized to early local therapy versus palliative local therapy. The change of FACT-B TOI scores over time will be compared between treatment arms as well. For the palliative local therapy arm, the change of QOL from randomization to the time of decision for local therapy will also be measured.
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 120 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
DISEASE CHARACTERISTICS:
-
Diagnosis of intact primary (not recurrent) invasive carcinoma of the breast
-
Stage IV disease
-
Confirmation of the primary tumor should be by needle biopsy (preferred)
-
Incisional surgical biopsy allowed as long as there is residual palpable or tumor image in the breast
-
Patients must be judged to be candidates for complete resection with free margins followed by radiation therapy (if radiation therapy is indicated)
-
For women not undergoing axillary dissection, sentinel node biopsy should document an axillary nodal burden of 1-2 involved lymph nodes (i.e., ACOSOG Z-11 criteria may be applied)
-
Prior non-invasive (DCIS) cancer allowed provided there has been no recurrence
-
Prior ipsilateral invasive cancer allowed if more than 5 years previous
-
No synchronous contralateral breast cancer
-
Patients should have at least one organ system involved with distant metastatic disease
-
If patient has only one metastatic lesion/focus, this must be proven by biopsy and the pathology report confirming the diagnosis of primary breast cancer, as well as the metastatic site, must be available
-
Must have available radiologic reports documenting disease status within the past 6 weeks prior to initiating systemic therapy
-
CNS metastases allowed provided projected survival > 6 months
-
Patients must have completed at least 16 weeks of optimal systemic therapy (appropriate to the tumor biological profile and the patient's age and menopausal status)
-
If systemic therapy is discontinued for toxicity, but there is no distant progression and at least 12 weeks of therapy have been delivered, then the patient remains eligible
-
Radiation therapy (if indicated) must begin within 12 weeks of final therapeutic surgical procedure (including re-excision for free margins and completion of axillary dissection)
-
Patients may register at any time from the time of diagnosis of stage IV breast cancer (if eligibility criteria met) to the time when a maximum of 30 weeks of induction systemic therapy has been completed
-
Patients must be randomized within 16-32 weeks after the start of systemic therapy
-
Patients must not have experienced disease progression since the start of systemic therapy, as evidenced by radiographic documentation of disease status before treatment and within 4 weeks +/- 2 weeks prior to randomization, including:
-
No new sites of disease
-
No enlargement of existing sites by 20% or more in longest diameter
-
No symptomatic deterioration
-
Patients who require radiotherapy to bone metastases during induction systemic therapy are eligible
-
Local disease at the primary site must be asymptomatic
-
Hormone receptor status known
PATIENT CHARACTERISTICS:
-
See Disease Characteristics
-
Menopausal status not specified
-
Patients must have adequate organ function to undergo local therapy 4 weeks +/- 2 weeks prior to randomization per investigator discretion and institutional guidelines
-
More than 5 years since other primary cancers that were curatively treated
-
Not pregnant or nursing
-
Negative pregnancy test
-
Fertile patients must use an accepted and effective contraception method
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | United States | 36604 |
| 2 | Providence Cancer Center | Anchorage | Alaska | United States | 99508 |
| 3 | Mayo Clinic Scottsdale | Scottsdale | Arizona | United States | 85259-5499 |
| 4 | East Bay Radiation Oncology Center | Castro Valley | California | United States | 94546 |
| 5 | Enloe Cancer Center at Enloe Medical Center | Chico | California | United States | 95926 |
| 6 | North Bay Cancer Center | Fairfield | California | United States | 94533 |
| 7 | California Cancer Care, Incorporated - Greenbrae | Greenbrae | California | United States | 94904 |
| 8 | Todd Cancer Institute at Long Beach Memorial Medical Center | Long Beach | California | United States | 90806 |
| 9 | Contra Costa Regional Medical Center | Martinez | California | United States | 94553-3156 |
| 10 | Community Hospital of the Monterey Peninsula Comprehensive Cancer Center | Monterey | California | United States | 93940 |
| 11 | El Camino Hospital Cancer Center | Mountain View | California | United States | 94040 |
| 12 | CCOP - Bay Area Tumor Institute | Oakland | California | United States | 94609 |
| 13 | St. Joseph Hospital Regional Cancer Center - Orange | Orange | California | United States | 92868 |
| 14 | Doctors Medical Center - San Pablo Campus | San Pablo | California | United States | 94806 |
| 15 | Stanford Cancer Center | Stanford | California | United States | 94305-5824 |
| 16 | Boulder Community Hospital | Boulder | Colorado | United States | 80301-9019 |
| 17 | Penrose Cancer Center at Penrose Hospital | Colorado Springs | Colorado | United States | 80933 |
| 18 | Presbyterian - St. Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 19 | Exempla Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 20 | Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center | Hartford | Connecticut | United States | 06105 |
| 21 | Norwalk Hospital | Norwalk | Connecticut | United States | 06856 |
| 22 | Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | United States | 06360 |
| 23 | Tunnell Cancer Center at Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 24 | CCOP - Christiana Care Health Services | Newark | Delaware | United States | 19713 |
| 25 | Herbert D. Kerman Regional Oncology Center - Daytona Beach | Daytona Beach | Florida | United States | 32114 |
| 26 | Mayo Clinic - Jacksonville | Jacksonville | Florida | United States | 32224 |
| 27 | Florida Hospital Cancer Institute at Florida Hospital Orlando | Orlando | Florida | United States | 32803-1273 |
| 28 | M.D. Anderson Cancer Center at Orlando | Orlando | Florida | United States | 32806 |
| 29 | H. Lee Moffitt Cancer Center and Research Institute at University of South Florida | Tampa | Florida | United States | 33612-9497 |
| 30 | Georgia Cancer Center for Excellence at Grady Memorial Hospital | Atlanta | Georgia | United States | 30303 |
| 31 | Emory Crawford Long Hospital | Atlanta | Georgia | United States | 30308 |
| 32 | Piedmont Hospital | Atlanta | Georgia | United States | 30309 |
| 33 | Winship Cancer Institute of Emory University | Atlanta | Georgia | United States | 30322 |
| 34 | Northside Hospital Cancer Center | Atlanta | Georgia | United States | 30342-1611 |
| 35 | Saint Joseph's Hospital of Atlanta | Atlanta | Georgia | United States | 30342-1701 |
| 36 | John B. Amos Cancer Center | Columbus | Georgia | United States | 31904 |
| 37 | Charles B. Eberhart Cancer Center at DeKalb Medical Center | Decatur | Georgia | United States | 30033 |
| 38 | Kennestone Cancer Center at Wellstar Kennestone Hospital | Marietta | Georgia | United States | 30060 |
| 39 | Southern Regional Medical Center | Riverdale | Georgia | United States | 30274-2600 |
| 40 | Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler | Savannah | Georgia | United States | 31405 |
| 41 | Kapiolani Medical Center at Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 42 | Leeward Radiation Oncology | 'Ewa Beach | Hawaii | United States | 96706 |
| 43 | Cancer Research Center of Hawaii | Honolulu | Hawaii | United States | 96813 |
| 44 | Queen's Cancer Institute at Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 45 | Straub Clinic and Hospital, Incorporated | Honolulu | Hawaii | United States | 96813 |
| 46 | Hawaii Medical Center - East | Honolulu | Hawaii | United States | 96817 |
| 47 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 48 | Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center | Boise | Idaho | United States | 83706 |
| 49 | Mountain States Tumor Institute at St. Luke's Regional Medical Center | Boise | Idaho | United States | 83712 |
| 50 | Saint Luke's Mountain States Tumor Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 51 | Mountain States Tumor Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 52 | Saint Luke's Mountain States Tumor Institute | Nampa | Idaho | United States | 83686 |
| 53 | Mountain States Tumor Institute at St. Luke's | Twin Falls | Idaho | United States | 83301 |
| 54 | St. Joseph Medical Center | Bloomington | Illinois | United States | 61701 |
| 55 | Graham Hospital | Canton | Illinois | United States | 61520 |
| 56 | Memorial Hospital | Carthage | Illinois | United States | 62321 |
| 57 | Robert H. Lurie Comprehensive Cancer Center at Northwestern University | Chicago | Illinois | United States | 60611-3013 |
| 58 | Hematology and Oncology Associates | Chicago | Illinois | United States | 60611 |
| 59 | John H. Stroger, Jr. Hospital of Cook County | Chicago | Illinois | United States | 60612-3785 |
| 60 | University of Illinois Cancer Center | Chicago | Illinois | United States | 60612-7243 |
| 61 | Resurrection Medical Center | Chicago | Illinois | United States | 60631 |
| 62 | University of Chicago Cancer Research Center | Chicago | Illinois | United States | 60637-1470 |
| 63 | Louis A. Weiss Memorial Hospital | Chicago | Illinois | United States | 60640 |
| 64 | Decatur Memorial Hospital Cancer Care Institute | Decatur | Illinois | United States | 62526 |
| 65 | Elmhurst Memorial Hospital | Elmhurst | Illinois | United States | 60126 |
| 66 | Eureka Community Hospital | Eureka | Illinois | United States | 61530 |
| 67 | Galesburg Clinic, PC | Galesburg | Illinois | United States | 61401 |
| 68 | Ingalls Cancer Care Center at Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 69 | Kellogg Cancer Care Center | Highland Park | Illinois | United States | 60035 |
| 70 | Hinsdale Hematology Oncology Associates | Hinsdale | Illinois | United States | 60521 |
| 71 | Provena St. Mary's Regional Cancer Center - Kankakee | Kankakee | Illinois | United States | 60901 |
| 72 | North Shore Oncology and Hematology Associates, Limited - Libertyville | Libertyville | Illinois | United States | 60048 |
| 73 | McDonough District Hospital | Macomb | Illinois | United States | 61455 |
| 74 | Cardinal Bernardin Cancer Center at Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 75 | Trinity Cancer Center at Trinity Medical Center - 7th Street Campus | Moline | Illinois | United States | 61265 |
| 76 | Cancer Care and Hematology Specialists of Chicagoland - Niles | Niles | Illinois | United States | 60714 |
| 77 | BroMenn Regional Medical Center | Normal | Illinois | United States | 61761 |
| 78 | Community Cancer Center | Normal | Illinois | United States | 61761 |
| 79 | Community Hospital of Ottawa | Ottawa | Illinois | United States | 61350 |
| 80 | Oncology Hematology Associates of Central Illinois, PC - Ottawa | Ottawa | Illinois | United States | 61350 |
| 81 | Cancer Treatment Center at Pekin Hospital | Pekin | Illinois | United States | 61554 |
| 82 | Proctor Hospital | Peoria | Illinois | United States | 61614 |
| 83 | CCOP - Illinois Oncology Research Association | Peoria | Illinois | United States | 61615 |
| 84 | Oncology Hematology Associates of Central Illinois, PC - Peoria | Peoria | Illinois | United States | 61615 |
| 85 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 86 | OSF St. Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 87 | Illinois Valley Community Hospital | Peru | Illinois | United States | 61354 |
| 88 | West Suburban Center for Cancer Care | River Forest | Illinois | United States | 60305 |
| 89 | Swedish-American Regional Cancer Center | Rockford | Illinois | United States | 61104-2315 |
| 90 | Hematology Oncology Associates - Skokie | Skokie | Illinois | United States | 60076 |
| 91 | Regional Cancer Center at Memorial Medical Center | Springfield | Illinois | United States | 62781-0001 |
| 92 | St. Francis Hospital and Health Centers - Beech Grove Campus | Beech Grove | Indiana | United States | 46107 |
| 93 | Elkhart General Hospital | Elkhart | Indiana | United States | 46515 |
| 94 | Center for Cancer Care at Goshen General Hospital | Goshen | Indiana | United States | 46526 |
| 95 | Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202-5289 |
| 96 | William N. Wishard Memorial Hospital | Indianapolis | Indiana | United States | 46202 |
| 97 | Howard Community Hospital | Kokomo | Indiana | United States | 46904 |
| 98 | Center for Cancer Therapy at LaPorte Hospital and Health Services | La Porte | Indiana | United States | 46350 |
| 99 | Michiana Hematology-Oncology, PC - South Bend | Mishawaka | Indiana | United States | 46545-1470 |
| 100 | Saint Joseph Regional Medical Center | Mishawaka | Indiana | United States | 46545-1470 |
| 101 | Reid Hospital & Health Care Services | Richmond | Indiana | United States | 47374 |
| 102 | CCOP - Northern Indiana CR Consortium | South Bend | Indiana | United States | 46601 |
| 103 | Memorial Hospital of South Bend | South Bend | Indiana | United States | 46601 |
| 104 | McFarland Clinic, PC | Ames | Iowa | United States | 50010 |
| 105 | Medical Oncology and Hematology Associates - West Des Moines | Clive | Iowa | United States | 50325 |
| 106 | CCOP - Iowa Oncology Research Association | Des Moines | Iowa | United States | 50309 |
| 107 | John Stoddard Cancer Center at Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 108 | Medical Oncology and Hematology Associates at John Stoddard Cancer Center | Des Moines | Iowa | United States | 50309 |
| 109 | Medical Oncology and Hematology Associates at Mercy Cancer Center | Des Moines | Iowa | United States | 50314 |
| 110 | Mercy Cancer Center at Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 111 | John Stoddard Cancer Center at Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 112 | McCreery Cancer Center at Ottumwa Regional | Ottumwa | Iowa | United States | 52501 |
| 113 | Siouxland Hematology-Oncology Associates, LLP | Sioux City | Iowa | United States | 51101 |
| 114 | Mercy Medical Center - Sioux City | Sioux City | Iowa | United States | 51102 |
| 115 | St. Luke's Regional Medical Center | Sioux City | Iowa | United States | 51104 |
| 116 | Cancer Center of Kansas, PA - Chanute | Chanute | Kansas | United States | 66720 |
| 117 | Cancer Center of Kansas, PA - Dodge City | Dodge City | Kansas | United States | 67801 |
| 118 | Cancer Center of Kansas, PA - El Dorado | El Dorado | Kansas | United States | 67042 |
| 119 | Cancer Center of Kansas - Fort Scott | Fort Scott | Kansas | United States | 66701 |
| 120 | Cancer Center of Kansas-Independence | Independence | Kansas | United States | 67301 |
| 121 | Cancer Center of Kansas, PA - Kingman | Kingman | Kansas | United States | 67068 |
| 122 | Lawrence Memorial Hospital | Lawrence | Kansas | United States | 66044 |
| 123 | Cancer Center of Kansas, PA - Liberal | Liberal | Kansas | United States | 67901 |
| 124 | Cancer Center of Kansas, PA - McPherson | McPherson | Kansas | United States | 67460 |
| 125 | Cancer Center of Kansas, PA - Newton | Newton | Kansas | United States | 67114 |
| 126 | Cancer Center of Kansas, PA - Parsons | Parsons | Kansas | United States | 67357 |
| 127 | CCOP - Kansas City | Prairie Village | Kansas | United States | 66208 |
| 128 | Cancer Center of Kansas, PA - Pratt | Pratt | Kansas | United States | 67124 |
| 129 | Cancer Center of Kansas, PA - Salina | Salina | Kansas | United States | 67401 |
| 130 | Cancer Center of Kansas, PA - Wellington | Wellington | Kansas | United States | 67152 |
| 131 | Cancer Center of Kansas, PA - Medical Arts Tower | Wichita | Kansas | United States | 67208 |
| 132 | Cancer Center of Kansas, PA - Wichita | Wichita | Kansas | United States | 67214 |
| 133 | CCOP - Wichita | Wichita | Kansas | United States | 67214 |
| 134 | Via Christi Cancer Center at Via Christi Regional Medical Center | Wichita | Kansas | United States | 67214 |
| 135 | Cancer Center of Kansas, PA - Winfield | Winfield | Kansas | United States | 67156 |
| 136 | St. Elizabeth Medical Center | Edgewood | Kentucky | United States | 41017 |
| 137 | Lucille P. Markey Cancer Center at University of Kentucky | Lexington | Kentucky | United States | 40536-0093 |
| 138 | Tulane Cancer Center Office of Clinical Research | Alexandria | Louisiana | United States | 71315-3198 |
| 139 | DeCesaris Cancer Institute at Anne Arundel Medical Center | Annapolis | Maryland | United States | 21401 |
| 140 | Greater Baltimore Medical Center Cancer Center | Baltimore | Maryland | United States | 21204 |
| 141 | St. Agnes Hospital Cancer Center | Baltimore | Maryland | United States | 21229 |
| 142 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | United States | 21231-2410 |
| 143 | Shore Regional Cancer Center at Memorial Hospital - Easton | Easton | Maryland | United States | 21601 |
| 144 | Union Hospital of Cecil County | Elkton | Maryland | United States | 21921 |
| 145 | Hickman Cancer Center at Bixby Medical Center | Adrian | Michigan | United States | 49221 |
| 146 | Saint Joseph Mercy Cancer Center | Ann Arbor | Michigan | United States | 48106-0995 |
| 147 | CCOP - Michigan Cancer Research Consortium | Ann Arbor | Michigan | United States | 48106 |
| 148 | Oakwood Cancer Center at Oakwood Hospital and Medical Center | Dearborn | Michigan | United States | 48123-2500 |
| 149 | Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | United States | 48201-1379 |
| 150 | Green Bay Oncology, Limited - Escanaba | Escanaba | Michigan | United States | 49431 |
| 151 | Genesys Hurley Cancer Institute | Flint | Michigan | United States | 48503 |
| 152 | Hurley Medical Center | Flint | Michigan | United States | 48503 |
| 153 | Butterworth Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 154 | Van Elslander Cancer Center at St. John Hospital and Medical Center | Grosse Pointe Woods | Michigan | United States | 48236 |
| 155 | Dickinson County Healthcare System | Iron Mountain | Michigan | United States | 49801 |
| 156 | Foote Memorial Hospital | Jackson | Michigan | United States | 49201 |
| 157 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49001 |
| 158 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007-3731 |
| 159 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 160 | Sparrow Regional Cancer Center | Lansing | Michigan | United States | 48912-1811 |
| 161 | St. Mary Mercy Hospital | Livonia | Michigan | United States | 48154 |
| 162 | MidMichigan Medical Center - Midland | Midland | Michigan | United States | 48670 |
| 163 | Community Cancer Center of Monroe | Monroe | Michigan | United States | 48162 |
| 164 | Mercy Memorial Hospital - Monroe | Monroe | Michigan | United States | 48162 |
| 165 | Mercy General Health Partners | Muskegon | Michigan | United States | 49444 |
| 166 | St. Joseph Mercy Oakland | Pontiac | Michigan | United States | 48341-2985 |
| 167 | Mercy Regional Cancer Center at Mercy Hospital | Port Huron | Michigan | United States | 48060 |
| 168 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 169 | William Beaumont Hospital - Royal Oak Campus | Royal Oak | Michigan | United States | 48073 |
| 170 | Seton Cancer Institute at Saint Mary's - Saginaw | Saginaw | Michigan | United States | 48601 |
| 171 | Lakeland Regional Cancer Care Center - St. Joseph | Saint Joseph | Michigan | United States | 49085 |
| 172 | Lakeside Cancer Specialists, PLLC | Saint Joseph | Michigan | United States | 49085 |
| 173 | Providence Cancer Institute at Providence Hospital - Southfield Campus | Southfield | Michigan | United States | 48075 |
| 174 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 175 | St. John Macomb Hospital | Warren | Michigan | United States | 48093 |
| 176 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 177 | Mercy and Unity Cancer Center at Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 178 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 179 | Mercy and Unity Cancer Center at Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 180 | Hutchinson Area Health Care | Hutchinson | Minnesota | United States | 55350 |
| 181 | Immanuel St. Joseph's | Mankato | Minnesota | United States | 56002 |
| 182 | HealthEast Cancer Care at St. John's Hospital | Maplewood | Minnesota | United States | 55109 |
| 183 | Minnesota Oncology - Maplewood | Maplewood | Minnesota | United States | 55109 |
| 184 | Virginia Piper Cancer Institute at Abbott - Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 185 | Hennepin County Medical Center - Minneapolis | Minneapolis | Minnesota | United States | 55415 |
| 186 | New Ulm Medical Center | New Ulm | Minnesota | United States | 56073 |
| 187 | Humphrey Cancer Center at North Memorial Outpatient Center | Robbinsdale | Minnesota | United States | 55422-2900 |
| 188 | Mayo Clinic Cancer Center | Rochester | Minnesota | United States | 55905 |
| 189 | CCOP - Metro-Minnesota | Saint Louis Park | Minnesota | United States | 55416 |
| 190 | Park Nicollet Cancer Center | Saint Louis Park | Minnesota | United States | 55416 |
| 191 | Regions Hospital Cancer Care Center | Saint Paul | Minnesota | United States | 55101 |
| 192 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 193 | St. Francis Cancer Center at St. Francis Medical Center | Shakopee | Minnesota | United States | 55379 |
| 194 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 195 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 196 | Willmar Cancer Center at Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 197 | Minnesota Oncology - Woodbury | Woodbury | Minnesota | United States | 55125 |
| 198 | University of Mississippi Cancer Clinic | Jackson | Mississippi | United States | 39216 |
| 199 | Regional Cancer Center at Singing River Hospital | Pascagoula | Mississippi | United States | 39581 |
| 200 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 201 | Saint Luke's Cancer Institute at Saint Luke's Hospital | Kansas City | Missouri | United States | 64111 |
| 202 | Research Medical Center | Kansas City | Missouri | United States | 64132 |
| 203 | Mercy Clinic Cancer and Hematology - Rolla | Rolla | Missouri | United States | 65401 |
| 204 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 205 | Saint Joseph Oncology, Incorporated | Saint Joseph | Missouri | United States | 64507 |
| 206 | St. Anthony's Cancer Center | Saint Louis | Missouri | United States | 63128 |
| 207 | David C. Pratt Cancer Center at St. John's Mercy | Saint Louis | Missouri | United States | 63141 |
| 208 | St. John's Regional Health Center | Springfield | Missouri | United States | 65804 |
| 209 | Hulston Cancer Center at Cox Medical Center South | Springfield | Missouri | United States | 65807 |
| 210 | CCOP - Montana Cancer Consortium | Billings | Montana | United States | 59101 |
| 211 | Billings Clinic - Downtown | Billings | Montana | United States | 59107-7000 |
| 212 | Big Sky Oncology | Great Falls | Montana | United States | 59405-5309 |
| 213 | Great Falls Clinic - Main Facility | Great Falls | Montana | United States | 59405 |
| 214 | Sletten Cancer Institute at Benefis Healthcare | Great Falls | Montana | United States | 59405 |
| 215 | Cancer Resource Center - Lincoln | Lincoln | Nebraska | United States | 68510 |
| 216 | CCOP - Missouri Valley Cancer Consortium | Omaha | Nebraska | United States | 68106 |
| 217 | Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 218 | Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 219 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131-2197 |
| 220 | Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756-0002 |
| 221 | Norris Cotton Cancer Center at Catholic Medical Center | Manchester | New Hampshire | United States | 03102 |
| 222 | Hunterdon Regional Cancer Center at Hunterdon Medical Center | Flemington | New Jersey | United States | 08822 |
| 223 | Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton | Marlton | New Jersey | United States | 08053 |
| 224 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 225 | Radiation Oncology Center at Kennedy Health System - Sewell | Sewell | New Jersey | United States | 08080 |
| 226 | J. Phillip Citta Regional Cancer Center at Community Medical Center | Toms River | New Jersey | United States | 08755 |
| 227 | Cancer Institute of New Jersey at Cooper - Voorhees | Voorhees | New Jersey | United States | 08043 |
| 228 | Fox Chase Virtua Health Cancer Program at Virtua West Jersey | Voorhees | New Jersey | United States | 08043 |
| 229 | Lovelace Medical Center - Downtown | Albuquerque | New Mexico | United States | 87102 |
| 230 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87131-5636 |
| 231 | University of New Mexico Cancer Center - South | Las Cruces | New Mexico | United States | 88011 |
| 232 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263-0001 |
| 233 | Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital | Cooperstown | New York | United States | 13326 |
| 234 | Winthrop University Hospital | Mineola | New York | United States | 11501 |
| 235 | Beth Israel Medical Center - Petrie Division | New York | New York | United States | 10003-3803 |
| 236 | St. Luke's - Roosevelt Hospital Center - St.Luke's Division | New York | New York | United States | 10025 |
| 237 | Mount Sinai Medical Center | New York | New York | United States | 10029 |
| 238 | Memorial Sloan-Kettering Cancer Center | New York | New York | United States | 10065 |
| 239 | Dyson Center for Cancer Care at Vassar Brothers Medical Center | Poughkeepsie | New York | United States | 12601-3990 |
| 240 | Highland Hospital of Rochester | Rochester | New York | United States | 14620 |
| 241 | James P. Wilmot Cancer Center at University of Rochester Medical Center | Rochester | New York | United States | 14642 |
| 242 | Nalitt Cancer Institute at Staten Island University Hospital | Staten Island | New York | United States | 10305 |
| 243 | Dickstein Cancer Treatment Center at White Plains Hospital Center | White Plains | New York | United States | 10601 |
| 244 | Blumenthal Cancer Center at Carolinas Medical Center | Charlotte | North Carolina | United States | 28232-2861 |
| 245 | Batte Cancer Center at Northeast Medical Center | Concord | North Carolina | United States | 28025 |
| 246 | Iredell Memorial Hospital | Statesville | North Carolina | United States | 28677 |
| 247 | Wake Forest University Comprehensive Cancer Center | Winston-Salem | North Carolina | United States | 27157-1096 |
| 248 | Medcenter One Hospital Cancer Care Center | Bismarck | North Dakota | United States | 58501 |
| 249 | Mid Dakota Clinic, PC | Bismarck | North Dakota | United States | 58501 |
| 250 | St. Alexius Medical Center Cancer Center | Bismarck | North Dakota | United States | 58502 |
| 251 | CCOP - MeritCare Hospital | Fargo | North Dakota | United States | 58122 |
| 252 | Trinity CancerCare Center | Minot | North Dakota | United States | 58701 |
| 253 | McDowell Cancer Center at Akron General Medical Center | Akron | Ohio | United States | 44307 |
| 254 | Summa Center for Cancer Care at Akron City Hospital | Akron | Ohio | United States | 44309-2090 |
| 255 | Wood County Oncology Center | Bowling Green | Ohio | United States | 43402 |
| 256 | Case Comprehensive Cancer Center | Cleveland | Ohio | United States | 44106-5065 |
| 257 | Riverside Methodist Hospital Cancer Care | Columbus | Ohio | United States | 43214-3998 |
| 258 | CCOP - Columbus | Columbus | Ohio | United States | 43215 |
| 259 | Grant Medical Center Cancer Care | Columbus | Ohio | United States | 43215 |
| 260 | Mount Carmel Health - West Hospital | Columbus | Ohio | United States | 43222 |
| 261 | Doctors Hospital at Ohio Health | Columbus | Ohio | United States | 43228 |
| 262 | Good Samaritan Hospital | Dayton | Ohio | United States | 45406 |
| 263 | David L. Rike Cancer Center at Miami Valley Hospital | Dayton | Ohio | United States | 45409 |
| 264 | Samaritan North Cancer Care Center | Dayton | Ohio | United States | 45415 |
| 265 | Grady Memorial Hospital | Delaware | Ohio | United States | 43015 |
| 266 | Community Cancer Center | Elyria | Ohio | United States | 44035 |
| 267 | Hematology Oncology Center | Elyria | Ohio | United States | 44035 |
| 268 | Blanchard Valley Medical Associates | Findlay | Ohio | United States | 45840 |
| 269 | Middletown Regional Hospital | Franklin | Ohio | United States | 45005-1066 |
| 270 | Fairfield Medical Center | Lancaster | Ohio | United States | 43130 |
| 271 | Lima Memorial Hospital | Lima | Ohio | United States | 45804 |
| 272 | Strecker Cancer Center at Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 273 | Northwest Ohio Oncology Center | Maumee | Ohio | United States | 43537-1839 |
| 274 | Knox Community Hospital | Mount Vernon | Ohio | United States | 43050 |
| 275 | Licking Memorial Cancer Care Program at Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 276 | St. Charles Mercy Hospital | Oregon | Ohio | United States | 43616 |
| 277 | Toledo Clinic - Oregon | Oregon | Ohio | United States | 43616 |
| 278 | Southern Ohio Medical Center Cancer Center | Portsmouth | Ohio | United States | 45662 |
| 279 | Community Hospital of Springfield and Clark County | Springfield | Ohio | United States | 45505 |
| 280 | Flower Hospital Cancer Center | Sylvania | Ohio | United States | 43560 |
| 281 | Mercy Hospital of Tiffin | Tiffin | Ohio | United States | 44883 |
| 282 | Toledo Hospital | Toledo | Ohio | United States | 43606 |
| 283 | St. Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 284 | Medical University of Ohio Cancer Center | Toledo | Ohio | United States | 43614 |
| 285 | CCOP - Toledo Community Hospital | Toledo | Ohio | United States | 43617 |
| 286 | St. Anne Mercy Hospital | Toledo | Ohio | United States | 43623 |
| 287 | Toledo Clinic, Incorporated - Main Clinic | Toledo | Ohio | United States | 43623 |
| 288 | UVMC Cancer Care Center at Upper Valley Medical Center | Troy | Ohio | United States | 45373-1300 |
| 289 | Fulton County Health Center | Wauseon | Ohio | United States | 43567 |
| 290 | Mount Carmel St. Ann's Cancer Center | Westerville | Ohio | United States | 43081 |
| 291 | Genesis - Good Samaritan Hospital | Zanesville | Ohio | United States | 43701 |
| 292 | Oklahoma University Cancer Institute | Oklahoma City | Oklahoma | United States | 73104 |
| 293 | St. Luke's Cancer Network at St. Luke's Hospital | Bethlehem | Pennsylvania | United States | 18015 |
| 294 | Easton Regional Cancer Center at Easton Hospital | Easton | Pennsylvania | United States | 18042 |
| 295 | Cherry Tree Cancer Center | Hanover | Pennsylvania | United States | 17331 |
| 296 | Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States | 17033-0850 |
| 297 | Lancaster General Hospital | Lancaster | Pennsylvania | United States | 17604 |
| 298 | St. Mary Regional Cancer Center | Langhorne | Pennsylvania | United States | 19047 |
| 299 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 300 | Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital | Meadowbrook | Pennsylvania | United States | 19046 |
| 301 | Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | Philadelphia | Pennsylvania | United States | 19107-5541 |
| 302 | Fox Chase Cancer Center - Philadelphia | Philadelphia | Pennsylvania | United States | 19111-2497 |
| 303 | UPMC Cancer Centers | Pittsburgh | Pennsylvania | United States | 15232 |
| 304 | Mount Nittany Medical Center | State College | Pennsylvania | United States | 16803 |
| 305 | Susquehanna Cancer Center at Divine Providence Hospital | Williamsport | Pennsylvania | United States | 17701 |
| 306 | York Cancer Center at Apple Hill Medical Center | York | Pennsylvania | United States | 17405 |
| 307 | Roper St. Francis Cancer Center at Roper Hospital | Charleston | South Carolina | United States | 29401 |
| 308 | Hollings Cancer Center at Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 309 | CCOP - Upstate Carolina | Spartanburg | South Carolina | United States | 29303 |
| 310 | Gibbs Regional Cancer Center at Spartanburg Regional Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 311 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 312 | Sanford Cancer Center at Sanford USD Medical Center | Sioux Falls | South Dakota | United States | 57117-5039 |
| 313 | West Tennessee Cancer Center at Jackson-Madison County General Hospital | Jackson | Tennessee | United States | 38301 |
| 314 | University of Texas Medical Branch | Galveston | Texas | United States | 77555-0361 |
| 315 | M. D. Anderson Cancer Center at University of Texas | Houston | Texas | United States | 77030-4009 |
| 316 | Methodist Hospital | Houston | Texas | United States | 77030 |
| 317 | Baylor Medical Center at Irving | Irving | Texas | United States | 75061 |
| 318 | Doctor's Hospital of Laredo | Laredo | Texas | United States | 78045 |
| 319 | CCOP - Scott and White Hospital | Temple | Texas | United States | 76508 |
| 320 | Huntsman Cancer Institute at University of Utah | Salt Lake City | Utah | United States | 84112 |
| 321 | Fredericksburg Oncology, Incorporated | Fredericksburg | Virginia | United States | 22401 |
| 322 | Virginia Commonwealth University Massey Cancer Center | Richmond | Virginia | United States | 23298-0037 |
| 323 | St. Joseph Cancer Center | Bellingham | Washington | United States | 98225 |
| 324 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 325 | Swedish Cancer Institute at Swedish Medical Center - First Hill Campus | Seattle | Washington | United States | 98122-4307 |
| 326 | University Cancer Center at University of Washington Medical Center | Seattle | Washington | United States | 98195 |
| 327 | St. Mary Regional Cancer Center at St. Mary Medical Center | Walla Walla | Washington | United States | 99362 |
| 328 | St. Mary's Regional Cancer Center at St. Mary's Medical Center | Huntington | West Virginia | United States | 25702 |
| 329 | Langlade Memorial Hospital | Antigo | Wisconsin | United States | 54409 |
| 330 | Fox Valley Hematology and Oncology - East Grant Street | Appleton | Wisconsin | United States | 54911-3496 |
| 331 | Fox Valley Surgical Associates at Appleton Medical Center | Appleton | Wisconsin | United States | 54911 |
| 332 | Theda Care Cancer Institute | Appleton | Wisconsin | United States | 54911 |
| 333 | Marshfield Clinic - Chippewa Center | Chippewa Falls | Wisconsin | United States | 54729 |
| 334 | Center for Cancer Treatment & Prevention at Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 335 | Marshfield Clinic Cancer Care at Regional Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 336 | Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54301-3526 |
| 337 | Green Bay Oncology, Limited at St. Mary's Hospital | Green Bay | Wisconsin | United States | 54303 |
| 338 | St. Mary's Hospital Medical Center - Green Bay | Green Bay | Wisconsin | United States | 54303 |
| 339 | St. Vincent Hospital Regional Cancer Center | Green Bay | Wisconsin | United States | 54307-3508 |
| 340 | Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 341 | UW Cancer Center Johnson Creek | Johnson Creek | Wisconsin | United States | 53038 |
| 342 | Gundersen Lutheran Center for Cancer and Blood | La Crosse | Wisconsin | United States | 54601 |
| 343 | University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | Madison | Wisconsin | United States | 53792-6164 |
| 344 | Holy Family Memorial Medical Center Cancer Care Center | Manitowoc | Wisconsin | United States | 54221-1450 |
| 345 | Bay Area Cancer Care Center at Bay Area Medical Center | Marinette | Wisconsin | United States | 54143 |
| 346 | Vince Lombardi Cancer Clinic - Marinette | Marinette | Wisconsin | United States | 54143 |
| 347 | Saint Joseph's Hospital | Marshfield | Wisconsin | United States | 54449 |
| 348 | Medical College of Wisconsin Cancer Center | Milwaukee | Wisconsin | United States | 53226 |
| 349 | Marshfield Clinic - Lakeland Center | Minocqua | Wisconsin | United States | 54548 |
| 350 | Regional Cancer Center at Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 351 | Green Bay Oncology, Limited - Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 352 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 353 | Ministry Medical Group at Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 354 | Marshfield Clinic - Indianhead Center | Rice Lake | Wisconsin | United States | 54868 |
| 355 | St. Nicholas Hospital | Sheboygan | Wisconsin | United States | 53081 |
| 356 | Vince Lombardi Cancer Clinic - Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 357 | Marshfield Clinic at Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 358 | Saint Michael's Hospital Cancer Center | Stevens Point | Wisconsin | United States | 54481 |
| 359 | Green Bay Oncology, Limited - Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235 |
| 360 | Aurora Medical Center | Summit | Wisconsin | United States | 53066 |
| 361 | Vince Lombardi Cancer Clinic - Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 362 | Waukesha Memorial Hospital Regional Cancer Center | Waukesha | Wisconsin | United States | 53188 |
| 363 | Marshfield Clinic - Wausau Center | Wausau | Wisconsin | United States | 54401 |
| 364 | University of Wisconcin Cancer Center at Aspirus Wausau Hospital | Wausau | Wisconsin | United States | 54401 |
| 365 | Oncology Alliance, SC - Milwaukee - West | Wauwatosa | Wisconsin | United States | 53226 |
| 366 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 367 | Marshfield Clinic - Weston Center | Weston | Wisconsin | United States | 54476 |
| 368 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 369 | Riverview UW Cancer Center at Riverview Hospital | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 370 | Cross Cancer Institute at University of Alberta | Edmonton | Alberta | Canada | T6G 1Z2 |
| 371 | CancerCare Manitoba | Winnipeg | Manitoba | Canada | R3E 0V9 |
| 372 | Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 373 | London Regional Cancer Program at London Health Sciences Centre | London | Ontario | Canada | N6A 4L6 |
| 374 | McGill Cancer Centre at McGill University | Montreal | Quebec | Canada | H2W 1S6 |
| 375 | Tel-Aviv Sourasky Medical Center | Tel Aviv | Israel | 64239 | |
| 376 | King Faisal Specialist Hospital and Research Center | Riyadh | Saudi Arabia | 11211 | |
| 377 | Pretoria Academic Hospital | Pretoria | South Africa | 0002 |
Sponsors and Collaborators
- Eastern Cooperative Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Seema A. Khan, MD, Robert H. Lurie Cancer Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Eastern Cooperative Oncology Group
ClinicalTrials.gov Identifier:
NCT01242800
Other Study ID Numbers:
- CDR0000688097
- ECOG-E2108
First Posted:
Nov 17, 2010
Last Update Posted:
Dec 22, 2021
Last Verified:
May 1, 2021
Keywords provided by Eastern Cooperative Oncology Group
Additional relevant MeSH terms: