A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Sponsor

NSABP Foundation Inc (Other)

Overall Status

Completed

CT.gov ID

NCT00887536

Collaborator

Genentech, Inc. (Industry), US Oncology Research (Industry)

1,613

Enrollment

533

Locations

Arms

105.1

Duration (Months)

Patients Per Site

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from returning. A second purpose of this study is to learn if adding bevacizumab to treatment with chemotherapy will help women with HER2-negative breast cancer live longer. The researchers also want to learn about the side effects of the combination of drugs used in this study.

Condition or Disease	Intervention/Treatment	Phase
Breast Cancer	Drug: bevacizumab Drug: docetaxel Drug: doxorubicin Drug: cyclophosphamide Drug: pegfilgrastim	Phase 3

Detailed Description

The B-46-I/07132 study, a multicenter, open-label, randomized Phase III, adjuvant therapy trial, will compare the value of adding bevacizumab to a non-anthracycline-based chemotherapy regimen relative to the same chemotherapy without bevacizumab and relative to an anthracycline-based chemotherapy regimen in women with resected node-positive or high-risk node-negative, HER2-negative breast cancer. This trial will determine whether the addition of bevacizumab to a regimen of docetaxel and cyclophosphamide (TCB) improves invasive disease-free survival relative to docetaxel and cyclophosphamide alone (TC). A secondary aim will be to determine whether the addition of bevacizumab to TC improves invasive disease-free survival compared to a regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC). Other secondary aims include whether TCB improves disease-free survival, overall survival, and recurrence-free interval relative to TC alone and to TAC. The toxicities of the three regimens will also be compared.

Patients in the B-46-I/07132 study will be randomized to one of three treatment regimens:

Group 1 patients will receive 6 cycles of TAC administered every 21 days (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2); Group 2 patients will receive 6 cycles of TC administered every 21 days (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2); and Group 3 patients will receive 6 cycles of TCB every 21 days with bevacizumab therapy continuing every 21 days after completion of chemotherapy until 1 year following the first dose (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2, and bevacizumab 15 mg/kg). Primary prophylaxis with pegfilgrastim or filgrastim is required for Group 1 patients (optional for patients in Groups 2 and 3). Patients will also receive adjuvant radiation therapy as clinically indicated and endocrine therapy for hormone receptor-positive tumors.

Tumor samples will be submitted for correlative science studies to evaluate predictors of study therapy benefit. Submission of a tumor sample is a study requirement for all patients.

Study Design

Study Type:

Interventional

Actual Enrollment :

1613 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Study Start Date :

May 1, 2009

Actual Primary Completion Date :

Feb 1, 2018

Actual Study Completion Date :

Feb 1, 2018

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Group 1: TAC then pegfilgrastim docetaxel, doxorubicin, cyclophosphamide, and pegfilgrastim/filgrastim	Drug: docetaxel docetaxel 75 mg/m2 IV every 21 days for 6 cycles Other Names: T Drug: doxorubicin doxorubicin 50 mg/m2 IV every 21 days for 6 cycles Other Names: A Drug: cyclophosphamide Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles Other Names: C Drug: pegfilgrastim pegfilgrastim 6 mg subcutaneous (SC) Day 2 every 21 days for 6 cycles [filgrastim (Neupogen®) 5 mcg/kg Days 2-10 may be given in lieu of pegfilgrastim (Neulasta®), but pegfilgrastim is preferred.]
Active Comparator: Group 2: TC docetaxel and cyclophosphamide	Drug: docetaxel docetaxel 75 mg/m2 IV every 21 days for 6 cycles Other Names: T Drug: cyclophosphamide Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles Other Names: C
Experimental: Group 3: TC + bevacizumab docetaxel, cyclophosphamide, and bevacizumab	Drug: bevacizumab bevacizumab 15 mg/kg IV every 21 days for 6 cycles followed by bevacizumab 15 mg/kg IV every 21 days until 1 year following the first dose of bevacizumab Drug: docetaxel docetaxel 75 mg/m2 IV every 21 days for 6 cycles Other Names: T Drug: cyclophosphamide Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles Other Names: C

Arm

Intervention/Treatment

Active Comparator: Group 1: TAC then pegfilgrastim

docetaxel, doxorubicin, cyclophosphamide, and pegfilgrastim/filgrastim

Drug: docetaxel

docetaxel 75 mg/m2 IV every 21 days for 6 cycles

Other Names:

Drug: doxorubicin

doxorubicin 50 mg/m2 IV every 21 days for 6 cycles

Other Names:

Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Names:

Drug: pegfilgrastim

pegfilgrastim 6 mg subcutaneous (SC) Day 2 every 21 days for 6 cycles [filgrastim (Neupogen®) 5 mcg/kg Days 2-10 may be given in lieu of pegfilgrastim (Neulasta®), but pegfilgrastim is preferred.]

Active Comparator: Group 2: TC

docetaxel and cyclophosphamide

Drug: docetaxel

docetaxel 75 mg/m2 IV every 21 days for 6 cycles

Other Names:

Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Names:

Experimental: Group 3: TC + bevacizumab

docetaxel, cyclophosphamide, and bevacizumab

Drug: bevacizumab

bevacizumab 15 mg/kg IV every 21 days for 6 cycles followed by bevacizumab 15 mg/kg IV every 21 days until 1 year following the first dose of bevacizumab

Drug: docetaxel

docetaxel 75 mg/m2 IV every 21 days for 6 cycles

Other Names:

Drug: cyclophosphamide

Group 1: cyclophosphamide 500 mg/m2 IV every 21 days for 6 cycles Group 2 and 3: cyclophosphamide 600 mg/m2 IV every 21 days for 6 cycles

Other Names:

Outcome Measures

Primary Outcome Measures

Invasive disease-free survival(IDFS)relative to the TAC chemotherapy regimen alone [Every 12 months until recurrence]

Secondary Outcome Measures

Invasive disease-free survival (IDFS) relative to the TAC chemotherapy regimen [Every 12 months until recurrence]
Disease-free survival (DFS-DCIS) relative to the TC alone regimen [Every 12 months until recurrence]
Overall survival (OS) relative to the TC alone regimen [Every 12 months from randomization until death from any cause]
OS relative to the TAC regimen [Every 12 months from randomization until death from any cause]
Recurrence-free interval (RFI) relative to the TC alone regimen [Every 12 months, from randomization to local, regional, or distant recurrence]
RFI relative to the TAC regimen [Every 12 months, from randomization to local, regional, or distant recurrence]
Develop molecular predictive markers for the degree of benefit from TCB over TC or TAC [6 years]
Provide the efficacy data from Group 1 patients and Group 2 patients enrolled in B-46-I/07132 to US Oncology Research, Inc. (USOR) for a planned combined analysis with efficacy data from patients receiving the same regimens in the USOR 06-090 trial [10 years]
Toxicity associated with each of the regimens [Every 6 months]
Determine the role of topoisomerase II alpha (TOP2A) in prognosis and prediction of degree of benefit from TAC over TC [6 years]
Develop predictive markers for benefit from doxorubicin [6 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

Patients must be female.
The patient must be greater than or equal to 18 years of age and less than or equal to 70 years of age.
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
The breast cancer must be HER2-negative based on current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. If the result of the in situ hybridization testing (FISH, chromagen in situ hybridization (CISH), or other) is equivocal, the patient is eligible if there is no plan to administer HER2-targeted therapy.
All of the following staging criteria (according to the 6th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: ER negative and PgR negative; or Pathologic tumor size greater than 2.0 cm; or T1c (pathologic tumor size greater than 1.0 cm but less than or equal to 2.0 cm) and ER positive (PgR status may be positive or negative) and either Oncotype DX® Recurrence Score of greater than or equal to 25 or grade 3 histology.
Patients must have undergone either a total mastectomy or breast-conserving surgery (lumpectomy).
For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and DCIS as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures must be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection.)
For patients who undergo mastectomy, margins must be histologically free of invasive tumor and DCIS.
Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi, or pN1b; Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; or Axillary lymphadenectomy without SN isolation procedure.
The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed. (Either a core biopsy or surgical resection specimen can be used for ER/PgR testing.)
The most recent postoperative blood counts must meet the following criteria: Absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3; platelet count must be greater than or equal to 100,000/mm3; and hemoglobin must be greater than or equal to 10 g/dL.
The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests: total bilirubin must be less than or equal to upper limits of normal (ULN)for the lab unless the patient has a bilirubin elevation less than ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and aspartate transaminase (AST) may not both be greater than the ULN. For example, if the alkaline phosphatase is greater than the ULN but less than or equal to 2.5 x ULN, then the AST must be less than or equal to the ULN. If the AST is greater than the ULN but less than or equal to 1.5 x ULN, then the alkaline phosphatase must be less than or equal to ULN.
Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET-CT, or PET scan) does not demonstrate metastatic disease and the requirements for adequate hepatic function are met.
Patients with alkaline phosphatase that is greater than ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT, or PET scan does not demonstrate metastatic disease.
The most recent postoperative serum creatinine must be less than or equal to ULN for the lab.
A urine sample must be tested for proteinuria by the dipstick method. Eligibility must be based on the most recent postoperative test result(s) performed within 6 weeks prior to randomization. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, a 24-hour urine specimen must be collected and must demonstrate less than 1 gram of protein.
Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or multigated acquisition (MUGA) scan must be performed within 90 days prior to randomization. The LVEF must be greater than or equal to 50% regardless of the facility's lower limits of normal (LLN).

Exclusion Criteria:

T4 tumors including inflammatory breast cancer.
Definitive clinical or radiologic evidence of metastatic disease.
Synchronous or metachronous contralateral invasive breast cancer. (Patients with synchronous and/or metachronous contralateral DCIS are eligible.)
Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.
History of non-breast malignancies within 5 years prior to randomization, except for the following: carcinoma in situ of the cervix, colorectal carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
Previous therapy with anthracyclines, taxanes, or bevacizumab for any malignancy.
Chemotherapy administered for the currently diagnosed breast cancer prior to randomization.
Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy. Patients are eligible if these medications are discontinued prior to randomization.
Active hepatitis B or hepatitis C with abnormal liver function tests.
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to 1) Active cardiac disease: angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis,

History of cardiac disease: myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function; history of documented congestive heart failure (CHF); and documented cardiomyopathy.

Uncontrolled hypertension defined as systolic BP greater than 150 mmHg or diastolic BP greater than 90 mmHg, with or without anti-hypertensive medication. Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
History of hypertensive crisis or hypertensive encephalopathy.
History of transient ischemic attack (TIA) or cerebrovascular accident (CVA).
History of any arterial thrombotic event within 12 months prior to randomization.
Symptomatic peripheral vascular disease.
Intrinsic lung disease resulting in dyspnea.
Unstable diabetes mellitus.
Active infection or chronic infection requiring suppressive antibiotics.
History of a major organ allograft or condition requiring chronic immunosuppression, e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases. (Patients who have received corneal transplants, cadaver skin, or bone transplants are eligible.)
Any significant bleeding within 180 days prior to randomization, exclusive of menorrhagia in premenopausal women.
Non-healing wound, skin ulcers, or incompletely healed bone fracture.
Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to the planned start of study therapy.
Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab.
Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization.
History of GI perforation, abdominal fistulae, or intra-abdominal abscess.
Known bleeding diathesis or coagulopathy.
Requirement for therapeutic doses of coumadin or equivalent.
Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0.
Conditions that would prohibit administration of corticosteroids.
Chronic daily treatment with corticosteroids (dose of greater than or equal to 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
History of hypersensitivity reaction to drugs formulated with polysorbate 80.
Pregnancy or lactation at the time of study entry.
Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
Use of any investigational product within 4 weeks prior to randomization.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Birmingham Hematology and Oncology	Bessemer	Alabama	United States	35022
2	Birmingham Hematology and Oncology	Birmingham	Alabama	United States	35205
3	Birmingham Hematology and Oncology - Brookwood	Birmingham	Alabama	United States	35209
4	Birmingham Hematology and Oncology - Princeton	Birmingham	Alabama	United States	35211
5	Birmingham Hematology and Oncology - Montclair	Birmingham	Alabama	United States	35213
6	Birmingham Hematology and Oncology - Pilot	Birmingham	Alabama	United States	35235
7	Clearview Cancer Institute- Huntsville	Huntsville	Alabama	United States	35805
8	Northern Arizona Hematology & Onclogy Associates	Flagstaff	Arizona	United States	86001
9	Arizona Oncolocy (CASA-Green Valley)	Green Valley	Arizona	United States	85614
10	Arizona Oncology (CASA- Oro Valley)	Oro Valley	Arizona	United States	85737
11	Hematology Oncology Associates	Phoenix	Arizona	United States	85012
12	Northern Arizona Hematology & Oncology Associates	Prescott Valley	Arizona	United States	86314
13	Arizona Oncology (CASA-Safford)	Safford	Arizona	United States	85546
14	Hematology Oncology Associates	Scottsdale	Arizona	United States	85258
15	Northern Arizona Hematology & Oncology Associates	Sedona	Arizona	United States	86336
16	Arizona Oncology Associates - Rudasill	Tucson	Arizona	United States	85704
17	Arizona Oncology Associates - Carondelet	Tucson	Arizona	United States	85710
18	Arizona Oncology (CASA-Craycroft)	Tucson	Arizona	United States	85712
19	Arizona Oncology (CASA-Office Only)	Tucson	Arizona	United States	85715
20	Arizona Oncology - CASA St. Mary's	Tucson	Arizona	United States	85745
21	Central Hematology/Oncology Medical Group, Inc.	Alhambra	California	United States	91801
22	Kaiser Permanente Deer Valley Med Center	Antioch	California	United States	94531
23	Comp Blook and Cancer Center	Bakersfield	California	United States	93309
24	Southwest Cancer Care (E. Grand)	Escondido	California	United States	92025
25	Kaiser Permanente Fremont	Fremont	California	United States	94538
26	St. Jude Heritage Healthcare	Fullerton	California	United States	92835
27	Kaiser Permanente Medical Center - Hayward	Hayward	California	United States	94545
28	Pacific Shores Medical Group	Huntington Beach	California	United States	92648
29	Southern California Permanente Medical Group	Irvine	California	United States	92618
30	Wilshire Oncology Medical Group (Business Office)	La Verne	California	United States	91750
31	Antelope Valley Cancer Center	Lancaster	California	United States	93534
32	Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center	Long Beach	California	United States	90806
33	Todd Cancer Institute at Long Beach Memorial Med Cent	Long Beach	California	United States	90806
34	Pacific Shores Medical Group	Long Beach	California	United States	90813
35	Pacific Shores Medical Group	Los Alamitos	California	United States	90720
36	TORI- N Valley Hematology Oncology Med Group	Mission Hills	California	United States	91345
37	TORI - Oncology Care Medical Assoc.	Montebello	California	United States	90640
38	Southwest Cancer Care (Medical Center)	Murrieta	California	United States	92562
39	NValley Hematology/Oncology Medical Group	Northridge	California	United States	91325
40	Kaiser Permanente-Oakland	Oakland	California	United States	94611
41	St. Joseph Hospital	Orange	California	United States	92868
42	Ventura County Hematology-Oncology Specialists	Oxnard	California	United States	93030
43	Stanford University Medical Center	Palo Alto	California	United States	94304
44	Kaiser Permanente Medical Center - Redwood City	Redwood City	California	United States	94063
45	Kaiser Permanente Medical Center - Richmond	Richmond	California	United States	94801
46	Sutter Roseville Medical Center	Roseville	California	United States	95661
47	Kaiser Permanente Roseville	Roseville	California	United States	95678
48	Sutter Medical Center	Sacramento	California	United States	95816
49	Kaiser Permanente, South Sacramento	Sacramento	California	United States	95823
50	Kaiser Permanente Medical Center - Sacramento	Sacramento	California	United States	95825
51	Kaiser Permanente-San Diego	San Diego	California	United States	92120
52	Kaiser Permanente Medical Center - San Francisco Geary Campus	San Francisco	California	United States	94115
53	TORI - Oncology Care Med Assoc	San Gabriel	California	United States	91776
54	Kaiser Permanente Santa Teresa	San Jose	California	United States	95119
55	Kaiser Permanente San Rafael	San Rafael	California	United States	94903
56	Santa Barbara Hematology Oncology Medical Group	Santa Barbara	California	United States	93105
57	Santa Barbara II (Samsum Clinic) - TORI	Santa Barbara	California	United States	93105
58	Kaiser Permanente Medical Center - Santa Clara Kiely Campus	Santa Clara	California	United States	95051
59	Central Coast Medical Oncology Corporation	Santa Maria	California	United States	93454
60	Kaiser Permanente Medical Center - Santa Rosa	Santa Rosa	California	United States	95403
61	Santa Barbara Hematology/Oncology Medical Group, Inc	Solvang	California	United States	93463
62	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
63	Kaiser Permanente Medical Facility - Stockton	Stockton	California	United States	95210
64	Olive View/UCLA Medical Center	Sylmar	California	United States	91342
65	Kaiser Permanente Medical Center Vacaville	Vacaville	California	United States	95688
66	Kaiser Permanente Medical Center - Vallejo	Vallejo	California	United States	94589
67	Kaiser Permanente Medical Center - Walnut Creek	Walnut Creek	California	United States	94596
68	Trivalley Oncology Hematology	Westlake Village	California	United States	91361
69	Westlake Infusion Center	Westlake Village	California	United States	91361
70	TORI - Oncology Care Med Assoc	Whittier	California	United States	90602
71	Medical Center of Aurora	Aurora	Colorado	United States	80012
72	Rocky Mountain Cancer Center	Aurora	Colorado	United States	80012
73	Rocky Mountain Cancer Centers - Boulder	Boulder	Colorado	United States	80303
74	Penrose/St. Francis Healthcare System	Colorado Springs	Colorado	United States	80907
75	Rocky Mountain Cancer Center at the Pivillion- Fontanero	Colorado Springs	Colorado	United States	80907
76	Rocky Mountain Cancer Center - CO Springs	Colorado Springs	Colorado	United States	80909
77	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
78	CCOP - Colorado Cancer Research Program, Inc.	Denver	Colorado	United States	80209-5031
79	Porter Adventist Hospital	Denver	Colorado	United States	80210
80	Exempla St. Joseph Hospital	Denver	Colorado	United States	80218
81	Rocky Mountain Cancer Center - Midtown	Denver	Colorado	United States	80218
82	Rocky Mountain Cancer Center - 9th Avenue	Denver	Colorado	United States	80220
83	Rocky Mountain Cancer Center - Rose	Denver	Colorado	United States	80220
84	University of Colorado	Denver	Colorado	United States	80262
85	Shaw Regional Cancer Center	Edwards	Colorado	United States	81632
86	Swedish Medical Center	Englewood	Colorado	United States	80110
87	Front Range Cancer Specialists	Fort Collins	Colorado	United States	80524
88	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
89	St. Mary's Hospital and Medical Center	Grand Junction	Colorado	United States	81502-1628
90	St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center	Grand Junction	Colorado	United States	81502
91	North Colorado Medical Center	Greeley	Colorado	United States	80631
92	Kaiser Permanente Rock Creek	Lafayette	Colorado	United States	80026
93	Rocky Mountain Cancer Center	Lakewood	Colorado	United States	80228
94	Rocky Mountain Cancer Center - Dry Creek	Littleton	Colorado	United States	80120-4413
95	Rocky Mountain Cancer Center- Sky Ridge	Lone Tree	Colorado	United States	80124
96	Rocky Mountain Cancer Center - Longmont	Longmont	Colorado	United States	80501
97	McKee Medical Center	Loveland	Colorado	United States	80539
98	Rocky Mountain Cancer Center	Parker	Colorado	United States	80138
99	Rocky Mountain Cancer Centers	Thornton	Colorado	United States	80260
100	Exempla Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
101	University of Connecticut	Farmington	Connecticut	United States	06032
102	Hartford Hospital	Hartford	Connecticut	United States	06102-5037
103	Washington Regional Cancer Center	Washington	District of Columbia	United States	20010
104	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
105	SCRI - Florida Cancer Specialists- Bonita Springs	Bonita Springs	Florida	United States	34135
106	SCRI - Florida Cancer Specialists - Bradenton	Bradenton	Florida	United States	34209
107	Florida Cancer Specialists	Brandon	Florida	United States	33511
108	SCRI Florida Cancer Specialists - Cape Coral (1708)	Cape Coral	Florida	United States	33914
109	SCRI Florida Cancer Specialists - Cape Coral (811)	Cape Coral	Florida	United States	33990
110	Morton Plant Mease Health Care	Clearwater	Florida	United States	33756
111	SCRI Florida Cancer Specialists - Englewood	Englewood	Florida	United States	33990
112	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
113	SCRI Florida Cancer Specialists - Fort Myers (Hampshire)	Fort Myers	Florida	United States	33908
114	SCRI Florida Cancer Specialists - Ft. Myers (Broadway)	Fort Myers	Florida	United States	33908
115	SCRI Florida Cancer Specialists- Fort Myers (Veronica)	Fort Myers	Florida	United States	33916
116	University of Florida Shands Cancer Center	Gainesville	Florida	United States	32610-0232
117	Florida Cancer Institute - New Hope	Hudson	Florida	United States	34667
118	TORI-ICON - Shircl	Jacksonville	Florida	United States	32204
119	Baptist Cancer Institute - Jacksonville	Jacksonville	Florida	United States	32207
120	Integrated Community Oncology Network (ICON)	Jacksonville	Florida	United States	32207
121	TORI-ICON St.Aug	Jacksonville	Florida	United States	32258
122	CCOP, Jupiter Medical Cener	Jupiter	Florida	United States	33458
123	Ocala Oncology Center - Lady Lake	Lady Lake	Florida	United States	32159
124	Melbourne International Medicine Associates	Melbourne	Florida	United States	32901
125	CCOP - Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
126	Advanced Medical Specialties - AMS	Miami	Florida	United States	33133
127	Advanced Medical Specialists- Sunset	Miami	Florida	United States	33143
128	Advanced Medical Specialties - N Kendall (STE 300E)	Miami	Florida	United States	33176
129	Advanced Medical Specialties - N. Kendall (STE 905E)	Miami	Florida	United States	33176
130	SCRI Florida Cancer Specialists - Naples (Goodlette)	Naples	Florida	United States	34102
131	SCRI Florida Cancer Specialists - Naples (Pine)	Naples	Florida	United States	34119
132	Florida Cancer Institute - New Hope	New Port Richey	Florida	United States	34655
133	Ocala Oncology Center	Ocala	Florida	United States	34478
134	Cancer Centers of Florida, P.A.	Ocoee	Florida	United States	34761
135	Tori-Icon	Orange Park	Florida	United States	32073
136	Florida Hospital	Orlando	Florida	United States	32803
137	Cancer Centers of Florida, P.A.	Orlando	Florida	United States	32806
138	MD Anderson Cancer Center	Orlando	Florida	United States	32806
139	SCRI - Florida Cancer Specialists - Port Charlotte	Port Charlotte	Florida	United States	33980
140	Tori-Icon	Saint Augustine	Florida	United States	32086
141	SCRI Florida Cancer Specialists - Sarasota (Cattleman)	Sarasota	Florida	United States	34232
142	SCRI- Florida Cancer Specialists - Sarasota	Sarasota	Florida	United States	34236
143	SCRI - Florida Cancer Specialists - Armenia	Tampa	Florida	United States	33603
144	SCRI - Florida Cancer Specialists - Tampa	Tampa	Florida	United States	33607
145	SCRI Florida Cancer Specialists - Venice (Tamiami)	Venice	Florida	United States	34285
146	SCRI Florida Cancer Specilaists - Venice	Venice	Florida	United States	34292
147	Cancer Centers of Florida, P.A.	Winter Park	Florida	United States	32789
148	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31703
149	Northwest Georgia Oncology Centers	Austell	Georgia	United States	30106
150	Northwest Georgia Oncology Centers	Carrollton	Georgia	United States	30117
151	Dublin Hematology/Oncology	Dublin	Georgia	United States	31021
152	Suburban Hematology-Oncology Associates	Lawrenceville	Georgia	United States	30045
153	Northwest Georgia Oncology Centers	Marietta	Georgia	United States	30060
154	SCRI Chattanooga Oncol & Hematol Assoc, PC - Ringgold	Ringgold	Georgia	United States	30736
155	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
156	University of Hawaii	Honolulu	Hawaii	United States	96813
157	Kaiser Permanente Hawaii - Moanalua Med Center	Honolulu	Hawaii	United States	96819
158	Cancer Care & Hematology Specialists of Chicagoland	Arlington	Illinois	United States	60005
159	Rush University Medical Center	Chicago	Illinois	United States	60612
160	Decatur Memorial Hospital Cancer Care Institute	Decatur	Illinois	United States	62526
161	CCOP NorthShore University HealthSystem	Evanston	Illinois	United States	60201
162	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
163	Hinsdale Hematology Oncology Associates	Hinsdale	Illinois	United States	60521
164	Edward Hospital	Naperville	Illinois	United States	60566
165	Cancer Care & Hematology Specialists of Chicagoland	Niles	Illinois	United States	60714
166	Advocate Lutheran General Cancer Care Center	Park Ridge	Illinois	United States	60068-1174
167	Carle Cancer Center, CCOP	Urbana	Illinois	United States	61801
168	Carle Foundation Hospital	Urbana	Illinois	United States	61801
169	Cancer Care and Hematology Specialists of Chicagoland	Winfield	Illinois	United States	60190
170	Central Indiana Cancer Centers	Carmel	Indiana	United States	46032
171	Central Indiana Cancer Centers	Fishers	Indiana	United States	46037
172	Central Indiana Cancer Centers	Greenfield	Indiana	United States	46140
173	Central Indiana Cancer Centers	Indianapolis	Indiana	United States	46219
174	Central Indiana Cancer Centers (E. County)	Indianapolis	Indiana	United States	46227
175	St. Vincent Hospital and Health Care Center	Indianapolis	Indiana	United States	46260
176	Clarian Arnett Cancer Care	Lafayette	Indiana	United States	47904
177	Community Hospital	Munster	Indiana	United States	46321
178	Genesis Medical Center	Davenport	Iowa	United States	52803
179	Finley Hospital	Dubuque	Iowa	United States	52001-6314
180	University of Iowa	Iowa City	Iowa	United States	52242
181	Mercy Medical Center - Sioux City	Sioux City	Iowa	United States	51101
182	Siouxland Hematology-Oncology Associates	Sioux City	Iowa	United States	51101
183	St. Luke's Regional Medical Center	Sioux City	Iowa	United States	51101
184	Covenant Cancer Treatment Center	Waterloo	Iowa	United States	50702
185	Kansas Cty Cancer Center - West	Kansas City	Kansas	United States	66112
186	Menorah Medical Center	Overland Park	Kansas	United States	66209
187	Kansas City Cancer Center (CBO)	Overland Park	Kansas	United States	66210
188	Kansas CityCancer Centers - Southwest	Overland Park	Kansas	United States	66210
189	Kansas City Cancer Center, Shawnee Mission	Shawnee Mission	Kansas	United States	66204
190	SCRI Oncology Hematology Care, Inc. Crestview Hills (CVH)	Crestview Hills	Kentucky	United States	41017
191	University of Kentucky Medical Center	Lexington	Kentucky	United States	40536
192	NortonHealtcare Inc.	Louisville	Kentucky	United States	40202
193	Consultants in Blood Disorders and Cancer	Louisville	Kentucky	United States	40207
194	Christus St. Frances Cabrini Hospital	Alexandria	Louisiana	United States	71301
195	Baton Rouge General Medical Center	Baton Rouge	Louisiana	United States	70806
196	Tulane University Medical Center	New Orleans	Louisiana	United States	70112
197	Eastern Maine Medical Center	Bangor	Maine	United States	04401
198	Mercy Medical Center	Baltimore	Maryland	United States	21202
199	St. Joseph's Medical Center	Baltimore	Maryland	United States	21204-7582
200	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
201	Franklin Square Hospital Center	Baltimore	Maryland	United States	21237
202	SCRI - Center for Cancer and Blood Disorders	Bethesda	Maryland	United States	20817
203	Suburban Hospital	Bethesda	Maryland	United States	20817
204	Chevy Chase Healthcare Management, LLC	Chevy Chase	Maryland	United States	20815
205	Maryland Oncology Hematology PA	Columbia	Maryland	United States	21044
206	Frederick Memorial Hospital	Frederick	Maryland	United States	21701
207	Alliance Hematology Oncology PA	Owings Mills	Maryland	United States	21117
208	Penisula Regional Medical Center	Salisbury	Maryland	United States	21801
209	Holy Cross Hospital	Silver Spring	Maryland	United States	20910
210	Alliance Hematology Oncology PA	Westminster	Maryland	United States	21157
211	Saint Anne's Hospital	Fall River	Massachusetts	United States	02721
212	Berkshire Hematology Oncology, P.C.	Pittsfield	Massachusetts	United States	01201
213	CCOP, St. Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
214	Bay Regional Medical Center	Bay City	Michigan	United States	48706
215	CCOP - Oakwood Hospital and Medical Center	Dearborn	Michigan	United States	48123-2500
216	Henry Ford Health System	Detroit	Michigan	United States	48202
217	CCOP - St. John Hospital and Medical Center	Detroit	Michigan	United States	48236-2172
218	Michigan State University	East Lansing	Michigan	United States	48824
219	CCOP - Genesys Regional Hospital	Flint	Michigan	United States	48503
220	CCOP - Hurley Medical Center	Flint	Michigan	United States	48503
221	McLaren Regional Medical Center	Flint	Michigan	United States	48532
222	CCOP - Allegiance Health	Jackson	Michigan	United States	49201
223	Borgess Medical Center	Kalamazoo	Michigan	United States	49001
224	Bronson Methodist Hospital	Kalamazoo	Michigan	United States	49007
225	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
226	Ingham Regional Medical Center - Lansing	Lansing	Michigan	United States	48910-0817
227	CCOP, Sparrow Health System	Lansing	Michigan	United States	48910
228	Lapeer Regional Hospital	Lapeer	Michigan	United States	48446
229	CCOP - St. Mary Mercy Hospital - Livonia	Livonia	Michigan	United States	48154
230	Marquette General Hospital	Marquette	Michigan	United States	49855
231	Mount Clemens Regional Medical Center	Mount Clemens	Michigan	United States	48043
232	Memorial Healthcare	Owosso	Michigan	United States	48867
233	CCOP - St. Joseph Mercy Hospital - Oakland	Pontiac	Michigan	United States	48341
234	CCOP - St. Joseph Mercy Port Huron	Port Huron	Michigan	United States	48060
235	CCOP, William Beaumont Hospital	Royal Oak	Michigan	United States	48073
236	CCOP, St. Mary's Medical Center	Saginaw	Michigan	United States	48601
237	Providence Hospital - Southfield	Southfield	Michigan	United States	48075-9975
238	CCOP, St. John Macomb Hospital	Warren	Michigan	United States	48093
239	Minnesota Oncology Hematology-Burnsville	Burnsville	Minnesota	United States	55337
240	Mercy and Unity Cancer Center at Mercy Hospital	Coon Rapids	Minnesota	United States	55433
241	St. Luke's Hospital	Duluth	Minnesota	United States	55802
242	Fairview Southdale Hospital	Edina	Minnesota	United States	55435
243	Minnesota Oncology Hematology-Edina	Edina	Minnesota	United States	55435
244	Unity Hospital	Fridley	Minnesota	United States	55432
245	Minnesota Oncology Hematology PA - Maplewood	Maplewood	Minnesota	United States	55109
246	St. John's Hospital Northeast/HealthEast, Inc.	Maplewood	Minnesota	United States	55109
247	Minnesota Oncology Hematology-Minneapolis	Minneapolis	Minnesota	United States	55404
248	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
249	Hennepin County Medical Center - Minneapolis	Minneapolis	Minnesota	United States	55415
250	North Memorial Health Care	Robbinsdale	Minnesota	United States	55422
251	CCOP - Metro-Minnesota	Saint Louis Park	Minnesota	United States	55416
252	Park Nicollet Health Services	Saint Louis Park	Minnesota	United States	55416
253	Regions Hospital Cancer Care Center	Saint Paul	Minnesota	United States	55101
254	Minnesota Hematology Oncology-St. Paul	Saint Paul	Minnesota	United States	55102
255	Minnesota Oncology Hematology	Woodbury	Minnesota	United States	55125
256	Missouri Cancer Associates	Columbia	Missouri	United States	65201
257	University of Missouri-Ellis Fischel	Columbia	Missouri	United States	65203
258	Kansas City Cancer Center - Central	Kansas City	Missouri	United States	64111
259	Saint Luke's Hospital	Kansas City	Missouri	United States	64111
260	CCOP - Kansas City	Kansas City	Missouri	United States	64131
261	Kansas City Cancer Center - South	Kansas City	Missouri	United States	64131
262	Research Medical Center	Kansas City	Missouri	United States	64131
263	Research Medical Center	Kansas City	Missouri	United States	64132
264	Kansas City Cancer Center - North	Kansas City	Missouri	United States	64154
265	Kansas City Cancer Centers - East	Lee's Summit	Missouri	United States	64064
266	St. Louis University Health Sciences Center	Saint Louis	Missouri	United States	63110-0250
267	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
268	St. Elizabeth Community Health Center	Lincoln	Nebraska	United States	68510
269	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
270	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
271	CCOP, Missouri Valley Cance Consortium	Omaha	Nebraska	United States	68131
272	Creighton University Cancer Center	Omaha	Nebraska	United States	68131
273	Alegent Health Midlands Hospital	Papillion	Nebraska	United States	68046
274	Comprehensive Cancer Centers of Nevada (Siena)	Henderson	Nevada	United States	89052
275	US Oncology West Region Office (Horizon Ridge)	Henderson	Nevada	United States	89052
276	Comprehensive Cancer Centers of Nevada (Wigwam)	Henderson	Nevada	United States	89074
277	Comprehensive Cancer Centers of Nevada (Peak Dr.)	Las Vegas	Nevada	United States	89128
278	Comprehensive Cancer Centers of Nevada (Southern Hills)	Las Vegas	Nevada	United States	89148
279	Comprehensive Cancer Centers of Nevada (Twain)	Las Vegas	Nevada	United States	89169
280	Renown Regional Medical Center	Reno	Nevada	United States	89502
281	Cancer Institute of New Jersey at Hamilton	Hamilton	New Jersey	United States	08690
282	Hematology-Oncology Associates of NNJ, PA	Morristown	New Jersey	United States	07960
283	Cancer Institute of New Jersey	New Brunswick	New Jersey	United States	08901
284	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
285	Saint Clare's Center at Parsippany Commons	Parsippany	New Jersey	United States	07054
286	Somerset Medical Center	Somerville	New Jersey	United States	08876
287	Sparta Cancer Center	Sparta	New Jersey	United States	07871
288	Texas Oncology PA Las Cruces	Las Cruces	New Mexico	United States	88011
289	New Mexico Cancer Care Associates	Santa Fe	New Mexico	United States	87505
290	New York Oncology Hematology PC-Albany	Albany	New York	United States	12206
291	New York Oncology Hematology, PC at Albany Medical Center	Albany	New York	United States	12208
292	Amsterdam Community Cancer Program	Amsterdam	New York	United States	12010
293	Interlakes Oncology Hematology PC	Brockport	New York	United States	14420
294	Interlakes Oncology & Hematology, P.C.	Canandaigua	New York	United States	14424
295	Interlakes Oncology Hematology PC	Geneva	New York	United States	14456
296	Cancer Center at Glens Falls Hospital	Glens Falls	New York	United States	12801
297	New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program	Hudson	New York	United States	12534
298	New York Oncology Hematology, PC	Latham	New York	United States	12110
299	CCOP - North Shore University Hospital	Manhasset	New York	United States	11030
300	CCOP, Long Island Jewish Medical Center	New Hyde Park	New York	United States	11040
301	New York University School of Medicine	New York	New York	United States	10016
302	New York Oncology Hematology PC	Rexford	New York	United States	12148
303	Interlakes Oncology Hematology PC - White Spruce	Rochester	New York	United States	14623
304	Interlakes Oncology Hematology PC- Long Pond	Rochester	New York	United States	14626
305	University Hospital and Medical Center - SUNY Stony Brook	Stony Brook	New York	United States	11794
306	Troy Cancer Treatment Program	Troy	New York	United States	12180
307	Alamance Regional Medical Center	Burlington	North Carolina	United States	27217
308	Cancer Centers of North Carolina	Cary	North Carolina	United States	27518
309	University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	United States	27599
310	CCOP Carolinas HealthCare System	Charlotte	North Carolina	United States	28232-2861
311	Presbyterian Hospital	Charlotte	North Carolina	United States	28233
312	Regional Cancer Care, PA	Durham	North Carolina	United States	27704
313	Virginia Oncology Associates	Elizabeth City	North Carolina	United States	27909
314	Cape Fear Valley Medical Center Cancer Center	Fayetteville	North Carolina	United States	28302-2000
315	Wayne Memorial Hospital, Incorporated	Goldsboro	North Carolina	United States	27534
316	CCOP, Moses Cone Health System-Regional CA Cntr	Greensboro	North Carolina	United States	27401
317	East Carolina University	Greenville	North Carolina	United States	27834
318	Margaret R. Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
319	High Point Regional Hospital	High Point	North Carolina	United States	27261
320	Cancer Centers of North Carolina	Raleigh	North Carolina	United States	27607
321	Cancer Centers of North Carolina- North Raleigh	Raleigh	North Carolina	United States	27614
322	CCOP Forsyth Memorial Hospital	Winston-Salem	North Carolina	United States	27103
323	Innovis Health	Fargo	North Dakota	United States	58103
324	Akron City Hospital	Akron	Ohio	United States	44304
325	Aultman Hospital	Canton	Ohio	United States	44710
326	SCRI Oncology Hematology Care, Inc. - Cincinnati (TFT)	Cincinnati	Ohio	United States	45219
327	SCRI Oncology Hematology Care, Inc - Cincinnati (AND)	Cincinnati	Ohio	United States	45230
328	SCRI Oncology Hematology Care, Inc. - Cincinnati (KWD)	Cincinnati	Ohio	United States	45236
329	SCRI Oncology Hematlogy Care, Inc. - Cincinnati (RPR)	Cincinnati	Ohio	United States	45238
330	SCRI Oncology Hematology Care, Inc - Cincinnati (BAM)	Cincinnati	Ohio	United States	45242
331	SCRI Oncology Hematology Care, Inc. Cincinnati (WST)	Cincinnati	Ohio	United States	45248
332	Good Samaritan Hospital	Dayton	Ohio	United States	45408
333	CCOP - Dayton	Dayton	Ohio	United States	45429
334	HemOnc Care, Inc.	Fairfield	Ohio	United States	45014
335	Atrium Medical Center - Middletown Regional Hosp	Franklin	Ohio	United States	45005-1066
336	Wayne Hospital	Greenville	Ohio	United States	45331
337	SCRI Oncology Hematology Care, Inc. - Hamilton (HAM)	Hamilton	Ohio	United States	45013
338	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
339	Kettering Medical Center	Kettering	Ohio	United States	45429
340	Upper Valley Medical Center	Troy	Ohio	United States	45373
341	Clinton Memorial Hospital	Wilmington	Ohio	United States	45177
342	SCRI Oncology Hematology Care, Inc. - Wilmington (WLM)	Wilmington	Ohio	United States	45177
343	St. Charles Medical Center - Bend	Bend	Oregon	United States	97701
344	Willamette Valley Cancer Institute and Research Center	Eugene	Oregon	United States	97401
345	Northwest Cancer Specialists-Portland	Portland	Oregon	United States	97213
346	Providence Medical Center	Portland	Oregon	United States	97213
347	Northwest Cancer Specialists- St. Vincent	Portland	Oregon	United States	97225
348	Providence St. Vincent Medical Center	Portland	Oregon	United States	97225
349	Northwest Cancer Specialists- Rose Qtr	Portland	Oregon	United States	97227
350	Williamette Valley Cancer Institute and Research Center	Springfield	Oregon	United States	97477
351	Celilo Center for Cancer Care	The Dalles	Oregon	United States	97058
352	Northwest Cancer Specialists-Tualatin	Tualatin	Oregon	United States	97062
353	Geisinger Clinic	Danville	Pennsylvania	United States	17882-2111
354	Oncology Hematology Associates of Northern PA	DuBois	Pennsylvania	United States	15801
355	Pocono Medical Center	East Stroudsburg	Pennsylvania	United States	18301
356	Ephrata Community Hopital	Ephrata	Pennsylvania	United States	17522-1002
357	Geisinger Hazleton Cancer Center	Hazleton	Pennsylvania	United States	18201
358	Medical Oncology Associates	Kingston	Pennsylvania	United States	18704
359	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
360	Rittenhouse Hematology/Oncology	Philadelphia	Pennsylvania	United States	19107
361	Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	United States	19107
362	Albert Einstein Healthcare Network	Philadelphia	Pennsylvania	United States	19141-3098
363	Allegheny General Hospital/Allegheny-Singer Research Institute	Pittsburgh	Pennsylvania	United States	15212
364	University of Pittsburgh	Pittsburgh	Pennsylvania	United States	15232-1305
365	Hematology and Oncology Associates of NEPA	Scranton	Pennsylvania	United States	18501
366	Scranton Hematology Oncology	Scranton	Pennsylvania	United States	18510
367	Geisinger Medical Group - Scenery Park	State College	Pennsylvania	United States	16801
368	Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center	Upland	Pennsylvania	United States	19013
369	Reading Hospital and Medical Center	West Reading	Pennsylvania	United States	19611
370	Geisinger Wyoming Valley Medical Center	Wilkes-Barre	Pennsylvania	United States	18711
371	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
372	Roper Hosp & Med Asso (Care Alliance Health)	Charleston	South Carolina	United States	29401
373	Medical University of South Carolina	Charleston	South Carolina	United States	29425-0721
374	SCRI - South Carolina Oncology Associates - Stoneridge	Columbia	South Carolina	United States	29210
375	Cancer Centers of the Carolinas Easley, SC	Easley	South Carolina	United States	29640
376	Georgetown Hospital System	Georgetown	South Carolina	United States	29440
377	Cancer Centers of the Carolinas (Butternut)	Greenville	South Carolina	United States	29605
378	Cancer Centers of the Carolinas-W. Faris Road	Greenville	South Carolina	United States	29605
379	Cancer Centers of the Carolinas (International)	Greenville	South Carolina	United States	29615
380	Cancer Centers of the Carolinas - Seneca	Seneca	South Carolina	United States	29672
381	Spartanburg Regional Healthcare System	Spartanburg	South Carolina	United States	29303
382	Cancer Centers of the Carolinas - Spartanburg	Spartanburg	South Carolina	United States	29307
383	Avera McKenna Hospital	Sioux Falls	South Dakota	United States	57101
384	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
385	CCOP, Sanford Cancer Center - Oncology Clinic	Sioux Falls	South Dakota	United States	57105
386	SCRI Chattanooga Oncol & Hematol Assoc, PC - Chattanooga	Chattanooga	Tennessee	United States	37404
387	SCRI Tennessee Oncology - PLLC Franklin	Franklin	Tennessee	United States	37067
388	SCRI Tennessee Oncology- Gallatin	Gallatin	Tennessee	United States	37066
389	SCRI Tennessee Oncology, PLLC Hermitage	Hermitage	Tennessee	United States	37076
390	SCRI Chattanooga Oncol & Hematol Assoc, PC Hixson	Hixson	Tennessee	United States	37404
391	CCOP Holston Valley Medical Center	Kingsport	Tennessee	United States	37662
392	SCRI Tennessee Oncology Lebanon	Lebanon	Tennessee	United States	37087
393	SCRI Tennessee Oncology Murfreesboro	Murfreesboro	Tennessee	United States	37130
394	SCRI - Tennessee Oncology PLLC	Nashville	Tennessee	United States	37203
395	SCRI Tennessee Oncology, PLLC (Harding)	Nashville	Tennessee	United States	37205
396	SCRI Tennessee Onclogy, PLLC (Dickerson)	Nashville	Tennessee	United States	37207
397	SCRI - Tennessee Oncology PLLC	Nashville	Tennessee	United States	37211
398	SCRI Tennessee Oncology, PLLC (Wallace)	Nashville	Tennessee	United States	37211
399	Tennessee Oncology	Shelbyville	Tennessee	United States	37160
400	SCRI Tennessee Oncology, PLLC Smyrna	Smyrna	Tennessee	United States	37167
401	Texas Cancer Center - Abilene South	Abilene	Texas	United States	79606-5208
402	Texas Oncology PA - Amarillo	Amarillo	Texas	United States	79106
403	Texas Oncology PA - Arlington North	Arlington	Texas	United States	76012
404	Texas Onclogy - Arlington South	Arlington	Texas	United States	76014
405	Texas Oncology Central Austin	Austin	Texas	United States	78705
406	Texas Oncology Cancer Center - Balcones	Austin	Texas	United States	78731
407	South Austin Cancer Center	Austin	Texas	United States	78745
408	Southwest Regional Cancer Center- North	Austin	Texas	United States	78759
409	Texas Oncology North Austin- Renfert	Austin	Texas	United States	78759
410	Mamie McFaddin Ward Cancer Center	Beaumont	Texas	United States	77702-1449
411	Edwards Cancer Center - Bedford	Bedford	Texas	United States	76022
412	Texas Oncology PA - Harris HEB	Bedford	Texas	United States	76022
413	Texas Oncology, PA - Cedar Park	Cedar Park	Texas	United States	78613
414	Texas Cancer Center at Medical City	Dallas	Texas	United States	75230-2510
415	Texas Oncology PA- Presbyterian	Dallas	Texas	United States	75231-4400
416	Methodist Charlton Cancer Center	Dallas	Texas	United States	75237
417	Texas Oncology- Sammons CC	Dallas	Texas	United States	75246
418	Texas Cancer Center	Denton	Texas	United States	76210
419	El Paso Cancer Treatment Center - West	El Paso	Texas	United States	79902
420	El Paso Cancer Treatment Center - East	El Paso	Texas	United States	79915
421	Texas Oncology - 8th Avenue	Fort Worth	Texas	United States	76104
422	Texas Oncology at Klabzuba	Fort Worth	Texas	United States	76104
423	Texas Oncology PA - 12th Avenue	Fort Worth	Texas	United States	76104
424	Southwest Fort Worth Cancer Center	Fort Worth	Texas	United States	76132
425	San Antonio Tumor and Blood Clinic	Fredericksburg	Texas	United States	78624
426	Texas Oncology PA	Garland	Texas	United States	75042-5788
427	Texas Oncology	Grapevine	Texas	United States	76051
428	Texas Oncology PA - Frostwood	Houston	Texas	United States	77024
429	MD Anderson Cancer Center	Houston	Texas	United States	77030
430	San Antonio Tumor and Blood Clinic	Kerrville	Texas	United States	78028
431	Lake Vista Cancer Center	Lewisville	Texas	United States	75067
432	Longview Cancer Center	Longview	Texas	United States	75601
433	Joe Arrington Cancer Research & Treatment Center	Lubbock	Texas	United States	79410
434	South Texas Cancer Center - McAllen	McAllen	Texas	United States	78503
435	Texas Cancer Center of Mesquite	Mesquite	Texas	United States	75150
436	Allison Cancer Center	Midland	Texas	United States	79701
437	HOAST - New Braunfels	New Braunfels	Texas	United States	78130
438	Texas Oncology - Odessa	Odessa	Texas	United States	79761
439	Paris Regional Cancer Center	Paris	Texas	United States	75460-5004
440	North Texas Regional Cancer Center	Plano	Texas	United States	75075
441	Texas Oncology Plano West Cancer Center	Plano	Texas	United States	75093
442	Texas Oncology Seton Williamson	Round Rock	Texas	United States	78665
443	Texas Oncology - Round Rock Cancer Center	Round Rock	Texas	United States	78681
444	Cancer Care Centers of South Texas- Brooklyn	San Antonio	Texas	United States	78212
445	Cancer Care Centers of South Texas - Loop 410	San Antonio	Texas	United States	78217
446	HOAST - Medical Drive	San Antonio	Texas	United States	78229
447	San Antonio Tumor and Blood Clinic - M.Oak	San Antonio	Texas	United States	78258-3912
448	University of Texas Health Science Center	San Antonio	Texas	United States	78284-7842
449	Texas Oncology - San Marcos	San Marcos	Texas	United States	78666
450	Texas Cancer Center	Sherman	Texas	United States	75090-0504
451	Texas Oncology Cancer Center - Sugar Land	Sugar Land	Texas	United States	77479
452	US Oncology	The Woodlands	Texas	United States	77380
453	Tyler Cancer Center	Tyler	Texas	United States	75702
454	Texas Oncology Cancer Care and Research Center	Waco	Texas	United States	76712
455	Texas Oncology - Clear Lake	Webster	Texas	United States	77598
456	South Texas Cancer Clinic	Weslaco	Texas	United States	78596
457	Texoma Cancer Center	Wichita Falls	Texas	United States	76310
458	Sandra L. Maxwell Cancer Center	Cedar City	Utah	United States	84720
459	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
460	Utah Valley Regional Medical Center - Provo	Provo	Utah	United States	84604
461	Dixie Regional Medical Center - East Campus	Saint George	Utah	United States	84770
462	Huntsman Cancer Inst. at the University of Utah- Salt Lake City	Salt Lake City	Utah	United States	84132
463	LDS Hospital	Salt Lake City	Utah	United States	84143
464	Southwestern Regional Cancer Center (SWORD)	Bennington	Vermont	United States	05201
465	Arlington Fairfax Hematology Oncology	Arlington	Virginia	United States	22205
466	Virginia Oncology Associates - Medical Pkwy	Chesapeake	Virginia	United States	23320
467	Oncology and Hematology Associates of SW VA, Inc	Christiansburg	Virginia	United States	24073
468	Fairfax Northern VA Hematology-Oncology PC	Fairfax	Virginia	United States	22031
469	Fair Oaks Office	Fairfax	Virginia	United States	22033
470	Fairfax-Northern Virginia Hematology-Oncology PC	Gainesville	Virginia	United States	20155
471	Virginia Oncology Associates	Hampton	Virginia	United States	23606
472	Fairfax-Northern Virginia Hematology-Oncology PC	Leesburg	Virginia	United States	20176
473	SCRI Virginia Cancer Institute (Flank)	Mechanicsville	Virginia	United States	23116
474	SCRI Virginia Cancer Institute	Midlothian	Virginia	United States	23114
475	Virginia Oncology Associates	Newport News	Virginia	United States	23606
476	Virginia Oncology Associates - Lake Wright	Norfolk	Virginia	United States	23502
477	SCRI Virginia Cancer Institute (6605)	Richmond	Virginia	United States	23226
478	SCRI Virginia Cancer Institute (1401)	Richmond	Virginia	United States	23235
479	MBCCOP, Virginia Commonwealth University	Richmond	Virginia	United States	23298
480	Oncology and Hematology Associates of SW VA, Inc	Roanoke	Virginia	United States	24014
481	Oncology and Hematology Associates of SW VA, Inc	Salem	Virginia	United States	24153
482	Virginia Oncology Associates	Virginia Beach	Virginia	United States	23456
483	Virginia Oncology Associates	Williamsburg	Virginia	United States	23188
484	Fairfax Northern Virginia Hematology-Oncology - Winchester	Winchester	Virginia	United States	22601
485	Fairfax-Northern Virginia Hematology-Oncology PC	Woodbridge	Virginia	United States	22191
486	Oncology and Hematology Associates of SW VA, Inc	Wytheville	Virginia	United States	24382
487	Highline Medical Oncology	Burien	Washington	United States	98166
488	Puget Sound Cancer Center- Edmonds	Edmonds	Washington	United States	98026
489	Columbia Basin Hematology and Oncology	Kennewick	Washington	United States	99336
490	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109-1024
491	Puget Sound Cancer Center - Seattle	Seattle	Washington	United States	98133
492	Cancer Care Northwest-South	Spokane	Washington	United States	99202
493	Rockwood Clinic Cancer Treatment Center	Spokane	Washington	United States	99204-2967
494	Cancer Care Northwest-Radiation Therapy (XRT)	Spokane	Washington	United States	99204
495	Cancer Care Northwest- Valley - Mission	Spokane	Washington	United States	99216
496	Cancer Care Northwest-North - Holland	Spokane	Washington	United States	99218
497	Evergreen Hematology & Oncology (Farwell)	Spokane	Washington	United States	99218
498	Northwest Cancer Specialists-136th Ave	Vancouver	Washington	United States	98684
499	Northwest Cancer Specialists-134th St.	Vancouver	Washington	United States	98686
500	Yakima Valley Memorial Hospital - North Star Lodge	Yakima	Washington	United States	98902
501	Raleigh Regional Cancer Center	Beckley	West Virginia	United States	25801
502	CAMC Health Education & Research Institute, Inc.	Charleston	West Virginia	United States	25304
503	West Virginia University Hospitals Inc.	Morgantown	West Virginia	United States	26506-9162
504	Camden-Clark Memorial Hospital	Parkersburg	West Virginia	United States	26101
505	Wheeling Hospital	Wheeling	West Virginia	United States	26003
506	Marshfield Clinic Chippewa Falls Center	Chippewa Falls	Wisconsin	United States	54729
507	Marshfield Clinic Regional CA Cntr - Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
508	CCOP, St. Vincent Hospital	Green Bay	Wisconsin	United States	54301
509	CCOP, St. Mary's Hospital Medical Center	Green Bay	Wisconsin	United States	54303
510	CCOP - Marshfield Clinic Research Foundation	Marshfield	Wisconsin	United States	54449
511	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53201-0342
512	Froedtert Hospital	Milwaukee	Wisconsin	United States	53226
513	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
514	Marshfield Clinic Minocqua Center	Minocqua	Wisconsin	United States	54548
515	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
516	Marshfield Clinic at James Beck Cancer Center	Rhinelander	Wisconsin	United States	54501
517	Marshfield Clinic Rice Lake Center	Rice Lake	Wisconsin	United States	54868
518	Marshfield Clinic Cancer Care at St. Michael's Hospital	Stevens Point	Wisconsin	United States	54481
519	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
520	Aurora Women's Pavilion of Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
521	CCOP Marshfield Clinic - Weston Center	Weston	Wisconsin	United States	54476
522	Marshfield Clinic Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
523	Bon Secours Hospital	Cork	CK	Ireland
524	Letterkenny General Hospital	Letterkenny	DL	Ireland
525	Mater Private Hospital	Dublin	DN	Ireland	7
526	Beaumont Hospital	Dublin		Ireland	9
527	St. Vincent's University Hospital	Dublin		Ireland	DN4
528	Mater Misericordiae	Dublin		Ireland	DN7
529	St James' Hospital	Dublin		Ireland	DN8
530	St. James' Hospital	Dublin		Ireland	DN8
531	University College Hospital	Galway		Ireland	GY
532	Sligo General Hospital	Sligo		Ireland	CO Sligo
533	Waterford Regional Hospital	Waterford		Ireland	0009