Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal Hormone Receptor-Positive Breast Cancer

• Sponsor: Stanford University (Other)
• Overall Status: Terminated
• CT.gov ID: NCT00481845
• Collaborator: AstraZeneca (Industry)
• Enrollment: 1
• Location: 1
• Arms: 2
• Duration (Months): 23
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

In this study we plan to study the combination of ZD6474, a dual inhibitor of EGFR and VEGFR-2 with anastrozole in the neoadjuvant setting for patients with Stage I-III breast cancer. The aim is to overcome mechanisms of resistance and simultaneously block multiple critical signaling pathways known to stimulate breast cancer.

Condition or Disease	Intervention/Treatment	Phase
Breast Cancer	Drug: Vandetanib; Drug: Anastrozole	Phase 2

Detailed Description

The use of adjuvant chemotherapy and endocrine therapy has had a significant impact on breast cancer survival. However, not all patients will benefit from each of these therapies. Increasing data suggests that patients with hormone receptor-positive breast cancer derive marginal benefit from the addition of adjuvant chemotherapy. Identification and characterization of cellular signaling pathways active in the pathogenesis of breast cancer has lead to the development of multiple targeted therapies that hold enormous promise for patients with less toxicity than conventional chemotherapy. Treatment strategies employing neoadjuvant therapy have found that pCR is predictive for ultimate outcome. Due to this, the use of neoadjuvant therapy has become an intense area of investigation in operable breast cancer. In the IMPACT trial, the aromatase inhibitor anastrozole was found to improve eligibility for breast conservation and was associated with a favorable clinical objective response after 12 weeks of therapy.

In this proposed study, we plan to study the combination of ZD6474, a dual inhibitor of EGFR and VEGFR-2, with anastrozole in the neoadjuvant setting for patients with Stage I-III breast cancer. The aim is to overcome mechanisms of resistance and simultaneously block multiple critical signaling pathways known to stimulate breast cancer. The two agents have non-overlapping toxicities and are both administered orally, allowing for a more tolerable treatment regimen. By using this combination in the neoadjuvant setting, we will target the critical signaling pathways early and follow tumor responses during therapy, allowing for prompt evaluation of the effectiveness of this treatment strategy. Pathologic tumor specimens obtained at the time of definitive surgery will be evaluated for pathologic complete response thus adding to the body of literature. By examining molecular markers such as ER, PR, EGFR, and Ki-67 pre- and post-treatment, we hope to correlate modulations in these biomarkers to response. Finally, using a novel second generation functional breast MRI we will investigate the ability of MRI to predict response to antiangiogenic therapy.

Study Design

• Study Type: Interventional
• Actual Enrollment: 1 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: Randomized Phase 2 Trial of Anastrozole Combined With Novel Agent ZD6474 in the Neoadjuvant Treatment of Postmenopausal Patients With Hormone Receptor-Positive Breast Cancer
• Study Start Date: Jan 1, 2008
• Actual Primary Completion Date: Dec 1, 2009
• Actual Study Completion Date: Dec 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Vandetanib + Anastrozole Vandetanib and Anastrozole as neoadjuvant therapy	Drug: Vandetanib; 300 mg daily; Other Names: Zactima ZD6474 ; Drug: Anastrozole; 1 mg daily; Other Names: Arimidex
Active Comparator: Anastrozole Anastrozole as neoadjuvant therapy	Drug: Anastrozole; 1 mg daily; Other Names: Arimidex

Outcome Measures

Primary Outcome Measures

1. Tumor Objective Response by MRI [1 year]

   Determine tumor objective response rate by MRI. (CR): Disappearance of the target lesion (PR): At least a 30% decrease in the longest diameter of the target lesion taking as reference the baseline LD (PD): At least a 20% increase in the LD of target lesion, taking as reference the baseline LD or the appearance of one or more new lesions (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the baseline LD.

Secondary Outcome Measures

1. Pathologic Complete Response [1 year]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: No

Inclusion Criteria:

Histologically confirmed invasive, hormone receptor-positive (ER and/or PR positive) breast cancer

• Stage I-III breast cancer including any primary tumor ≥ 1 cm by ultrasound

• Diagnosis by core needle biopsy with placement of metallic clip at tumor site

• Sentinel lymph node biopsy (US-guided FNA may be substituted if palpable axillary lymphadenopathy)

• Evaluation by a surgeon to determine eligibility for breast conservation

• Postmenopausal status (age ≥ 60 yo; or < 60 yo and FSH and estradiol in the postmenopausal range, prior bilateral oophorectomy)

• Serum creatinine < 1.5 x upper limit of normal (ULN) or creatinine clearance > 50 mL/minute (calculated by Cockcroft-Gault formula.)

• Serum bilirubin < 1.5 x ULN

• Serum potassium ≥ 4 mmol/L (supplementation allowed)

• Serum calcium or magnesium within normal range (supplementation allowed)

• Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≤ 2.5 x ULN or alkaline phosphatase (ALP) ≤ 2.5 x ULN

• ECOG Performance Status 0,1,2

• ECG QTc < 480 msec

• Measurable disease

• Written, informed consent

Exclusion Criteria:- Inflammatory breast cancer

• Metastatic breast cancer excluding disease in regional lymph nodes

• Inoperable disease considered irreversible with neoadjuvant endocrine therapy

• HER2-overexpressed breast cancer

• Prior chemotherapy or radiotherapy for the treatment of the current breast cancer

• Prior hormonal therapy for the treatment of the current breast cancer

• Prior surgical biopsy, lumpectomy, mastectomy for the current breast cancer

• Any concurrent condition which in the Investigator's opinion makes it inappropriate for the patient to participate in the trial or which would jeopardize compliance with the protocol

• Currently active diarrhea that may affect the ability of the patient to absorb ZD6474 or tolerate diarrhea

• Clinically significant cardiac event such as myocardial infarction; New York Heart Association (NYHA) classification of heart disease >2 within 3 months before entry; or presence of cardiac disease that, in the opinion of the Investigator, increases the risk of ventricular arrhythmia.

• History of arrhythmia (multifocal premature ventricular contractions (PVCs), bigeminy, trigeminy, ventricular tachycardia (VT) or uncontrolled atrial fibrillation) which is symptomatic or requires treatment (CTCAE grade 3) or asymptomatic sustained VT. Atrial fibrillation controlled on medication is not excluded.

• Previous history of QTc prolongation as a result of another medication that required discontinuation of that medication.

• Congenital long QT syndrome or 1st degree relative with unexplained sudden death < 40 years of age.

• Presence of left bundle branch block (LBBB).

• QTc with Bazett's correction that is unmeasurable, or ≥ 480 msec on screening ECG. If a patient has QTc ≥ 480 msec on screening ECG, the screen ECG may be repeated twice (at least 24 hours apart). The average QTc from the three screening ECGs must be < 480 msec in order for the patient to be eligible for the study.

• Use of any concomitant medication that may cause QTc prolongation, induce Torsades de Pointes or induce CYP3A4 function.

• Hypertension not controlled by medical therapy (systolic blood pressure greater than 160 mm Hg or diastolic blood pressure greater than 100 mm hg).

• Previous or current malignancies of other histologies within the last 5 years, with the exception of cervical carcinoma in situ and adequately treated basal cell or squamous cell carcinoma of the skin.

• Major surgery within 4 weeks or incompletely healed surgical incision before starting study therapy.

• Receipt of any investigational agents within 30 days prior to commencing study treatment

• Previous enrollment or randomization of treatment in the present study

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Stanford University School of Medicine	Stanford	California	United States	94305

Sponsors and Collaborators

• Stanford University
• AstraZeneca

Investigators

• Principal Investigator: Mark D Pegram, MD, Stanford Cancer Institute, Stanford University Medical Center

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Mark Pegram, Susy Yuan-Huey Hung Professor, Stanford University
• ClinicalTrials.gov Identifier: NCT00481845
• Other Study ID Numbers: IRB-08051; BRSADJ0008; 97923
• First Posted: Jun 4, 2007
• Last Update Posted: Feb 7, 2017
• Last Verified: Dec 1, 2016

• Additional relevant MeSH terms: Breast Neoplasms; Anastrozole

Study Results

Participant Flow

Arm/Group Title	Vandetanib + Anastrozole	Anastrozole
Arm/Group Description	Vandetanib and Anastrozole as neoadjuvant therapy	Anastrozole as neoadjuvant therapy
Period Title: Overall Study
STARTED	1	0
COMPLETED	1	0
NOT COMPLETED	0	0

Baseline Characteristics

Arm/Group Title	Vandetanib + Anastrozole	Anastrozole	Total
Arm/Group Description	Vandetanib and Anastrozole as neoadjuvant therapy	Anastrozole as neoadjuvant therapy	Total of all reporting groups
Overall Participants	1	0	1
Age (Count of Participants)
<=18 years	0 0%	0 NaN	0 0%
Between 18 and 65 years	1 100%	0 NaN	1 100%
>=65 years	0 0%	0 NaN	0 0%
Gender (Count of Participants)
Female	1 100%	0 NaN	1 100%
Male	0 0%	0 NaN	0 0%
Ethnicity (NIH/OMB) (Count of Participants)
Hispanic or Latino	0 0%	0 NaN	0 0%
Not Hispanic or Latino	1 100%	0 NaN	1 100%
Unknown or Not Reported	0 0%	0 NaN	0 0%
Race (NIH/OMB) (Count of Participants)
American Indian or Alaska Native	0 0%	0 NaN	0 0%
Asian	0 0%	0 NaN	0 0%
Native Hawaiian or Other Pacific Islander	0 0%	0 NaN	0 0%
Black or African American	0 0%	0 NaN	0 0%
White	1 100%	0 NaN	1 100%
More than one race	0 0%	0 NaN	0 0%
Unknown or Not Reported	0 0%	0 NaN	0 0%

Outcome Measures

1. Primary Outcome

Title	Tumor Objective Response by MRI
Description	Determine tumor objective response rate by MRI. (CR): Disappearance of the target lesion (PR): At least a 30% decrease in the longest diameter of the target lesion taking as reference the baseline LD (PD): At least a 20% increase in the LD of target lesion, taking as reference the baseline LD or the appearance of one or more new lesions (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the baseline LD.
Time Frame	1 year

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title	Vandetanib + Anastrozole	Anastrozole
Arm/Group Description	Vandetanib and Anastrozole as neoadjuvant therapy	Anastrozole as neoadjuvant therapy
Measure Participants	1	0
Complete Response- CR	0 0%	0 NaN
Partial Response- PR	0 0%	0 NaN
Progressive Disease- PD	0 0%	0 NaN
Stable Disease-SD	1 100%	0 NaN

2. Secondary Outcome

Title	Pathologic Complete Response
Time Frame	1 year

Outcome Measure Data

Analysis Population Description

CR+PR

Arm/Group Title	Vandetanib + Anastrozole	Anastrozole
Arm/Group Description	Vandetanib and Anastrozole as neoadjuvant therapy	Anastrozole as neoadjuvant therapy
Measure Participants	1	0
Count of Participants [Participants]	0 0%	0 NaN

Adverse Events

Time Frame	1 year
Adverse Event Reporting Description	All AEs or SAEs collected during the 4 months (12 cycles) span on treatment
Arm/Group Title	Vandetanib + Anastrozole		Anastrozole
Arm/Group Description	Vandetanib and Anastrozole as neoadjuvant therapy		Anastrozole as neoadjuvant therapy
All Cause Mortality
	Vandetanib + Anastrozole		Anastrozole
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	/ (NaN)		/ (NaN)
Serious Adverse Events
	Vandetanib + Anastrozole		Anastrozole
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	1/1 (100%)		0/0 (NaN)
Blood and lymphatic system disorders
Hypertension	1/1 (100%)	2	0/0 (NaN)	0
Respiratory, thoracic and mediastinal disorders
Dyspnea	1/1 (100%)	2	0/0 (NaN)	0
Other (Not Including Serious) Adverse Events
	Vandetanib + Anastrozole		Anastrozole
	Affected / at Risk (%)	# Events	Affected / at Risk (%)	# Events
Total	1/1 (100%)		0/0 (NaN)
Cardiac disorders
Vague chest discomfort	1/1 (100%)	2	0/0 (NaN)	0
Gastrointestinal disorders
Constipation	1/1 (100%)	1	0/0 (NaN)	0
increasing reflux symptoms	1/1 (100%)	1	0/0 (NaN)	0
esophageal spasm	1/1 (100%)	1	0/0 (NaN)	0
vomiting	1/1 (100%)	1	0/0 (NaN)	0
Nervous system disorders
Sweaty palms	1/1 (100%)	1	0/0 (NaN)	0
Painic attack	1/1 (100%)	1	0/0 (NaN)	0
Respiratory, thoracic and mediastinal disorders
Onset asthma symptoms	1/1 (100%)	1	0/0 (NaN)	0

Limitations/Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.