PUMP: Unnecessary Mastectomy Due to False Size Prediction by Preoperative Imaging Studies in Breast Cancer
Study Details
Study Description
Brief Summary
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The surgical method for breast cancer is determined according to the size and location of the remaining lesions after prior chemotherapy.
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There are many patients who were able to undergo partial resection when confirming the final results of patients who underwent total resection after prior chemotherapy.
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Therefore, we would like to investigate whether it is effective to make decisions based on the results of pre-operative tests after prior chemotherapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
In a study published by Jennifer F. et al., sensitivity to lesions remaining after prior chemotherapy of breast magnetic resonance imaging was measured as 83%, specificity 47%, PPV 47%, NPV 83%, and accuracy 74%. have.
Most of the preoperative examinations after prior chemotherapy have the most confidence in the results of breast magnetic resonance imaging, but there will be other factors to predict this result as there will be differences in the actual postoperative pathology results. .
After prior chemotherapy, total resection was performed, and cases where partial resection is possible in the postoperative pathologic results are prospectively identified and compared and analyzed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Breast cancer patients undergoing mastectomy after neoadjuvant chemotherapy Patients who underwent total mastectomy (including simultaneous reconstruction surgery) through preoperative examinations (MRI, breast ultrasound, mammography, etc.) after receiving neoadjuvant chemotherapy |
Diagnostic Test: Preoperative imaging study
MRI, Breast ultrasound sonography, mammography
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| Active Comparator: Breast cancer patients without neoadjuvant chemotherapy and undergoing mastectomy Patients who underwent total mastectomy (including simultaneous reconstruction surgery) through preoperative examinations (MRI, breast ultrasound, mammography, etc.) even in patients who did not receive neoadjuvant chemotherapy as a control group. |
Diagnostic Test: Preoperative imaging study
MRI, Breast ultrasound sonography, mammography
|
Outcome Measures
Primary Outcome Measures
- Final pathology report [2 weeks after surgery]
Comparison of the difference in size of lesions confirmed by preoperative imaging and final pathology results
Eligibility Criteria
Criteria
Inclusion Criteria:
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Breast cancer patients over 20 years of age undergoing surgery at Seoul National University Hospital
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Patients to undergo total mastectomy
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Patients who received neoadjuvant chemotherapy and undergoing total mastectomy were the main subjects, but as a control group, patients who did not receive neoadjuvant chemotherapy but undergoing total mastectomy were included as subjects.
Exclusion Criteria:
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In case of total mastectomy at the request of the patient
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Except for cases where total resection is performed regardless of size because it is a lesion under the areola and is close to the nipple.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Seoul National University Hospital | Seoul | Jongno-gu | Korea, Republic of | 03080 |
Sponsors and Collaborators
- Seoul National University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 1711-048-898