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SCCOR Bronch: Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects

Sponsor
University of North Carolina, Chapel Hill (Other)
Overall Status
Completed
CT.gov ID
NCT00840723
Collaborator
(none)
30
Enrollment
1
Location
53.9
Duration (Months)
0.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this research study is to collect cells and liquid from the air passages of healthy adults, both smokers and non-smokers. These samples will be used for test-tube studies to explore mechanisms of diseases of the respiratory tract, and to compare the samples between people who smoke cigarettes and people who don't. Obtaining these samples requires an invasive procedure called "bronchoscopy".

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    30 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Bronchoscopy-Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects
    Study Start Date :
    Feb 1, 2009
    Actual Primary Completion Date :
    Aug 1, 2013
    Actual Study Completion Date :
    Aug 1, 2013

    Arms and Interventions

    Arm Intervention/Treatment
    Current smokers

    Current cigarette smokers with no other illness
    Healthy controls

    Healthy non smokers

    Outcome Measures

    Primary Outcome Measures

    1. The goal of this project is to define the effect of smoking on key aspects of airway biology. These studies will also provide crucial & novel definition of airway biology in smokers against which COPD & CF patients will be compared. [At the time of bronchoscopy]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 75 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Current cigarette smokers

    • Must be otherwise healthy with no chronic illness

    Exclusion Criteria:

    • Asthma

    • Smoking related lung disease (including bronchitis)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 UNC Center for Environmental Medicine, Asthma and Lung Biology Chapel Hill North Carolina United States 27599

    Sponsors and Collaborators

    • University of North Carolina, Chapel Hill

    Investigators

    • Principal Investigator: Raymond Coakley, MD, University of North Carolina

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Raymond Coakley, MD, Assistant Professor of Medicine, University of North Carolina, Chapel Hill
    ClinicalTrials.gov Identifier:
    NCT00840723
    Other Study ID Numbers:
    • CTRC 2799
    • NHLBI P50-HL084934
    First Posted:
    Feb 10, 2009
    Last Update Posted:
    Sep 5, 2013
    Last Verified:
    Sep 1, 2013
    Keywords provided by Raymond Coakley, MD, Assistant Professor of Medicine, University of North Carolina, Chapel Hill
    Healthy smokers
    Current cigarette smokers
    No lung disease
    Additional relevant MeSH terms:
    Respiration Disorders
    Respiratory Tract Diseases

    Study Results

    No Results Posted as of Sep 5, 2013