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Brown Fat Activity and White Fat Accumulation

Sponsor
Children's Hospital Los Angeles (Other)
Overall Status
Completed
CT.gov ID
NCT01517581
Collaborator
(none)
32
Enrollment
1
Location
35
Duration (Months)
0.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    32 participants
    Observational Model:
    Cohort
    Time Perspective:
    Retrospective
    Official Title:
    Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
    Study Start Date :
    Oct 1, 2008
    Actual Primary Completion Date :
    Sep 1, 2011
    Actual Study Completion Date :
    Sep 1, 2011

    Arms and Interventions

    Arm Intervention/Treatment
    Malignant Disease with no visualized BAT

    Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis.

    Outcome Measures

    Primary Outcome Measures

    1. Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

    2. Change from Baseline in Visceral Adipose Tissue Volume at Follow-up [Baseline and up to 1 year]

    3. Change from Baseline in Presence of Brown Adipose Tissue [Baseline and up to 1 year]

    4. Change from Baseline in Abdominal Musculature Volume [Baseline and up to 1 year]

    Secondary Outcome Measures

    1. Change from Baseline in Anthropometric Measures at Follow-up [Baseline and up to 1 year]

      Age, height, weight and BMI

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    6 Years to 18 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patients had PET/CT scans with evidence of malignant disease

    • Patients had no metabolically active BAT at diagnosis on their PET/CT scan

    • Patients were disease free within 1 year of diagnosis

    Exclusion Criteria:

    • Patients had PET/CT scans with no evidence of malignant disease

    • Patients with metabolically active BAT at diagnosis on their PET/CT scan

    • Patients were not disease free within 1 year of diagnosis

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Children's Hospital Los Angeles Los Angeles California United States 90027-6062

    Sponsors and Collaborators

    • Children's Hospital Los Angeles

    Investigators

    • Principal Investigator: Vicente Gilsanz, MD, PhD, Children's Hospital Los Angeles

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    Vicente Gilsanz, Professor, Children's Hospital Los Angeles
    ClinicalTrials.gov Identifier:
    NCT01517581
    Other Study ID Numbers:
    • CHLA-Gilsanz-BAT/WAT
    First Posted:
    Jan 25, 2012
    Last Update Posted:
    Jan 25, 2012
    Last Verified:
    Jan 1, 2012
    Keywords provided by Vicente Gilsanz, Professor, Children's Hospital Los Angeles
    Brown adipose tissue
    Additional relevant MeSH terms:
    Lymphoma

    Study Results

    No Results Posted as of Jan 25, 2012