The Effects of e+Shots Energy Beverage on Mental Energy
Sponsor
Clarkson University (Other)
Overall Status
Completed
CT.gov ID
NCT03850275
Collaborator
Isagenix International LLC (Industry)
30
6
14.7
Study Details
Study Description
Brief Summary
The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially available energy product. The purpose of this study is determine whether e+shot, a product containing natural caffeine, will impact mood and performance up to 108 minutes post consumption compared to a sweetened solution containing synthetic caffeine.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Enrolled participants who are low consumers of caffeine will be administered either a placebo (3mg caffeine), caffeinated placebo (~100mg of caffeine) or e+shot first and then will be crossed over to receive the other two interventions. The study consists of 3 treatment periods of 108 minutes each with a washout period of 48 hours.
Study Design
Study Type:
Interventional
Actual Enrollment
:
30 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Intervention Model Description:
Crosover AssignmentCrosover Assignment
Masking:
Triple (Participant, Investigator, Outcomes Assessor)
Masking Description:
Double-blinded placebo controlled
Primary Purpose:
Treatment
Official Title:
The Effects of E+Shots Energy Beverage on Mood, Cognitive Function, Heart Rate, Blood Pressure, and Fine Motor Task Performance
Actual Study Start Date
:
Sep 26, 2015
Actual Primary Completion Date
:
Dec 15, 2016
Actual Study Completion Date
:
Dec 15, 2016
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Experimental: Placebo, then caffeinated placebo, then e+shots Participants received placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
| Experimental: Experimental: Caffeinated placebo, then placebo, then e+shots Participants received caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
| Experimental: Experimental: placebo, then e+shots, then caffeinated placebo Participants received placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes. |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
| Experimental: Experimental: caffeinated placebo, then e+shots, then placebo Participants received caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes. |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
| Experimental: Experimental: e+shots, then caffeinated placebo, then placebo Participants received e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes. |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
| Experimental: Experimental: e+shots, then placebo, then caffeinated placebo Participants received e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes. |
Dietary Supplement: Intervention/treatment
Subjects received all 3 interventions Placebo ~3mg caffeine Caffeinated placebo ~100mg caffeine E+shots- The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis.
|
Outcome Measures
Primary Outcome Measures
- Change in POMS Vigor [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
POMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome
- Change in POMS Fatigue [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
POMS Fatigue Scores range from 0-20with higher scores indicating worse outcome
- Change in POMS Depression [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
POMS Depression Scores range from 0-20 with higher scores indicating worse outcome
- Change in POMS Anxiety [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
POMS Anxiety Scores range from 0-20 with higher scores indicating worse outcome
- Change in POMS Anger [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
POMS Anger Scores range from 0-20 with higher scores indicating worse outcome
- Change in POMS Confusion [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minute]
POMS Anger Scores range from -4 to 16 with higher scores indicating worse outcome
- Change in Serial Subtraction 3 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 3- Number of attempts
- Change in Serial Subtraction 3 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 3- Number correct
- Change in Serial Subtraction 3 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 3- Percentage correct
- Change in Serial Subtraction 7 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 7- Number of attempts
- Change in Serial Subtraction 7 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 7- Number correct
- Change in Serial Subtraction 7 Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Serial subtraction 7- Percentage correct
- Change in Blood Pressure [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Blood pressure- systolic and diastolic measured in mmHg
- Change in Heart Rate [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Heart rate- beats per minute
- Change in Fine Motor Task Performance [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
9-hole peg test- measured in seconds- The validated nine-hole peg test of finger dexterity was used to measure fine motor control. The 12 cm × 12 cm wooden pegboard contained nine holes and was placed on the desktop in front of the seated participant. There were nine 0.64 cm wide cylindrical pegs, were placed on the desktop outside of the container on the right side of the board and on the left side of the board for when the participant's right hand and left hand were tested, respectively. Participants were instructed to place one peg at a time into the pegboard holes until they were filled, and then remove each peg one at a time onto the desktop as fast as they could, first with their dominant hand and next with their non-dominant hand. Each test was performed twice.
- Change in State Mental Energy [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
State Mental Energy- scores range from 0 to 300 with higher scores indicating better outcome
- Change in State Physical Energy [pre-beverage-0 minutes, Post beverage 1-30 minutes, Post beverage 2-68 minutes, Post beverage 3 -108 minutes]
State Physical Energy- scores range from 0 to 300 with higher scores indicating better outcome
- Change in State Mental Fatigue [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
State mental fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
- Change in State Physical Fatigue [pre beverage-0, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes]
State physical fatigue- scores range from 0 to 300 with higher scores indicating worse outcome
- Change in Continuous Performance Task Performance Percent Correct [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68, post beverage 3-108 minutes]
Continuous Performance Task- Percentage of correct responses Participants monitored a continuous series of letters (A-Z; Tahoma Regular font, size 20 pt) presented on the screen for 1000 ms. Participants were told to respond to the detection of the letter "X" only when it was preceded by the letter "A" by striking the left key on the key pad. The task was scored for percentage of target strings correctly detected, errors of omission (missed targets), average reaction time for correct detections, and the number of false alarms. The task lasted for two minutes and 48 targets were randomly presented
- Change in Continuous Performance Task Performance Number Incorrect [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes]
Continuous Performance Task- Number of incorrect responses
- Change in Continuous Performance Task Performance Missed Responses [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes]
Continuous Performance Task- Percentage of missed responses
- Change in Continuous Performance Task Performance Reaction Time Correct Responses [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Continuous Performance Task- reaction time for correct responses
- Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct [pre beverage- 0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Primary task- percentage correct
- Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3- 108 minutes]
Rapid Visual Input Processing task- Primary task- percentage missed
- Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Primary task- incorrect responses
- Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct [pre beverage- 0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Primary task- reaction time for percent correct
- Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Secondary task- percentage correct
- Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Secondary task- percentage missed responses
- Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Secondary task- incorrect responses
- Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Secondary task- reaction time for correct responses
- Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Tertiary task- percentage correct responses
- Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses [pre beverage-0 minute, post beverage-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Tertiary task- percentage missed responses
- Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses [pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Tertiary task- number of incorrect responses
- Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses [pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes]
Rapid Visual Input Processing task- Tertiary task- reaction time for correct responses
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 45 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
-
Ages 18-45
-
Body Mass Index (BMI) < 30
-
Profile of Mood Status Short Scale (POMS) score <13 on the energy scale
-
Energy and Fatigue trait scale score <=10
-
Consumption of <200mg of caffeine/day
-
Consumption of <150 servings of polyphenols/month
Exclusion Criteria:
-
Subjects taking prescription or over the counter medications (except for oral contraceptives) for a chronic medical condition or recreational drugs will be excluded Chronic medical conditions are any health condition that is expected to last more than 3 months and requires on going medical care such as coronary artery disease, multiple sclerosis, etc..
-
Women who are pregnant or may be trying to become pregnant
-
Women who are breastfeeding
-
People who have been diagnosed with heart conditions and/or hypertension
-
People who have liver disorders
-
People who have sensitivity or allergy to caffeine
-
People who have bipolar disorder
-
People who have iron deficiency
-
People who are allergic to plants of the Asteraceae/Compositae/Daisy family
-
Day of testing
-
Subjects who have had a change of ±2 hours of sleep from their regular sleep time will be re-scheduled.
-
If subjects begin taking a prescription or over the counter medication for an acute condition (i.e. required to take the prescription or over the counter medication for < 3 months) during the study they will be given the option of continuing the study after they are no longer taking the prescription or over the counter medication or dropping out of the study.
-
If subjects are diagnosed with a chronic condition that requires the use of prescription medications for > 3 months after they have started the study they will be eliminated from the study.
-
Resting systolic BP > 180mmHg and diastolic BP > 90mmHg after consuming the caffeine beverage.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Clarkson University
- Isagenix International LLC
Investigators
None specified.Study Documents (Full-Text)
More Information
Publications
None provided.Responsible Party:
Ali Boolani,
Assistant Professor,
Clarkson University
ClinicalTrials.gov Identifier:
NCT03850275
Other Study ID Numbers:
- 16-05
First Posted:
Feb 21, 2019
Last Update Posted:
Aug 2, 2021
Last Verified:
Jul 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Study Results
Participant Flow
| Recruitment Details | After screening 1035 surveys, 30 participants completed the study (see Figure 1). Recruitment and data collection lasted from September 25th 2015 to December 10th, 2016 until 30 participants had completed all 3 days of treatment. There were no harms or unintended consequences for any of the interventions. |
|---|---|
| Pre-assignment Detail | 43 participants were randomized. Of the 43 participants who were randomized, 13 did not start the study due to scheduling conflicts and were un-enrolled from the study. |
| Arm/Group Title | Placebo, Then Caffeinated Placebo, Then e+Shots | Placebo, Then e+Shots, Then Caffeine | Caffeinated Placebo, Then Placebo, Then e+Shots | Caffeinated Placebo, Then e+Shots, Then Placebo | e+Shots, Then Placebo, Then Caffeinated Placebo | e+Shots, Then Caffeinated Placebo, Then Placebo |
|---|---|---|---|---|---|---|
| Arm/Group Description | Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes | Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes | Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes | Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes | Participants received the e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes | Participants received the e+shots and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes |
| Period Title: Overall Study | ||||||
| STARTED | 5 | 5 | 5 | 5 | 5 | 5 |
| COMPLETED | 5 | 5 | 5 | 5 | 5 | 5 |
| NOT COMPLETED | 0 | 0 | 0 | 0 | 0 | 0 |
Baseline Characteristics
| Arm/Group Title | Placebo, Then Caffeinated Placebo, Then e+Shots | Placebo, Then e+Shots, the Caffeinated Placebo | Caffeinated Placebo, Then Placebo, Then e+Shots | Caffeinated Placebo, Then e+Shots, Then Placebo | E+Shots, Then Placebo, Then Caffeinated Placebo | E+Shot, Then Caffeinated Placebo, Then Placebo | Total |
|---|---|---|---|---|---|---|---|
| Arm/Group Description | Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes | Participants received the placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shots and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes | Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the e+shot and were tested for 108 minutes | Participants received the caffeinated placebo and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the e+shot and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes | Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the placebo and tested for 108 minutes. After another 48 hour washout period they received the caffeinated placebo and were tested for 108 minutes | Participants received the e+shot and were tested for 108 minutes after consumption. After a 48 hour washout period, they received the caffeinated placebo and tested for 108 minutes. After another 48 hour washout period they received the placebo and were tested for 108 minutes | Total of all reporting groups |
| Overall Participants | 5 | 5 | 5 | 5 | 5 | 5 | 30 |
| Age (years) [Mean (Standard Deviation) ] | |||||||
| Mean (Standard Deviation) [years] |
19.4
(1.34)
|
21.8
(5.85)
|
22
(3.94)
|
20
(1.87)
|
20.4
(2.88)
|
26
(6.89)
|
21.8
(4.4)
|
| Sex: Female, Male (Count of Participants) | |||||||
| Female |
2
40%
|
3
60%
|
4
80%
|
3
60%
|
2
40%
|
3
60%
|
17
56.7%
|
| Male |
3
60%
|
2
40%
|
1
20%
|
2
40%
|
3
60%
|
2
40%
|
13
43.3%
|
| Race (NIH/OMB) (Count of Participants) | |||||||
| American Indian or Alaska Native |
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
| Asian |
1
20%
|
2
40%
|
0
0%
|
0
0%
|
0
0%
|
1
20%
|
4
13.3%
|
| Native Hawaiian or Other Pacific Islander |
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
| Black or African American |
1
20%
|
1
20%
|
0
0%
|
0
0%
|
0
0%
|
2
40%
|
4
13.3%
|
| White |
2
40%
|
2
40%
|
5
100%
|
5
100%
|
5
100%
|
2
40%
|
21
70%
|
| More than one race |
1
20%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
1
3.3%
|
| Unknown or Not Reported |
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
0
0%
|
| Height (cm) [Mean (Standard Deviation) ] | |||||||
| Mean (Standard Deviation) [cm] |
165.61
(15.28)
|
164.59
(10.38)
|
163.58
(8.91)
|
164.59
(16.40)
|
179.32
(6.86)
|
174.75
(17.08)
|
169.6
(12.4)
|
| Weight (kg) [Mean (Standard Deviation) ] | |||||||
| Mean (Standard Deviation) [kg] |
67.68
(9.47)
|
67.27
(25.62)
|
66.73
(12.48)
|
67.18
(17.64)
|
71.18
(7.58)
|
74.91
(16.30)
|
67.6
(11.0)
|
Outcome Measures
| Title | Change in POMS Vigor |
|---|---|
| Description | POMS Vigor, Scores range from 0-20 with higher scores indicating improved outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | Caffeinated Placebo | E+Shots |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
9.03
(4.63)
|
8.93
(4.60)
|
8.80
(4.60)
|
| Post-beverage 1- 30 minutes |
9.03
(4.17)
|
10.13
(3.91)
|
9.67
(4.03)
|
| Post-beverage 2-68 minutes |
9.33
(4.33)
|
9.87
(4.38)
|
9.76
(4.27)
|
| Post-beverage 3-108 minutes |
9.38
(4.59)
|
9.89
(5.22)
|
10.15
(4.54)
|
| Title | Change in POMS Fatigue |
|---|---|
| Description | POMS Fatigue Scores range from 0-20with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage- 0 minutes |
8.03
(2.94)
|
8.00
(2.89)
|
8.17
(2.81)
|
| Post -beverage 1-30 minutes |
8.13
(2.98)
|
7.07
(2.48)
|
7.67
(2.94)
|
| Post -beverage 2-68 minutes |
8.23
(2.62)
|
7.66
(3.27)
|
7.57
(2.81)
|
| Post-beverage 3-108 minutes |
7.72
(2.55)
|
7.77
(3.15)
|
8.07
(3.22)
|
| Title | Change in POMS Depression |
|---|---|
| Description | POMS Depression Scores range from 0-20 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage- 0 minutes |
5.37
(1.07)
|
5.50
(1.41)
|
5.30
(0.65)
|
| Post-beverage 1- 30 minutes |
5.43
(1.04)
|
5.50
(1.20)
|
5.23
(0.63)
|
| Post-beverage 2-68 minutes |
5.30
(0.84)
|
5.45
(1.27)
|
5.20
(0.61)
|
| Post-beverage 3-108 minutes |
5.28
(0.65)
|
5.31
(1.01)
|
5.25
(0.59)
|
| Title | Change in POMS Anxiety |
|---|---|
| Description | POMS Anxiety Scores range from 0-20 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
5.43
(0.73)
|
5.63
(1.16)
|
5.60
(1.30)
|
| Post-beverage 1- 30 minutes |
5.40
(0.77)
|
5.73
(1.34)
|
5.77
(1.28)
|
| Post-beverage 2-68 minutes |
5.40
(0.72)
|
5.66
(1.52)
|
5.87
(1.25)
|
| Post-beverage 3-108 minutes |
5.52
(0.91)
|
5.62
(1.10)
|
5.64
(1.03)
|
| Title | Change in POMS Anger |
|---|---|
| Description | POMS Anger Scores range from 0-20 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
5.27
(0.79)
|
5.47
(0.71)
|
5.90
(1.27)
|
| Post-beverage 1- 30 minutes |
5.30
(0.65)
|
5.33
(0.71)
|
5.53
(1.31)
|
| Post-beverage 2-68 minutes |
5.60
(1.04)
|
5.41
(1.35)
|
5.47
(0.94)
|
| Post-beverage 3-108 minutes |
5.31
(0.85)
|
5.27
(0.53)
|
5.57
(1.20)
|
| Title | Change in POMS Confusion |
|---|---|
| Description | POMS Anger Scores range from -4 to 16 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minute |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
2.50
(1.25)
|
2.73
(1.57)
|
2.70
(1.54)
|
| Post-beverage 1- 30 minutes |
2.57
(1.17)
|
2.33
(1.45)
|
2.17
(1.21)
|
| Post-beverage 2-68 minutes |
2.50
(1.04)
|
2.59
(1.57)
|
2.43
(1.43)
|
| Post-beverage 3-108 minutes |
2.34
(1.05)
|
2.58
(1.60)
|
2.29
(1.56)
|
| Title | Change in Serial Subtraction 3 Task Performance |
|---|---|
| Description | Serial subtraction 3- Number of attempts |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
46.23
(16.18)
|
48.20
(14.59)
|
46.27
(16.45)
|
| Post-beverage 1- 30 minutes |
52.77
(15.84)
|
50.63
(15.90)
|
54.86
(15.92)
|
| Post-beverage 2-68 minutes |
54.47
(16.11)
|
53.50
(15.36)
|
54.34
(16.32)
|
| Post-beverage 3-108 minutes |
56.10
(16.01)
|
57.21
(15.98)
|
55.33
(16.60)
|
| Title | Change in Serial Subtraction 3 Task Performance |
|---|---|
| Description | Serial subtraction 3- Number correct |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
44.80
(16.24)
|
46.27
(14.70)
|
44.23
(17.08)
|
| Post-beverage 1- 30 minutes |
51.17
(15.57)
|
48.70
(16.08)
|
52.97
(16.16)
|
| Post-beverage 2-68 minutes |
52.63
(16.26)
|
51.37
(15.54)
|
51.82
(16.91)
|
| Post-beverage 3-108 minutes |
53.38
(16.15)
|
54.59
(16.90)
|
52.17
(17.85)
|
| Title | Change in Serial Subtraction 3 Task Performance |
|---|---|
| Description | Serial subtraction 3- Percentage correct |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
96.35
(3.98)
|
95.69
(4.23)
|
94.43
(6.85)
|
| Post-beverage 1- 30 minutes |
96.98
(3.07)
|
95.76
(3.69)
|
96.22
(3.88)
|
| Post-beverage 2-68 minutes |
96.21
(3.18)
|
95.57
(3.38)
|
92.78
(7.83)
|
| Post-beverage 3-108 minutes |
95.09
(4.48)
|
93.96
(8.89)
|
93.79
(6.63)
|
| Title | Change in Serial Subtraction 7 Task Performance |
|---|---|
| Description | Serial subtraction 7- Number of attempts |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
26.53
(10.19)
|
27.90
(10.13)
|
28.77
(11.04)
|
| Post-beverage 1- 30 minutes |
29.38
(10.71)
|
30.80
(11.25)
|
32.60
(10.99)
|
| Post-beverage 2-68 minutes |
31.57
(12.09)
|
33.07
(11.38)
|
33.47
(11.60)
|
| Post-beverage 3-108 minutes |
33.90
(12.11)
|
35.69
(12.02)
|
34.27
(13.02)
|
| Title | Change in Serial Subtraction 7 Task Performance |
|---|---|
| Description | Serial subtraction 7- Number correct |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
24.73
(10.70)
|
26.17
(10.30)
|
27.00
(11.23)
|
| Post -beverage 1-30 minutes |
27.83
(10.70)
|
29.03
(10.81)
|
30.20
(10.95)
|
| Post-beverage 2-68 minutes |
28.83
(11.81)
|
31.27
(11.59)
|
30.41
(11.84)
|
| Post-beverage 3-108 minutes |
30.43
(11.43)
|
33.48
(11.96)
|
31.60
(13.15)
|
| Title | Change in Serial Subtraction 7 Task Performance |
|---|---|
| Description | Serial subtraction 7- Percentage correct |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
92.53
(8.80)
|
92.78
(7.99)
|
92.72
(11.29)
|
| Post-beverage 1- 30 minutes |
94.36
(4.98)
|
93.59
(8.08)
|
91.65
(8.13)
|
| Post-beverage 2-68 minutes |
92.92
(8.42)
|
93.80
(6.60)
|
91.44
(7.21)
|
| Post-beverage 3-108 minutes |
91.21
(8.74)
|
93.17
(6.07)
|
90.60
(9.18)
|
| Title | Change in Blood Pressure |
|---|---|
| Description | Blood pressure- systolic and diastolic measured in mmHg |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo Systolic | Placebo Diastolic | E+Shot Systolic | E+Shot Diastolic | Caffeinated Placebo Systolic | Caffeinated Placebo Diastolic |
|---|---|---|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
111.80
(12.22)
|
71.00
(8.51)
|
111.00
(16.18)
|
71.50
(9.44)
|
109.63
(12.99)
|
68.97
(9.04)
|
| Post-beverage 1- 30 minutes |
109.53
(12.62)
|
71.30
(8.12)
|
113.60
(13.74)
|
72.30
(7.91)
|
114.93
(16.41)
|
74.07
(7.70)
|
| Post-beverage 2-68 minutes |
111.30
(15.50)
|
73.60
(12.14)
|
114.57
(16.45)
|
74.80
(17.78)
|
113.40
(15.07)
|
74.37
(8.20)
|
| Post-beverage 3-108 minutes |
112.30
(13.37)
|
72.57
(8.02)
|
114.67
(14.21)
|
72.03
(10.32)
|
112.80
(15.04)
|
73.17
(8.45)
|
| Title | Change in Heart Rate |
|---|---|
| Description | Heart rate- beats per minute |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
72.50
(13.86)
|
70.13
(1.84)
|
69.80
(13.99)
|
| Post-beverage 1- 30 minutes |
70.10
(13.98)
|
65.23
(11.31)
|
67.37
(12.35)
|
| Post-beverage 2-68 minutes |
68.00
(13.86)
|
67.90
(14.51)
|
67.10
(13.33)
|
| Post-beverage 3-108 minutes |
66.83
(14.18)
|
64.47
(13.64)
|
63.83
(12.36)
|
| Title | Change in Fine Motor Task Performance |
|---|---|
| Description | 9-hole peg test- measured in seconds- The validated nine-hole peg test of finger dexterity was used to measure fine motor control. The 12 cm × 12 cm wooden pegboard contained nine holes and was placed on the desktop in front of the seated participant. There were nine 0.64 cm wide cylindrical pegs, were placed on the desktop outside of the container on the right side of the board and on the left side of the board for when the participant's right hand and left hand were tested, respectively. Participants were instructed to place one peg at a time into the pegboard holes until they were filled, and then remove each peg one at a time onto the desktop as fast as they could, first with their dominant hand and next with their non-dominant hand. Each test was performed twice. |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo Non-dominant Hand | Placebo Dominant Hand | E+Shot Non-dominant Hand | E+Shot Dominant Hand | Caffeinated Placebo Non-Dominant Hand | Caffeinated Placebo Dominant Hand |
|---|---|---|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
19.42
(2.94)
|
18.87
(2.64)
|
19.27
(2.65)
|
18.60
(2.45)
|
19.31
(3.40)
|
18.65
(2.93)
|
| Post-beverage 1- 30 minutes |
18.80
(2.45)
|
18.21
(2.50)
|
18.88
(2.83)
|
17.93
(2.09)
|
18.73
(3.23)
|
17.95
(2.79)
|
| Post-beverage 2-68 minutes |
18.70
(2.76)
|
18.22
(2.86)
|
18.58
(2.55)
|
17.68
(12.07)
|
18.78
(3.38)
|
18.02
(2.95)
|
| Post-beverage 3-108 minutes |
18.54
(2.94)
|
17.86
(2.75)
|
18.17
(2.93)
|
17.50
(2.20)
|
18.44
(3.37)
|
17.56
(2.84)
|
| Title | Change in State Mental Energy |
|---|---|
| Description | State Mental Energy- scores range from 0 to 300 with higher scores indicating better outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre-beverage-0 minutes |
9.93
(6.01)
|
10.27
(6.26)
|
10.13
(7.39)
|
| Post-beverage 1- 30 minutes |
9.23
(6.30)
|
8.70
(6.51)
|
9.43
(7.23)
|
| Post-beverage 2-68 minutes |
9.90
(6.38)
|
9.17
(6.66)
|
9.52
(7.16)
|
| Post-beverage 3-108 minutes |
8.83
(5.42)
|
9.73
(6.75)
|
10.16
(7.71)
|
| Title | Change in State Physical Energy |
|---|---|
| Description | State Physical Energy- scores range from 0 to 300 with higher scores indicating better outcome |
| Time Frame | pre-beverage-0 minutes, Post beverage 1-30 minutes, Post beverage 2-68 minutes, Post beverage 3 -108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
9.13
(5.87)
|
9.50
(6.55)
|
8.67
(6.14)
|
| Post 1 beverage-30 minutes |
8.43
(5.55)
|
7.93
(6.11)
|
8.67
(6.23)
|
| Post 2 beverage- 60 minutes |
8.63
(5.37)
|
8.62
(6.38)
|
8.83
(6.05)
|
| Post 3 beverage-108 minutes |
8.31
(5.55)
|
8.37
(5.84)
|
8.84
(6.58)
|
| Title | Change in State Mental Fatigue |
|---|---|
| Description | State mental fatigue- scores range from 0 to 300 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage- 0 minutes |
13.27
(6.59)
|
13.40
(6.75)
|
15.13
(6.58)
|
| Post 1 beverage-30 minutes |
13.30
(6.20)
|
14.60
(7.12)
|
15.60
(7.31)
|
| Post 2 beverage- 60 minutes |
13.67
(6.77)
|
14.07
(7.10)
|
15.34
(7.49)
|
| Post 3 beverage- 108 minutes |
13.90
(7.39)
|
14.46
(7.12)
|
16.44
(8.30)
|
| Title | Change in State Physical Fatigue |
|---|---|
| Description | State physical fatigue- scores range from 0 to 300 with higher scores indicating worse outcome |
| Time Frame | pre beverage-0, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
13.87
(6.34)
|
14.63
(15.97)
|
16.40
(6.89)
|
| Post 1 beverage-30 minutes |
14.23
(6.35)
|
15.37
(6.56)
|
16.40
(7.38)
|
| Post 2 beverage- 60 minutes |
14.57
(6.36)
|
15.31
(6.56)
|
16.38
(7.27)
|
| Post 3 beverage- 108 minutes |
14.69
(6.89)
|
15.31
(6.63)
|
16.92
(7.24)
|
| Title | Change in Continuous Performance Task Performance Percent Correct |
|---|---|
| Description | Continuous Performance Task- Percentage of correct responses Participants monitored a continuous series of letters (A-Z; Tahoma Regular font, size 20 pt) presented on the screen for 1000 ms. Participants were told to respond to the detection of the letter "X" only when it was preceded by the letter "A" by striking the left key on the key pad. The task was scored for percentage of target strings correctly detected, errors of omission (missed targets), average reaction time for correct detections, and the number of false alarms. The task lasted for two minutes and 48 targets were randomly presented |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
83.92
(25.53)
|
80.46
(29.50)
|
84.93
(17.69)
|
| Post 1 beverage-30 minutes |
77.79
(25.49)
|
78.18
(27.49)
|
83.32
(21.01)
|
| Post 2 beverage- 60 minutes |
79.07
(23.83)
|
82.95
(27.88)
|
85.26
(22.34)
|
| Post 3 beverage- 108 minutes |
79.07
(23.83)
|
86.40
(16.47)
|
85.56
(14.23)
|
| Title | Change in Continuous Performance Task Performance Number Incorrect |
|---|---|
| Description | Continuous Performance Task- Number of incorrect responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage- 0 minutes |
0.44
(0.51)
|
0.49
(0.79)
|
0.44
(0.58)
|
| Post 1 beverage-30 minutes |
0.48
(0.48)
|
0.59
(0.80)
|
0.45
(0.71)
|
| Post 2 beverage- 60 minutes |
0.37
(0.82)
|
0.51
(1.13)
|
0.56
(0.78)
|
| Post 3 beverage- 108 minutes |
0.48
(0.74)
|
0.41
(0.58)
|
0.37
(0.63)
|
| Title | Change in Continuous Performance Task Performance Missed Responses |
|---|---|
| Description | Continuous Performance Task- Percentage of missed responses |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2- 68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
16.08
(25.53)
|
19.54
(29.50)
|
14.97
(17.36)
|
| Post 1 beverage-30 minutes |
22.21
(24.49)
|
21.81
(27.49)
|
16.68
(21.01)
|
| Post 2 beverage- 60 minutes |
20.21
(23.72)
|
17.05
(27.88)
|
14.73
(22.34)
|
| Post 3 beverage- 108 minutes |
20.91
(24.73)
|
13.60
(16.47)
|
14.44
(14.23)
|
| Title | Change in Continuous Performance Task Performance Reaction Time Correct Responses |
|---|---|
| Description | Continuous Performance Task- reaction time for correct responses |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
1441.63
(304.19)
|
1475.20
(76.56)
|
1499.64
(102.77)
|
| Post 1 beverage-30 minutes |
1515.54
(95.82)
|
157.81
(158.49)
|
1495.55
(85.77)
|
| Post 2 beverage- 60 minutes |
1516.12
(111.05)
|
1506.42
(91.91)
|
1527.74
(122.18)
|
| Post 3 beverage- 108 minutes |
1498.28
(72.03)
|
1525.09
(82.97)
|
1474.22
(75.06)
|
| Title | Change in Rapid Visual Input Processing Task Performance Primary Task Percentage Correct |
|---|---|
| Description | Rapid Visual Input Processing task- Primary task- percentage correct |
| Time Frame | pre beverage- 0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutese |
59.45
(24.98)
|
60.78
(26.18)
|
57.18
(27.66)
|
| Post 1 beverage-30 minutes |
61.79
(25.86)
|
67.16
(23.99)
|
64.70
(25.18)
|
| Post 2 beverage- 60 minutes |
65.18
(20.86)
|
70.27
(24.57)
|
67.13
(24.75)
|
| Post 3 beverage- 108 minutes |
62.52
(26.73)
|
64.65
(20.36)
|
71.38
(19.06)
|
| Title | Change in Rapid Visual Input Processing Task Performance Primary Task Percent Missed |
|---|---|
| Description | Rapid Visual Input Processing task- Primary task- percentage missed |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3- 108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
31.85
(22.01)
|
29.82
(20.67)
|
34.13
(24.30)
|
| Post 1 beverage-30 minutes |
28.65
(24.00)
|
39.62
(25.39)
|
28.85
(25.07)
|
| Post 2 beverage- 60 minutes |
27.43
(19.29)
|
22.82
(20.58)
|
20.51
(16.77)
|
| Post 3 beverage- 108 minutes |
30.73
(26.00)
|
27.90
(19.70)
|
20.69
(17.00)
|
| Title | Change in Rapid Visual Input Processing Task Performance Primary Task Incorrect Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Primary task- incorrect responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
8.70
(9.57)
|
9.40
(9.64)
|
8.65
(10.28)
|
| Post 1 beverage-30 minutes |
9.55
(8.72)
|
6.58
(8.34)
|
6.50
(7.30)
|
| Post 2 beverage- 60 minutes |
7.33
(8.27)
|
6.47
(8.96)
|
9.88
(10.50)
|
| Post 3 beverage- 108 minutes |
7.33
(8.27)
|
7.27
(5.79)
|
7.54
(7.88)
|
| Title | Change in Rapid Visual Input Processing Task Performance Primary Task Reaction Time for Percent Correct |
|---|---|
| Description | Rapid Visual Input Processing task- Primary task- reaction time for percent correct |
| Time Frame | pre beverage- 0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
777.76
(93.09)
|
782.84
(99.82)
|
786.74
(121.13)
|
| Post 1 beverage-30 minutes |
761.51
(74.29)
|
774.57
(71.21)
|
773.95
(75.76)
|
| Post 2 beverage- 60 minutes |
791.83
(55.05)
|
752.33
(85.85)
|
73.10
(76.58)
|
| Post 3 beverage- 108 minutes |
770.84
(71.41)
|
736.22
(49.30)
|
727.96
(79.60)
|
| Title | Change in Rapid Visual Input Processing Task Performance Secondary Task Percent Correct |
|---|---|
| Description | Rapid Visual Input Processing task- Secondary task- percentage correct |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
58.75
(21.45)
|
55.24
(23.10)
|
55.28
(58.93)
|
| Post 1 beverage-30 minutes |
54.75
(19.69)
|
59.98
(25.75)
|
58.93
(27.25)
|
| Post 2 beverage- 60 minutes |
54.32
(24.46)
|
57.05
(30.08)
|
58.56
(28.20)
|
| Post 3 beverage- 108 minutes |
61.11
(24.75)
|
61.56
(23.46)
|
63.98
(24.26)
|
| Title | Change in Rapid Visual Input Processing Task Performance Secondary Task Percentage Missed Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Secondary task- percentage missed responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
39.85
(20.24)
|
42.08
(22.55)
|
43.64
(24.28)
|
| Post 1 beverage-30 minutes |
44.42
(19.59)
|
39.62
(25.39)
|
41.07
(27.25)
|
| Post 2 beverage- 60 minutes |
45.17
(24.55)
|
0.42
(29.88)
|
41.07
(28.36)
|
| Post 3 beverage- 108 minutes |
38.28
(24.45)
|
37.35
(22.83)
|
35.63
(24.38)
|
| Title | Change in Rapid Visual Input Processing Task Performance Secondary Task Incorrect Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Secondary task- incorrect responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2- 68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
1.36
(3.19)
|
2.64
(5.37)
|
1.09
(3.81)
|
| Post 1 beverage-30 minutes |
0.42
(1.86)
|
0.00
(0.00)
|
0.00
(0.00)
|
| Post 2 beverage- 60 minutes |
0.46
(1.96)
|
0.83
(2.56)
|
0.36
(1.71)
|
| Post 3 beverage- 108 minutes |
0.52
(2.08)
|
1.04
(2.85)
|
0.38
(1.78)
|
| Title | Change in Rapid Visual Input Processing Task Performance Secondary Task Reaction Time for Correct Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Secondary task- reaction time for correct responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
610.31
(124.82)
|
66.66
(98.86)
|
612.76
(65.11)
|
| Post 1 beverage-30 minutes |
627.79
(59.08)
|
601.89
(76.14)
|
604.52
(87.25)
|
| Post 2 beverage- 60 minutes |
628.47
(108.98)
|
634.83
(102.15)
|
621.75
(129.66)
|
| Post 3 beverage- 108 minutes |
649.46
(90.90)
|
633.80
(67.24)
|
598.90
(92.00)
|
| Title | Change in Rapid Visual Input Processing Task Performance Tertiary Task Percentage Correct Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Tertiary task- percentage correct responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
83.76
(19.05)
|
88.89
(12.38)
|
86.45
(11.74)
|
| Post 1 beverage-30 minutes |
84.05
(15.79)
|
88.21
(14.81)
|
90.61
(8.10)
|
| Post 2 beverage- 60 minutes |
85.57
(13.61)
|
87.77
(16.48)
|
85.90
(16.46)
|
| Post 3 beverage- 108 minutes |
88.09
(12.85)
|
88.73
(14.23)
|
89.59
(10.67)
|
| Title | Change in Rapid Visual Input Processing Task Performance- Tertiary Task Percent Missed Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Tertiary task- percentage missed responses |
| Time Frame | pre beverage-0 minute, post beverage-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
12.56
(16.49)
|
9.55
(11.72)
|
11.18
(10.17)
|
| Post 1 beverage-30 minutes |
15.32
(15.85)
|
10.30
(14.14)
|
9.20
(11.32)
|
| Post 2 beverage- 60 minutes |
11.47
(11.41)
|
11.40
(16.71)
|
12.43
(15.63)
|
| Post 3 beverage- 108 minutes |
10.16
(13.55)
|
8.42
(13.00)
|
9.41
(10.60)
|
| Title | Change in Rapid Visual Input Processing Task Performance Tertiary Task Number of Incorrect Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Tertiary task- number of incorrect responses |
| Time Frame | pre beverage-0 minutes, post beverage 1- 30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
4.68
(7.09)
|
3.10
(5.36)
|
2.40
(4.55)
|
| Post 1 beverage-30 minutes |
2.57
(3.97)
|
1.81
(4.35)
|
2.98
(8.17)
|
| Post 2 beverage- 60 minutes |
3.05
(7.95)
|
1.62
(3.42)
|
3.07
(4.89)
|
| Post 3 beverage- 108 minutes |
2.92
(5.03)
|
1.94
(3.61)
|
1.52
(4.18)
|
| Title | Change in Rapid Visual Input Processing Task Performance Tertiary Task Reaction Time for Correct Responses |
|---|---|
| Description | Rapid Visual Input Processing task- Tertiary task- reaction time for correct responses |
| Time Frame | pre beverage-0 minutes, post beverage 1-30 minutes, post beverage 2-68 minutes, post beverage 3-108 minutes |
Outcome Measure Data
| Analysis Population Description |
|---|
| [Not Specified] |
| Arm/Group Title | Placebo | E+Shot | Caffeinated Placebo |
|---|---|---|---|
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine |
| Measure Participants | 30 | 30 | 30 |
| Pre beverage-0 minutes |
749.10
(56.08)
|
761.78
(60.50)
|
752.61
(61.42)
|
| Post 1 beverage-30 minutes |
745.10
(61.10)
|
731.21
(44.10)
|
746.90
(53.46)
|
| Post 2 beverage- 60 minutes |
738.66
(56.00)
|
728.52
(46.69)
|
751.04
(55.61)
|
| Post 3 beverage- 108 minutes |
717.86
(40.95)
|
737.23
(49.38)
|
739.53
(58.21)
|
Adverse Events
| Time Frame | Adverse event data was collected for up to 141 minutes after beverage consumption | |||||
|---|---|---|---|---|---|---|
| Adverse Event Reporting Description | No adverse events were reported | |||||
| Arm/Group Title | Placebo | Caffeinated Placebo | E+Shots | |||
| Arm/Group Description | <3mg of caffeine Placebo: ~3mg caffeine | ~100mg caffeine Caffeinated placebo: ~100mg of synthetic caffeine | ~100mg caffeine + adaptogens E+shots: The 4oz adaptogen-rich (E+shots) was E+ Shots (Isagenix International, LLC) containing approximately 90mg caffeine from green tea Camellia sinesis leaf extract (50%) and yerba maté extract (25%) along with a proprietary blend of adaptogenic herbs, including: eleutherococcus senticosus, crateagus oxycantha, rhodiola rosea and Schisandra chinensis. | |||
All Cause Mortality |
||||||
| Placebo | Caffeinated Placebo | E+Shots | ||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | / (NaN) | / (NaN) | / (NaN) | |||
Serious Adverse Events |
||||||
| Placebo | Caffeinated Placebo | E+Shots | ||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | 0/30 (0%) | 0/30 (0%) | 0/30 (0%) | |||
Other (Not Including Serious) Adverse Events |
||||||
| Placebo | Caffeinated Placebo | E+Shots | ||||
| Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
| Total | 0/30 (0%) | 0/30 (0%) | 0/30 (0%) | |||
Limitations/Caveats
There were technical problems with the Continuous Performance Task and Rapid Visual Input Processing task and not all data were interpretable.
More Information
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
| Name/Title | Ali Boolani |
|---|---|
| Organization | Clarkson University |
| Phone | 3152681663 |
| aboolani@clarkson.edu |
Responsible Party:
Ali Boolani,
Assistant Professor,
Clarkson University
ClinicalTrials.gov Identifier:
NCT03850275
Other Study ID Numbers:
- 16-05
First Posted:
Feb 21, 2019
Last Update Posted:
Aug 2, 2021
Last Verified:
Jul 1, 2021