Effects Of Caffeine On Cognitive Performance

Sponsor

University of Castilla-La Mancha (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT05995314

Collaborator

(none)

Enrollment

Location

Arms

Anticipated Duration (Days)

32.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Caffeine is a potent central nervous system stimulant that increases the activity in the prefrontal cortex and can improve cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance.The aim of this research will be to determine the effects of different doses of caffeine on sport-related cognitive aspects.

Condition or Disease	Intervention/Treatment	Phase
Caffeine	Dietary Supplement: PLACEBO Dietary Supplement: 3 mg/kg of caffeine Dietary Supplement: 6 mg/kg of caffeine	N/A

Detailed Description

The investigators will require healthy, physically active young adults to complete three trials under the conditions: a) placebo, b) 3 mg/kg, or c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities will be assessed using the following test batteries: reaction time (DynavisionTM D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. In addition, side effects and the perceived sensation index will be recorded 24 h after each test.

Study Design

Study Type:

Interventional

Actual Enrollment :

30 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

Triple (Participant, Investigator, Outcomes Assessor)

Masking Description:

To achieve the blinded placebo situation, a researcher not associated with the study will be performed the blinding and prepared identical capsules containing placebo or the corresponding dose of caffeine. This researcher will be assigned an alphanumeric code to each trial to blind participants and investigators

Primary Purpose:

Other

Official Title:

Effects Of Different Doses Of Caffeine On Cognitive Performance In Healthy Physically Active Individuals

Actual Study Start Date :

Aug 7, 2023

Anticipated Primary Completion Date :

Sep 4, 2023

Anticipated Study Completion Date :

Sep 4, 2023

Arms and Interventions

Arm	Intervention/Treatment
Placebo Comparator: PLACEBO placebo (0 mg/kg of body mass of caffeine). The capsule will be filled with 3 mg/kg of body mass of cellulose.	Dietary Supplement: PLACEBO 3 mg/kg of cellulose (0 mg/kg of caffeine)
Experimental: 3mg/kg 3 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).	Dietary Supplement: 3 mg/kg of caffeine Ingestion of 3 mg/kg of body mass of caffeine
Experimental: 6mg/kg 6 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).	Dietary Supplement: 6 mg/kg of caffeine Ingestion of 6 mg/kg of body mass of caffeine

Arm

Intervention/Treatment

Placebo Comparator: PLACEBO

placebo (0 mg/kg of body mass of caffeine). The capsule will be filled with 3 mg/kg of body mass of cellulose.

Dietary Supplement: PLACEBO

3 mg/kg of cellulose (0 mg/kg of caffeine)

Experimental: 3mg/kg

3 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).

Dietary Supplement: 3 mg/kg of caffeine

Ingestion of 3 mg/kg of body mass of caffeine

Experimental: 6mg/kg

6 mg/kg of body mass of caffeine (99% caffeine, Bulkpowders, United Kingdom).

Dietary Supplement: 6 mg/kg of caffeine

Ingestion of 6 mg/kg of body mass of caffeine

Outcome Measures

Primary Outcome Measures

Reaction Time [10 minutes]
Reaction time (in seconds) shall be assessed with the Dynavision™ D2 Visomotor Device using the "Reaction Time Test". In this test the fastest visual, motor and physical reaction time will be measured.
Anticipation [5 minutes]
Visual acuity related to hand-eye coordination and anticipation will be assessed using the Bassin Anticipation Timer instrument. The best anticipation time (in seconds) of each condition (5, 10 and 15 mph) will be taken.
Sustained attention [10 minutes]
The ability of maintaining the attention and inhibiting an appropriate response will be measured by "Go/No-Go Test" [fastest, slowest, and average response time (in seconds), and successful attempts (percentage; %)] and "Eriksen Flanker Test" [congruent and incongruent reaction time (in seconds)].
Memory [20 minutes]
To study the modulation of memory storage processes, three 20-item word lists were created. Each word in the list will be presented for 5 s. This will be followed by a 100 s memory consolidation interval, after which there will be a 120 s period in which as many words as the participants can remember will be written down (First time). After 15 min, participants will perform a recall task (Second time) in which they will have to rewrite all the words they remember at that time.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Physically active individuals ( >150 min/week moderate physical activity or >75 min/week vigorous physical activity)
Individuals without serious and undiagnosed health problems.