Calprotectine in Spondyloarthritis
Study Details
Study Description
Brief Summary
To date, there are no biomarkers in spondyloarthritis that can differentiate between spondyloarthritis and fibromyalgia or other pathologies. Fecal calprotectin is a biomarker that is increasingly used in inflammatory diseases of the digestive tract. A growing interest in this biomarker is emerging in rheumatology, several publications have focused on its interest in rheumatoid arthritis, highlighting an association between serum calprotectin levels and disease activity. In spondyloarthritis, a few studies seem to show that it could be a marker of disease activity. Although a 2012 study found no difference in serum calprotectin levels between subjects with spondyloarthritis and controls. Still others have shown that it could be a predictive factor of radiological evolution in the same disease key. These data support, despite the questionable results of the Klingberg study, the value of this dosage in spondyloarthritis. The objective of this work is to show that this assay could be useful to differentiate spondyloarthritis from other pathologies with similar clinical presentation such as fibromyalgia. Difficulties classically encountered in common practice in rheumatology
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| active spondyloarthritis subjects with active spondyloarthritis with a BASDAI greater than 4 |
Other: NO INTERVENTION
no intervention
|
| remission spondyloarthritis subjects presenting with a remission spondyloarthritis defined by a BASDAI less than 4 |
Other: NO INTERVENTION
no intervention
|
| controls without spondyloarthritis controls without spondyloarthritis or other chronic inflammatory rheumatism and without fibromyalgia |
Other: NO INTERVENTION
no intervention
|
| fibromyalgia subjects with fibromyalgia |
Other: NO INTERVENTION
no intervention
|
Outcome Measures
Primary Outcome Measures
- calprotectine rate [5 months]
blood test
Eligibility Criteria
Criteria
Inclusion Criteria:
Patients in the active line of the rheumatology department with one of the following criteria:
active spondyloarthritis (BASDAI >4), or spondyloarthritis in low activity (BASDAI<4), or fibromyalgia without associated inflammatory rheumatism, or healthy subjects (without inflammatory rheumatism and without fibromyalgia. Patients who have not objected to the use of their samples
Exclusion Criteria:
Minor patient Subject not affiliated to the social security system Subject deprived of liberty Patient under guardianship or curatorship
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Nice University Hospital | Nice | France | 06000 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire de Nice
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 22Rhumato01