Study of CRLX101 (NLG207) in the Treatment of Advanced Solid Tumors

Sponsor

NewLink Genetics Corporation (Industry)

Overall Status

Completed

CT.gov ID

NCT00333502

Collaborator

(none)

Enrollment

Locations

Arm

Duration (Months)

20.7

Patients Per Site

0.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

CRLX101 is a nanopharmaceutical comprised of the chemotherapeutic camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer. CRLX101 is designed to increase the exposure of tumor cells to CPT while minimizing side effects.

OBJECTIVES:

• Determine the safety, toxicity, and the maximum tolerated dose (MTD) of CRLX101 when administered intravenously to subjects with advanced solid tumors.

Condition or Disease	Intervention/Treatment	Phase
Cancer Solid Tumor	Drug: Camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer	Phase 1/Phase 2

Study Design

Study Type:

Interventional

Actual Enrollment :

62 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase 1b/2a Safety and Pharmacokinetic Study of CRLX101 (Formerly Named IT-101) in the Treatment of Advanced Solid Tumors

Study Start Date :

May 1, 2006

Actual Primary Completion Date :

Nov 1, 2011

Actual Study Completion Date :

Apr 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: CRLX101 (formerly known as IT-101) CRLX101 dosing per protocol dose escalation cohorts to MTD, then expansion cohort treated at MTD of CRLX101 15mg/m2	Drug: Camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer Subjects who meet inclusion/exclusion criteria will receive CRLX101 every other week. Other Names: NLG207 IT-101

Arm

Intervention/Treatment

Experimental: CRLX101 (formerly known as IT-101)

CRLX101 dosing per protocol dose escalation cohorts to MTD, then expansion cohort treated at MTD of CRLX101 15mg/m2

Drug: Camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer

Subjects who meet inclusion/exclusion criteria will receive CRLX101 every other week.

Other Names:

NLG207

IT-101

Outcome Measures

Primary Outcome Measures

To determine the safety, toxicity and maximum tolerated dose of CRLX101 when administered intravenously to subjects with advanced solid tumors. [6 months]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Male and female subjects >18 years of age with advanced, histologically-confirmed solid tumors refractory to standard therapy or for which no standard therapy exists and who have evidence of disease progression documented since their prior therapy.
Subjects must have measurable or evaluable disease.
Subjects must not have received prior chemotherapy or radiation for >/= 4 weeks prior to first dose of study drug.
Subjects may be entered if they have received prior radiation therapy involving </= 30% of the bone marrow. Any prior radiation therapy must have been administered >/= 4 weeks prior to first dose of study drug and the subject must be recovered from the acute toxic effects of the treatment prior to study entry.
Subjects may be enrolled with a history of treated brain metastases that are clinically stable for >/= 4 weeks prior to first dose of study drug. Subjects may not be currently receiving dexamethasone.
ECOG performance status of < 2.
Life expectancy of greater than 12 weeks.
Subjects must have acceptable organ and marrow function at screening and pre-dose visits.
Electrocardiogram without evidence of clinically significant conduction abnormalities or active ischemia as determined by the investigator and an acceptable QTc interval.
The effects of CRLX101 on the developing human fetus are unknown, therefore, women of childbearing potential must agree to use adequate contraception prior to study entry and for the duration of study participation.
Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

Female subjects who are pregnant or nursing.
Subjects who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to first dose of study drug or those who have not had adverse events return to baseline severity level or a severity level Grade 1 due to agents administered more than 4 weeks prior to first dose of study drug.
Subjects with a history of congestive heart failure (CHF) requiring medical therapy.
Subjects with serum amylase or lipase > 1.5X upper limit of normal (ULN).
Subjects with previous high dose chemotherapy with autologous stem cell rescue bone marrow transplantation.
Use of any investigational agent or drug within 4 weeks prior to first dose of study drug.
Metastatic disease to the CNS requiring treatment or radiation therapy.
Subjects with known untreated brain metastases or treated brain metastases that have not been stable >/= 4 weeks prior to first dose of study drug.
Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, hypertension, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements, as determined by the investigator.
The presence of active coagulation disorder.
Subjects with marked baseline prolongation of QT/QTc interval (QTc interval >/= 470 msec for females and QTc interval >/= 450 msec for males).
Any prior treatment with a topoisomerase I inhibitor.
Any major surgery </= 4 weeks prior to first dose of study drug.
Concurrent use of G-CSF or growth factors at the time of initiation of study drug.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Virginia G. Piper Cancer Center	Scottsdale	Arizona	United States	85258
2	City of Hope National Medical Center	Duarte	California	United States	91010
3	San Juan Oncology Associates	Farmington	New Mexico	United States	87401

Sponsors and Collaborators

NewLink Genetics Corporation

Investigators

Principal Investigator: Yun Yen, M.D., Ph.D., City of Hope National Medical Center
Principal Investigator: Glenn Weiss, M.D., Virginia G. Piper Cancer Center
Principal Investigator: Jeffrey D. Neidhart, M.D., San Juan Oncology Associates