Candidate Gene Association Study With Injury in Elite Male Youth Football Players

Sponsor

St Mary's University College (Other)

Overall Status

Completed

CT.gov ID

NCT04952662

Collaborator

Fulham Football Club (Other)

123

Enrollment

Locations

Actual Duration (Months)

61.5

Patients Per Site

3.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Understanding how candidate genes, previously associated with injury susceptibility, influence the incidence of muscle, bone, ligament, and tendon injuries across the development pathway of elite footballers may provide valuable insight into inherent injury predisposition to support the long-term development of every individual. Therefore, the aim of the present study was to investigate the association between candidate genetic variants and muscle, bone, ligament, and tendon injuries in elite football with sub-analysis of the influence of age and maturation on injury susceptibility.

Condition or Disease	Intervention/Treatment	Phase
Injuries Genetic Change	Genetic: Genetic variants

Detailed Description

Genetic variants in several candidate genes which code for structural constituents (COL1A1 rs1800012, COL1A2 rs412777, COL5A1 rs12722 and ACTN3 rs1815739), regulatory components (ACE rs1799752, ESR1 rs2234693 and MMP3 rs679620) and transcription factors (VDR rs2228570 and GDF5 rs143383) affecting the form, function and injury susceptibility of muscle, bone, ligament, and tendon tissue will be associated with overall injury, non-contact, bone, ligament, tendon and apophysitis injury risk in elite male youth and adult footballers.

Study Design

Study Type:

Observational

Actual Enrollment :

123 participants

Observational Model:

Case-Control

Time Perspective:

Retrospective

Official Title:

Candidate Gene Association Study With Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury in Elite Male Youth Football Players

Actual Study Start Date :

Dec 1, 2019

Actual Primary Completion Date :

May 31, 2021

Actual Study Completion Date :

May 31, 2021

Outcome Measures

Primary Outcome Measures

Number of non-injured and injured participants with injury risk alleles [8 Years]
Injury, Non-Contact Injury, Non-Contact Muscle Injury, Fracture and Apophysitis Injury

Eligibility Criteria

Criteria

Ages Eligible for Study:

8 Years to 40 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Elite Male Footballer Player Registered at Fulham Football Club

Exclusion Criteria:

Female no longer registered at Fulham Football Club

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Fulham Football Club	London	New Malden	United Kingdom	KT3 6PT
2	St Mary's University, Twickenham	London	Twickenham	United Kingdom	TW1 4SX

Sponsors and Collaborators

St Mary's University College
Fulham Football Club

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

St Mary's University College

ClinicalTrials.gov Identifier:

NCT04952662

Other Study ID Numbers:

SMEC_2019-20_002

First Posted:

Jul 7, 2021

Last Update Posted:

Jul 7, 2021

Last Verified:

Jul 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Yes

Studies a U.S. FDA-regulated Device Product:

Keywords provided by St Mary's University College

Additional relevant MeSH terms:

Wounds and Injuries

Study Results

No Results Posted as of Jul 7, 2021