Bystander Fatigue and CPR Quality Using Continuous Compressions Versus 30:2 Compressions to Ventilation
Study Details
Study Description
Brief Summary
STUDY OBJECTIVES The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes of continuous chest compressions versus the 2005 30:2 chest compression to ventilation Resuscitation Guidelines, in a population aged 55 or greater.
More specifically, the investigators will compare each CPR ratio with regard to:
-
The achieved frequency and depth of chest compressions, and
-
Participant rating of their perceived level of exertion.
STUDY HYPOTHESIS
In a population aged 55 or greater, the new CPR recommendations will lead to:
-
less frequent and shallower chest compressions over the 5-minute study period; and
-
higher rating of perceived level of exertion when compared to the 2005 30:2 CPR ratio.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
Background: Cardiac arrest is the number one cause of mortality in the Canadian population. Out-of-hospital bystander cardiopulmonary resuscitation (CPR) is associated with a 3 to 4 fold increase in survival for cardiac arrest, but citizens are often reluctant to initiate CPR because of its mouth-to-mouth component. In an effort to increase bystander CPR rates in the community and minimize interruptions in chest compressions, the 2010 Resuscitation Guidelines changed the 2005 recommended 30:2 compression to ventilation ratio to continuous chest compressions for laymen. Although the 30:2 ratio is meant to increase survival for cardiac arrest, the ability of rescuers to deliver continuous chest compressions has never been studied. Little is known about the impact of the new recommendations on bystander fatigue and resulting CPR quality.
Objectives: The overall goal of this study is to compare bystander fatigue and CPR quality after 5 minutes continuous chest compressions versus the 2005 30:2 chest compression to ventilation Resuscitation Guidelines in a population aged 55 or greater.
More specifically, the investigators will compare each CPR ratio with regard to:
-
The achieved frequency and depth of chest compressions, and
-
Participants' rating of their perceived level of exertion.
Methods: The investigators will conduct a randomized cross-over trial comparing bystander fatigue and CPR quality using two different CPR ratios. Intervention: All participants will be asked to perform two 5-minute sessions of CPR on a manikin - one session using the 30:2 ratio, the other using continuous chest compressions. There will be a supervised practice session in the beginning, and resting periods in between. The order in which the sessions will be executed will be determined in a random fashion. The study population will consist of volunteers aged 55 or older, a group most susceptible to perform CPR on a real victim. The study will take place in a busy public area of The Ottawa Hospital, Civic Campus, and in senior's activity centres in Ottawa. Participants will have to score 3 or less on the validated Clinical Frailty Scale in order to participate in the study. Participants with physical limitations or disease processes precluding their ability to safely perform CPR will be excluded. Outcome measures: Information on age, gender, prior CPR training, and measure of frailty will be collected at the time of enrollment. The number, frequency, and quality of chest compressions (depth and release) will be measured during each CPR session using a Zoll cardiac monitor with the ability to measure CPR processes. Heart rate and blood pressure will be measured before and after each CPR session. The participants will be asked to rate their level of fatigue before and after each CPR session using the validated Borg Rating of Perceived Exertion scale. Sample size: The investigators hope to recruit 60 participants. Data analysis for Objective#1 will include descriptive statistics and a paired t-test with 95% confidence interval; Objective#2 will be analyzed using descriptive statistics and Wilcoxon Rank Sum test. In addition, as an exploratory analysis, the investigators also assessed the rate of change over time in the number of chest compressions performed adequately using a random coefficient model. This study protocol will be reviewed by the OHREB before implementation, and will be entered in a trial registry.
Importance of the study: Data from this study will evaluate bystander fatigue and resulting CPR quality when comparing the 2010 continuous chest compression to the 2005 30:2 chest compression to ventilation Resuscitation Guidelines. This project will improve our understanding of the physiological demands associated with the implementation of the new CPR Resuscitation Guidelines for laymen. The investigators anticipated the results from this study will be widely distributed, and will help shape the 2015 iteration of the Resuscitation Guidelines.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: CPR 30:2 30 chest compressions to 2 ventilations followed by cross-over to CPR with Continuous Compressions |
Procedure: CPR using 30:2 ratio
Participants will begin performing CPR using a ratio of 30 compressions to 2 ventilations. Participants will then cross over to the other intervention and use continuous compressions.
Other Names:
|
Active Comparator: CPR with Continuous Compressions Continuous Chest Compressions without ventilation followed by CPR 30:2 (30 chest compressions to 2 ventilations) |
Procedure: CPR using continuous compressions
Participants will begin performing CPR using continuous chest compressions. Participants will then cross-over to the other intervention arm and perform CPR using a ratio of 30 compressions to 2 ventilations.
Other Names:
|
Outcome Measures
Primary Outcome Measures
- CPR Quality [5 minutes]
Count of compressions at a depth over 2 inches
Secondary Outcome Measures
- Heart Rate [Assessed immediately before and after 5 minutes of CPR]
- Blood Pressure [Assessed immediately before and after 5 minutes of CPR]
Mean arterial pressure (mmHg)
- Borg Rating of Perceived Exertion Scale [Assessed immediately before and after 5 minutes of CPR]
The Borg Rating of Perceived Exertion scale ranges from 6-20, where a score of 6 is associated with the least fatigue
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Male or female person aged 55 or older
-
Must score 3 or less on the validated Clinical Frailty Scale
-
Able to follow instructions in English or French
-
Able to understand and give informed consent
Exclusion Criteria:
-
Musculoskeletal condition precluding the ability to kneel down and perform CPR (e.g. severe arthritis, cast, wrist sprain, recent joint surgery)
-
Cardiovascular condition precluding the ability to perform a moderate effort (e.g. myocardial infarction or cardiovascular procedure in the last 3 months, recurrent angina, chest pain under investigation)
-
Pulmonary condition precluding the ability to perform a moderate effort (e.g. emphysema, severe asthma, pneumonia)
-
Active communicable disease (e.g. tuberculosis, meningitis, gastro enteritis, hepatitis A or B, herpes simplex)
-
Inability to perform chest compressions at appropriate rate and depth despite positive feedback during one to two-minute practice session
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | The Ottawa Hospital, Civic Campus | Ottawa | Ontario | Canada | K1Y4E9 |
Sponsors and Collaborators
- Ottawa Hospital Research Institute
Investigators
- Principal Investigator: Christian Vaillancourt, MD, MSc, Ottawa Hospital Research Institute
Study Documents (Full-Text)
None provided.More Information
Publications
- 2011358-01H
Study Results
Participant Flow
Recruitment Details | |
---|---|
Pre-assignment Detail |
Arm/Group Title | CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 |
---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations, then continuous chest compressions Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation | Continuous Chest Compressions without ventilation then CPR using 30:2 ratio Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation |
Period Title: Overall Study | ||
STARTED | 33 | 30 |
COMPLETED | 33 | 30 |
NOT COMPLETED | 0 | 0 |
Baseline Characteristics
Arm/Group Title | CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 | Total |
---|---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation | Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation | Total of all reporting groups |
Overall Participants | 33 | 30 | 63 |
Age (years) [Mean (Standard Deviation) ] | |||
Mean (Standard Deviation) [years] |
71.6
(6.5)
|
69.9
(6.3)
|
70.8
(6.4)
|
Sex: Female, Male (Count of Participants) | |||
Female |
23
69.7%
|
19
63.3%
|
42
66.7%
|
Male |
10
30.3%
|
11
36.7%
|
21
33.3%
|
Region of Enrollment (participants) [Number] | |||
Canada |
33
100%
|
30
100%
|
63
100%
|
CPR Training (Count of Participants) | |||
Count of Participants [Participants] |
18
54.5%
|
20
66.7%
|
38
60.3%
|
CPR Experience (Count of Participants) | |||
Count of Participants [Participants] |
3
9.1%
|
3
10%
|
6
9.5%
|
Outcome Measures
Title | CPR Quality |
---|---|
Description | Count of compressions at a depth over 2 inches |
Time Frame | 5 minutes |
Outcome Measure Data
Analysis Population Description |
---|
[Not Specified] |
Arm/Group Title | CPR 30:2 | CPR With Continuous Compressions |
---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations | Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation |
Measure Participants | 62 | 63 |
Mean (Standard Deviation) [Compressions] |
324.9
(120)
|
381.5
(68.5)
|
Title | Heart Rate |
---|---|
Description | |
Time Frame | Assessed immediately before and after 5 minutes of CPR |
Outcome Measure Data
Analysis Population Description |
---|
[Not Specified] |
Arm/Group Title | CPR 30:2 | CPR With Continuous Compressions |
---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations | Continuous Chest Compressions without ventilation |
Measure Participants | 62 | 63 |
Mean (Standard Deviation) [beats per minute] |
82.8
(16.1)
|
82.4
(15.1)
|
Title | Blood Pressure |
---|---|
Description | Mean arterial pressure (mmHg) |
Time Frame | Assessed immediately before and after 5 minutes of CPR |
Outcome Measure Data
Analysis Population Description |
---|
[Not Specified] |
Arm/Group Title | CPR 30:2 | CPR With Continuous Compressions |
---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations | Continuous Chest Compressions without ventilation |
Measure Participants | 62 | 63 |
Mean (Standard Deviation) [mmHg] |
109.8
(10.7)
|
110.3
(11.5)
|
Title | Borg Rating of Perceived Exertion Scale |
---|---|
Description | The Borg Rating of Perceived Exertion scale ranges from 6-20, where a score of 6 is associated with the least fatigue |
Time Frame | Assessed immediately before and after 5 minutes of CPR |
Outcome Measure Data
Analysis Population Description |
---|
[Not Specified] |
Arm/Group Title | CPR 30:2 | CPR With Continuous Compressions |
---|---|---|
Arm/Group Description | 30 chest compressions to 2 ventilations | Continuous Chest Compressions |
Measure Participants | 62 | 63 |
Mean (Standard Deviation) [units on a scale] |
11.0
(2.6)
|
11.6
(3.0)
|
Adverse Events
Time Frame | ||||
---|---|---|---|---|
Adverse Event Reporting Description | ||||
Arm/Group Title | CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 | ||
Arm/Group Description | 30 chest compressions to 2 ventilations Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation | Continuous Chest Compressions without ventilation Bystander CPR using 30:2 ratio versus continuous compression: Participants will use 2 CPR techniques, one with 30 compressions to 2 ventilations and the other with continuous compressions without ventilation | ||
All Cause Mortality |
||||
CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 | |||
Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
Total | / (NaN) | / (NaN) | ||
Serious Adverse Events |
||||
CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 | |||
Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
Total | 0/63 (0%) | 0/63 (0%) | ||
Other (Not Including Serious) Adverse Events |
||||
CPR 30:2 Then CPR With Continuous Compressions | CPR With Continuous Compressions Then CPR 30:2 | |||
Affected / at Risk (%) | # Events | Affected / at Risk (%) | # Events | |
Total | 0/63 (0%) | 0/63 (0%) |
Limitations/Caveats
More Information
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
Name/Title | Dr. Christian Vaillancourt |
---|---|
Organization | Ottawa Hospital Research Institute |
Phone | 613-798-5555 ext 17012 |
cvaillancourt@ohri.ca |
- 2011358-01H