Cardiac Effects in Long-Term Survivors of Hodgkin's and Non-Hodgkin's Lymphoma

• Sponsor: University of Rochester (Other)
• Overall Status: Completed
• CT.gov ID: NCT00903890
• Collaborator: (none)
• Enrollment: 32
• Location: 1
• Duration (Months): 140.3
• Patients Per Site Per Month: 0.2

Study Details

Study Description

Brief Summary

This study is to inquire by mailed survey regarding the cardiac and general health of patients previously treated for Hodgkin's and non-Hodgkin's lymphoma with radiation therapy/anthracycline chemotherapy.

Condition or Disease	Intervention/Treatment	Phase
Hodgkin Disease; Lymphoma, Non-Hodgkin	Other: Survey

Study Design

• Study Type: Observational
• Actual Enrollment: 32 participants
• Observational Model: Case-Only
• Time Perspective: Retrospective
• Official Title: Cardiac Effects in Long-Term Survivors of Hodgkin's and Non-Hodgkin's Lymphoma After Radiation Therapy/Anthracycline Chemotherapy
• Study Start Date: Aug 1, 2008
• Actual Primary Completion Date: Nov 1, 2018
• Actual Study Completion Date: Apr 9, 2020

Arms and Interventions

Arm	Intervention/Treatment
A Individuals who have previously received radiation therapy and anthracycline chemotherapy for their Hodgkin's or non-Hodgkin's lymphoma.	Other: Survey; Survey asking questions regarding the subjects cardiac and general health.

Outcome Measures

Primary Outcome Measures

1. Measure changes in Cardiac ejection fraction score [Post Radiation Treatment]

2. Measure changes in perfusion imaging score on the radionuclide cardiac profusion scan [Post Radiation]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• All patients with Hodgkin's Lymphoma and Non Hodgkin's lymphoma who underwent Radiation Therapy (RT) to either a mantle or modified mantle field with or without adriamycin at the Wilmot Cancer Center at the University of Rochester are eligible for the study.

Exclusion Criteria:

• Any severe preexisting cardiac disease (e.g., arrhythmia, angina, coronary disease, myocardial infarction, or congestive heart failure) prior to diagnosis

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Rochester Medical Center	Rochester	New York	United States	14642

Sponsors and Collaborators

• University of Rochester

Investigators

• Principal Investigator: Louis S Constine, MD, University of Rochester

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Louis Constine, Professor, University of Rochester
• ClinicalTrials.gov Identifier: NCT00903890
• Other Study ID Numbers: ULYM07056
• First Posted: May 19, 2009
• Last Update Posted: Mar 5, 2021
• Last Verified: Mar 1, 2021

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Additional relevant MeSH terms: Lymphoma; Lymphoma, Non-Hodgkin; Hodgkin Disease

Study Results

No Results Posted as of Mar 5, 2021