Cardiorespiratory Fitness, Apolipoprotein E Genotype, and Cognitive Functions: A Prospective Study
Study Details
Study Description
Brief Summary
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The current research project aims to investigate the interaction of cardiorespiratory fitness (CRF) and the ApoE genotype with neurocognitive functions. The three main purposes of the current research project seek to achieve:
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An exploration of the associations of, as well as the interactions between, CRF assessed at the Baseline Stage, and the ApoE genotype, along with cognitive functions in cognitively healthy late-middle-aged older adults.
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The employing of an event-related potential (ERP) to investigate the associations between the baseline CRF, the ApoE genotype, and cognitive functions in cognitively healthy late-middle-aged older adults, as well as the potential underlying neuroelectrical mechanisms.
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An investigation of the interactions between the changes of CRFs assessed at the Baseline and the Follow-Up Stages and the ApoE genotype in relation to neurocognitive function, as well as the underlying neuroelectrical mechanisms, in cognitively healthy late-middle-aged older adults.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| High-Risk with increased CRF ApoE e4 carriers with increased CRF from Baseline to the Follow-Up Stages. |
Other: Data collections
Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.
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| High-Risk with decreased CRF ApoE e4 carriers with decreased CRF from Baseline to the Follow-Up Stages. |
Other: Data collections
Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.
|
| Low-Risk with increased CRF Non-ApoE e4 carriers with increased CRF from Baseline to the Follow-Up Stages. |
Other: Data collections
Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.
|
| Low-Risk with decreased CRF Non-ApoE e4 carriers with decreased CRF from Baseline to the Follow-Up Stages. |
Other: Data collections
Data collections of cognitive function, neuroelectrical activities, ApoE genotype, and physical fitness.
|
Outcome Measures
Primary Outcome Measures
- Changes in inhibitory performance: Stroop task [30 minutes each at the Baseline and the Follow-Up Stages.]
Inhibitory performance was assessed using the computerized Stroop task at the baseline and at the follow-up assessments. Changes in inhibitory performance from Baseline to the Follow-Up Stages were assessed.
- Changes in higher order executive performance: Tower of London Test [25 minutes each at the Baseline and the Follow-Up Stages.]
Higher order executive performance was assessed using the Tower of London Test at the baseline and at the follow-up assessments. Changes in higher order executive performance from Baseline to the Follow-Up Stages were assessed.
- Changes in neuroelectrical activities [30 minutes each at the Baseline and the Follow-Up Stages.]
The neuroelectrical activities during the Stroop task were recorded and analyzed using the Neuroscan system. Changes in the neuroelectrical activities from Baseline to the Follow-Up Stages were assessed.
Secondary Outcome Measures
- ApoE genotype [5 minutes at the Baseline Stage.]
Based on the genetic biomarkers (rs429358 and rs7412), participants' ApoE genotype was determined.
- Physical fitness measurements: Changes in aerobic fitness [20 minutes each at the Baseline and the Follow-Up Stages.]
Participants' aerobic fitness was estimated using the submaximal cycle ergometer test at the baseline and at the follow-up assessments. Changes in aerobic fitness from Baseline to the Follow-Up Stages were assessed.
Eligibility Criteria
Criteria
Inclusion Criteria:
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right handed
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no history of cardiorespiratory disease
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normal or corrected-to-normal vision based on the 20/20 standard
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no risk of performing physical activities, as measured by the Physical Activity Readiness Questionnaire
Exclusion Criteria:
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the scores of Mini-Mental Status Examination (MMSE) < 25 and cognitively intact upon study entry
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history of psychiatric or neurological diseases
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color-blindness
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of Physical Education and Sport Sciences, National Taiwan Normal University | Taipei | Taiwan | 106308 |
Sponsors and Collaborators
- National Taiwan Normal University
Investigators
- Study Director: Yu-Kai Chang, Ph.D., Department of Physical Education and Sport Sciences, National Taiwan Normal University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PACNL_APOE_PROSPECTIVE