Lp(a)HORIZON: Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
Sponsor
Novartis Pharmaceuticals (Industry)
Overall Status
Active, not recruiting
CT.gov ID
NCT04023552
Collaborator
(none)
7,680
793
2
65.6
9.7
0.1
Study Details
Study Description
Brief Summary
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Actual Enrollment
:
7680 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Treatment
Official Title:
A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular Disease
Actual Study Start Date
:
Dec 12, 2019
Anticipated Primary Completion Date
:
May 29, 2025
Anticipated Study Completion Date
:
May 30, 2025
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: TQJ230 TQJ230 80 mg injected monthly administered subcutaneously |
Drug: TQJ230
TQJ230 80 mg injected monthly administered subcutaneously
|
| Placebo Comparator: Placebo Monthly subcutaneous injections. |
Drug: Placebo
Placebo to match TQJ230 prefilled syringe to be injected subcutaneously
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Time to first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in patients with elevated Lp(a) ≥ 70 mg/dL [approximately 4 years]
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 70 mg/dL)
- Time to the first occurrence of clinical endpoint committee confirmed expanded major adverse cardiovascular events in a population of patients with elevated Lp(a) ≥ 90 mg/dL. [approximately 4 years]
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of expanded MACE (cardiovascular death, non-fatal MI, non-fatal stroke and urgent coronary re-vascularization requiring hospitalization) in the overall study population with established CVD and (Lp(a) ≥ 90 mg/dL)
Secondary Outcome Measures
- Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of major adverse cardiovascular events (CV death, non-fatal MI, and non-fatal stroke) [approximately 4 years]
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of the MACE composite of CV death, nonfatal MI and non-fatal stroke.
- Time to the first occurrence of the clinical endpoint committee confirmed composite endpoint of coronary heart disease: coronary heart disease death, non-fatal MI, urgent coronary re-vascularization requiring hospitalization [approximately 4 years]
Demonstrate the superiority of pelacarsen (TQJ230) compared to placebo in reducing the risk of the composite of coronary heart disease (CHD) outcomes: death due to CHD, nonfatal MI and urgent coronary revascularization requiring hospitalization.
- Number of participants with confirmed all-cause death [approximately 4 years]
Evaluation by clinical endpoint committee the rate of all-cause death
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Key Inclusion Criteria
-
Lp(a) ≥ 70 mg/dL at the screening visit, measured at the Central laboratory
-
Myocardial infarction: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
-
Ischemic stroke: ≥ 3 months from screening and randomization to ≤ 10 years prior to the screening visit
-
Clinically significant symptomatic peripheral artery disease
Key Exclusion Criteria
-
Uncontrolled hypertension
-
Heart failure New York Heart Association (NYHA) class IV
-
History of malignancy of any organ system
-
History of hemorrhagic stroke or other major bleeding
-
Platelet count ≤LLN
-
Active liver disease or hepatic dysfunction
-
Significant kidney disease
-
Pregnant or nursing women
Other protocol-defined inclusion/exclusion criteria may apply at the end.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Novartis Investigative Site | Andalusia | Alabama | United States | 36420 |
| 2 | Novartis Investigative Site | Birmingham | Alabama | United States | 35243 |
| 3 | Novartis Investigative Site | Huntsville | Alabama | United States | 35801 |
| 4 | Novartis Investigative Site | Mobile | Alabama | United States | 36608 |
| 5 | Novartis Investigative Site | Cottonwood | Arizona | United States | 86326 |
| 6 | Novartis Investigative Site | Gilbert | Arizona | United States | 85297 |
| 7 | Novartis Investigative Site | Sun City West | Arizona | United States | 85375 |
| 8 | Novartis Investigative Site | Tucson | Arizona | United States | 85745 |
| 9 | Novartis Investigative Site | Little Rock | Arkansas | United States | 72204 |
| 10 | Novartis Investigative Site | Beverly Hills | California | United States | 90210 |
| 11 | Novartis Investigative Site | Beverly Hills | California | United States | 90211 |
| 12 | Novartis Investigative Site | Covina | California | United States | 91723 |
| 13 | Novartis Investigative Site | Huntington Beach | California | United States | 92648 |
| 14 | Novartis Investigative Site | La Jolla | California | United States | 92037 |
| 15 | Novartis Investigative Site | Long Beach | California | United States | 90806 |
| 16 | Novartis Investigative Site | Los Angeles | California | United States | 90033 |
| 17 | Novartis Investigative Site | Los Angeles | California | United States | 90073 |
| 18 | Novartis Investigative Site | Northridge | California | United States | 91325 |
| 19 | Novartis Investigative Site | Orange | California | United States | 92868 |
| 20 | Novartis Investigative Site | San Diego | California | United States | 92103 |
| 21 | Novartis Investigative Site | San Francisco | California | United States | 94143 |
| 22 | Novartis Investigative Site | San Francisco | California | United States | 94158 |
| 23 | Novartis Investigative Site | Santa Ana | California | United States | 92704 |
| 24 | Novartis Investigative Site | Stanford | California | United States | 94305 |
| 25 | Novartis Investigative Site | Stockton | California | United States | 95204 |
| 26 | Novartis Investigative Site | West Hills | California | United States | 91307 |
| 27 | Novartis Investigative Site | Aurora | Colorado | United States | 80045 |
| 28 | Novartis Investigative Site | Bridgeport | Connecticut | United States | 06610 |
| 29 | Novartis Investigative Site | Hartford | Connecticut | United States | 06102-5037 |
| 30 | Novartis Investigative Site | Waterbury | Connecticut | United States | 06708 |
| 31 | Novartis Investigative Site | Boca Raton | Florida | United States | 33434 |
| 32 | Novartis Investigative Site | Bradenton | Florida | United States | 34209 |
| 33 | Novartis Investigative Site | Brandon | Florida | United States | 33511 |
| 34 | Novartis Investigative Site | Fort Lauderdale | Florida | United States | 33312 |
| 35 | Novartis Investigative Site | Jacksonville | Florida | United States | 32205 |
| 36 | Novartis Investigative Site | Jacksonville | Florida | United States | 32216 |
| 37 | Novartis Investigative Site | Jacksonville | Florida | United States | 32223 |
| 38 | Novartis Investigative Site | Miami | Florida | United States | 33133 |
| 39 | Novartis Investigative Site | Naples | Florida | United States | 34102 |
| 40 | Novartis Investigative Site | Port Charlotte | Florida | United States | 33952 |
| 41 | Novartis Investigative Site | Port Orange | Florida | United States | 32127 |
| 42 | Novartis Investigative Site | Saint Augustine | Florida | United States | 32086 |
| 43 | Novartis Investigative Site | Wellington | Florida | United States | 33449 |
| 44 | Novartis Investigative Site | Atlanta | Georgia | United States | 30084 |
| 45 | Novartis Investigative Site | Atlanta | Georgia | United States | 30309 |
| 46 | Novartis Investigative Site | Atlanta | Georgia | United States | 30322 |
| 47 | Novartis Investigative Site | Atlanta | Georgia | United States | 30324 |
| 48 | Novartis Investigative Site | Dunwoody | Georgia | United States | 30338 |
| 49 | Novartis Investigative Site | Thomasville | Georgia | United States | 31792 |
| 50 | Novartis Investigative Site | Chicago | Illinois | United States | 60612 |
| 51 | Novartis Investigative Site | Park Ridge | Illinois | United States | 60068 |
| 52 | Novartis Investigative Site | Indianapolis | Indiana | United States | 46202 4800 |
| 53 | Novartis Investigative Site | Iowa City | Iowa | United States | 52242 |
| 54 | Novartis Investigative Site | Kansas City | Kansas | United States | 66160 |
| 55 | Novartis Investigative Site | Topeka | Kansas | United States | 66606 |
| 56 | Novartis Investigative Site | Alexandria | Louisiana | United States | 71301 |
| 57 | Novartis Investigative Site | Baton Rouge | Louisiana | United States | 70808 |
| 58 | Novartis Investigative Site | Bogalusa | Louisiana | United States | 70427 |
| 59 | Novartis Investigative Site | Bossier City | Louisiana | United States | 71111 |
| 60 | Novartis Investigative Site | Covington | Louisiana | United States | 70433 |
| 61 | Novartis Investigative Site | Eunice | Louisiana | United States | 70535 |
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| 63 | Novartis Investigative Site | Houma | Louisiana | United States | 70360 |
| 64 | Novartis Investigative Site | Lafayette | Louisiana | United States | 70501 |
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| 71 | Novartis Investigative Site | Slidell | Louisiana | United States | 70458 |
| 72 | Novartis Investigative Site | Zachary | Louisiana | United States | 70791 |
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| 77 | Novartis Investigative Site | Columbia | Maryland | United States | 21044 |
| 78 | Novartis Investigative Site | Fort Washington | Maryland | United States | 20744 |
| 79 | Novartis Investigative Site | Rockville | Maryland | United States | 20850 |
| 80 | Novartis Investigative Site | Boston | Massachusetts | United States | 02114-2696 |
| 81 | Novartis Investigative Site | Boston | Massachusetts | United States | 02115 |
| 82 | Novartis Investigative Site | Detroit | Michigan | United States | 48201 |
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| 89 | Novartis Investigative Site | Wyoming | Michigan | United States | 49519 |
| 90 | Novartis Investigative Site | Maplewood | Minnesota | United States | 55109 |
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| 96 | Novartis Investigative Site | Saint Louis | Missouri | United States | 63110 |
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| 98 | Novartis Investigative Site | Saint Louis | Missouri | United States | 63141 |
| 99 | Novartis Investigative Site | Saint Peters | Missouri | United States | 63303 |
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| 102 | Novartis Investigative Site | Omaha | Nebraska | United States | 68134 |
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| 108 | Novartis Investigative Site | New York | New York | United States | 10016 |
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| 111 | Novartis Investigative Site | New York | New York | United States | 10075 |
| 112 | Novartis Investigative Site | New York | New York | United States | 43210 |
| 113 | Novartis Investigative Site | Rochester | New York | United States | 14621 |
| 114 | Novartis Investigative Site | Rochester | New York | United States | 14642 |
| 115 | Novartis Investigative Site | Southampton | New York | United States | 11968 |
| 116 | Novartis Investigative Site | Charlotte | North Carolina | United States | 28204 |
| 117 | Novartis Investigative Site | Greensboro | North Carolina | United States | 27405 |
| 118 | Novartis Investigative Site | Greensboro | North Carolina | United States | 27408 |
| 119 | Novartis Investigative Site | High Point | North Carolina | United States | 27262 |
| 120 | Novartis Investigative Site | Raleigh | North Carolina | United States | 27609 |
| 121 | Novartis Investigative Site | Sanford | North Carolina | United States | 27330 |
| 122 | Novartis Investigative Site | Shelby | North Carolina | United States | 28150 |
| 123 | Novartis Investigative Site | Winston-Salem | North Carolina | United States | 27157 |
| 124 | Novartis Investigative Site | Akron | Ohio | United States | 44304 |
| 125 | Novartis Investigative Site | Akron | Ohio | United States | 44309 |
| 126 | Novartis Investigative Site | Canton | Ohio | United States | 44710 |
| 127 | Novartis Investigative Site | Cincinnati | Ohio | United States | 45219 |
| 128 | Novartis Investigative Site | Cincinnati | Ohio | United States | 45246 |
| 129 | Novartis Investigative Site | Cincinnati | Ohio | United States | 45267 |
| 130 | Novartis Investigative Site | Cleveland | Ohio | United States | 44195 |
| 131 | Novartis Investigative Site | Columbus | Ohio | United States | 43210 |
| 132 | Novartis Investigative Site | Marion | Ohio | United States | 43302 |
| 133 | Novartis Investigative Site | Portland | Oregon | United States | 97239 |
| 134 | Novartis Investigative Site | Lancaster | Pennsylvania | United States | 17603 |
| 135 | Novartis Investigative Site | Philadelphia | Pennsylvania | United States | 19104 |
| 136 | Novartis Investigative Site | Pittsburgh | Pennsylvania | United States | 15212 |
| 137 | Novartis Investigative Site | Yardley | Pennsylvania | United States | 19067 |
| 138 | Novartis Investigative Site | Providence | Rhode Island | United States | 02906 |
| 139 | Novartis Investigative Site | Fort Mill | South Carolina | United States | 29707 |
| 140 | Novartis Investigative Site | Summerville | South Carolina | United States | 29485 |
| 141 | Novartis Investigative Site | Rapid City | South Dakota | United States | 57701 |
| 142 | Novartis Investigative Site | Germantown | Tennessee | United States | 38138 |
| 143 | Novartis Investigative Site | Jackson | Tennessee | United States | 38301 |
| 144 | Novartis Investigative Site | Knoxville | Tennessee | United States | 37917 |
| 145 | Novartis Investigative Site | Nashville | Tennessee | United States | 37232 |
| 146 | Novartis Investigative Site | Powell | Tennessee | United States | 37849 |
| 147 | Novartis Investigative Site | Dallas | Texas | United States | 75226 |
| 148 | Novartis Investigative Site | Dallas | Texas | United States | 75231 |
| 149 | Novartis Investigative Site | Dallas | Texas | United States | 75235 |
| 150 | Novartis Investigative Site | Dallas | Texas | United States | 75390 |
| 151 | Novartis Investigative Site | Houston | Texas | United States | 77030 |
| 152 | Novartis Investigative Site | Livingston | Texas | United States | 77351 |
| 153 | Novartis Investigative Site | Marshall | Texas | United States | 75670 |
| 154 | Novartis Investigative Site | Temple | Texas | United States | 76508 |
| 155 | Novartis Investigative Site | Tomball | Texas | United States | 77375 |
| 156 | Novartis Investigative Site | Bountiful | Utah | United States | 84010 |
| 157 | Novartis Investigative Site | Layton | Utah | United States | 84041 |
| 158 | Novartis Investigative Site | Murray | Utah | United States | 84107 |
| 159 | Novartis Investigative Site | Salt Lake City | Utah | United States | 84132 |
| 160 | Novartis Investigative Site | Danville | Virginia | United States | 24541 |
| 161 | Novartis Investigative Site | Falls Church | Virginia | United States | 22042 |
| 162 | Novartis Investigative Site | Manassas | Virginia | United States | 20109 |
| 163 | Novartis Investigative Site | Norfolk | Virginia | United States | 23510 |
| 164 | Novartis Investigative Site | Richmond | Virginia | United States | 23219 |
| 165 | Novartis Investigative Site | Seattle | Washington | United States | 98104 |
| 166 | Novartis Investigative Site | Seattle | Washington | United States | 98122 |
| 167 | Novartis Investigative Site | Seattle | Washington | United States | 98195 |
| 168 | Novartis Investigative Site | Morgantown | West Virginia | United States | 26506 |
| 169 | Novartis Investigative Site | Milwaukee | Wisconsin | United States | 53215 |
| 170 | Novartis Investigative Site | Caba | Buenos Aires | Argentina | 1407 |
| 171 | Novartis Investigative Site | Caba | Buenos Aires | Argentina | C1056ABJ |
| 172 | Novartis Investigative Site | Caba | Buenos Aires | Argentina | C1280AEB |
| 173 | Novartis Investigative Site | Mar del Plata | Buenos Aires | Argentina | 7600 |
| 174 | Novartis Investigative Site | Ramos Mejia | Buenos Aires | Argentina | B1704ETD |
| 175 | Novartis Investigative Site | Tucuman | San Miguel De Tucuman | Argentina | T4000ICL |
| 176 | Novartis Investigative Site | Rosario | Santa Fe | Argentina | 2000 |
| 177 | Novartis Investigative Site | Rosario | Santa Fe | Argentina | S200CVD |
| 178 | Novartis Investigative Site | San Miguel de Tucuman | Tucuman | Argentina | T4000IFL |
| 179 | Novartis Investigative Site | Buenos Aires | Argentina | C1430EGF | |
| 180 | Novartis Investigative Site | Caba | Argentina | 1426 | |
| 181 | Novartis Investigative Site | Capital Federal | Argentina | C1023AAB | |
| 182 | Novartis Investigative Site | Cordoba | Argentina | X5000EVQ | |
| 183 | Novartis Investigative Site | Cordoba | Argentina | X5016KET | |
| 184 | Novartis Investigative Site | Corrientes | Argentina | W3400 | |
| 185 | Novartis Investigative Site | San Luis | Argentina | D5702JRS | |
| 186 | Novartis Investigative Site | Santa Fe | Argentina | S3000FWO | |
| 187 | Novartis Investigative Site | Camperdown | New South Wales | Australia | 2050 |
| 188 | Novartis Investigative Site | Liverpool | New South Wales | Australia | 2170 |
| 189 | Novartis Investigative Site | Chemside | Queensland | Australia | 4032 |
| 190 | Novartis Investigative Site | Southport | Queensland | Australia | 4215 |
| 191 | Novartis Investigative Site | Woolloongabba | Queensland | Australia | 4102 |
| 192 | Novartis Investigative Site | Clayton | Victoria | Australia | 3168 |
| 193 | Novartis Investigative Site | Perth | Western Australia | Australia | 6000 |
| 194 | Novartis Investigative Site | Graz | Austria | 8036 | |
| 195 | Novartis Investigative Site | Innsbruck | Austria | 6020 | |
| 196 | Novartis Investigative Site | Linz | Austria | 4021 | |
| 197 | Novartis Investigative Site | Salzburg | Austria | A-5020 | |
| 198 | Novartis Investigative Site | Wien | Austria | 1090 | |
| 199 | Novartis Investigative Site | Wien | Austria | 1210 | |
| 200 | Novartis Investigative Site | Aalst | Belgium | 9300 | |
| 201 | Novartis Investigative Site | Brugge | Belgium | 8000 | |
| 202 | Novartis Investigative Site | Bruxelles | Belgium | 1070 | |
| 203 | Novartis Investigative Site | Dendermonde | Belgium | 9200 | |
| 204 | Novartis Investigative Site | Genk | Belgium | 3600 | |
| 205 | Novartis Investigative Site | Huy | Belgium | 4500 | |
| 206 | Novartis Investigative Site | Kortrijk | Belgium | 8500 | |
| 207 | Novartis Investigative Site | Mechelen | Belgium | 2800 | |
| 208 | Novartis Investigative Site | Maceio | AL | Brazil | 57051 160 |
| 209 | Novartis Investigative Site | Salvador | BA | Brazil | 40170-130 |
| 210 | Novartis Investigative Site | Brasilia | DF | Brazil | 70390-903 |
| 211 | Novartis Investigative Site | Vitoria | ES | Brazil | 29055-450 |
| 212 | Novartis Investigative Site | Goiania | GO | Brazil | 74605-020 |
| 213 | Novartis Investigative Site | Belo Horizonte | MG | Brazil | 30150-221 |
| 214 | Novartis Investigative Site | Belo Horizonte | MG | Brazil | 30220330 |
| 215 | Novartis Investigative Site | Juiz de Fora | MG | Brazil | 36033-318 |
| 216 | Novartis Investigative Site | Uberlandia | Minas Gerais | Brazil | 38411 186 |
| 217 | Novartis Investigative Site | Curitiba | Parana | Brazil | 80230-130 |
| 218 | Novartis Investigative Site | Curitiba | PR | Brazil | 80730-150 |
| 219 | Novartis Investigative Site | Canoas | RS | Brazil | 92425 900 |
| 220 | Novartis Investigative Site | Porto Alegre | RS | Brazil | 90160093 |
| 221 | Novartis Investigative Site | Porto Alegre | RS | Brazil | 90880-480 |
| 222 | Novartis Investigative Site | Blumenau | Santa Catarina | Brazil | 89020 430 |
| 223 | Novartis Investigative Site | Aracaju | SE | Brazil | 49055530 |
| 224 | Novartis Investigative Site | Campinas | SP | Brazil | 13010-001 |
| 225 | Novartis Investigative Site | Campinas | SP | Brazil | 13060 080 |
| 226 | Novartis Investigative Site | Ribeirao Preto | SP | Brazil | 14026 020 |
| 227 | Novartis Investigative Site | Santo Andre | SP | Brazil | 09060-870 |
| 228 | Novartis Investigative Site | Santo Andre | SP | Brazil | 09090-790 |
| 229 | Novartis Investigative Site | Sao Jose do Rio Preto | SP | Brazil | 15015-750 |
| 230 | Novartis Investigative Site | Sao Jose do Rio Preto | SP | Brazil | 15090 000 |
| 231 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 01141-020 |
| 232 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 01323 000 |
| 233 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 04005-003 |
| 234 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 04023-900 |
| 235 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 04266 010 |
| 236 | Novartis Investigative Site | Sao Paulo | SP | Brazil | 05403 000 |
| 237 | Novartis Investigative Site | Rio de Janeiro | Brazil | 20241-180 | |
| 238 | Novartis Investigative Site | Sao Paulo | Brazil | 05403-900 | |
| 239 | Novartis Investigative Site | Blagoevgrad | Bulgaria | 2700 | |
| 240 | Novartis Investigative Site | Burgas | Bulgaria | 8000 | |
| 241 | Novartis Investigative Site | Pernik | Bulgaria | 2300 | |
| 242 | Novartis Investigative Site | Pleven | Bulgaria | 5800 | |
| 243 | Novartis Investigative Site | Plovdiv | Bulgaria | 4000 | |
| 244 | Novartis Investigative Site | Ruse | Bulgaria | 7002 | |
| 245 | Novartis Investigative Site | Sofia | Bulgaria | 1233 | |
| 246 | Novartis Investigative Site | Sofia | Bulgaria | 1709 | |
| 247 | Novartis Investigative Site | Vancouver | British Columbia | Canada | V5Z 1M9 |
| 248 | Novartis Investigative Site | Vancouver | British Columbia | Canada | V6Z 1Y6 |
| 249 | Novartis Investigative Site | Victoria | British Columbia | Canada | V8R4R2 |
| 250 | Novartis Investigative Site | Victoria | British Columbia | Canada | V8T 5G4 |
| 251 | Novartis Investigative Site | Oakville | Ontario | Canada | L6K 3W7 |
| 252 | Novartis Investigative Site | Toronto | Ontario | Canada | M9V 4B4 |
| 253 | Novartis Investigative Site | Levis | Quebec | Canada | G6V 4Z5 |
| 254 | Novartis Investigative Site | Montreal | Quebec | Canada | H1T 1C8 |
| 255 | Novartis Investigative Site | Montreal | Quebec | Canada | H2X 0A9 |
| 256 | Novartis Investigative Site | Montreal | Quebec | Canada | H3T 1E2 |
| 257 | Novartis Investigative Site | Montreal | Quebec | Canada | H4A 3J1 |
| 258 | Novartis Investigative Site | Sainte Foy | Quebec | Canada | G1V 4G5 |
| 259 | Novartis Investigative Site | Terrebonne | Quebec | Canada | J6V 2H2 |
| 260 | Novartis Investigative Site | Ouest-Montreal | Canada | H2W1R7 | |
| 261 | Novartis Investigative Site | Quebec | Canada | G1R 2J6 | |
| 262 | Novartis Investigative Site | Quebec | Canada | G1V 4G2 | |
| 263 | Novartis Investigative Site | Quebec | Canada | G1V 4W2 | |
| 264 | Novartis Investigative Site | Santiago | RM | Chile | 7500588 |
| 265 | Novartis Investigative Site | Santiago | RM | Chile | 8380465 |
| 266 | Novartis Investigative Site | Santiago | Chile | 7500710 | |
| 267 | Novartis Investigative Site | Santiago | Chile | 838 0456 | |
| 268 | Novartis Investigative Site | Santiago | Chile | ||
| 269 | Novartis Investigative Site | Lanzhou | Gansu | China | |
| 270 | Novartis Investigative Site | Foshan | Guangdong | China | 528000 |
| 271 | Novartis Investigative Site | Guangzhou | Guangdong | China | 51000 |
| 272 | Novartis Investigative Site | Guangzhou | Guangdong | China | 510080 |
| 273 | Novartis Investigative Site | Harbin | Heilongjiang | China | 150000 |
| 274 | Novartis Investigative Site | Wuhan | Hubei | China | 430030 |
| 275 | Novartis Investigative Site | Changsha | Hunan | China | 410003 |
| 276 | Novartis Investigative Site | Changsha | Hunan | China | 410011 |
| 277 | Novartis Investigative Site | Baotou | Inner Mongolia | China | 014040 |
| 278 | Novartis Investigative Site | Nanjing | Jiangsu | China | 210009 |
| 279 | Novartis Investigative Site | Nanjing | Jiangsu | China | 211166 |
| 280 | Novartis Investigative Site | Suzhou | Jiangsu | China | 215006 |
| 281 | Novartis Investigative Site | Xuzhou | Jiangsu | China | 221003 |
| 282 | Novartis Investigative Site | Changchun | Jilin | China | 130022 |
| 283 | Novartis Investigative Site | Dalian | Liaoning | China | 116011 |
| 284 | Novartis Investigative Site | Shenyang | Liaoning | China | 110003 |
| 285 | Novartis Investigative Site | Shenyang | Liaoning | China | 110016 |
| 286 | Novartis Investigative Site | Jinan | Shandong | China | 250013 |
| 287 | Novartis Investigative Site | Xian | Shanxi | China | 710061 |
| 288 | Novartis Investigative Site | Chengdu | Sichuan | China | 610041 |
| 289 | Novartis Investigative Site | Tianjin | Tianjin | China | 300121 |
| 290 | Novartis Investigative Site | Wulumuqi | Xinjiang | China | 830054 |
| 291 | Novartis Investigative Site | Hangzhou | Zhejiang | China | 310014 |
| 292 | Novartis Investigative Site | Hangzhou | Zhejiang | China | 310016 |
| 293 | Novartis Investigative Site | Wenzhou | Zhejiang | China | 325000 |
| 294 | Novartis Investigative Site | Beijing | China | 100029 | |
| 295 | Novartis Investigative Site | Beijing | China | 100050 | |
| 296 | Novartis Investigative Site | Beijing | China | 100191 | |
| 297 | Novartis Investigative Site | Beijing | China | 100730 | |
| 298 | Novartis Investigative Site | Nanjing | China | 210036 | |
| 299 | Novartis Investigative Site | Shanghai | China | 200025 | |
| 300 | Novartis Investigative Site | Shanghai | China | 200040 | |
| 301 | Novartis Investigative Site | Shanghai | China | 200120 | |
| 302 | Novartis Investigative Site | Tianjin | China | 300052 | |
| 303 | Novartis Investigative Site | Tianjin | China | 30045 | |
| 304 | Novartis Investigative Site | Xiamen | China | 361004 | |
| 305 | Novartis Investigative Site | Medellin | Antioquia | Colombia | 050001 |
| 306 | Novartis Investigative Site | Bogota | Cundinamarca | Colombia | 110911 |
| 307 | Novartis Investigative Site | Bucaramanga | Santander | Colombia | |
| 308 | Novartis Investigative Site | Cali | Valle Del Cauca | Colombia | 760001 |
| 309 | Novartis Investigative Site | Cali | Valle Del Cauca | Colombia | |
| 310 | Novartis Investigative Site | Barranquilla | Colombia | 080020 | |
| 311 | Novartis Investigative Site | Bogota | Colombia | ||
| 312 | Novartis Investigative Site | Medellin | Colombia | ||
| 313 | Novartis Investigative Site | San Gil | Colombia | 684031 | |
| 314 | Novartis Investigative Site | Brandys nad Labem | Czech Republic | Czechia | 250 01 |
| 315 | Novartis Investigative Site | Brno | Czech Republic | Czechia | 60200 |
| 316 | Novartis Investigative Site | Brno | Czech Republic | Czechia | 656 91 |
| 317 | Novartis Investigative Site | Cesky Krumlov | Czech Republic | Czechia | 381 01 |
| 318 | Novartis Investigative Site | Kromeriz | Czech Republic | Czechia | 767 55 |
| 319 | Novartis Investigative Site | Liberec V Kristianova | Czech Republic | Czechia | 460 05 |
| 320 | Novartis Investigative Site | Louny | Czech Republic | Czechia | |
| 321 | Novartis Investigative Site | Ostrava | Czech Republic | Czechia | 70200 |
| 322 | Novartis Investigative Site | Pardubice | Czech Republic | Czechia | 532 03 |
| 323 | Novartis Investigative Site | Svitavy | Czech Republic | Czechia | 568 25 |
| 324 | Novartis Investigative Site | Trebic | Czech Republic | Czechia | 674 01 |
| 325 | Novartis Investigative Site | Usti nad Labem | Czech Republic | Czechia | 400 01 |
| 326 | Novartis Investigative Site | Most | CZE | Czechia | 434 01 |
| 327 | Novartis Investigative Site | Policska | CZE | Czechia | 57201 |
| 328 | Novartis Investigative Site | Trutnov | CZE | Czechia | 46063 |
| 329 | Novartis Investigative Site | Brno Bohunice | Czechia | 625 00 | |
| 330 | Novartis Investigative Site | Brno | Czechia | 60200 | |
| 331 | Novartis Investigative Site | Broumov | Czechia | 550 01 | |
| 332 | Novartis Investigative Site | Chlumec nad Cidlinou | Czechia | 50351 | |
| 333 | Novartis Investigative Site | CZE | Czechia | 11000 | |
| 334 | Novartis Investigative Site | Hlucin | Czechia | 748 01 | |
| 335 | Novartis Investigative Site | Hodonin | Czechia | 69501 | |
| 336 | Novartis Investigative Site | JIhlava | Czechia | 586 01 | |
| 337 | Novartis Investigative Site | Kolin | Czechia | 280 20 | |
| 338 | Novartis Investigative Site | Liberec | Czechia | 460 01 | |
| 339 | Novartis Investigative Site | Marianske lazne | Czechia | 353 01 | |
| 340 | Novartis Investigative Site | Melnik | Czechia | 27601 | |
| 341 | Novartis Investigative Site | Olomouc | Czechia | 77900 | |
| 342 | Novartis Investigative Site | Ostrava | Czechia | 700 30 | |
| 343 | Novartis Investigative Site | Ostrava | Czechia | 70030 | |
| 344 | Novartis Investigative Site | Ostrava | Czechia | 71000 | |
| 345 | Novartis Investigative Site | Praha 5 | Czechia | 158 00 | |
| 346 | Novartis Investigative Site | Praha | Czechia | 101 00 | |
| 347 | Novartis Investigative Site | Praha | Czechia | 110 00 | |
| 348 | Novartis Investigative Site | Praha | Czechia | 12808 | |
| 349 | Novartis Investigative Site | Prerov | Czechia | 751 52 | |
| 350 | Novartis Investigative Site | Slany | Czechia | 27401 | |
| 351 | Novartis Investigative Site | Uherske Hradiste | Czechia | 68601 | |
| 352 | Novartis Investigative Site | Valasske Mezirici | Czechia | 75742 | |
| 353 | Novartis Investigative Site | Zlin | Czechia | 76001 | |
| 354 | Novartis Investigative Site | Aalborg | Denmark | 9000 | |
| 355 | Novartis Investigative Site | Arhus N | Denmark | DK-8200 | |
| 356 | Novartis Investigative Site | Esbjerg | Denmark | DK-6700 | |
| 357 | Novartis Investigative Site | Glostrup | Denmark | 2600 | |
| 358 | Novartis Investigative Site | Herlev | Denmark | DK 2730 | |
| 359 | Novartis Investigative Site | Roskilde | Denmark | 4000 | |
| 360 | Novartis Investigative Site | Viborg | Denmark | DK-8800 | |
| 361 | Novartis Investigative Site | Bron | France | 69677 | |
| 362 | Novartis Investigative Site | Chambray les Tours | France | 37170 | |
| 363 | Novartis Investigative Site | Compiègne | France | 60321 | |
| 364 | Novartis Investigative Site | Grenoble Cedex 9 | France | 38043 | |
| 365 | Novartis Investigative Site | Le Coudray | France | 28630 | |
| 366 | Novartis Investigative Site | Lille | France | 59037 | |
| 367 | Novartis Investigative Site | Paris cedex 18 | France | 75877 | |
| 368 | Novartis Investigative Site | Paris | France | 75015 | |
| 369 | Novartis Investigative Site | Paris | France | 75571 | |
| 370 | Novartis Investigative Site | St Herblain | France | 44800 | |
| 371 | Novartis Investigative Site | Toulouse Cedex | France | 31059 | |
| 372 | Novartis Investigative Site | Tourcoing | France | 59200 | |
| 373 | Novartis Investigative Site | Valenciennes | France | 59300 | |
| 374 | Novartis Investigative Site | Mannheim | Baden-Wuerttemberg | Germany | 68305 |
| 375 | Novartis Investigative Site | Hannover | Niedersachsen | Germany | 30159 |
| 376 | Novartis Investigative Site | Bad Gottleuba | Sachsen | Germany | 01816 |
| 377 | Novartis Investigative Site | Dresden | Sachsen | Germany | 01099 |
| 378 | Novartis Investigative Site | Leipzig | Sachsen | Germany | 04315 |
| 379 | Novartis Investigative Site | Chemnitz | Saxony | Germany | 09113 |
| 380 | Novartis Investigative Site | Aachen | Germany | 52074 | |
| 381 | Novartis Investigative Site | Bad Homburg | Germany | 61348 | |
| 382 | Novartis Investigative Site | Bad Krozingen | Germany | 79189 | |
| 383 | Novartis Investigative Site | Bad Oeynhausen | Germany | 32545 | |
| 384 | Novartis Investigative Site | Bamberg | Germany | 96049 | |
| 385 | Novartis Investigative Site | Berlin | Germany | 10367 | |
| 386 | Novartis Investigative Site | Berlin | Germany | 10787 | |
| 387 | Novartis Investigative Site | Berlin | Germany | 10789 | |
| 388 | Novartis Investigative Site | Berlin | Germany | 13347 | |
| 389 | Novartis Investigative Site | Berlin | Germany | 13353 | |
| 390 | Novartis Investigative Site | Berlin | Germany | D 10559 | |
| 391 | Novartis Investigative Site | Bielefeld | Germany | 33604 | |
| 392 | Novartis Investigative Site | Chemnitz | Germany | 09122 | |
| 393 | Novartis Investigative Site | Dessau-Roßlau | Germany | 06846 | |
| 394 | Novartis Investigative Site | Dortmund | Germany | 44137 | |
| 395 | Novartis Investigative Site | Dresden | Germany | 01069 | |
| 396 | Novartis Investigative Site | Dresden | Germany | 01277 | |
| 397 | Novartis Investigative Site | Dresden | Germany | 01307 | |
| 398 | Novartis Investigative Site | Essen | Germany | 45277 | |
| 399 | Novartis Investigative Site | Essen | Germany | 45355 | |
| 400 | Novartis Investigative Site | Essen | Germany | 45359 | |
| 401 | Novartis Investigative Site | Frankfurt | Germany | 60590 | |
| 402 | Novartis Investigative Site | Frankfurt | Germany | 60594 | |
| 403 | Novartis Investigative Site | Gelnhausen | Germany | 63571 | |
| 404 | Novartis Investigative Site | Hamburg | Germany | 22041 | |
| 405 | Novartis Investigative Site | Hamburg | Germany | 22607 | |
| 406 | Novartis Investigative Site | Jena | Germany | 07740 | |
| 407 | Novartis Investigative Site | Kassel | Germany | 34121 | |
| 408 | Novartis Investigative Site | Koeln-Nippes | Germany | 50733 | |
| 409 | Novartis Investigative Site | Koeln | Germany | 50937 | |
| 410 | Novartis Investigative Site | Kuenzing | Germany | 94550 | |
| 411 | Novartis Investigative Site | Leipzig | Germany | 04103 | |
| 412 | Novartis Investigative Site | Loehne | Germany | 32584 | |
| 413 | Novartis Investigative Site | Lutherstadt Wittenberg | Germany | 06886 | |
| 414 | Novartis Investigative Site | Lüneburg | Germany | 21339 | |
| 415 | Novartis Investigative Site | Magdeburg | Germany | 39120 | |
| 416 | Novartis Investigative Site | Mannheim | Germany | 68165 | |
| 417 | Novartis Investigative Site | Meißen | Germany | 01662 | |
| 418 | Novartis Investigative Site | Muehldorf | Germany | 84453 | |
| 419 | Novartis Investigative Site | Muenchen | Germany | 80636 | |
| 420 | Novartis Investigative Site | Muenchen | Germany | 81377 | |
| 421 | Novartis Investigative Site | Muenster | Germany | 48149 | |
| 422 | Novartis Investigative Site | Potsdam | Germany | 14471 | |
| 423 | Novartis Investigative Site | Rüdersdorf | Germany | 15562 | |
| 424 | Novartis Investigative Site | Saint Ingbert - Oberwuerzbach | Germany | 66386 | |
| 425 | Novartis Investigative Site | Ulm | Germany | 89077 | |
| 426 | Novartis Investigative Site | Warendorf | Germany | 48231 | |
| 427 | Novartis Investigative Site | Weiden | Germany | 92637 | |
| 428 | Novartis Investigative Site | Athens | GR | Greece | 14233 |
| 429 | Novartis Investigative Site | Ioannina | GR | Greece | 455 00 |
| 430 | Novartis Investigative Site | Larissa | GR | Greece | 411 10 |
| 431 | Novartis Investigative Site | Athens | Greece | 115 21 | |
| 432 | Novartis Investigative Site | Athens | Greece | 115 27 | |
| 433 | Novartis Investigative Site | Chalkida | Greece | GR 341 00 | |
| 434 | Novartis Investigative Site | Thessaloniki | Greece | GR 54636 | |
| 435 | Novartis Investigative Site | Guatemala City | Guatemala | 01001 | |
| 436 | Novartis Investigative Site | Guatemala City | Guatemala | 01010 | |
| 437 | Novartis Investigative Site | Guatemala City | Guatemala | 01011 | |
| 438 | Novartis Investigative Site | Guatemala | Guatemala | 01001 | |
| 439 | Novartis Investigative Site | Hong Kong | Hong Kong | HONG KONG | |
| 440 | Novartis Investigative Site | Hongkong | Hong Kong | ||
| 441 | Novartis Investigative Site | Pecs | Baranya | Hungary | 7621 |
| 442 | Novartis Investigative Site | Pecs | Baranya | Hungary | 7624 |
| 443 | Novartis Investigative Site | Szekesfehervar | Fejer | Hungary | H-8000 |
| 444 | Novartis Investigative Site | Budapest | HUN | Hungary | 1204 |
| 445 | Novartis Investigative Site | Baja | Hungary | 6500 | |
| 446 | Novartis Investigative Site | Budapest | Hungary | 1085 | |
| 447 | Novartis Investigative Site | Budapest | Hungary | 1145 | |
| 448 | Novartis Investigative Site | Budapest | Hungary | H-1097 | |
| 449 | Novartis Investigative Site | Debrecen | Hungary | 4032 | |
| 450 | Novartis Investigative Site | Kistarcsa | Hungary | 2143 | |
| 451 | Novartis Investigative Site | Mako | Hungary | 6900 | |
| 452 | Novartis Investigative Site | Mateszalka | Hungary | 4700 | |
| 453 | Novartis Investigative Site | Miskolc | Hungary | 3526 | |
| 454 | Novartis Investigative Site | Nyiregyhaza | Hungary | 4400 | |
| 455 | Novartis Investigative Site | Szeged | Hungary | 6720 | |
| 456 | Novartis Investigative Site | Kopavogur | Iceland | 201 | |
| 457 | Novartis Investigative Site | Reykjavik | Iceland | IS-101 | |
| 458 | Novartis Investigative Site | Hyderabad | Andhra Pradesh | India | 500033 |
| 459 | Novartis Investigative Site | Guntur | Andhrapradesh | India | 522001 |
| 460 | Novartis Investigative Site | New Delhi | Delhi | India | 110 060 |
| 461 | Novartis Investigative Site | Ahmedabad | Gujarat | India | 380 060 |
| 462 | Novartis Investigative Site | Vadodara | Gujarat | India | 390022 |
| 463 | Novartis Investigative Site | Ahmedabad | Gujrat | India | 380060 |
| 464 | Novartis Investigative Site | Bengaluru | Karnataka | India | 560024 |
| 465 | Novartis Investigative Site | Mangalore | Karnataka | India | 575018 |
| 466 | Novartis Investigative Site | Manipal | Karnataka | India | 576104 |
| 467 | Novartis Investigative Site | Kochi | Kerala | India | 682 018 |
| 468 | Novartis Investigative Site | Kochi | Kerala | India | 682027 |
| 469 | Novartis Investigative Site | Kochi | Kerala | India | 682041 |
| 470 | Novartis Investigative Site | Kozhikode | Kerala | India | 673008 |
| 471 | Novartis Investigative Site | Mumbai | Maharashtra | India | 401107 |
| 472 | Novartis Investigative Site | Nagpur | Maharashtra | India | 440008 |
| 473 | Novartis Investigative Site | Nagpur | Maharashtra | India | 440009 |
| 474 | Novartis Investigative Site | Nagpur | Maharashtra | India | 440012 |
| 475 | Novartis Investigative Site | Nagpur | Maharashtra | India | 440033 |
| 476 | Novartis Investigative Site | Nashik | Maharashtra | India | 422 005 |
| 477 | Novartis Investigative Site | Pune | Maharashtra | India | 411 019 |
| 478 | Novartis Investigative Site | Pune | Maharashtra | India | 411004 |
| 479 | Novartis Investigative Site | Pune | Maharashtra | India | |
| 480 | Novartis Investigative Site | Bikaner | Rajasthan | India | 334003 |
| 481 | Novartis Investigative Site | Chennai | Tamil Nadu | India | 600081 |
| 482 | Novartis Investigative Site | Coimbatore | Tamil Nadu | India | 641037 |
| 483 | Novartis Investigative Site | Hyderabad | Telangana | India | 500034 |
| 484 | Novartis Investigative Site | Hyderabad | Telangana | India | 500082 |
| 485 | Novartis Investigative Site | Secunderabad | Telangana | India | 500003 |
| 486 | Novartis Investigative Site | Ghaziabad | Uttar Pradesh | India | |
| 487 | Novartis Investigative Site | Lucknow | Uttar Pradesh | India | 226003 |
| 488 | Novartis Investigative Site | Varanasi | Uttar Pradesh | India | 221010 |
| 489 | Novartis Investigative Site | DehraDun | Uttarakhand | India | 248001 |
| 490 | Novartis Investigative Site | Belagavi | India | 590010 | |
| 491 | Novartis Investigative Site | Coimbatore | India | 641 009 | |
| 492 | Novartis Investigative Site | New Delhi | India | 110025 | |
| 493 | Novartis Investigative Site | New Delhi | India | 110075 | |
| 494 | Novartis Investigative Site | Beer-Sheva | Israel | 8457108 | |
| 495 | Novartis Investigative Site | Haifa | Israel | 3339419 | |
| 496 | Novartis Investigative Site | Haifa | Israel | 3436212 | |
| 497 | Novartis Investigative Site | Jerusalem | Israel | 9112001 | |
| 498 | Novartis Investigative Site | Petach Tikva | Israel | 4941492 | |
| 499 | Novartis Investigative Site | Ramat Gan | Israel | 52621 | |
| 500 | Novartis Investigative Site | Tel Giborim, Holon | Israel | 58100 | |
| 501 | Novartis Investigative Site | Ancona | AN | Italy | 60128 |
| 502 | Novartis Investigative Site | Bergamo | BG | Italy | 24127 |
| 503 | Novartis Investigative Site | Bologna | BO | Italy | 40138 |
| 504 | Novartis Investigative Site | Brescia | BS | Italy | 25123 |
| 505 | Novartis Investigative Site | Cona | FE | Italy | 44100 |
| 506 | Novartis Investigative Site | Firenze | FI | Italy | FI |
| 507 | Novartis Investigative Site | Pozzilli | IS | Italy | 86077 |
| 508 | Novartis Investigative Site | Milano | MI | Italy | 20132 |
| 509 | Novartis Investigative Site | Milano | MI | Italy | 20138 |
| 510 | Novartis Investigative Site | Milano | MI | Italy | 20149 |
| 511 | Novartis Investigative Site | Milano | MI | Italy | 20162 |
| 512 | Novartis Investigative Site | Rozzano | MI | Italy | 20089 |
| 513 | Novartis Investigative Site | Palermo | PA | Italy | 90127 |
| 514 | Novartis Investigative Site | Perugia | PG | Italy | 06129 |
| 515 | Novartis Investigative Site | Pisa | PI | Italy | 56124 |
| 516 | Novartis Investigative Site | Pisa | PI | Italy | 56126 |
| 517 | Novartis Investigative Site | Roma | RM | Italy | 00100 |
| 518 | Novartis Investigative Site | Roma | RM | Italy | 00189 |
| 519 | Novartis Investigative Site | Salerno | SA | Italy | 84131 |
| 520 | Novartis Investigative Site | Varese | VA | Italy | 21100 |
| 521 | Novartis Investigative Site | Napoli | Italy | 80131 | |
| 522 | Novartis Investigative Site | Nagoya | Aichi | Japan | 453-8511 |
| 523 | Novartis Investigative Site | Seto-city | Aichi | Japan | 489-8642 |
| 524 | Novartis Investigative Site | Hirosaki | Aomori | Japan | 036 8563 |
| 525 | Novartis Investigative Site | Asahi | Chiba | Japan | 289-2511 |
| 526 | Novartis Investigative Site | Funabashi | Chiba | Japan | 273-8588 |
| 527 | Novartis Investigative Site | Matsudo-city | Chiba | Japan | 270-2251 |
| 528 | Novartis Investigative Site | Fukuoka city | Fukuoka | Japan | 814 0180 |
| 529 | Novartis Investigative Site | Kitakyushu-city | Fukuoka | Japan | 802-8555 |
| 530 | Novartis Investigative Site | Ogaki-city | Gifu | Japan | 503-8502 |
| 531 | Novartis Investigative Site | Kure-city | Hiroshima | Japan | 737-0023 |
| 532 | Novartis Investigative Site | Tsuchiura | Ibaraki | Japan | 300-0028 |
| 533 | Novartis Investigative Site | Kahoku-gun | Ishikawa | Japan | 920-0293 |
| 534 | Novartis Investigative Site | Kanazawa-city | Ishikawa | Japan | 920-8641 |
| 535 | Novartis Investigative Site | Komatsu | Ishikawa | Japan | 923-0961 |
| 536 | Novartis Investigative Site | Takamatsu city | Kagawa | Japan | 760 8557 |
| 537 | Novartis Investigative Site | Kawasaki | Kanagawa | Japan | 212-0021 |
| 538 | Novartis Investigative Site | Sagamihara-city | Kanagawa | Japan | 252-0375 |
| 539 | Novartis Investigative Site | Yokohama city | Kanagawa | Japan | 232 0024 |
| 540 | Novartis Investigative Site | Yokohama-city | Kanagawa | Japan | 236 0037 |
| 541 | Novartis Investigative Site | Sendai city | Miyagi | Japan | 980 0873 |
| 542 | Novartis Investigative Site | Miyhazaki-city | Miyazaki | Japan | 880-2102 |
| 543 | Novartis Investigative Site | Nagaoka-city | Niigata | Japan | 940-8621 |
| 544 | Novartis Investigative Site | Osaka city | Osaka | Japan | 530 0001 |
| 545 | Novartis Investigative Site | Osaka-city | Osaka | Japan | 543-0035 |
| 546 | Novartis Investigative Site | Kawaguchi-city | Saitama | Japan | 333-0842 |
| 547 | Novartis Investigative Site | Sayama-city | Saitama | Japan | 350-1305 |
| 548 | Novartis Investigative Site | Omihachiman | Shiga | Japan | 523-0082 |
| 549 | Novartis Investigative Site | Bunkyo ku | Tokyo | Japan | 113-8431 |
| 550 | Novartis Investigative Site | Chuo ku | Tokyo | Japan | 104-8560 |
| 551 | Novartis Investigative Site | Chuo-ku | Tokyo | Japan | 103-0027 |
| 552 | Novartis Investigative Site | Hachioji-city | Tokyo | Japan | 192-0918 |
| 553 | Novartis Investigative Site | Itabashi-ku | Tokyo | Japan | 173-8610 |
| 554 | Novartis Investigative Site | Ota-ku | Tokyo | Japan | 143 8541 |
| 555 | Novartis Investigative Site | Shinagawa-ku | Tokyo | Japan | 142-8666 |
| 556 | Novartis Investigative Site | Toshima-ku | Tokyo | Japan | 171-0014 |
| 557 | Novartis Investigative Site | Daegu | Dalseo Gu | Korea, Republic of | 42602 |
| 558 | Novartis Investigative Site | Wonju | Gangwon-Do | Korea, Republic of | 26426 |
| 559 | Novartis Investigative Site | Bundang Gu | Gyeonggi Do | Korea, Republic of | 13620 |
| 560 | Novartis Investigative Site | Suwon si | Gyeonggi Do | Korea, Republic of | 16499 |
| 561 | Novartis Investigative Site | Seoul | Korea | Korea, Republic of | 08308 |
| 562 | Novartis Investigative Site | Seoul | KOR | Korea, Republic of | 03181 |
| 563 | Novartis Investigative Site | Seoul | Seocho Gu | Korea, Republic of | 06591 |
| 564 | Novartis Investigative Site | Busan | Korea, Republic of | 49201 | |
| 565 | Novartis Investigative Site | Gwangju | Korea, Republic of | 61469 | |
| 566 | Novartis Investigative Site | Incheon | Korea, Republic of | 405 760 | |
| 567 | Novartis Investigative Site | Seoul | Korea, Republic of | 02841 | |
| 568 | Novartis Investigative Site | Seoul | Korea, Republic of | 03080 | |
| 569 | Novartis Investigative Site | Cuernavaca | Morelos | Mexico | 62250 |
| 570 | Novartis Investigative Site | Aguascalientes | Mexico | 20230 | |
| 571 | Novartis Investigative Site | Culiacan Sinaloa | Mexico | 80230 | |
| 572 | Novartis Investigative Site | Distrito Federal | Mexico | 14080 | |
| 573 | Novartis Investigative Site | San Luis Potosi | Mexico | 78200 | |
| 574 | Novartis Investigative Site | Apeldoorn | DZ | Netherlands | 7334 |
| 575 | Novartis Investigative Site | Arnhem | Gelderland | Netherlands | 6815 AD |
| 576 | Novartis Investigative Site | Sneek | The Netherlands | Netherlands | 8601 ZR |
| 577 | Novartis Investigative Site | Alkmaar | Netherlands | 1815 JD | |
| 578 | Novartis Investigative Site | Amersfoort | Netherlands | 3813 TZ | |
| 579 | Novartis Investigative Site | Amsterdam | Netherlands | 1090 HM | |
| 580 | Novartis Investigative Site | Amsterdam | Netherlands | 1105 AZ | |
| 581 | Novartis Investigative Site | Delft | Netherlands | 2625 AD | |
| 582 | Novartis Investigative Site | Den Haag | Netherlands | 2545 CH | |
| 583 | Novartis Investigative Site | Deventer | Netherlands | 7416 SE | |
| 584 | Novartis Investigative Site | Enschede | Netherlands | 7512KZ | |
| 585 | Novartis Investigative Site | Gouda | Netherlands | 2803 HH | |
| 586 | Novartis Investigative Site | Groningen | Netherlands | 9728 NZ | |
| 587 | Novartis Investigative Site | Hardenberg | Netherlands | 7770 AA | |
| 588 | Novartis Investigative Site | Heemstede | Netherlands | 2102 CW | |
| 589 | Novartis Investigative Site | Heerlen | Netherlands | 6419 | |
| 590 | Novartis Investigative Site | Leiden | Netherlands | 2300 RC | |
| 591 | Novartis Investigative Site | Leiderdorp | Netherlands | 2353 GA | |
| 592 | Novartis Investigative Site | Nijmegen | Netherlands | 6500 HB | |
| 593 | Novartis Investigative Site | Nijmegen | Netherlands | 6532 SZ | |
| 594 | Novartis Investigative Site | Tiel | Netherlands | 4002 WP | |
| 595 | Novartis Investigative Site | Tilburg | Netherlands | 5042 AD | |
| 596 | Novartis Investigative Site | Utrecht | Netherlands | 3584 CX | |
| 597 | Novartis Investigative Site | Venlo | Netherlands | 5912 BL | |
| 598 | Novartis Investigative Site | Zwolle | Netherlands | 8025 AB | |
| 599 | Novartis Investigative Site | Oslo | Norway | 0514 | |
| 600 | Novartis Investigative Site | Skedsmokorset | Norway | 2020 | |
| 601 | Novartis Investigative Site | San Miguel | Lima | Peru | 32 |
| 602 | Novartis Investigative Site | Tarnow | Malopolskie | Poland | 33-100 |
| 603 | Novartis Investigative Site | Warszawa | Mazowieckie | Poland | 00-892 |
| 604 | Novartis Investigative Site | Bielsko-Biala | Poland | 43-300 | |
| 605 | Novartis Investigative Site | Chrzanow | Poland | 32-500 | |
| 606 | Novartis Investigative Site | Gdansk | Poland | 80 952 | |
| 607 | Novartis Investigative Site | Gdynia | Poland | 81-157 | |
| 608 | Novartis Investigative Site | Kedzierzyn Kozle | Poland | 47 220 | |
| 609 | Novartis Investigative Site | Krakow | Poland | 30-082 | |
| 610 | Novartis Investigative Site | Krakow | Poland | 31 216 | |
| 611 | Novartis Investigative Site | Lodz | Poland | 91-347 | |
| 612 | Novartis Investigative Site | Lodz | Poland | 93-338 | |
| 613 | Novartis Investigative Site | Poznan | Poland | ||
| 614 | Novartis Investigative Site | Coimbra | Portugal | 3000 075 | |
| 615 | Novartis Investigative Site | Guimaraes | Portugal | 4835-044 | |
| 616 | Novartis Investigative Site | Setubal | Portugal | 2910-446 | |
| 617 | Novartis Investigative Site | Ponce | Puerto Rico | 00717-1322 | |
| 618 | Novartis Investigative Site | Iasi | Jud Iasi | Romania | 700732 |
| 619 | Novartis Investigative Site | Craiova | Jud. Dolj | Romania | 200497 |
| 620 | Novartis Investigative Site | Timisoara | Timis | Romania | 300362 |
| 621 | Novartis Investigative Site | Baia Mare | Romania | 430123 | |
| 622 | Novartis Investigative Site | Baia Mare | Romania | 430222 | |
| 623 | Novartis Investigative Site | Brasov | Romania | 500283 | |
| 624 | Novartis Investigative Site | Bucharest | Romania | 050098 | |
| 625 | Novartis Investigative Site | Bucuresti | Romania | 062272 | |
| 626 | Novartis Investigative Site | Buzau | Romania | 120133 | |
| 627 | Novartis Investigative Site | Iasi | Romania | 700503 | |
| 628 | Novartis Investigative Site | Chelyabinsk | Russian Federation | 454047 | |
| 629 | Novartis Investigative Site | Ekaterinburg | Russian Federation | 620028 | |
| 630 | Novartis Investigative Site | Ekaterinburg | Russian Federation | 620137 | |
| 631 | Novartis Investigative Site | Ivanovo | Russian Federation | 153012 | |
| 632 | Novartis Investigative Site | Izhevsk | Russian Federation | 426061 | |
| 633 | Novartis Investigative Site | Kemerovo | Russian Federation | 650002 | |
| 634 | Novartis Investigative Site | Kirov | Russian Federation | 610035 | |
| 635 | Novartis Investigative Site | Korolev Moscow Region | Russian Federation | 141060 | |
| 636 | Novartis Investigative Site | Krasnodar | Russian Federation | 350086 | |
| 637 | Novartis Investigative Site | Moscow | Russian Federation | 101990 | |
| 638 | Novartis Investigative Site | Moscow | Russian Federation | 117198 | |
| 639 | Novartis Investigative Site | Moscow | Russian Federation | 117997 | |
| 640 | Novartis Investigative Site | Moscow | Russian Federation | 121552 | |
| 641 | Novartis Investigative Site | Moscow | Russian Federation | 127473 | |
| 642 | Novartis Investigative Site | Moscow | Russian Federation | 143420 | |
| 643 | Novartis Investigative Site | Novosibirsk | Russian Federation | 630090 | |
| 644 | Novartis Investigative Site | Perm | Russian Federation | 614097 | |
| 645 | Novartis Investigative Site | Petrozavodsk | Russian Federation | 185019 | |
| 646 | Novartis Investigative Site | Rostov on Don | Russian Federation | 344022 | |
| 647 | Novartis Investigative Site | Ryazan | Russian Federation | 390039 | |
| 648 | Novartis Investigative Site | Saint Petersburg | Russian Federation | 194354 | |
| 649 | Novartis Investigative Site | Saint Petersburg | Russian Federation | 195067 | |
| 650 | Novartis Investigative Site | Saint Petersburg | Russian Federation | 195197 | |
| 651 | Novartis Investigative Site | Saint Petersburg | Russian Federation | 197341 | |
| 652 | Novartis Investigative Site | Saint Petersburg | Russian Federation | 198328 | |
| 653 | Novartis Investigative Site | Saint-Petersburg | Russian Federation | 196143 | |
| 654 | Novartis Investigative Site | Samara | Russian Federation | 443070 | |
| 655 | Novartis Investigative Site | Saratov | Russian Federation | 410012 | |
| 656 | Novartis Investigative Site | Saratov | Russian Federation | 410028 | |
| 657 | Novartis Investigative Site | Sochy | Russian Federation | 354002 | |
| 658 | Novartis Investigative Site | St Petersburg | Russian Federation | 192007 | |
| 659 | Novartis Investigative Site | St Petersburg | Russian Federation | 195197 | |
| 660 | Novartis Investigative Site | St Petersburg | Russian Federation | 196084 | |
| 661 | Novartis Investigative Site | St Petersburg | Russian Federation | 197136 | |
| 662 | Novartis Investigative Site | St.- Petersburg | Russian Federation | 197110 | |
| 663 | Novartis Investigative Site | Tomsk | Russian Federation | 634009 | |
| 664 | Novartis Investigative Site | Ulyanovsk | Russian Federation | 432063 | |
| 665 | Novartis Investigative Site | Vsevolozhsk | Russian Federation | 188640 | |
| 666 | Novartis Investigative Site | Yaroslavl | Russian Federation | 150047 | |
| 667 | Novartis Investigative Site | Yekaterinburg | Russian Federation | 620109 | |
| 668 | Novartis Investigative Site | Bardejovske Kupele | Bardejov | Slovakia | 085 01 |
| 669 | Novartis Investigative Site | Turcianske Teplice | Okr Turcianske Teplice | Slovakia | 03901 |
| 670 | Novartis Investigative Site | Banska Bystrica | Slovak Republic | Slovakia | 974 01 |
| 671 | Novartis Investigative Site | Komarno | Slovak Republic | Slovakia | 94501 |
| 672 | Novartis Investigative Site | Kosice | Slovak Republic | Slovakia | 040 22 |
| 673 | Novartis Investigative Site | Nitra | Slovak Republic | Slovakia | 949 01 |
| 674 | Novartis Investigative Site | Rimavska Sobota | Slovak Republic | Slovakia | 97901 |
| 675 | Novartis Investigative Site | Roznava | Slovak Republic | Slovakia | 04801 |
| 676 | Novartis Investigative Site | Handlova | SVK | Slovakia | 97251 |
| 677 | Novartis Investigative Site | Zilina | Zilinsky Kraj | Slovakia | 010 01 |
| 678 | Novartis Investigative Site | Bardejov | Slovakia | 085 01 | |
| 679 | Novartis Investigative Site | Bardejov | Slovakia | 08501 | |
| 680 | Novartis Investigative Site | Bratislava | Slovakia | 821 07 | |
| 681 | Novartis Investigative Site | Bratislava | Slovakia | 833 05 | |
| 682 | Novartis Investigative Site | Bratislava | Slovakia | 833 48 | |
| 683 | Novartis Investigative Site | Bratislava | Slovakia | 841 07 | |
| 684 | Novartis Investigative Site | Bratislava | Slovakia | 85101 | |
| 685 | Novartis Investigative Site | Bratislava | Slovakia | 85107 | |
| 686 | Novartis Investigative Site | Brezno | Slovakia | 97701 | |
| 687 | Novartis Investigative Site | Dolny Kubin | Slovakia | ||
| 688 | Novartis Investigative Site | Komarno | Slovakia | 94501 | |
| 689 | Novartis Investigative Site | Kosice | Slovakia | 040 01 | |
| 690 | Novartis Investigative Site | Lucenec | Slovakia | 98439 | |
| 691 | Novartis Investigative Site | Nitra | Slovakia | 949 01 | |
| 692 | Novartis Investigative Site | Nitra | Slovakia | 94901 | |
| 693 | Novartis Investigative Site | Nitra | Slovakia | 950 01 | |
| 694 | Novartis Investigative Site | Nove Zamky | Slovakia | 940 01 | |
| 695 | Novartis Investigative Site | Nove Zamky | Slovakia | 94002 | |
| 696 | Novartis Investigative Site | Piestany | Slovakia | 921 01 | |
| 697 | Novartis Investigative Site | Povazska Bystrica | Slovakia | 01701 | |
| 698 | Novartis Investigative Site | Presov | Slovakia | 080 01 | |
| 699 | Novartis Investigative Site | Presov | Slovakia | 08001 | |
| 700 | Novartis Investigative Site | Rimavska Sobota | Slovakia | 97901 | |
| 701 | Novartis Investigative Site | Svidnik | Slovakia | 089 01 | |
| 702 | Novartis Investigative Site | Trnava | Slovakia | 917 75 | |
| 703 | Novartis Investigative Site | Ljubljana | Slovenia | 1000 | |
| 704 | Novartis Investigative Site | Soweto | Gauteng | South Africa | 2013 |
| 705 | Novartis Investigative Site | Cape Town | Western Cape | South Africa | |
| 706 | Novartis Investigative Site | George | Western Cape | South Africa | 6529 |
| 707 | Novartis Investigative Site | Cape Town | South Africa | 7405 | |
| 708 | Novartis Investigative Site | Cape Town | South Africa | 7925 | |
| 709 | Novartis Investigative Site | Cape Town | South Africa | ||
| 710 | Novartis Investigative Site | Cordoba | Andalucia | Spain | 14004 |
| 711 | Novartis Investigative Site | Malaga | Andalucia | Spain | 29010 |
| 712 | Novartis Investigative Site | Sevilla | Andalucia | Spain | 41009 |
| 713 | Novartis Investigative Site | Sevilla | Andalucia | Spain | 41013 |
| 714 | Novartis Investigative Site | Sevilla | Andalucia | Spain | 41014 |
| 715 | Novartis Investigative Site | Hospitalet de Llobregat | Barcelona | Spain | 08907 |
| 716 | Novartis Investigative Site | Santander | Cantabria | Spain | 39008 |
| 717 | Novartis Investigative Site | Reus | Cataluna | Spain | 43201 |
| 718 | Novartis Investigative Site | Badalona | Catalunya | Spain | 08916 |
| 719 | Novartis Investigative Site | Barcelona | Catalunya | Spain | 08036 |
| 720 | Novartis Investigative Site | Valencia | Comunidad Valenciana | Spain | 46010 |
| 721 | Novartis Investigative Site | Caceres | Extremadura | Spain | 10003 |
| 722 | Novartis Investigative Site | Santiago de Compostela | Galicia | Spain | 15706 |
| 723 | Novartis Investigative Site | A Coruna | Spain | 15001 | |
| 724 | Novartis Investigative Site | Barcelona | Spain | 08025 | |
| 725 | Novartis Investigative Site | Huelva | Spain | 21007 | |
| 726 | Novartis Investigative Site | Madrid | Spain | 28040 | |
| 727 | Novartis Investigative Site | Madrid | Spain | 28041 | |
| 728 | Novartis Investigative Site | Zaragoza | Spain | 50009 | |
| 729 | Novartis Investigative Site | Goethenburg | Sweden | ||
| 730 | Novartis Investigative Site | Lund | Sweden | 22221 | |
| 731 | Novartis Investigative Site | Stockholm | Sweden | 14186 | |
| 732 | Novartis Investigative Site | Basel | Switzerland | 4031 | |
| 733 | Novartis Investigative Site | Bern | Switzerland | 3010 | |
| 734 | Novartis Investigative Site | Geneve 14 | Switzerland | 1211 | |
| 735 | Novartis Investigative Site | Lausanne | Switzerland | 1011 | |
| 736 | Novartis Investigative Site | Liestal | Switzerland | 4410 | |
| 737 | Novartis Investigative Site | Zuerich | Switzerland | 8091 | |
| 738 | Novartis Investigative Site | Taichung | Taiwan ROC | Taiwan | 40201 |
| 739 | Novartis Investigative Site | Hsinchu | Taiwan | 30069 | |
| 740 | Novartis Investigative Site | Kaohsiung City | Taiwan | 83301 | |
| 741 | Novartis Investigative Site | Kaohsiung | Taiwan | 80756 | |
| 742 | Novartis Investigative Site | Keelung City | Taiwan | 20401 | |
| 743 | Novartis Investigative Site | Tainan | Taiwan | 71004 | |
| 744 | Novartis Investigative Site | Taipei | Taiwan | 11217 | |
| 745 | Novartis Investigative Site | Taoyuan | Taiwan | 33305 | |
| 746 | Novartis Investigative Site | Yilan | Taiwan | 26058 | |
| 747 | Novartis Investigative Site | Ankara | Cankaya | Turkey | 06100 |
| 748 | Novartis Investigative Site | Eskisehir | Meselik | Turkey | 26480 |
| 749 | Novartis Investigative Site | Haydarpasa Istanbul | Turkey | 34668 | |
| 750 | Novartis Investigative Site | Istanbul | Turkey | 34304 | |
| 751 | Novartis Investigative Site | Izmir | Turkey | 35340 | |
| 752 | Novartis Investigative Site | Izmir | Turkey | ||
| 753 | Novartis Investigative Site | Mersin | Turkey | 33079 | |
| 754 | Novartis Investigative Site | Samsun | Turkey | 55090 | |
| 755 | Novartis Investigative Site | Stockton on Tees | Cleveland | United Kingdom | TS19 8PE |
| 756 | Novartis Investigative Site | Dorchester | Dorset | United Kingdom | DT1 2JY |
| 757 | Novartis Investigative Site | London | GBR | United Kingdom | EC1M 6BQ |
| 758 | Novartis Investigative Site | London | Greater London | United Kingdom | EN3 4GS |
| 759 | Novartis Investigative Site | Preston | Lancashire | United Kingdom | PR2 9QB |
| 760 | Novartis Investigative Site | Rochdale | North Manchester | United Kingdom | OL11 4AU |
| 761 | Novartis Investigative Site | Portadown | Nothern Ireland | United Kingdom | BT63 5QQ |
| 762 | Novartis Investigative Site | Dundee | Perthshire | United Kingdom | DD1 9SY |
| 763 | Novartis Investigative Site | Taunton | Somerset | United Kingdom | TA1 5DA |
| 764 | Novartis Investigative Site | Chertsey | Surrey | United Kingdom | KT160PZ |
| 765 | Novartis Investigative Site | Sketty | Swansea | United Kingdom | SA2 8PP |
| 766 | Novartis Investigative Site | Sunderland | Tyne And Wear | United Kingdom | SR4 7TP |
| 767 | Novartis Investigative Site | Cardiff | Wales | United Kingdom | CF5 4AD |
| 768 | Novartis Investigative Site | Rhyl | Wales | United Kingdom | LL18 5UJ |
| 769 | Novartis Investigative Site | Chichester | West Sussex | United Kingdom | PO19 6SE |
| 770 | Novartis Investigative Site | Birmingham | United Kingdom | B9 5SS | |
| 771 | Novartis Investigative Site | Bournemouth | United Kingdom | BH7 7DW | |
| 772 | Novartis Investigative Site | Bristol | United Kingdom | BS2 8HN | |
| 773 | Novartis Investigative Site | Cardiff | United Kingdom | CF64 2XX | |
| 774 | Novartis Investigative Site | Chesterfield | United Kingdom | S40 4AA | |
| 775 | Novartis Investigative Site | Edinburgh | United Kingdom | ED16 4SA | |
| 776 | Novartis Investigative Site | Glasgow | United Kingdom | G20 0XA | |
| 777 | Novartis Investigative Site | Harrow | United Kingdom | HA1 3UJ | |
| 778 | Novartis Investigative Site | Leicester | United Kingdom | LE3 9QP | |
| 779 | Novartis Investigative Site | Liverpool | United Kingdom | L7 8XP | |
| 780 | Novartis Investigative Site | Londonderry | United Kingdom | BT47 1SB | |
| 781 | Novartis Investigative Site | London | United Kingdom | W12 0HS | |
| 782 | Novartis Investigative Site | Manchester | United Kingdom | M13 9NT | |
| 783 | Novartis Investigative Site | Middlesbrough | United Kingdom | TS4 3BW | |
| 784 | Novartis Investigative Site | Middlesex | United Kingdom | UB9 6JH | |
| 785 | Novartis Investigative Site | Newcastle upon Tyne | United Kingdom | NE7 7DN | |
| 786 | Novartis Investigative Site | Newport | United Kingdom | NP20 2UB | |
| 787 | Novartis Investigative Site | Norwich | United Kingdom | NR4 7UY | |
| 788 | Novartis Investigative Site | Plymouth | United Kingdom | PL6 8DH | |
| 789 | Novartis Investigative Site | Sheffield | United Kingdom | S5 7AU | |
| 790 | Novartis Investigative Site | Tyne And Wear | United Kingdom | NE29 8NH | |
| 791 | Novartis Investigative Site | West Midlands | United Kingdom | B71 4HJ | |
| 792 | Novartis Investigative Site | Wiltshire | United Kingdom | SN15 2SB | |
| 793 | Novartis Investigative Site | Wrexham | United Kingdom | LL13 7TD |
Sponsors and Collaborators
- Novartis Pharmaceuticals
Investigators
- Study Director: Novartis Pharmaceuticals, Novartis Pharmaceuticals
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Novartis Pharmaceuticals
ClinicalTrials.gov Identifier:
NCT04023552
Other Study ID Numbers:
- CTQJ230A12301
- CTQJ230A12301
- 2019-001076-11
First Posted:
Jul 17, 2019
Last Update Posted:
Aug 25, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Novartis Pharmaceuticals
Additional relevant MeSH terms: