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Effects of Angiotensin Receptor Antagonist on Prohibiting Cardiovascular Events on Hemodialysis Patients

Sponsor
Saitama Medical University (Other)
Overall Status
Completed
CT.gov ID
NCT00530595
Collaborator
(none)

Study Details

Study Description

Brief Summary

Cardiovascular disease is a leading cause of mortality in patients on hemodialysis therapy (HD), accounting for 30 to 50% of all death. Although angiotensin receptor blockers (ARBs) are effective for patients with diabetes and chronic kidney disease in reducing or preventing cardiovascular diseases, there has been no decisive study that demonstrated treatment with ARBs is effective in patients on HD.

Condition or Disease Intervention/Treatment Phase
  • Drug: candesartan or valsartan or losartan
 N/A

Study Design

Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    30 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • 30 to 80 years of age

    • Receiving hemodialysis at least 12 months and less than 5 years

    • Pre-dialysis systolic blood pressure was more than 160 mmHg, or more than 150 mmHg if the patients received antihypertensive agents.

    Exclusion Criteria:
    • Use of angiotensin receptor blocker or angiotensin converting enzyme inhibitor

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Saitama Medical University

    Investigators

    • Study Director: Hiromichi Suzuki, MD, PhD, Department of Nephrology, Saitama Medical University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00530595
    Other Study ID Numbers:
    • S-01
    First Posted:
    Sep 17, 2007
    Last Update Posted:
    Sep 17, 2007
    Last Verified:
    Sep 1, 2007
    Keywords provided by , ,
    hemodialysis
    Additional relevant MeSH terms:
    Cardiovascular Diseases
    Losartan
    Valsartan
    Candesartan

    Study Results

    No Results Posted as of Sep 17, 2007