Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health
Study Details
Study Description
Brief Summary
The disruption of colonic microbiota has been linked to a number of diseases, mainly cardiovascular and kidney diseases. One possible means to improve the microbiota is to increase dietary fiber intake as the intake of dietary fiber shifts the fermentation from proteolytic saccharolytic fermentation.
Beta-glucans are soluble dietary fibers mainly found in oats and barley. Results from previous studies suggest that the consumption of barley reduces the risk of cardiovascular and kidney diseases. Therefore, this study will explore the effect of barley beta-glucans on markers of Cardiovascular and Renal health.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Whole wheat bread Whole wheat bread will be used as control bread. |
Other: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health
Intervention will involve intake of 50% barley substituted wheat bread.
|
| Experimental: Barley supplemented wheat bread Barley supplemented wheat bread (50% substitution) will be used as experimental bread. |
Other: Effect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health
Intervention will involve intake of 50% barley substituted wheat bread.
|
Outcome Measures
Primary Outcome Measures
- Change in Serum Thiobarbituric acid reactive substances (TBARs) from baseline to 4 weeks [Baseline and after 4 weeks]
- Change in Serum Total antioxidant capacity (TAC) from baseline to 4 weeks [Baseline and after 4 weeks]
- Change in Serum Nitric oxide from baseline to 4 weeks [Baseline and after 4 weeks]
- change in Serum E-selectin from baseline to 4 weeks [Baseline and after 4 weeks]
- Change in Serum P-cresyl sulfate from baseline to 4 weeks [Baseline and after 4 weeks]
- Change in Serum Indoxyl sulfate from baseline to 4 weeks [Baseline and after 4 weeks]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Healthy individuals of age 18 years or older
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BMI ranged between 18.5 and 24.9
Exclusion Criteria:
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Celiac disease, Cancer, Diabetes , cardiovascular diseases
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Gastro intestinal tract disease
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Pregnant women
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Use of pre-, pro- or antibiotics 15 days before the enrollment into the study
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Food allergy to food used in the trial
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Khyber Medical University, Peshawar | Peshawar | KPK | Pakistan | 25000 |
Sponsors and Collaborators
- Khyber Medical University Peshawar
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- Bacchetti T, Tullii D, Masciangelo S, Gesuita R, Skrami E, Brugè F, Silvestri S, Orlando P, Tiano L, Ferretti G. Effect of a barley-vegetable soup on plasma carotenoids and biomarkers of cardiovascular disease. J Clin Biochem Nutr. 2015 Jul;57(1):66-73. doi: 10.3164/jcbn.15-11. Epub 2015 Jun 5.
- Cosola C, De Angelis M, Rocchetti MT, Montemurno E, Maranzano V, Dalfino G, Manno C, Zito A, Gesualdo M, Ciccone MM, Gobbetti M, Gesualdo L. Beta-Glucans Supplementation Associates with Reduction in P-Cresyl Sulfate Levels and Improved Endothelial Vascular Reactivity in Healthy Individuals. PLoS One. 2017 Jan 20;12(1):e0169635. doi: 10.1371/journal.pone.0169635. eCollection 2017.
- Gaesser GA, Rodriguez J, Patrie JT, Whisner CM, Angadi SS. Effects of Glycemic Index and Cereal Fiber on Postprandial Endothelial Function, Glycemia, and Insulinemia in Healthy Adults. Nutrients. 2019 Oct 6;11(10). pii: E2387. doi: 10.3390/nu11102387.
- Sirich TL, Plummer NS, Gardner CD, Hostetter TH, Meyer TW. Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients. Clin J Am Soc Nephrol. 2014 Sep 5;9(9):1603-10. doi: 10.2215/CJN.00490114. Epub 2014 Aug 21.
- ASRB001313/EB/IBMS