ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
Sponsor
Novo Nordisk A/S (Industry)
Overall Status
Recruiting
CT.gov ID
NCT05021835
Collaborator
(none)
6,200
486
2
49.5
12.8
0.3
Study Details
Study Description
Brief Summary
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same.
Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe.
Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly.
The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits.
Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram).
Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 3 |
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
6200 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose:
Treatment
Official Title:
ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation
Actual Study Start Date
:
Aug 30, 2021
Anticipated Primary Completion Date
:
Sep 24, 2025
Anticipated Study Completion Date
:
Oct 15, 2025
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: ziltivekimab 15 mg Participants will receive ziltivekimab 15 mg for up to 4 years. |
Drug: Ziltivekimab
Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care
|
| Placebo Comparator: Placebo (ziltivekimab) Participants will receive placebo (ziltivekimab) for up to 4 years. |
Drug: Placebo (ziltivekimab)
Administered subcutaneously (s.c., under skin) once-monthly and added to standard of care
|
Outcome Measures
Primary Outcome Measures
- Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke. [From randomisation (month 0) to end-of-study (up to 48 months)]
Months
Secondary Outcome Measures
- Time to first occurrence of 3-point MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation [From randomisation (month 0) to end-of-study (up to 48 months)]
Months
- Number of hospitalisations for heart failure or urgent heart failure visit. [From randomisation (month 0) to end-of-study (up to 48 months)]
Count
- Time to occurrence of all-cause mortality. [From randomisation (month 0) to end-of-study (up to 48 months)]
Months
- Time to first occ. of composite Chronic Kidney Disease (CKD) endpoint consisting of onset of persistent at least 40% reduction in estimated glomerular filtration rate (eGFR) CKD-Epidemiology Collaboration (CKD-EPI) compared with baseline, kidney failure [From randomisation (month 0) to end-of-study (up to 48 months)]
Months
- Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint. [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Time to first occurrence of MI (fatal and non-fatal). [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Time to first occurrence of stroke (fatal and non-fatal). [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke. [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Time to first occurrence of an expanded composite kidney endpoint consisting of: CV death, onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure. [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Time to first occurrence of coronary revascularisation [From randomisation (month 0) to end-of-study (up to 48 months).]
Months
- Change in Urinary Abumin-to-Ceatinine ratio (UACR). [From randomisation (month 0) to 2 years (24 months).]
Percentage
- Change in eGFR (CKD-EPI)) [From randomisation (month 0) to 2 years (24 months)]
mL/min/1.73 m^2
- Annual rate of change in eGFR (CKD-EPI) (total eGFR slope) [From randomisation (month 0) to end-of-study (up to 48 months).]
mL/min/1.73 m^2/ year
- Change in high-sensitivity C-reactive protein (hs-CRP) [From randomisation (month 0) to 2 years (24 months]
Percentage
- Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP) [From randomisation (month 0) to 2 years (24 months)]
Percentage
- Change in left ventricular ejection fraction (LVEF) [From randomisation (month 0) to 2 years (24 months)]
Percentage
- Number of events of atrial fibrillation [From randomisation (month 0) to end-of-study (up to 48 months).]
Count
- Number of hospitalisations with infection as primary cause or death due to infection. [From randomisation (month 0) to end-of-study (up to 48 months).]
Count
- Change in Short Form 36 (SF-36) Physical Component Score (PCS) [From randomisation (month 0) to 2 years (24 months)]
Score on scale
Eligibility Criteria
Criteria
Ages Eligible for Study:
18 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
Estimated glomerular filtration rate (eGFR) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation)
-
Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 mg/L at screening (visit 1)
-
Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:
-
Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound.
-
Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis).
Exclusion Criteria:
-
Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.
-
Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).
-
Planned coronary, carotid or peripheral artery revascularisation known on the day of screening (visit 1).
-
Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit
- or any major surgical procedure planned at the time of randomisation (visit 2).
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Novo Nordisk Investigational Site | Birmingham | Alabama | United States | 35294 |
| 2 | Novo Nordisk Investigational Site | Montgomery | Alabama | United States | 36106 |
| 3 | Novo Nordisk Investigational Site | Glendale | Arizona | United States | 85308 |
| 4 | Novo Nordisk Investigational Site | Mesa | Arizona | United States | 85210 |
| 5 | Novo Nordisk Investigational Site | Searcy | Arkansas | United States | 72143 |
| 6 | Novo Nordisk Investigational Site | Covina | California | United States | 91723 |
| 7 | Novo Nordisk Investigational Site | La Jolla | California | United States | 92037 |
| 8 | Novo Nordisk Investigational Site | La Mesa | California | United States | 91942 |
| 9 | Novo Nordisk Investigational Site | Lancaster | California | United States | 93534 |
| 10 | Novo Nordisk Investigational Site | Loma Linda | California | United States | 92357 |
| 11 | Novo Nordisk Investigational Site | Los Alamitos | California | United States | 90720 |
| 12 | Novo Nordisk Investigational Site | Los Angeles | California | United States | 90010 |
| 13 | Novo Nordisk Investigational Site | Lynwood | California | United States | 90262 |
| 14 | Novo Nordisk Investigational Site | Northridge | California | United States | 91325 |
| 15 | Novo Nordisk Investigational Site | Palm Springs | California | United States | 92262 |
| 16 | Novo Nordisk Investigational Site | Riverside | California | United States | 92503 |
| 17 | Novo Nordisk Investigational Site | S. Gate | California | United States | 90280 |
| 18 | Novo Nordisk Investigational Site | San Dimas | California | United States | 91773 |
| 19 | Novo Nordisk Investigational Site | Torrance | California | United States | 90502 |
| 20 | Novo Nordisk Investigational Site | Bridgeport | Connecticut | United States | 06610 |
| 21 | Novo Nordisk Investigational Site | West Haven | Connecticut | United States | 06516 |
| 22 | Novo Nordisk Investigational Site | Boca Raton | Florida | United States | 33434 |
| 23 | Novo Nordisk Investigational Site | Boynton Beach | Florida | United States | 33437 |
| 24 | Novo Nordisk Investigational Site | Clearwater | Florida | United States | 33756 |
| 25 | Novo Nordisk Investigational Site | Fleming Island | Florida | United States | 32003 |
| 26 | Novo Nordisk Investigational Site | Fort Lauderdale | Florida | United States | 33312 |
| 27 | Novo Nordisk Investigational Site | Hollywood | Florida | United States | 33021 |
| 28 | Novo Nordisk Investigational Site | Hollywood | Florida | United States | 33024 |
| 29 | Novo Nordisk Investigational Site | Jacksonville | Florida | United States | 32204 |
| 30 | Novo Nordisk Investigational Site | Jacksonville | Florida | United States | 32216 |
| 31 | Novo Nordisk Investigational Site | Jacksonville | Florida | United States | 32258 |
| 32 | Novo Nordisk Investigational Site | Miami Lakes | Florida | United States | 33014 |
| 33 | Novo Nordisk Investigational Site | Miami | Florida | United States | 33126 |
| 34 | Novo Nordisk Investigational Site | Miami | Florida | United States | 33130 |
| 35 | Novo Nordisk Investigational Site | Miami | Florida | United States | 33155 |
| 36 | Novo Nordisk Investigational Site | New Port Richey | Florida | United States | 34652 |
| 37 | Novo Nordisk Investigational Site | Palm Harbor | Florida | United States | 34684 |
| 38 | Novo Nordisk Investigational Site | Pembroke Pines | Florida | United States | 33024 |
| 39 | Novo Nordisk Investigational Site | Pembroke Pines | Florida | United States | 33027 |
| 40 | Novo Nordisk Investigational Site | Port Charlotte | Florida | United States | 33952 |
| 41 | Novo Nordisk Investigational Site | Port Charlotte | Florida | United States | 33952 |
| 42 | Novo Nordisk Investigational Site | Saint Augustine | Florida | United States | 32080 |
| 43 | Novo Nordisk Investigational Site | Saint Augustine | Florida | United States | 32086 |
| 44 | Novo Nordisk Investigational Site | Winter Haven | Florida | United States | 33880 |
| 45 | Novo Nordisk Investigational Site | Albany | Georgia | United States | 31707 |
| 46 | Novo Nordisk Investigational Site | Augusta | Georgia | United States | 30904 |
| 47 | Novo Nordisk Investigational Site | Conyers | Georgia | United States | 30094 |
| 48 | Novo Nordisk Investigational Site | Fayetteville | Georgia | United States | 30214 |
| 49 | Novo Nordisk Investigational Site | Johns Creek | Georgia | United States | 30024 |
| 50 | Novo Nordisk Investigational Site | Roswell | Georgia | United States | 30076 |
| 51 | Novo Nordisk Investigational Site | Savannah | Georgia | United States | 31406 |
| 52 | Novo Nordisk Investigational Site | Nampa | Idaho | United States | 83686-6011 |
| 53 | Novo Nordisk Investigational Site | Arlington Heights | Illinois | United States | 60005 |
| 54 | Novo Nordisk Investigational Site | Chicago | Illinois | United States | 60643 |
| 55 | Novo Nordisk Investigational Site | Gurnee | Illinois | United States | 60031 |
| 56 | Novo Nordisk Investigational Site | Hazel Crest | Illinois | United States | 60429 |
| 57 | Novo Nordisk Investigational Site | Skokie | Illinois | United States | 60077 |
| 58 | Novo Nordisk Investigational Site | Springfield | Illinois | United States | 62711 |
| 59 | Novo Nordisk Investigational Site | Wauconda | Illinois | United States | 60084 |
| 60 | Novo Nordisk Investigational Site | Evansville | Indiana | United States | 47714 |
| 61 | Novo Nordisk Investigational Site | Valparaiso | Indiana | United States | 46383 |
| 62 | Novo Nordisk Investigational Site | Overland Park | Kansas | United States | 66211 |
| 63 | Novo Nordisk Investigational Site | Topeka | Kansas | United States | 66606 |
| 64 | Novo Nordisk Investigational Site | Lexington | Kentucky | United States | 40502 |
| 65 | Novo Nordisk Investigational Site | Lexington | Kentucky | United States | 40503 |
| 66 | Novo Nordisk Investigational Site | Louisville | Kentucky | United States | 40205 |
| 67 | Novo Nordisk Investigational Site | Bossier City | Louisiana | United States | 71111 |
| 68 | Novo Nordisk Investigational Site | Monroe | Louisiana | United States | 71201 |
| 69 | Novo Nordisk Investigational Site | Shreveport | Louisiana | United States | 71105 |
| 70 | Novo Nordisk Investigational Site | Slidell | Louisiana | United States | 70458 |
| 71 | Novo Nordisk Investigational Site | West Monroe | Louisiana | United States | 71291 |
| 72 | Novo Nordisk Investigational Site | Annapolis | Maryland | United States | 21401 |
| 73 | Novo Nordisk Investigational Site | Bethesda | Maryland | United States | 20814 |
| 74 | Novo Nordisk Investigational Site | Camp Springs | Maryland | United States | 20746 |
| 75 | Novo Nordisk Investigational Site | Boston | Massachusetts | United States | 02115-5804 |
| 76 | Novo Nordisk Investigational Site | Haverhill | Massachusetts | United States | 01830 |
| 77 | Novo Nordisk Investigational Site | Detroit | Michigan | United States | 48202 |
| 78 | Novo Nordisk Investigational Site | Flint | Michigan | United States | 48532 |
| 79 | Novo Nordisk Investigational Site | Grand Rapids | Michigan | United States | 49546 |
| 80 | Novo Nordisk Investigational Site | Petoskey | Michigan | United States | 49770 |
| 81 | Novo Nordisk Investigational Site | Minneapolis | Minnesota | United States | 55407 |
| 82 | Novo Nordisk Investigational Site | Minneapolis | Minnesota | United States | 55455 |
| 83 | Novo Nordisk Investigational Site | Kansas City | Missouri | United States | 64111 |
| 84 | Novo Nordisk Investigational Site | Saint Louis | Missouri | United States | 63128 |
| 85 | Novo Nordisk Investigational Site | Saint Louis | Missouri | United States | 63136 |
| 86 | Novo Nordisk Investigational Site | Lincoln | Nebraska | United States | 68526 |
| 87 | Novo Nordisk Investigational Site | Omaha | Nebraska | United States | 68105 |
| 88 | Novo Nordisk Investigational Site | Omaha | Nebraska | United States | 68114 |
| 89 | Novo Nordisk Investigational Site | Omaha | Nebraska | United States | 68198-3020 |
| 90 | Novo Nordisk Investigational Site | Las Vegas | Nevada | United States | 89128 |
| 91 | Novo Nordisk Investigational Site | Bridgewater | New Jersey | United States | 08807-3064 |
| 92 | Novo Nordisk Investigational Site | Albuquerque | New Mexico | United States | 87106 |
| 93 | Novo Nordisk Investigational Site | Northport | New York | United States | 11768 |
| 94 | Novo Nordisk Investigational Site | Ridgewood | New York | United States | 11385 |
| 95 | Novo Nordisk Investigational Site | Saratoga Springs | New York | United States | 12866 |
| 96 | Novo Nordisk Investigational Site | West Seneca | New York | United States | 14224 |
| 97 | Novo Nordisk Investigational Site | Westfield | New York | United States | 14787 |
| 98 | Novo Nordisk Investigational Site | Asheville | North Carolina | United States | 28801 |
| 99 | Novo Nordisk Investigational Site | Burlington | North Carolina | United States | 27215 |
| 100 | Novo Nordisk Investigational Site | Chapel Hill | North Carolina | United States | 27599 |
| 101 | Novo Nordisk Investigational Site | Charlotte | North Carolina | United States | 28207 |
| 102 | Novo Nordisk Investigational Site | Charlotte | North Carolina | United States | 28210 |
| 103 | Novo Nordisk Investigational Site | Greensboro | North Carolina | United States | 27408 |
| 104 | Novo Nordisk Investigational Site | Greenville | North Carolina | United States | 27834 |
| 105 | Novo Nordisk Investigational Site | Morehead City | North Carolina | United States | 28557-4346 |
| 106 | Novo Nordisk Investigational Site | Fargo | North Dakota | United States | 58104 |
| 107 | Novo Nordisk Investigational Site | Cleveland | Ohio | United States | 44106 |
| 108 | Novo Nordisk Investigational Site | Maumee | Ohio | United States | 43537 |
| 109 | Novo Nordisk Investigational Site | Bethlehem | Pennsylvania | United States | 18017 |
| 110 | Novo Nordisk Investigational Site | Philadelphia | Pennsylvania | United States | 19114 |
| 111 | Novo Nordisk Investigational Site | Philadelphia | Pennsylvania | United States | 19144 |
| 112 | Novo Nordisk Investigational Site | Lincoln | Rhode Island | United States | 02865 |
| 113 | Novo Nordisk Investigational Site | Fort Mill | South Carolina | United States | 29707 |
| 114 | Novo Nordisk Investigational Site | Greenville | South Carolina | United States | 29615 |
| 115 | Novo Nordisk Investigational Site | Myrtle Beach | South Carolina | United States | 29588 |
| 116 | Novo Nordisk Investigational Site | Spartanburg | South Carolina | United States | 29303 |
| 117 | Novo Nordisk Investigational Site | Chattanooga | Tennessee | United States | 37411 |
| 118 | Novo Nordisk Investigational Site | Greeneville | Tennessee | United States | 37745 |
| 119 | Novo Nordisk Investigational Site | Knoxville | Tennessee | United States | 37934 |
| 120 | Novo Nordisk Investigational Site | Memphis | Tennessee | United States | 38119 |
| 121 | Novo Nordisk Investigational Site | Powell | Tennessee | United States | 37849 |
| 122 | Novo Nordisk Investigational Site | Arlington | Texas | United States | 76012-4637 |
| 123 | Novo Nordisk Investigational Site | Corpus Christi | Texas | United States | 78414 |
| 124 | Novo Nordisk Investigational Site | Dallas | Texas | United States | 75208 |
| 125 | Novo Nordisk Investigational Site | Dallas | Texas | United States | 75230 |
| 126 | Novo Nordisk Investigational Site | Dallas | Texas | United States | 75235 |
| 127 | Novo Nordisk Investigational Site | Edinburg | Texas | United States | 78539 |
| 128 | Novo Nordisk Investigational Site | El Paso | Texas | United States | 79935 |
| 129 | Novo Nordisk Investigational Site | Forney | Texas | United States | 75126 |
| 130 | Novo Nordisk Investigational Site | Fort Worth | Texas | United States | 76132 |
| 131 | Novo Nordisk Investigational Site | Fort Worth | Texas | United States | 76133 |
| 132 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77024 |
| 133 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77030 |
| 134 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77043 |
| 135 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77054 |
| 136 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77079 |
| 137 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77084 |
| 138 | Novo Nordisk Investigational Site | Houston | Texas | United States | 77090 |
| 139 | Novo Nordisk Investigational Site | Live Oak | Texas | United States | 78233 |
| 140 | Novo Nordisk Investigational Site | Longview | Texas | United States | 75605 |
| 141 | Novo Nordisk Investigational Site | Lufkin | Texas | United States | 75904 |
| 142 | Novo Nordisk Investigational Site | Rockwall | Texas | United States | 75032 |
| 143 | Novo Nordisk Investigational Site | San Antonio | Texas | United States | 78212 |
| 144 | Novo Nordisk Investigational Site | San Antonio | Texas | United States | 78215 |
| 145 | Novo Nordisk Investigational Site | San Antonio | Texas | United States | 78224 |
| 146 | Novo Nordisk Investigational Site | San Antonio | Texas | United States | 78230 |
| 147 | Novo Nordisk Investigational Site | San Marcos | Texas | United States | 78666 |
| 148 | Novo Nordisk Investigational Site | Sugar Land | Texas | United States | 77478 |
| 149 | Novo Nordisk Investigational Site | Waco | Texas | United States | 76708 |
| 150 | Novo Nordisk Investigational Site | Webster | Texas | United States | 77598 |
| 151 | Novo Nordisk Investigational Site | Forest | Virginia | United States | 24551 |
| 152 | Novo Nordisk Investigational Site | Norfolk | Virginia | United States | 23510-2015 |
| 153 | Novo Nordisk Investigational Site | Richmond | Virginia | United States | 23298-5058 |
| 154 | Novo Nordisk Investigational Site | Salem | Virginia | United States | 24153-6404 |
| 155 | Novo Nordisk Investigational Site | Winchester | Virginia | United States | 22601-3834 |
| 156 | Novo Nordisk Investigational Site | Spokane | Washington | United States | 99204 |
| 157 | Novo Nordisk Investigational Site | Wausau | Wisconsin | United States | 54401 |
| 158 | Novo Nordisk Investigational Site | Buenos Aires | Argentina | B6000BHA | |
| 159 | Novo Nordisk Investigational Site | Caba | Argentina | C1213 | |
| 160 | Novo Nordisk Investigational Site | Caba | Argentina | C1428ART | |
| 161 | Novo Nordisk Investigational Site | Caba | Argentina | C1440CFD | |
| 162 | Novo Nordisk Investigational Site | Ciudad Autónoma de Buenos Aire | Argentina | 1425 | |
| 163 | Novo Nordisk Investigational Site | Mar del Plata | Argentina | B7600GNY | |
| 164 | Novo Nordisk Investigational Site | Quilmes - Buenos Aires | Argentina | B1878DVB | |
| 165 | Novo Nordisk Investigational Site | San Nicolás | Argentina | B2900 | |
| 166 | Novo Nordisk Investigational Site | Garran | Australian Capital Territory | Australia | 2605 |
| 167 | Novo Nordisk Investigational Site | Gosford | New South Wales | Australia | 2250 |
| 168 | Novo Nordisk Investigational Site | Milton | Queensland | Australia | 4064 |
| 169 | Novo Nordisk Investigational Site | Adelaide | South Australia | Australia | 5000 |
| 170 | Novo Nordisk Investigational Site | Clayton | Victoria | Australia | 3168 |
| 171 | Novo Nordisk Investigational Site | Fitzroy | Victoria | Australia | 3065 |
| 172 | Novo Nordisk Investigational Site | Geelong | Victoria | Australia | 3220 |
| 173 | Novo Nordisk Investigational Site | Joondalup | Western Australia | Australia | 6027 |
| 174 | Novo Nordisk Investigational Site | Aalst | Belgium | 9300 | |
| 175 | Novo Nordisk Investigational Site | Brasschaat | Belgium | 2930 | |
| 176 | Novo Nordisk Investigational Site | Brugge | Belgium | 8000 | |
| 177 | Novo Nordisk Investigational Site | Genk | Belgium | 3600 | |
| 178 | Novo Nordisk Investigational Site | Kortrijk | Belgium | 8500 | |
| 179 | Novo Nordisk Investigational Site | Liège | Belgium | 4000 | |
| 180 | Novo Nordisk Investigational Site | Mechelen | Belgium | 2800 | |
| 181 | Novo Nordisk Investigational Site | Vitória | Espirito Santo | Brazil | 29055-450 |
| 182 | Novo Nordisk Investigational Site | Curitiba | Parana | Brazil | 80440-020 |
| 183 | Novo Nordisk Investigational Site | Curitiba | Parana | Brazil | 80730-150 |
| 184 | Novo Nordisk Investigational Site | Blumenau | Santa Catarina | Brazil | 89020-430 |
| 185 | Novo Nordisk Investigational Site | Campinas | Sao Paulo | Brazil | 13010-001 |
| 186 | Novo Nordisk Investigational Site | Campinas | Sao Paulo | Brazil | 13060-080 |
| 187 | Novo Nordisk Investigational Site | São José do Rio Preto | Sao Paulo | Brazil | 15090-000 |
| 188 | Novo Nordisk Investigational Site | Pleven | Bulgaria | 5800 | |
| 189 | Novo Nordisk Investigational Site | Plovdiv | Bulgaria | 4002 | |
| 190 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1309 | |
| 191 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1407 | |
| 192 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1431 | |
| 193 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1431 | |
| 194 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1527 | |
| 195 | Novo Nordisk Investigational Site | Sofia | Bulgaria | 1750 | |
| 196 | Novo Nordisk Investigational Site | Varna | Bulgaria | 9010 | |
| 197 | Novo Nordisk Investigational Site | Calgary | Alberta | Canada | T2H 2G4 |
| 198 | Novo Nordisk Investigational Site | Calgary | Alberta | Canada | T2V 4J2 |
| 199 | Novo Nordisk Investigational Site | Sherwood Park | Alberta | Canada | T8H 0N2 |
| 200 | Novo Nordisk Investigational Site | Vancouver | British Columbia | Canada | V5Y 3W2 |
| 201 | Novo Nordisk Investigational Site | Halifax | Nova Scotia | Canada | B3H 2Y9 |
| 202 | Novo Nordisk Investigational Site | Barrie | Ontario | Canada | L4N 7L3 |
| 203 | Novo Nordisk Investigational Site | Brampton | Ontario | Canada | L6S 0C6 |
| 204 | Novo Nordisk Investigational Site | Concord | Ontario | Canada | L4K 4M2 |
| 205 | Novo Nordisk Investigational Site | Etobicoke | Ontario | Canada | M9R 4E1 |
| 206 | Novo Nordisk Investigational Site | Hamilton | Ontario | Canada | L8M 1K7 |
| 207 | Novo Nordisk Investigational Site | Nepean | Ontario | Canada | K2J 0V2 |
| 208 | Novo Nordisk Investigational Site | North York | Ontario | Canada | M6B 3H7 |
| 209 | Novo Nordisk Investigational Site | Oakville | Ontario | Canada | L6K 3W7 |
| 210 | Novo Nordisk Investigational Site | Oakville | Ontario | Canada | L6M 1M1 |
| 211 | Novo Nordisk Investigational Site | Peterborough | Ontario | Canada | K9J 0B2 |
| 212 | Novo Nordisk Investigational Site | Scarborough | Ontario | Canada | M1B 4Z8 |
| 213 | Novo Nordisk Investigational Site | Toronto | Ontario | Canada | M4G 3E8 |
| 214 | Novo Nordisk Investigational Site | Toronto | Ontario | Canada | M6G 1M2 |
| 215 | Novo Nordisk Investigational Site | Waterloo | Ontario | Canada | N2T 0C1 |
| 216 | Novo Nordisk Investigational Site | Brossard | Quebec | Canada | J4Z-2K9 |
| 217 | Novo Nordisk Investigational Site | Laval | Quebec | Canada | H7T 2P5 |
| 218 | Novo Nordisk Investigational Site | Sherbrooke | Quebec | Canada | J1H 5N4 |
| 219 | Novo Nordisk Investigational Site | Quebec | Canada | G1G 3Y8 | |
| 220 | Novo Nordisk Investigational Site | Beijing | Beijing | China | 100191 |
| 221 | Novo Nordisk Investigational Site | Beijing | Beijing | China | 100853 |
| 222 | Novo Nordisk Investigational Site | Chongqing | Chongqing | China | 402260 |
| 223 | Novo Nordisk Investigational Site | Wuhan | Hubei | China | 430022 |
| 224 | Novo Nordisk Investigational Site | Changzhou | Jiangsu | China | 213003 |
| 225 | Novo Nordisk Investigational Site | Shanghai | Shanghai | China | 200080 |
| 226 | Novo Nordisk Investigational Site | Shanghai | Shanghai | China | 201199 |
| 227 | Novo Nordisk Investigational Site | Aarhus N | Denmark | 8200 | |
| 228 | Novo Nordisk Investigational Site | Herning | Denmark | 7400 | |
| 229 | Novo Nordisk Investigational Site | Hvidovre | Denmark | 2650 | |
| 230 | Novo Nordisk Investigational Site | Svendborg | Denmark | 5700 | |
| 231 | Novo Nordisk Investigational Site | Aachen | Germany | 52074 | |
| 232 | Novo Nordisk Investigational Site | Bad Homburg | Germany | 61348 | |
| 233 | Novo Nordisk Investigational Site | Dresden | Germany | 01277 | |
| 234 | Novo Nordisk Investigational Site | Düsseldorf | Germany | 40210 | |
| 235 | Novo Nordisk Investigational Site | Elsterwerda | Germany | 04910 | |
| 236 | Novo Nordisk Investigational Site | Essen | Germany | 45136 | |
| 237 | Novo Nordisk Investigational Site | Falkensee | Germany | 14612 | |
| 238 | Novo Nordisk Investigational Site | Lübeck | Germany | 23562 | |
| 239 | Novo Nordisk Investigational Site | Oldenburg I. Holst | Germany | 23758 | |
| 240 | Novo Nordisk Investigational Site | Witten | Germany | 58455 | |
| 241 | Novo Nordisk Investigational Site | Athens | Greece | 11527 | |
| 242 | Novo Nordisk Investigational Site | Athens | Greece | GR-11527 | |
| 243 | Novo Nordisk Investigational Site | Athens | Greece | GR-11528 | |
| 244 | Novo Nordisk Investigational Site | Athens | Greece | GR-14233 | |
| 245 | Novo Nordisk Investigational Site | Athens | Greece | GR-15123 | |
| 246 | Novo Nordisk Investigational Site | Chios | Greece | GR82100 | |
| 247 | Novo Nordisk Investigational Site | Haidari-Athens | Greece | GR-12462 | |
| 248 | Novo Nordisk Investigational Site | Ioannina | Greece | 45500 | |
| 249 | Novo Nordisk Investigational Site | Kifissia | Greece | GR-14561 | |
| 250 | Novo Nordisk Investigational Site | Lamia | Greece | GR35100 | |
| 251 | Novo Nordisk Investigational Site | Larissa | Greece | GR-41110 | |
| 252 | Novo Nordisk Investigational Site | Patra | Greece | GR-26504 | |
| 253 | Novo Nordisk Investigational Site | Thessaloniki | Greece | GR-57010 | |
| 254 | Novo Nordisk Investigational Site | Vijayawada | Andhra Pradesh | India | 520002 |
| 255 | Novo Nordisk Investigational Site | Mangalore | Karnataka | India | 575002 |
| 256 | Novo Nordisk Investigational Site | Manipal | Karnataka | India | 576104 |
| 257 | Novo Nordisk Investigational Site | Nagpur | Maharashtra | India | 440003 |
| 258 | Novo Nordisk Investigational Site | Nagpur | Maharashtra | India | 440010 |
| 259 | Novo Nordisk Investigational Site | New Dehli | New Delhi | India | 110029 |
| 260 | Novo Nordisk Investigational Site | Hyderabad | Telengana | India | 500012 |
| 261 | Novo Nordisk Investigational Site | Lucknow | Uttar Pradesh | India | 226030 |
| 262 | Novo Nordisk Investigational Site | Belgaum | India | 590010 | |
| 263 | Novo Nordisk Investigational Site | New Delhi | India | 110002 | |
| 264 | Novo Nordisk Investigational Site | New Delhi | India | 110060 | |
| 265 | Novo Nordisk Investigational Site | Holon | Israel | 58100 | |
| 266 | Novo Nordisk Investigational Site | Jerusalem | Israel | 91120 | |
| 267 | Novo Nordisk Investigational Site | Rehovot | Israel | 7661041 | |
| 268 | Novo Nordisk Investigational Site | Tel Aviv | Israel | 6423906 | |
| 269 | Novo Nordisk Investigational Site | Tel Hashomer | Israel | 5265601 | |
| 270 | Novo Nordisk Investigational Site | Arzignano (VI) | Italy | 36071 | |
| 271 | Novo Nordisk Investigational Site | Bologna | Italy | 40138 | |
| 272 | Novo Nordisk Investigational Site | Catania | Italy | 95126 | |
| 273 | Novo Nordisk Investigational Site | Catanzaro | Italy | 88100 | |
| 274 | Novo Nordisk Investigational Site | Milano | Italy | 20138 | |
| 275 | Novo Nordisk Investigational Site | Milan | Italy | 20132 | |
| 276 | Novo Nordisk Investigational Site | Montichiari | Italy | 25018 | |
| 277 | Novo Nordisk Investigational Site | Roma | Italy | 00168 | |
| 278 | Novo Nordisk Investigational Site | Rome | Italy | 00189 | |
| 279 | Novo Nordisk Investigational Site | Trieste | Italy | 34128 | |
| 280 | Novo Nordisk Investigational Site | Verona | Italy | 37126 | |
| 281 | Novo Nordisk Investigational Site | Bunkyo-ku, Tokyo | Japan | 113-8655 | |
| 282 | Novo Nordisk Investigational Site | Fukuoka-shi, Fukuoka | Japan | 810-0001 | |
| 283 | Novo Nordisk Investigational Site | Fukushima | Japan | 963-8851 | |
| 284 | Novo Nordisk Investigational Site | Hamada-shi, Shimane | Japan | 697-8511 | |
| 285 | Novo Nordisk Investigational Site | Ibaraki | Japan | 311-0113 | |
| 286 | Novo Nordisk Investigational Site | Kishiwada, Osaka | Japan | 596-0042 | |
| 287 | Novo Nordisk Investigational Site | Kita-azumi-gun, Nagano | Japan | 399-8695 | |
| 288 | Novo Nordisk Investigational Site | Kumamoto-shi, Kumamoto | Japan | 860-8556 | |
| 289 | Novo Nordisk Investigational Site | Kumamoto | Japan | 862-0976 | |
| 290 | Novo Nordisk Investigational Site | Kusegun, Kyoto | Japan | 613-0034 | |
| 291 | Novo Nordisk Investigational Site | Kyoto-shi, Kyoto | Japan | 607-8062 | |
| 292 | Novo Nordisk Investigational Site | Kyoto-shi,Kyoto | Japan | 601-1495 | |
| 293 | Novo Nordisk Investigational Site | Matsudo-shi | Japan | 270-2251 | |
| 294 | Novo Nordisk Investigational Site | Matsumoto-shi, Nagano | Japan | 390-8621 | |
| 295 | Novo Nordisk Investigational Site | Meguro-ku, Tokyo | Japan | 153-0051 | |
| 296 | Novo Nordisk Investigational Site | Nagoya-shi, Aichi | Japan | 457-0818 | |
| 297 | Novo Nordisk Investigational Site | Naha-shi, Okinawa | Japan | 902-8511 | |
| 298 | Novo Nordisk Investigational Site | Okayama | Japan | 701-0192 | |
| 299 | Novo Nordisk Investigational Site | Omihachiman-shi, Siga | Japan | 523-0082 | |
| 300 | Novo Nordisk Investigational Site | Osaka-shi, Osaka | Japan | 533-0024 | |
| 301 | Novo Nordisk Investigational Site | Osaka-shi,Osaka | Japan | 559-0012 | |
| 302 | Novo Nordisk Investigational Site | Sagamihara-shi, Kanagawa | Japan | 252-0392 | |
| 303 | Novo Nordisk Investigational Site | Saitama-shi, Saitama | Japan | 338-0837 | |
| 304 | Novo Nordisk Investigational Site | Sapporo-shi, Hokkaido | Japan | 062-0003 | |
| 305 | Novo Nordisk Investigational Site | Sendai-shi, Miyagi | Japan | 980-8574 | |
| 306 | Novo Nordisk Investigational Site | Suita-shi, Osaka | Japan | 564-0013 | |
| 307 | Novo Nordisk Investigational Site | Takamatsu-shi, Kagawa | Japan | 760-8557 | |
| 308 | Novo Nordisk Investigational Site | Tokyo | Japan | 192-0918 | |
| 309 | Novo Nordisk Investigational Site | Wako-shi, Saitama | Japan | 351-0102 | |
| 310 | Novo Nordisk Investigational Site | Yao-shi, Osaka | Japan | 581-0011 | |
| 311 | Novo Nordisk Investigational Site | Yokohama-shi, Kanagawa | Japan | 236-0004 | |
| 312 | Novo Nordisk Investigational Site | Yonezawa-shi, Yamagata | Japan | 992-0045 | |
| 313 | Novo Nordisk Investigational Site | Busan | Korea, Republic of | 49201 | |
| 314 | Novo Nordisk Investigational Site | Busan | Korea, Republic of | 49241 | |
| 315 | Novo Nordisk Investigational Site | Daegu | Korea, Republic of | 42472 | |
| 316 | Novo Nordisk Investigational Site | Daegu | Korea, Republic of | 42601 | |
| 317 | Novo Nordisk Investigational Site | Daejeon | Korea, Republic of | 35015 | |
| 318 | Novo Nordisk Investigational Site | Gangwon-do | Korea, Republic of | 26426 | |
| 319 | Novo Nordisk Investigational Site | Gwangju | Korea, Republic of | 61469 | |
| 320 | Novo Nordisk Investigational Site | Gyeonggi-do | Korea, Republic of | 13620 | |
| 321 | Novo Nordisk Investigational Site | Incheon | Korea, Republic of | 21565 | |
| 322 | Novo Nordisk Investigational Site | Seoul | Korea, Republic of | 02841 | |
| 323 | Novo Nordisk Investigational Site | Seoul | Korea, Republic of | 03722 | |
| 324 | Novo Nordisk Investigational Site | Seoul | Korea, Republic of | 05278 | |
| 325 | Novo Nordisk Investigational Site | Seoul | Korea, Republic of | 06591 | |
| 326 | Novo Nordisk Investigational Site | Seoul | Korea, Republic of | 08308 | |
| 327 | Novo Nordisk Investigational Site | Kaunas | Lithuania | 48259 | |
| 328 | Novo Nordisk Investigational Site | Kaunas | Lithuania | 49449 | |
| 329 | Novo Nordisk Investigational Site | Siauliai | Lithuania | 76231 | |
| 330 | Novo Nordisk Investigational Site | Alor Setar | Malaysia | 05460 | |
| 331 | Novo Nordisk Investigational Site | Ipoh, Perak | Malaysia | 30450 | |
| 332 | Novo Nordisk Investigational Site | Kedah | Malaysia | 08000 | |
| 333 | Novo Nordisk Investigational Site | Kota Bharu, Kelantan | Malaysia | 16150 | |
| 334 | Novo Nordisk Investigational Site | Kota Bharu | Malaysia | 15586 | |
| 335 | Novo Nordisk Investigational Site | Kota Samarahan | Malaysia | 94300 | |
| 336 | Novo Nordisk Investigational Site | Kuala Lumpur | Malaysia | 59100 | |
| 337 | Novo Nordisk Investigational Site | Sabah | Malaysia | 88300 | |
| 338 | Novo Nordisk Investigational Site | Seremban | Malaysia | 70300 | |
| 339 | Novo Nordisk Investigational Site | Mexico City | México, D.F. | Mexico | 03300 |
| 340 | Novo Nordisk Investigational Site | Monterrey | Nuevo León | Mexico | 64020 |
| 341 | Novo Nordisk Investigational Site | Monterrey | Nuevo León | Mexico | 64060 |
| 342 | Novo Nordisk Investigational Site | Monterrey | Nuevo León | Mexico | 64460 |
| 343 | Novo Nordisk Investigational Site | San Luis Potosí | San Luis Potosi | Mexico | 78200 |
| 344 | Novo Nordisk Investigational Site | Culiacán | Sinaloa | Mexico | 80230 |
| 345 | Novo Nordisk Investigational Site | Aguascalientes | Mexico | 20230 | |
| 346 | Novo Nordisk Investigational Site | Queretaro | Mexico | 76000 | |
| 347 | Novo Nordisk Investigational Site | Veracruz | Mexico | 91900 | |
| 348 | Novo Nordisk Investigational Site | Alkmaar | Netherlands | 1815 JD | |
| 349 | Novo Nordisk Investigational Site | Almelo | Netherlands | 7609 PP | |
| 350 | Novo Nordisk Investigational Site | Amsterdam | Netherlands | 1105 AZ | |
| 351 | Novo Nordisk Investigational Site | Apeldoorn | Netherlands | 7334 DZ | |
| 352 | Novo Nordisk Investigational Site | Hilversum | Netherlands | 1213 XZ | |
| 353 | Novo Nordisk Investigational Site | Leiden | Netherlands | 2333 ZA | |
| 354 | Novo Nordisk Investigational Site | Rotterdam | Netherlands | 3083 AN | |
| 355 | Novo Nordisk Investigational Site | Sneek | Netherlands | 8601 ZR | |
| 356 | Novo Nordisk Investigational Site | Zaandam | Netherlands | 1502 DV | |
| 357 | Novo Nordisk Investigational Site | Bialystok | Poland | 15-276 | |
| 358 | Novo Nordisk Investigational Site | Bialystok | Poland | 15-481 | |
| 359 | Novo Nordisk Investigational Site | Elblag | Poland | 82-300 | |
| 360 | Novo Nordisk Investigational Site | Gorzow Wielkopolski | Poland | 66-400 | |
| 361 | Novo Nordisk Investigational Site | Grodzisk Mazowiecki | Poland | 05-825 | |
| 362 | Novo Nordisk Investigational Site | Krakow | Poland | 30-082 | |
| 363 | Novo Nordisk Investigational Site | Krakow | Poland | 31-209 | |
| 364 | Novo Nordisk Investigational Site | Krakow | Poland | 31-261 | |
| 365 | Novo Nordisk Investigational Site | Krakow | Poland | 31-261 | |
| 366 | Novo Nordisk Investigational Site | Kraków | Poland | 31-202 | |
| 367 | Novo Nordisk Investigational Site | Lodz | Poland | 90-242 | |
| 368 | Novo Nordisk Investigational Site | Lodz | Poland | 90-549 | |
| 369 | Novo Nordisk Investigational Site | Lodz | Poland | 91-211 | |
| 370 | Novo Nordisk Investigational Site | Lublin | Poland | 20-044 | |
| 371 | Novo Nordisk Investigational Site | Pulawy | Poland | 24-100 | |
| 372 | Novo Nordisk Investigational Site | Ruda Slaska | Poland | 41-710 | |
| 373 | Novo Nordisk Investigational Site | Szczecin | Poland | 70-341 | |
| 374 | Novo Nordisk Investigational Site | Warszawa | Poland | 04-628 | |
| 375 | Novo Nordisk Investigational Site | Warszawa | Poland | 04-628 | |
| 376 | Novo Nordisk Investigational Site | Wroclaw | Poland | 51-162 | |
| 377 | Novo Nordisk Investigational Site | Zamosc | Poland | 22-400 | |
| 378 | Novo Nordisk Investigational Site | Almada | Portugal | 2805-267 | |
| 379 | Novo Nordisk Investigational Site | Aveiro | Portugal | 3814-501 | |
| 380 | Novo Nordisk Investigational Site | Braga | Portugal | 4710-243 | |
| 381 | Novo Nordisk Investigational Site | Carnaxide | Portugal | 2790-134 | |
| 382 | Novo Nordisk Investigational Site | Coimbra | Portugal | 3000-561 | |
| 383 | Novo Nordisk Investigational Site | Lisboa | Portugal | 1649-035 | |
| 384 | Novo Nordisk Investigational Site | Matosinhos | Portugal | 4464-513 | |
| 385 | Novo Nordisk Investigational Site | Barnaul | Russian Federation | 656055 | |
| 386 | Novo Nordisk Investigational Site | Chita | Russian Federation | 672000 | |
| 387 | Novo Nordisk Investigational Site | Irkutsk | Russian Federation | 664049 | |
| 388 | Novo Nordisk Investigational Site | Kazan | Russian Federation | 420029 | |
| 389 | Novo Nordisk Investigational Site | Kazan | Russian Federation | 420101 | |
| 390 | Novo Nordisk Investigational Site | Moscow | Russian Federation | 129226 | |
| 391 | Novo Nordisk Investigational Site | Moscow | Russian Federation | 129327 | |
| 392 | Novo Nordisk Investigational Site | Novosibirsk | Russian Federation | 630087 | |
| 393 | Novo Nordisk Investigational Site | Novosibirsk | Russian Federation | 630099 | |
| 394 | Novo Nordisk Investigational Site | Petrozavodsk | Russian Federation | 185019 | |
| 395 | Novo Nordisk Investigational Site | Sochi | Russian Federation | 354057 | |
| 396 | Novo Nordisk Investigational Site | Tomsk | Russian Federation | 634034 | |
| 397 | Novo Nordisk Investigational Site | Belgrade | Serbia | 11000 | |
| 398 | Novo Nordisk Investigational Site | Kragujevac | Serbia | 34000 | |
| 399 | Novo Nordisk Investigational Site | Novi Sad | Serbia | 21000 | |
| 400 | Novo Nordisk Investigational Site | Bratislava | Slovakia | 81369 | |
| 401 | Novo Nordisk Investigational Site | Bratislava | Slovakia | 831 06 | |
| 402 | Novo Nordisk Investigational Site | Bratislava | Slovakia | 83305 | |
| 403 | Novo Nordisk Investigational Site | Kosice | Slovakia | 040 01 | |
| 404 | Novo Nordisk Investigational Site | Lubochna | Slovakia | 03491 | |
| 405 | Novo Nordisk Investigational Site | Martin | Slovakia | 036 59 | |
| 406 | Novo Nordisk Investigational Site | Presov | Slovakia | 08-181 | |
| 407 | Novo Nordisk Investigational Site | Bloemfontein | Free State | South Africa | 9301 |
| 408 | Novo Nordisk Investigational Site | Bloemfontein | Free State | South Africa | 9301 |
| 409 | Novo Nordisk Investigational Site | Centurion | Gauteng | South Africa | 0157 |
| 410 | Novo Nordisk Investigational Site | Johannesburg | Gauteng | South Africa | 2013 |
| 411 | Novo Nordisk Investigational Site | Johannesburg | Gauteng | South Africa | 2157 |
| 412 | Novo Nordisk Investigational Site | Johannesburg | Gauteng | South Africa | 2193 |
| 413 | Novo Nordisk Investigational Site | Pretoria | Gauteng | South Africa | 0183 |
| 414 | Novo Nordisk Investigational Site | Pretoria | Gauteng | South Africa | 0184 |
| 415 | Novo Nordisk Investigational Site | Pretoria | Gauteng | South Africa | 0186 |
| 416 | Novo Nordisk Investigational Site | Cape Town | Western Cape | South Africa | 7130 |
| 417 | Novo Nordisk Investigational Site | Cape Town | Western Cape | South Africa | 7130 |
| 418 | Novo Nordisk Investigational Site | Cape Town | Western Cape | South Africa | 7500 |
| 419 | Novo Nordisk Investigational Site | Cape Town | Western Cape | South Africa | 7925 |
| 420 | Novo Nordisk Investigational Site | Paarl | Western Cape | South Africa | 7646 |
| 421 | Novo Nordisk Investigational Site | Baracaldo | Spain | 48903 | |
| 422 | Novo Nordisk Investigational Site | Córdoba | Spain | 14004 | |
| 423 | Novo Nordisk Investigational Site | L' Hospitalet Del Llobregat | Spain | 08907 | |
| 424 | Novo Nordisk Investigational Site | Sanlúcar de Barrameda | Spain | 11540 | |
| 425 | Novo Nordisk Investigational Site | Valencia | Spain | 46010 | |
| 426 | Novo Nordisk Investigational Site | Valencia | Spain | 46017 | |
| 427 | Novo Nordisk Investigational Site | Zaragoza | Spain | 50009 | |
| 428 | Novo Nordisk Investigational Site | Lund | Sweden | 222 21 | |
| 429 | Novo Nordisk Investigational Site | Malmö | Sweden | 205 02 | |
| 430 | Novo Nordisk Investigational Site | Stockholm | Sweden | 141 85 | |
| 431 | Novo Nordisk Investigational Site | Stockholm | Sweden | 171 64 | |
| 432 | Novo Nordisk Investigational Site | Uppsala | Sweden | 751 85 | |
| 433 | Novo Nordisk Investigational Site | Hsinchu City | Taiwan | 300 | |
| 434 | Novo Nordisk Investigational Site | Tainan City | Taiwan | 704 | |
| 435 | Novo Nordisk Investigational Site | Taipei | Taiwan | 100 | |
| 436 | Novo Nordisk Investigational Site | Taipei | Taiwan | 112 | |
| 437 | Novo Nordisk Investigational Site | Taoyuan City | Taiwan | 333 | |
| 438 | Novo Nordisk Investigational Site | Afyon | Turkey | 03200 | |
| 439 | Novo Nordisk Investigational Site | Ankara | Turkey | 06230 | |
| 440 | Novo Nordisk Investigational Site | Ankara | Turkey | 06230 | |
| 441 | Novo Nordisk Investigational Site | Antalya | Turkey | 07058 | |
| 442 | Novo Nordisk Investigational Site | Aydin | Turkey | 09100 | |
| 443 | Novo Nordisk Investigational Site | Eskisehir | Turkey | 26040 | |
| 444 | Novo Nordisk Investigational Site | Istanbul | Turkey | 34098 | |
| 445 | Novo Nordisk Investigational Site | Istanbul | Turkey | 34098 | |
| 446 | Novo Nordisk Investigational Site | Istanbul | Turkey | 34381 | |
| 447 | Novo Nordisk Investigational Site | Istanbul | Turkey | 34668 | |
| 448 | Novo Nordisk Investigational Site | Izmir | Turkey | 35100 | |
| 449 | Novo Nordisk Investigational Site | Izmir | Turkey | 35340 | |
| 450 | Novo Nordisk Investigational Site | Kahramanmaras | Turkey | 46040 | |
| 451 | Novo Nordisk Investigational Site | Kayseri | Turkey | 38039 | |
| 452 | Novo Nordisk Investigational Site | Kocaeli | Turkey | 41380 | |
| 453 | Novo Nordisk Investigational Site | Mugla | Turkey | 48000 | |
| 454 | Novo Nordisk Investigational Site | Chernivtsi | Ukraine | 58023 | |
| 455 | Novo Nordisk Investigational Site | Ivano-Frankivsk | Ukraine | 76008 | |
| 456 | Novo Nordisk Investigational Site | Kharkiv | Ukraine | 61039 | |
| 457 | Novo Nordisk Investigational Site | Kharkiv | Ukraine | 61178 | |
| 458 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 02091 | |
| 459 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 02660 | |
| 460 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 03037 | |
| 461 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 03049 | |
| 462 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 03151 | |
| 463 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 03680 | |
| 464 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 04050 | |
| 465 | Novo Nordisk Investigational Site | Kyiv | Ukraine | 04053 | |
| 466 | Novo Nordisk Investigational Site | Zaporizhzhia | Ukraine | 69063 | |
| 467 | Novo Nordisk Investigational Site | Zhytomyr | Ukraine | 10002 | |
| 468 | Novo Nordisk Investigational Site | Addlestone | United Kingdom | KT15 2BH | |
| 469 | Novo Nordisk Investigational Site | Barnet | United Kingdom | EN5 3DJ | |
| 470 | Novo Nordisk Investigational Site | Bradford-on-Avon | United Kingdom | BA15 1DQ | |
| 471 | Novo Nordisk Investigational Site | Bradford | United Kingdom | BD9 6RJ | |
| 472 | Novo Nordisk Investigational Site | Denmark Hill, London | United Kingdom | SE5 9RS | |
| 473 | Novo Nordisk Investigational Site | Dorest | United Kingdom | BH7 7DW | |
| 474 | Novo Nordisk Investigational Site | Dorset | United Kingdom | BH16 5PW | |
| 475 | Novo Nordisk Investigational Site | Exeter | United Kingdom | EX2 5DW | |
| 476 | Novo Nordisk Investigational Site | High Wycombe | United Kingdom | HP11 2TT | |
| 477 | Novo Nordisk Investigational Site | Leicester | United Kingdom | LE3 9QP | |
| 478 | Novo Nordisk Investigational Site | Lincoln | United Kingdom | LN2 5QY | |
| 479 | Novo Nordisk Investigational Site | Newcastle Upon Tyne | United Kingdom | NE7 7DN | |
| 480 | Novo Nordisk Investigational Site | Oxford | United Kingdom | OX3 9DU | |
| 481 | Novo Nordisk Investigational Site | Sandbach | United Kingdom | CW11 1EQ | |
| 482 | Novo Nordisk Investigational Site | Stockton-on-Tees | United Kingdom | TS19 8PE | |
| 483 | Novo Nordisk Investigational Site | Taunton | United Kingdom | TA1 5DA | |
| 484 | Novo Nordisk Investigational Site | Torquay | United Kingdom | TQ2 7AA | |
| 485 | Novo Nordisk Investigational Site | Wellingborough | United Kingdom | NN8 4RW | |
| 486 | Novo Nordisk Investigational Site | West Sussex | United Kingdom | PO19 6SE |
Sponsors and Collaborators
- Novo Nordisk A/S
Investigators
- Study Director: Clinical Transparency (dept. 2834), Novo Nordisk A/S
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
Novo Nordisk A/S
ClinicalTrials.gov Identifier:
NCT05021835
Other Study ID Numbers:
- EX6018-4758
- U1111-1259-3422
- 2020-004853-59
- jRCT2021210033
First Posted:
Aug 26, 2021
Last Update Posted:
May 6, 2022
Last Verified:
May 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: