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Efficacy of Licorice on Reducing Salivary Streptococcus Mutans Versus Chlorohexidine in Caries Risk Patients

Sponsor
Cairo University (Other)
Overall Status
Unknown status
CT.gov ID
NCT03590977
Collaborator
(none)
52
Enrollment
2
Arms
13
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

To compare the effect of a natural herbal licorice containing preventive measure alternative to chlorohexidine preventive measure to decrease the effect of streptococcus mutans.

Condition or Disease Intervention/Treatment Phase
  • Other: licorice extract mouthwash
  • Other: chlorohexidine mouthwash
 N/A

Detailed Description

A total number of fifty-two patients will be enrolled in the study. They will be divided into two groups: study group and control group. Study group will be subjected to licorice mouthwash and the control will be subjected to chlorohexidine mouth wash. Salivary bacterial count will be evaluated for both groups.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
52 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Outcomes Assessor)
Primary Purpose:
Prevention
Official Title:
Evaluation the Efficacy of a Herbal Licorice on Reducing Salivary Streptococcus Mutans Levels (A Randomized Clinical Trial)
Anticipated Study Start Date :
Sep 1, 2018
Anticipated Primary Completion Date :
Aug 30, 2019
Anticipated Study Completion Date :
Oct 1, 2019

Arms and Interventions

Arm Intervention/Treatment
Experimental: licorice extract mouthwash

administration of a mouthwash containing licorice as a preventive measure to high caries risk patients (faculty of pharmacy, cairo university)

Other: licorice extract mouthwash
mouth rinse that contains a natural herbal licorice root extract used as a preventive measure that reduce caries index.
Placebo Comparator: chlorohexidine mouthwash

administration of chlorohexidine 0.2% in 1:1 diluation mouthwash that is broad spectrum antimicrobial activity to high caries risk patients

Other: chlorohexidine mouthwash
mouth wash that contains chlorohexidine as an active component

Outcome Measures

Primary Outcome Measures

  1. salivary bacterial count [after one week]

    streotococcus mutans bacterial count

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • over 18 years old

  • co-operative patients

  • not allergic to licorice

  • not allergic to chlorohexidine

Exclusion Criteria:

  • pregnancy

  • allergic patients to licorice

  • allergic patients to chlorohexidine

  • lack of compliance

  • evidence of parafunctional habits

  • patients with periodontal disease

  • xerostomia

  • participants that receive any microbial agent two weeks prior to the study

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Cairo University

Investigators

  • Principal Investigator: nancy helmy, Msc, Faculty of Dentistry, Cairo univerisity

Study Documents (Full-Text)

None provided.

More Information

Publications

Responsible Party:
Nancy Helmy Blamon Mikhael, Assistant lecturer, Cairo University
ClinicalTrials.gov Identifier:
NCT03590977
Other Study ID Numbers:
  • CEBD-CU-2018-07-5
First Posted:
Jul 18, 2018
Last Update Posted:
Jul 18, 2018
Last Verified:
Jul 1, 2018
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Nancy Helmy Blamon Mikhael, Assistant lecturer, Cairo University
Streptococcus Mutans
licorice
chlorohexidine
caries index
Additional relevant MeSH terms:
Dental Caries

Study Results

No Results Posted as of Jul 18, 2018