Carotid Plaque Imaging Project (CPIP)
Study Details
Study Description
Brief Summary
The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions, vulnerable plaques (VP), and their treatment before the occurrence of events is, therefore, one of the greatest cardiovascular challenges today. Possible approaches for early detection of VP include imaging techniques allowing visualization of plaque structure, circulating biomarkers and better understanding of the pathophysiologic mechanisms of the disease. In the carotid plaque imaging project the investigators study human atherosclerotic plaques (that are removed by endarterectomy) to disclose their underlying structure and mechanisms, finding possible novel therapeutic targets or markers for VP. The investigators also study plaque structure with imaging methods and try to develop new ways to detect VP using circulating or imaging markers.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Carotid Plaque Imaging Project (CPIP)
|
Other: Observational study
|
Outcome Measures
Primary Outcome Measures
- Number of participants suffering post-operative cardiovascular events (by 2025) [Follow up assessment year 2025 (recording of events occurring since 2023)]
Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
- Number of participants suffering post-operative cardiovascular events (by 2027) [Follow up assessment year 2027 (recording of events occurring since 2025)]
Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
- Number of participants suffering post-operative cardiovascular events (by 2029) [Follow up assessment year 2029 (recording of events occurring since 2027)]
Post-operative myocardial infarction, stroke, transient ischaemic attack, amaurosis fugax, cardiovascular death (according to Swedish National Registers)
Eligibility Criteria
Criteria
Inclusion Criteria:
- Patients older than 18 years old, male or female that are eligible for carotid endarterectomy due to atherosclerosis and that can provide informed consent.
Exclusion Criteria:
- Patients younger than 18 years old that cannot provide informed consent; pregnant.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Skåne University Hospital (SUS) | Malmö | Skåne | Sweden | 214 28 |
Sponsors and Collaborators
- Lund University
- Region Skåne
- The Swedish Research Council
- Swedish Heart Lung Foundation
- Skåne University Hospital funds (incl. the Medical Training and Research Agreement/ALF)
- Swedish Foundation for Strategic Research
Investigators
- Principal Investigator: Isabel Goncalves, MD, PhD, Lund University
Study Documents (Full-Text)
More Information
Publications
None provided.- CPIP