Case Fatalities in Hospitalised COVID-19 Patients in the UK
Sponsor
University of Edinburgh (Other)
Overall Status
Completed
CT.gov ID
NCT04527458
Collaborator
International Severe Acute Respiratory and Emerging Infection Consortium (Other), BREATHE Health Data Research Hub (Other)
70,000
1
5.3
13316.4
Study Details
Study Description
Brief Summary
This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes. This analysis will enhance our understanding of the virus, which will be important for researchers and clinicians to respond appropriately.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Study Type:
Observational
Actual Enrollment
:
70000 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Case Fatalities in Hospitalised COVID-19 Patients in the UK: An ISARIC Study
Actual Study Start Date
:
Feb 24, 2020
Actual Primary Completion Date
:
Aug 2, 2020
Actual Study Completion Date
:
Aug 2, 2020
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Hospitalisations All hospitalised COVID patients |
Other: Patient Characteristics
Characteristics of the patients
Other: COVID-19 treatments
Specific treatments used on COVID-19 patients
Other: Differences in triage
Triage criteria for treating COVID-19 patients
Other: Surge capacity
Capacity of hospitals
|
| Critical care All hospitalised COVID patients in critical care |
Other: Patient Characteristics
Characteristics of the patients
Other: COVID-19 treatments
Specific treatments used on COVID-19 patients
Other: Differences in triage
Triage criteria for treating COVID-19 patients
Other: Surge capacity
Capacity of hospitals
|
Outcome Measures
Primary Outcome Measures
- Case fatality [23 weeks]
The proportion of new admissions with COVID-19 who died over time
Eligibility Criteria
Criteria
Ages Eligible for Study:
N/A
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
- All patients admitted with a proven or high likelihood of COVID-19
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Edinburgh | Edinburgh | United Kingdom |
Sponsors and Collaborators
- University of Edinburgh
- International Severe Acute Respiratory and Emerging Infection Consortium
- BREATHE Health Data Research Hub
Investigators
- Principal Investigator: Annemarie B Docherty, Usher Institute, University of Edinburgh
- Principal Investigator: Ewen M Harrison, Usher Institute, University of Edinburgh
- Principal Investigator: Rachel H Mulholland, Usher Institute, University of Edinburgh
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
Responsible Party:
University of Edinburgh
ClinicalTrials.gov Identifier:
NCT04527458
Other Study ID Numbers:
- ISARIC_COVID_CF
First Posted:
Aug 26, 2020
Last Update Posted:
Aug 26, 2020
Last Verified:
Aug 1, 2020
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by University of Edinburgh
Additional relevant MeSH terms: