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Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel

Sponsor
ECOG-ACRIN Cancer Research Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT03419234
Collaborator
National Cancer Institute (NCI) (NIH)
210
Enrollment
672
Locations
2
Arms
85.7
Anticipated Duration (Months)
0.3
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This randomized phase II trial studies how well abiraterone acetate and antiandrogen therapy, with or without cabazitaxel and prednisone, work in treating patients with castration-resistant prostate cancer previously treated with docetaxel that has spread to other parts of the body. Androgens can cause the growth of prostate cancer cells. Hormone therapy using abiraterone acetate and antiandrogen therapy may fight prostate cancer by lowering and/or blocking the use of androgens by the tumor cells. Drugs used in chemotherapy, such as cabazitaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving abiraterone acetate and antiandrogen therapy with or without cabazitaxel and prednisone may help kill more tumor cells.

Condition or Disease Intervention/Treatment Phase
  • Drug: Abiraterone Acetate
  • Drug: Antiandrogen Therapy
  • Drug: Cabazitaxel
  • Other: Laboratory Biomarker Analysis
  • Procedure: Orchiectomy
  • Other: Pharmacological Study
  • Drug: Prednisone
 Phase 2

Detailed Description

PRIMARY OBJECTIVES:
  1. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with castration-resistant prostate cancer (CRPC) that have previously received docetaxel and androgen deprivation therapy (ADT) for hormone-sensitive prostate cancer (HSPC) can improve progression-free survival (PFS) compared to abiraterone acetate alone.
SECONDARY OBJECTIVES:

  1. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can increase the percentage of change in prostate-specific antigen (PSA) from baseline to week 12 of treatment as well as the maximum decline in PSA that occurs at any point after treatment compared to abiraterone acetate alone.

  2. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel for HSPC can prolong time to PSA progression compared to abiraterone acetate alone.

  3. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel for HSPC can improve radiographic response (per Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) compared to abiraterone acetate alone.

  4. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can prolong the overall survival (OS) compared to abiraterone acetate alone.

  5. To assess safety and tolerability of the combination of 6 cycles of cabazitaxel and abiraterone acetate.

TERTIARY OBJECTIVES:

  1. To examine whether patients with circulating tumor cells (CTCs) positive for AR-V7 at baseline have a longer radiographic or clinical PFS to the combination of cabazitaxel and abiraterone acetate vs. abiraterone acetate alone.

  2. To examine whether the addition of cabazitaxel to abiraterone acetate can change the AR-V7 status of patients who are positive at study entry.

  3. To examine whether the addition of cabazitaxel to abiraterone acetate has any impact on future development of AR-V7 positivity at the time of disease progression.

  4. To assess if the changes in total tumor burden from baseline to week 12 as assessed with sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) will differ between two arms.

  5. To correlate total tumor burden at the baseline as assessed with NaF PET/CT with the PFS.

  6. To correlate heterogeneity of response from baseline to week 12 as assessed with NaF PET/CT with the PFS.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive abiraterone acetate orally (PO) once daily (QD) on days 1-21, prednisone PO twice daily (BID) on days 1-21. Courses of abiraterone acetate and prednisone repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients receive cabazitaxel intravenously (IV) over 1 hour on day 1, and treatment with cabazitaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive standard of care antiandrogen therapy with either luteinizing hormone-releasing hormone (LHRH) agonist or antagonist, or surgical castration with bilateral orchiectomy.

ARM B: Patients receive abiraterone acetate and prednisone as in Arm A. Patients also receive standard of care antiandrogen therapy with either LHRH agonist or antagonist, or surgical castration with bilateral orchiectomy.

After completion of study treatment, patients are followed up every 3 or 6 months and then annually for up to 5 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
210 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Cabazitaxel With Abiraterone Versus Abiraterone Alone Randomized Trial for Extensive Disease Following Docetaxel: The CHAARTED2 Trial
Actual Study Start Date :
Feb 8, 2018
Anticipated Primary Completion Date :
Apr 1, 2023
Anticipated Study Completion Date :
Apr 1, 2025

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm A (abiraterone acetate, prednisone, cabazitaxel)

Patients receive abiraterone acetate PO QD on days 1-21, prednisone PO BID on days 1-21. Courses of abiraterone acetate and prednisone repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients receive cabazitaxel IV over 1 hour on day 1, and treatment with cabazitaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive standard of care antiandrogen therapy with either LHRH agonist or antagonist, or surgical castration with bilateral orchiectomy.

Drug: Abiraterone Acetate
Given PO
Other Names:
  • CB7630
  • Zytiga

    • Drug: Antiandrogen Therapy
    Receive standard of care antiandrogen therapy with either LHRH agonist or antagonist
    Other Names:
  • ADT
  • Androgen Deprivation Therapy
  • Anti-androgen Therapy
  • Anti-androgen Treatment
  • Antiandrogen Treatment
  • Hormone Deprivation Therapy
  • Hormone-Deprivation Therapy

    • Drug: Cabazitaxel
    Given IV
    Other Names:
  • Jevtana
  • RPR-116258A
  • Taxoid XRP6258
  • XRP-6258

    • Other: Laboratory Biomarker Analysis
    Correlative studies

    Procedure: Orchiectomy
    Undergo standard of care surgical castration with bilateral orchiectomy
    Other Names:
  • Castration
  • Male Castration
  • Male Gonadectomy
  • orchidectomy

    • Other: Pharmacological Study
    Correlative studies

    Drug: Prednisone
    Given PO
    Other Names:
  • .delta.1-Cortisone
  • 1, 2-Dehydrocortisone
  • Adasone
  • Cortancyl
  • Dacortin
  • DeCortin
  • Decortisyl
  • Decorton
  • Delta 1-Cortisone
  • Delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltadehydrocortisone
  • Deltasone
  • Deltison
  • Deltra
  • Econosone
  • Lisacort
  • Meprosona-F
  • Metacortandracin
  • Meticorten
  • Ofisolona
  • Orasone
  • Panafcort
  • Panasol-S
  • Paracort
  • PRED
  • Predicor
  • Predicorten
  • Prednicen-M
  • Prednicort
  • Prednidib
  • Prednilonga
  • Predniment
  • Prednisonum
  • Prednitone
  • Promifen
  • Servisone
  • SK-Prednisone

    		•
    Active Comparator: Arm B (abiraterone acetate, prednisone)

    Patients receive abiraterone acetate and prednisone as in Arm A. Patients also receive standard of care antiandrogen therapy with either LHRH agonist or antagonist, or surgical castration with bilateral orchiectomy.

    Drug: Abiraterone Acetate
    Given PO
    Other Names:
  • CB7630
  • Zytiga

    • Drug: Antiandrogen Therapy
    Receive standard of care antiandrogen therapy with either LHRH agonist or antagonist
    Other Names:
  • ADT
  • Androgen Deprivation Therapy
  • Anti-androgen Therapy
  • Anti-androgen Treatment
  • Antiandrogen Treatment
  • Hormone Deprivation Therapy
  • Hormone-Deprivation Therapy

    • Other: Laboratory Biomarker Analysis
    Correlative studies

    Procedure: Orchiectomy
    Undergo standard of care surgical castration with bilateral orchiectomy
    Other Names:
  • Castration
  • Male Castration
  • Male Gonadectomy
  • orchidectomy

    • Other: Pharmacological Study
    Correlative studies

    Drug: Prednisone
    Given PO
    Other Names:
  • .delta.1-Cortisone
  • 1, 2-Dehydrocortisone
  • Adasone
  • Cortancyl
  • Dacortin
  • DeCortin
  • Decortisyl
  • Decorton
  • Delta 1-Cortisone
  • Delta-Dome
  • Deltacortene
  • Deltacortisone
  • Deltadehydrocortisone
  • Deltasone
  • Deltison
  • Deltra
  • Econosone
  • Lisacort
  • Meprosona-F
  • Metacortandracin
  • Meticorten
  • Ofisolona
  • Orasone
  • Panafcort
  • Panasol-S
  • Paracort
  • PRED
  • Predicor
  • Predicorten
  • Prednicen-M
  • Prednicort
  • Prednidib
  • Prednilonga
  • Predniment
  • Prednisonum
  • Prednitone
  • Promifen
  • Servisone
  • SK-Prednisone

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression free survival (PFS) [From randomization to radiographic progression, symptomatic deterioration or death, whichever occurs first, assessed for up to 5 years]

      Will be compared between the two arms. Patients who are alive without progression will be censored at the date of last disease assessment.

    Secondary Outcome Measures

    1. Percent change in PSA in serum [Baseline to 12 weeks]

      Will be compared between the two arms using Wilcoxon rank sum test.

    2. Maximum decline in PSA while on treatment [Baseline up to 30 days from last treatment on study]

      Will be compared between the two arms using Wilcoxon rank sum test.

    3. Time to PSA progression [Time from randomization to PSA progression, assessed for up to 30 days from last treatment on study]

      Will be estimated using the Kaplan-Meier method. Stratified log rank test will be used to compare between the two arms.

    4. Overall survival (OS) [Time from randomization to time of death or date last known alive, assessed for up to 5 years]

      Will be estimated for each arm using the Kaplan-Meier method and the stratified logrank test will be used to compare this endpoint across treatments.

    5. Radiographic response (complete and partial response) assessed per Response Evaluation Criteria in Solid Tumors 1.1 [Up to 5 years]

      Fisher's exact test will be used to compare rates between the two arms. Patients with radiographic response unknown or unevaluable will be considered as non-responders in this analysis.

    6. Incidence of adverse events assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0 [Up to 30 days from last treatment on study]

      Will be evaluated for toxicity and the percent of patients with various toxicities will be tabulated.

    Other Outcome Measures

    1. Change in AR-V7 status in circulating tumor cells [Baseline up to 5 years]

      Fisher's exact test will be used to compare the proportion of patients who become AR-V7 negative at follow-up assessments between the two arms among patients who are AR-V7 positive at baseline. Cox regression will be used to evaluate the associations between baseline AR-V7 status and PFS as well as OS and its interaction with treatment.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    Male
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Histologically confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate)

    • Previous chemotherapy with at least 3 cycles of docetaxel for hormone-sensitive metastatic prostate cancer

    • Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/magnetic resonance imaging [MRI] of abdomen/pelvis, bone scintigraphy or NaF PET/CT)

    • Ability to swallow abiraterone acetate tablets as a whole

    • All patients must be receiving standard of care androgen deprivation treatment (surgical castration versus LHRH agonist or antagonist treatment); subjects receiving LHRH agonist or antagonist must continue treatment throughout the time on this study

    • Patients must have castrate serum level of testosterone of < 50 ng/dL (< 1.73 nmol/L)

    • Patients must have progressive disease while receiving androgen deprivation therapy defined by any one of the following as per the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) criteria for PSA, measurable disease or non-measurable (bone) disease during treatment with ADT:

    • PSA: At least two consecutive rises in serum PSA, obtained at a minimum of 1-week intervals, with the final value >= 2.0 ng/mL

    • Measurable disease (by RECIST 1.1): > 20% increase in the sum of the longest diameters of all measurable lesions or the development of new measurable lesions; the short axis of a target lymph node must be more that 15 mm to be assessed for change in size

    • Non-measurable (bone) disease: The appearance of two or more new areas of uptake on bone scan (or NaF PET/CT) consistent with metastatic disease compared to previous imaging during castration therapy; the increased uptake of pre-existing lesions on bone scan will not be taken to constitute progression, and ambiguous results must be confirmed by other imaging modalities (e.g. X-ray, CT or MRI)

    • Patients may or may not have been treated previously with a nonsteroidal antiandrogen, such as flutamide, bicalutamide or nilutamide; for patients previously treated with an antiandrogen, they must be off treatment for at least 4 weeks (for flutamide) or 6 weeks (for bicalutamide or nilutamide) prior to registration and must have shown PSA progression after discontinuing the anti-androgen

    • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

    • Absolute neutrophil count (ANC) >= 1500/mm^3

    • Hemoglobin (HgB) >= 9.0 gr/dL

    • Platelets >= 100,000/mm^3

    • Creatinine < 2.0 mg/dL

    • Patients must be informed of the experimental nature of the study and its potential risks, and must sign an Institutional Review Board (IRB)-approved written informed consent form indicating such an understanding

    • Patients with resected or irradiated brain metastases or those treated with stereotactic radiation therapy are eligible to enroll, provided that they do not require treatment with steroids that exceeds 10 mg of prednisone daily or equivalent

    • Sexually active males must use an accepted and effective method of double barrier contraception or abstain from sexual intercourse for the duration of their participation in the study and for 26 weeks after the last dose of study drug

    • NaF PET/CT OPTIONAL SUB-STUDY ELIGIBILITY CRITERIA

    • Ability to lie still for imaging

    • Weight =< 300 lbs (pounds)

    Exclusion Criteria:

    • Any prior chemotherapy or androgen receptor (AR)-directed therapy for CRPC, (e.g. docetaxel, cabazitaxel, mitoxantrone, abiraterone acetate, ketoconazole, or enzalutamide); previous treatment with radium-223 or sipuleucel-T is allowed

    • Pure small cell or other variant (non-adenocarcinoma) prostate cancer histology for which treatment with abiraterone would not be considered appropriate

    • Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy; concurrent treatment with agents to prevent skeletal-related events (such as zoledronic acid or denosumab) will be allowed as long as it was initiated prior to study entry

    • Any medical condition for which prednisone (corticosteroid) is contraindicated

    • If total bilirubin is > upper limit of normal (ULN) (NOTE: in subjects with Gilbert?s syndrome, if total bilirubin is

    ULN, measure direct and indirect bilirubin and if direct bilirubin is within normal range, subject may be eligible) or

    • Alanine (ALT) or aspartate (AST) aminotransferase > 1.5 x ULN

    • Active infection requiring treatment with antibiotics

    • History of adrenal insufficiency or hypoaldosteronism

    • Myocardial infarction or arterial thrombotic event within 6 months, heart failure of New York Heart Association class II or higher, uncontrolled angina, severe uncontrolled ventricular arrhythmia

    • External beam radiation therapy within 4 weeks of registration

    • Prior history of allergic reactions to G-CSF

    • Prior history of allergic reactions to docetaxel and/or to medications formulated with polysorbate 80

    • History of active malignancy; patients with a history of cancer that has been adequately treated and are free of disease recurrence for 3 years or more are allowed to participate; patients with non-melanoma skin cancers or carcinoma in situ of the bladder that have been adequately excised are eligible to participate

    • Life expectancy of < 12 months at screening

    • Grade >= 2 neuropathy

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    2 CTCA at Western Regional Medical Center Goodyear Arizona United States 85338
    3 Kingman Regional Medical Center Kingman Arizona United States 86401
    4 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    5 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    6 Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro Jonesboro Arkansas United States 72401
    7 John L McClellan Memorial Veterans Hospital Little Rock Arkansas United States 72205
    8 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    9 PCR Oncology Arroyo Grande California United States 93420
    10 Sutter Auburn Faith Hospital Auburn California United States 95602
    11 Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California United States 95603
    12 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    13 Mills-Peninsula Medical Center Burlingame California United States 94010
    14 Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California United States 95682
    15 Eden Hospital Medical Center Castro Valley California United States 94546
    16 Adventist Health Cancer Care Center Chico Chico California United States 95973
    17 Sutter Davis Hospital Davis California United States 95616
    18 Epic Care-Dublin Dublin California United States 94568
    19 Kaiser Permanente Dublin Dublin California United States 94568
    20 Bay Area Breast Surgeons Inc Emeryville California United States 94608
    21 Epic Care Partners in Cancer Care Emeryville California United States 94608
    22 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    23 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    24 Memorial Medical Center Modesto California United States 95355
    25 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    26 Palo Alto Medical Foundation-Gynecologic Oncology Mountain View California United States 94040
    27 Sutter Cancer Research Consortium Novato California United States 94945
    28 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    29 Bay Area Tumor Institute Oakland California United States 94609
    30 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    31 VA Palo Alto Health Care System Palo Alto California United States 94304
    32 Kaiser Permanente-Redwood City Redwood City California United States 94063
    33 Kaiser Permanente-Richmond Richmond California United States 94801
    34 Kaiser Permanente-Roseville Roseville California United States 95661
    35 Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California United States 95661
    36 Sutter Roseville Medical Center Roseville California United States 95661
    37 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    38 Sutter Medical Center Sacramento Sacramento California United States 95816
    39 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    40 Kaiser Permanente - Sacramento Sacramento California United States 95825
    41 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    42 Kaiser Permanente-San Francisco San Francisco California United States 94115
    43 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    44 Kaiser Permanente-San Rafael San Rafael California United States 94903
    45 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    46 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    47 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    48 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    49 Sutter Pacific Medical Foundation Santa Rosa California United States 95403
    50 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    51 Kaiser Permanente-Stockton Stockton California United States 95210
    52 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    53 Sutter Cancer Centers Radiation Oncology Services-Vacaville Vacaville California United States 95687
    54 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    55 Kaiser Permanente-Vallejo Vallejo California United States 94589
    56 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    57 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    58 Epic Care Cyberknife Center Walnut Creek California United States 94597
    59 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    60 The Medical Center of Aurora Aurora Colorado United States 80012
    61 Boulder Community Hospital Boulder Colorado United States 80301
    62 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    63 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    64 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    65 Cancer Center of Colorado at Sloan's Lake Denver Colorado United States 80204
    66 Denver Health Medical Center Denver Colorado United States 80204
    67 National Jewish Health-Main Campus Denver Colorado United States 80206
    68 The Women's Imaging Center Denver Colorado United States 80209
    69 Porter Adventist Hospital Denver Colorado United States 80210
    70 Colorado Blood Cancer Institute Denver Colorado United States 80218
    71 Presbyterian - Saint Lukes Medical Center - Health One Denver Colorado United States 80218
    72 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    73 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    74 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    75 Rose Medical Center Denver Colorado United States 80220
    76 Western Surgical Care Denver Colorado United States 80220
    77 Mercy Medical Center Durango Colorado United States 81301
    78 Southwest Oncology PC Durango Colorado United States 81301
    79 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    80 Swedish Medical Center Englewood Colorado United States 80113
    81 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    82 National Jewish Health-Western Hematology Oncology Golden Colorado United States 80401
    83 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    84 Grand Valley Oncology Grand Junction Colorado United States 81505
    85 North Colorado Medical Center Greeley Colorado United States 80631
    86 Good Samaritan Medical Center Lafayette Colorado United States 80026
    87 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    88 Saint Anthony Hospital Lakewood Colorado United States 80228
    89 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    90 Littleton Adventist Hospital Littleton Colorado United States 80122
    91 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    92 Sky Ridge Medical Center Lone Tree Colorado United States 80124
    93 Longmont United Hospital Longmont Colorado United States 80501
    94 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    95 McKee Medical Center Loveland Colorado United States 80539
    96 Parker Adventist Hospital Parker Colorado United States 80138
    97 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    98 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    99 Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado United States 81008
    100 National Jewish Health-Northern Hematology Oncology Thornton Colorado United States 80260
    101 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    102 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    103 Smilow Cancer Hospital-Derby Care Center Derby Connecticut United States 06418
    104 Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut United States 06824
    105 Greenwich Hospital Greenwich Connecticut United States 06830
    106 Smilow Cancer Hospital Care Center - Guiford Guilford Connecticut United States 06437
    107 Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut United States 06105
    108 Middlesex Hospital Middletown Connecticut United States 06457
    109 Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut United States 06510
    110 Yale University New Haven Connecticut United States 06520
    111 Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut United States 06473
    112 Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut United States 06611
    113 Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut United States 06708
    114 Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut United States 06385
    115 Bayhealth Hospital Kent Campus Dover Delaware United States 19901
    116 Beebe Medical Center Lewes Delaware United States 19958
    117 Bayhealth Hospital Sussex Campus Milford Delaware United States 19963
    118 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    119 Helen F Graham Cancer Center Newark Delaware United States 19713
    120 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    121 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    122 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    123 Nanticoke Memorial Hospital Seaford Delaware United States 19973
    124 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    125 Sibley Memorial Hospital Washington District of Columbia United States 20016
    126 George Washington University Medical Center Washington District of Columbia United States 20037
    127 Grady Health System Atlanta Georgia United States 30303
    128 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    129 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    130 John B Amos Cancer Center Columbus Georgia United States 31904
    131 Atlanta VA Medical Center Decatur Georgia United States 30033
    132 CTCA at Southeastern Regional Medical Center Newnan Georgia United States 30265
    133 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    134 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    135 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    136 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    137 Hawaii Cancer Care Inc-POB II Honolulu Hawaii United States 96813
    138 Island Urology Honolulu Hawaii United States 96813
    139 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    140 Queen's Medical Center Honolulu Hawaii United States 96813
    141 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    142 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    143 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    144 Kuakini Medical Center Honolulu Hawaii United States 96817
    145 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    146 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    147 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    148 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    149 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    150 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    151 Kootenai Medical Center Coeur d'Alene Idaho United States 83814
    152 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    153 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    154 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    155 Kootenai Cancer Center Post Falls Idaho United States 83854
    156 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    157 Rush - Copley Medical Center Aurora Illinois United States 60504
    158 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    159 Illinois CancerCare-Canton Canton Illinois United States 61520
    160 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    161 SIH Cancer Institute Carterville Illinois United States 62918
    162 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    163 Centralia Oncology Clinic Centralia Illinois United States 62801
    164 Northwestern University Chicago Illinois United States 60611
    165 Carle on Vermilion Danville Illinois United States 61832
    166 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    167 Decatur Memorial Hospital Decatur Illinois United States 62526
    168 Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois United States 60115
    169 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    170 Carle Physician Group-Effingham Effingham Illinois United States 62401
    171 Crossroads Cancer Center Effingham Illinois United States 62401
    172 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    173 NorthShore University HealthSystem-Evanston Hospital Evanston Illinois United States 60201
    174 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    175 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    176 Northwestern Medicine Cancer Center Delnor Geneva Illinois United States 60134
    177 NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois United States 60026
    178 NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois United States 60035
    179 Joliet Oncology-Hematology Associates Limited Joliet Illinois United States 60435
    180 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    181 Northwestern Medicine Lake Forest Hospital Lake Forest Illinois United States 60045
    182 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    183 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    184 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    185 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    186 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    187 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    188 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    189 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    190 Illinois CancerCare-Peru Peru Illinois United States 61354
    191 Valley Radiation Oncology Peru Illinois United States 61354
    192 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    193 North Shore Medical Center Skokie Illinois United States 60076
    194 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    195 Springfield Clinic Springfield Illinois United States 62702
    196 Memorial Medical Center Springfield Illinois United States 62781
    197 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    198 Carle Cancer Center Urbana Illinois United States 61801
    199 The Carle Foundation Hospital Urbana Illinois United States 61801
    200 Northwestern Medicine Cancer Center Warrenville Warrenville Illinois United States 60555
    201 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    202 Deaconess Clinic Downtown Evansville Indiana United States 47713
    203 Parkview Hospital Randallia Fort Wayne Indiana United States 46805
    204 Parkview Regional Medical Center Fort Wayne Indiana United States 46845
    205 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis Indiana United States 46202
    206 Richard L. Roudebush Veterans Affairs Medical Center Indianapolis Indiana United States 46202
    207 Sidney and Lois Eskenazi Hospital Indianapolis Indiana United States 46202
    208 Memorial Regional Cancer Center Day Road Mishawaka Indiana United States 46545
    209 Chancellor Center for Oncology Newburgh Indiana United States 47630
    210 Reid Health Richmond Indiana United States 47374
    211 Memorial Hospital of South Bend South Bend Indiana United States 46601
    212 Mary Greeley Medical Center Ames Iowa United States 50010
    213 McFarland Clinic PC - Ames Ames Iowa United States 50010
    214 McFarland Clinic PC-Boone Boone Iowa United States 50036
    215 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    216 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    217 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    218 Greater Regional Medical Center Creston Iowa United States 50801
    219 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    220 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    221 Broadlawns Medical Center Des Moines Iowa United States 50314
    222 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    223 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    224 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    225 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    226 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    227 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    228 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    229 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    230 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    231 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    232 Coffeyville Regional Medical Center Coffeyville Kansas United States 67337
    233 University of Kansas Clinical Research Center Fairway Kansas United States 66205
    234 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    235 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    236 HaysMed University of Kansas Health System Hays Kansas United States 67601
    237 University of Kansas Cancer Center-West Kansas City Kansas United States 66112
    238 University of Kansas Cancer Center Kansas City Kansas United States 66160
    239 Lawrence Memorial Hospital Lawrence Kansas United States 66044
    240 Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas United States 66219
    241 Minimally Invasive Surgery Hospital Lenexa Kansas United States 66219
    242 Olathe Health Cancer Center Olathe Kansas United States 66061
    243 Menorah Medical Center Overland Park Kansas United States 66209
    244 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    245 Ascension Via Christi - Pittsburg Pittsburg Kansas United States 66762
    246 Salina Regional Health Center Salina Kansas United States 67401
    247 University of Kansas Health System Saint Francis Campus Topeka Kansas United States 66606
    248 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    249 Cancer Center of Kansas-Wichita Medical Arts Tower Wichita Kansas United States 67208
    250 Cancer Center of Kansas - Wichita Wichita Kansas United States 67214
    251 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    252 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    253 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    254 Saint Joseph Hospital East Lexington Kentucky United States 40509
    255 University of Kentucky/Markey Cancer Center Lexington Kentucky United States 40536
    256 Saint Joseph London London Kentucky United States 40741
    257 Jewish Hospital Louisville Kentucky United States 40202
    258 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    259 Jewish Hospital Medical Center Northeast Louisville Kentucky United States 40245
    260 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    261 East Jefferson General Hospital Metairie Louisiana United States 70006
    262 LSU Healthcare Network / Metairie Multi-Specialty Clinic Metairie Louisiana United States 70006
    263 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    264 University Medical Center New Orleans New Orleans Louisiana United States 70112
    265 Veteran's Administration Medical Center - New Orleans New Orleans Louisiana United States 70112
    266 Harold Alfond Center for Cancer Care Augusta Maine United States 04330
    267 Waldo County General Hospital Belfast Maine United States 04915
    268 MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford Biddeford Maine United States 04005
    269 Stephens Memorial Hospital Norway Maine United States 04268
    270 Penobscot Bay Medical Center Rockport Maine United States 04856
    271 MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford Sanford Maine United States 04073
    272 Maine Medical Partners - South Portland South Portland Maine United States 04106
    273 Anne Arundel Medical Center Annapolis Maryland United States 21401
    274 Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland United States 21287
    275 Walter Reed National Military Medical Center Bethesda Maryland United States 20889-5600
    276 Simonds-Sinon Regional Cancer Center Fitchburg Massachusetts United States 01420
    277 Baystate Medical Center Springfield Massachusetts United States 01199
    278 UMass Memorial Medical Center - University Campus Worcester Massachusetts United States 01655
    279 Hickman Cancer Center Adrian Michigan United States 49221
    280 Bronson Battle Creek Battle Creek Michigan United States 49017
    281 McLaren Cancer Institute-Bay City Bay City Michigan United States 48706
    282 McLaren Cancer Institute-Bloomfield Bloomfield Michigan United States 48302
    283 McLaren Cancer Institute-Clarkston Clarkston Michigan United States 48346
    284 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    285 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    286 McLaren Cancer Institute-Flint Flint Michigan United States 48532
    287 Singh and Arora Hematology Oncology PC Flint Michigan United States 48532
    288 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    289 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    290 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    291 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    292 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    293 Borgess Medical Center Kalamazoo Michigan United States 49048
    294 McLaren-Greater Lansing Lansing Michigan United States 48910
    295 McLaren Cancer Institute-Lapeer Region Lapeer Michigan United States 48446
    296 Toledo Clinic Cancer Centers-Monroe Monroe Michigan United States 48162
    297 McLaren Cancer Institute-Macomb Mount Clemens Michigan United States 48043
    298 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    299 Lakeland Hospital Niles Niles Michigan United States 49120
    300 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    301 McLaren Cancer Institute-Northern Michigan Petoskey Michigan United States 49770
    302 Huron Medical Center PC Port Huron Michigan United States 48060
    303 Lake Huron Medical Center Port Huron Michigan United States 48060
    304 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    305 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    306 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    307 Munson Medical Center Traverse City Michigan United States 49684
    308 Metro Health Hospital Wyoming Michigan United States 49519
    309 Riverwood Healthcare Center Aitkin Minnesota United States 56431
    310 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    311 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    312 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    313 Cambridge Medical Center Cambridge Minnesota United States 55008
    314 Mercy Hospital Coon Rapids Minnesota United States 55433
    315 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    316 Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota United States 56501
    317 Essentia Health Cancer Center Duluth Minnesota United States 55805
    318 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    319 Miller-Dwan Hospital Duluth Minnesota United States 55805
    320 Fairview Southdale Hospital Edina Minnesota United States 55435
    321 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    322 Essentia Health - Fosston Fosston Minnesota United States 56542
    323 Unity Hospital Fridley Minnesota United States 55432
    324 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    325 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    326 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    327 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    328 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    329 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    330 Health Partners Inc Minneapolis Minnesota United States 55454
    331 Monticello Cancer Center Monticello Minnesota United States 55362
    332 New Ulm Medical Center New Ulm Minnesota United States 56073
    333 Essentia Health - Park Rapids Park Rapids Minnesota United States 56470
    334 Fairview Northland Medical Center Princeton Minnesota United States 55371
    335 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    336 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota United States 56303
    337 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    338 Regions Hospital Saint Paul Minnesota United States 55101
    339 United Hospital Saint Paul Minnesota United States 55102
    340 Essentia Health Sandstone Sandstone Minnesota United States 55072
    341 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    342 Lakeview Hospital Stillwater Minnesota United States 55082
    343 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    344 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    345 Ridgeview Medical Center Waconia Minnesota United States 55387
    346 Rice Memorial Hospital Willmar Minnesota United States 56201
    347 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    348 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    349 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    350 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    351 University of Mississippi Medical Center Jackson Mississippi United States 39216
    352 Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi United States 38652
    353 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    354 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    355 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    356 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    357 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    358 Cox Cancer Center Branson Branson Missouri United States 65616
    359 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    360 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    361 University of Missouri - Ellis Fischel Columbia Missouri United States 65212
    362 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    363 Parkland Health Center - Farmington Farmington Missouri United States 63640
    364 Centerpoint Medical Center LLC Independence Missouri United States 64057
    365 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    366 Freeman Health System Joplin Missouri United States 64804
    367 Mercy Hospital Joplin Joplin Missouri United States 64804
    368 Truman Medical Centers Kansas City Missouri United States 64108
    369 The University of Kansas Cancer Center-South Kansas City Missouri United States 64131
    370 Research Medical Center Kansas City Missouri United States 64132
    371 University of Kansas Cancer Center - North Kansas City Missouri United States 64154
    372 University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri United States 64064
    373 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    374 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    375 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    376 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    377 Washington University School of Medicine Saint Louis Missouri United States 63110
    378 Veteran's Affairs Medical Center - Saint Louis Saint Louis Missouri United States 63125
    379 Mercy Hospital South Saint Louis Missouri United States 63128
    380 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    381 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    382 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    383 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    384 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    385 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    386 Mercy Hospital Springfield Springfield Missouri United States 65804
    387 CoxHealth South Hospital Springfield Missouri United States 65807
    388 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    389 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    390 Mercy Hospital Washington Washington Missouri United States 63090
    391 Community Hospital of Anaconda Anaconda Montana United States 59711
    392 Billings Clinic Cancer Center Billings Montana United States 59101
    393 Saint Vincent Healthcare Billings Montana United States 59101
    394 Saint Vincent Frontier Cancer Center Billings Montana United States 59102
    395 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    396 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    397 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    398 Great Falls Clinic Great Falls Montana United States 59405
    399 Saint Peter's Community Hospital Helena Montana United States 59601
    400 Kalispell Regional Medical Center Kalispell Montana United States 59901
    401 Community Medical Hospital Missoula Montana United States 59804
    402 CHI Health Saint Francis Grand Island Nebraska United States 68803
    403 Heartland Hematology and Oncology Kearney Nebraska United States 68845
    404 CHI Health Good Samaritan Kearney Nebraska United States 68847
    405 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    406 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    407 Hematology and Oncology Consultants PC Omaha Nebraska United States 68122
    408 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    409 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    410 Creighton University Medical Center Omaha Nebraska United States 68131
    411 Midlands Community Hospital Papillion Nebraska United States 68046
    412 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    413 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    414 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    415 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    416 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    417 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    418 21st Century Oncology-Henderson Henderson Nevada United States 89074
    419 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    420 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    421 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    422 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    423 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    424 Desert West Surgery Las Vegas Nevada United States 89102
    425 OptumCare Cancer Care at Oakey Las Vegas Nevada United States 89102
    426 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    427 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    428 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    429 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    430 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    431 21st Century Oncology Las Vegas Nevada United States 89109
    432 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    433 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    434 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    435 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    436 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    437 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    438 Cancer Therapy and Integrative Medicine Las Vegas Nevada United States 89121
    439 21st Century Oncology-Vegas Tenaya Las Vegas Nevada United States 89128
    440 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    441 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    442 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    443 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    444 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    445 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    446 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    447 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    448 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    449 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    450 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    451 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    452 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    453 21st Century Oncology-Fort Apache Las Vegas Nevada United States 89148
    454 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    455 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    456 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89148
    457 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    458 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    459 University Cancer Center Las Vegas Nevada United States 89169
    460 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    461 Renown Regional Medical Center Reno Nevada United States 89502
    462 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    463 Radiation Oncology Associates Reno Nevada United States 89509
    464 AtlantiCare Health Park-Cape May Court House Cape May Court House New Jersey United States 08210
    465 AtlantiCare Surgery Center Egg Harbor Township New Jersey United States 08234
    466 Holy Name Hospital Teaneck New Jersey United States 07666
    467 Montefiore Medical Center-Einstein Campus Bronx New York United States 10461
    468 Montefiore Medical Center-Weiler Hospital Bronx New York United States 10461
    469 Montefiore Medical Center - Moses Campus Bronx New York United States 10467
    470 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    471 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    472 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    473 East Carolina University Greenville North Carolina United States 27834
    474 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    475 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    476 Vidant Oncology-Kenansville Kenansville North Carolina United States 28349
    477 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    478 Vidant Oncology-Richlands Richlands North Carolina United States 28574
    479 Marion L Shepard Cancer Center at Vidant Beaufort Hospital Washington North Carolina United States 27889
    480 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    481 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    482 Sanford South University Medical Center Fargo North Dakota United States 58103
    483 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    484 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    485 Essentia Health - Jamestown Clinic Jamestown North Dakota United States 58401
    486 Cleveland Clinic Akron General Akron Ohio United States 44307
    487 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    488 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    489 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    490 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    491 Miami Valley Hospital South Centerville Ohio United States 45459
    492 Geauga Hospital Chardon Ohio United States 44024
    493 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    494 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    495 Bethesda North Hospital Cincinnati Ohio United States 45242
    496 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    497 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    498 Case Western Reserve University Cleveland Ohio United States 44106
    499 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    500 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    501 Miami Valley Hospital Dayton Ohio United States 45409
    502 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    503 Miami Valley Hospital North Dayton Ohio United States 45415
    504 Mercy Cancer Center-Elyria Elyria Ohio United States 44035
    505 Armes Family Cancer Center Findlay Ohio United States 45840
    506 Blanchard Valley Hospital Findlay Ohio United States 45840
    507 Orion Cancer Care Findlay Ohio United States 45840
    508 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    509 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    510 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    511 Wayne Hospital Greenville Ohio United States 45331
    512 Greater Dayton Cancer Center Kettering Ohio United States 45409
    513 First Dayton Cancer Care Kettering Ohio United States 45420
    514 Kettering Medical Center Kettering Ohio United States 45429
    515 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
    516 Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio United States 43537
    517 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    518 University Hospitals Parma Medical Center Parma Ohio United States 44129
    519 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    520 UH Seidman Cancer Center at Firelands Regional Medical Center Sandusky Ohio United States 44870
    521 Springfield Regional Cancer Center Springfield Ohio United States 45504
    522 Springfield Regional Medical Center Springfield Ohio United States 45505
    523 ProMedica Flower Hospital Sylvania Ohio United States 43560
    524 ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital Toledo Ohio United States 43606
    525 Mercy Saint Anne Hospital Toledo Ohio United States 43623
    526 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    527 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    528 Upper Valley Medical Center Troy Ohio United States 45373
    529 Saint Joseph Warren Hospital Warren Ohio United States 44484
    530 UHHS-Westlake Medical Center Westlake Ohio United States 44145
    531 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    532 Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma United States 73505
    533 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    534 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    535 Cancer Treatment Centers of America Tulsa Oklahoma United States 74133
    536 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    537 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    538 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    539 Abington Memorial Hospital Abington Pennsylvania United States 19001
    540 UPMC-Heritage Valley Health System Beaver Beaver Pennsylvania United States 15009
    541 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    542 Geisinger Medical Center Danville Pennsylvania United States 17822
    543 UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania United States 15601
    544 UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania United States 17109
    545 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    546 Penn State Milton S Hershey Medical Center Hershey Pennsylvania United States 17033-0850
    547 UPMC-Johnstown/John P. Murtha Regional Cancer Center Johnstown Pennsylvania United States 15901
    548 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    549 Lewistown Hospital Lewistown Pennsylvania United States 17044
    550 UPMC Cancer Center at UPMC McKeesport McKeesport Pennsylvania United States 15132
    551 UPMC-Coraopolis/Heritage Valley Radiation Oncology Moon Pennsylvania United States 15108
    552 University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania United States 19104
    553 Temple University Hospital Philadelphia Pennsylvania United States 19140
    554 UPMC-Magee Womens Hospital Pittsburgh Pennsylvania United States 15213
    555 UPMC-Presbyterian Hospital Pittsburgh Pennsylvania United States 15213
    556 UPMC-Saint Margaret Pittsburgh Pennsylvania United States 15215
    557 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania United States 15232
    558 UPMC-Shadyside Hospital Pittsburgh Pennsylvania United States 15232
    559 UPMC-Passavant Hospital Pittsburgh Pennsylvania United States 15237
    560 UPMC-Saint Clair Hospital Cancer Center Pittsburgh Pennsylvania United States 15243
    561 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    562 Guthrie Medical Group PC-Robert Packer Hospital Sayre Pennsylvania United States 18840
    563 Community Medical Center Scranton Pennsylvania United States 18510
    564 Geisinger Medical Oncology-Selinsgrove Selinsgrove Pennsylvania United States 17870
    565 UPMC Cancer Center at UPMC Northwest Seneca Pennsylvania United States 16346
    566 Geisinger Medical Group State College Pennsylvania United States 16801
    567 UPMC Uniontown Hospital Radiation Oncology Uniontown Pennsylvania United States 15401
    568 UPMC Washington Hospital Radiation Oncology Washington Pennsylvania United States 15301
    569 Reading Hospital West Reading Pennsylvania United States 19611
    570 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    571 UPMC Susquehanna Williamsport Pennsylvania United States 17701
    572 Abington Memorial Hospital-Asplundh Cancer Pavilion Willow Grove Pennsylvania United States 19090
    573 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    574 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    575 Wellmont Bristol Regional Medical Center Bristol Tennessee United States 37620
    576 Memorial Hospital Chattanooga Tennessee United States 37404
    577 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    578 Vanderbilt-Ingram Cancer Center Cool Springs Franklin Tennessee United States 37067
    579 Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee United States 37343
    580 Wellmont Medical Associates Oncology and Hematology-Johnson City Johnson City Tennessee United States 37604
    581 Regional Cancer Center at Indian Path Community Hospital Kingsport Tennessee United States 37660
    582 Wellmont Holston Valley Hospital and Medical Center Kingsport Tennessee United States 37660
    583 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    584 Vanderbilt Breast Center at One Hundred Oaks Nashville Tennessee United States 37204
    585 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    586 Memorial GYN Plus Ooltewah Tennessee United States 37363
    587 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    588 MD Anderson in The Woodlands Conroe Texas United States 77384
    589 Lyndon Baines Johnson General Hospital Houston Texas United States 77026-1967
    590 M D Anderson Cancer Center Houston Texas United States 77030
    591 MD Anderson West Houston Houston Texas United States 77079
    592 MD Anderson League City League City Texas United States 77573
    593 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229
    594 MD Anderson in Sugar Land Sugar Land Texas United States 77478
    595 American Fork Hospital / Huntsman Intermountain Cancer Center American Fork Utah United States 84003
    596 Sandra L Maxwell Cancer Center Cedar City Utah United States 84720
    597 Farmington Health Center Farmington Utah United States 84025
    598 Logan Regional Hospital Logan Utah United States 84321
    599 Intermountain Medical Center Murray Utah United States 84107
    600 McKay-Dee Hospital Center Ogden Utah United States 84403
    601 Utah Valley Regional Medical Center Provo Utah United States 84604
    602 Riverton Hospital Riverton Utah United States 84065
    603 Dixie Medical Center Regional Cancer Center Saint George Utah United States 84770
    604 Utah Cancer Specialists-Salt Lake City Salt Lake City Utah United States 84106
    605 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    606 LDS Hospital Salt Lake City Utah United States 84143
    607 South Jordan Health Center South Jordan Utah United States 84009
    608 Wellmont Medical Associates-Bristol Bristol Virginia United States 24201
    609 University of Virginia Cancer Center Charlottesville Virginia United States 22908
    610 Sovah Health Martinsville Martinsville Virginia United States 24115
    611 Bon Secours Memorial Regional Medical Center Mechanicsville Virginia United States 23116
    612 Bon Secours Saint Francis Medical Center Midlothian Virginia United States 23114
    613 Bon Secours DePaul Medical Center Norfolk Virginia United States 23505
    614 Southwest VA Regional Cancer Center Norton Virginia United States 24273
    615 Bon Secours Maryview Medical Center Portsmouth Virginia United States 23707
    616 Bon Secours Saint Mary's Hospital Richmond Virginia United States 23226
    617 Bon Secours Cancer Institute at Reynolds Crossing Richmond Virginia United States 23230
    618 Bon Secours Health Center at Harbour View Suffolk Virginia United States 23435
    619 MultiCare Auburn Medical Center Auburn Washington United States 98001
    620 Overlake Hospital Medical Center Bellevue Washington United States 98004
    621 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    622 Harrison Medical Center Bremerton Washington United States 98310
    623 Highline Medical Center-Main Campus Burien Washington United States 98166
    624 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    625 Saint Francis Hospital Federal Way Washington United States 98003
    626 MultiCare Gig Harbor Medical Park Gig Harbor Washington United States 98335
    627 Saint Clare Hospital Lakewood Washington United States 98499
    628 Jefferson Healthcare Port Townsend Washington United States 98368
    629 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    630 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    631 Valley Medical Center Renton Washington United States 98055
    632 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    633 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    634 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    635 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    636 Mary Bridge Children's Hospital and Health Center Tacoma Washington United States 98405
    637 MultiCare Tacoma General Hospital Tacoma Washington United States 98405
    638 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    639 West Virginia University Charleston Division Charleston West Virginia United States 25304
    640 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    641 Northwest Wisconsin Cancer Center Ashland Wisconsin United States 54806
    642 Marshfield Clinic-Chippewa Center Chippewa Falls Wisconsin United States 54729
    643 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    644 Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin United States 54301
    645 Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin United States 54303
    646 UW Cancer Center Johnson Creek Johnson Creek Wisconsin United States 53038
    647 Marshfield Clinic - Ladysmith Center Ladysmith Wisconsin United States 54848
    648 University of Wisconsin Hospital and Clinics Madison Wisconsin United States 53792
    649 Holy Family Memorial Hospital Manitowoc Wisconsin United States 54221
    650 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    651 Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin United States 53051
    652 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    653 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    654 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    655 Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin United States 54154
    656 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    657 Marshfield Clinic Stevens Point Center Stevens Point Wisconsin United States 54482
    658 Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin United States 54235-1495
    659 Marshfield Clinic-Wausau Center Wausau Wisconsin United States 54401
    660 Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin United States 53095
    661 Marshfield Clinic - Weston Center Weston Wisconsin United States 54476
    662 Marshfield Clinic - Wisconsin Rapids Center Wisconsin Rapids Wisconsin United States 54494
    663 Cheyenne Regional Medical Center-West Cheyenne Wyoming United States 82001
    664 Billings Clinic-Cody Cody Wyoming United States 82414
    665 Welch Cancer Center Sheridan Wyoming United States 82801
    666 Cancer Center-Metro Medical Center Bayamon Bayamon Puerto Rico 00959-5060
    667 HIMA San Pablo Oncologic Hospital Caguas Puerto Rico 00726
    668 Doctors Cancer Center Manati Puerto Rico 00674
    669 Instituto Oncologia Moderna Ponce Ponce Puerto Rico 00716
    670 San Juan Community Oncology Group San Juan Puerto Rico 00917
    671 Centro Comprensivo de Cancer de UPR San Juan Puerto Rico 00927
    672 San Juan City Hospital San Juan Puerto Rico 00936

    Sponsors and Collaborators

    • ECOG-ACRIN Cancer Research Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Christos Kyriakopoulos, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    ECOG-ACRIN Cancer Research Group
    ClinicalTrials.gov Identifier:
    NCT03419234
    Other Study ID Numbers:
    • EA8153
    • NCI-2017-00389
    • EA8153
    • EA8153
    • U10CA180820
    First Posted:
    Feb 1, 2018
    Last Update Posted:
    Jan 3, 2022
    Last Verified:
    Dec 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Product Manufactured in and Exported from the U.S.:
    Yes
    Additional relevant MeSH terms:
    Carcinoma
    Prostatic Neoplasms
    Ascorbic Acid
    Prednisone
    Cortisone
    Methyltestosterone
    Abiraterone Acetate
    Hormones
    Estrogens, Conjugated (USP)
    Androgens
    Androgen Antagonists

    Study Results

    No Results Posted as of Jan 3, 2022