ANEMIA: Causes and Mechanisms of Space Hemolysis at High Altitudes
Study Details
Study Description
Brief Summary
Anemia is a lack of red blood cells (RBCs) in the circulation. Because RBCs carry the oxygen your body needs to function, anemia can affect one's ability to stay awake, alert, and perform physical activities. Anemia may happen for several reasons, including increased RBC destruction. Anemia often occurs in people who have been in bed for long periods (e.g., if they are very sick) or have decreased mobility (anemia of immobility). Interestingly, astronauts who have left Earth and traveled in space also return anemic. In fact, 5 decades of NASA data showed that astronauts' anemia was more severe the longer they were in space. In another study, astronauts aboard the International Space Station were shown to destroy 54% more of their RBCs in space. RBC destruction may be the culprit of space anemia as well as anemia of immobility on Earth. The ANEMIA Study proposes to measure key aspects of RBC destruction in astronauts in space. These measures will test critical hypotheses on the effects of spaceflight on red blood cells.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Group The group is a cohort of 4 persons. |
Outcome Measures
Primary Outcome Measures
- Hemolysis in astronauts is assessed using exhaled breath samples. [Before spaceflight.]
- Change from baseline hemolysis in astronauts is assessed during spaceflight using exhaled breath samples. [Baseline and during spaceflight.]
- Change from baseline hemolysis in astronauts is assessed after spaceflight, up to 1 month, using exhaled breath samples. [After spaceflight, up to 1 month.]
- Hemolysis in astronauts is assessed using blood markers CBC, reticulocytes, haptoglobin, bilirubin (total+direct), LDH, ferritin, iron, and TIBC. [Before spaceflight.]
- Change from baseline hemolysis in astronauts is assessed during spaceflight using blood markers CBC, reticulocytes, haptoglobin, bilirubin (total+direct), LDH, ferritin, iron, and TIBC. [Baseline and during spaceflight.]
- Change from baseline hemolysis in astronauts is assessed after spaceflight, up to 1 month, using blood markers CBC, reticulocytes, haptoglobin, bilirubin (total+direct), LDH, ferritin, iron, and TIBC. [After spaceflight, up to 1 month.]
Eligibility Criteria
Criteria
Inclusion Criteria:
- Astronauts selected to fly on a space mission.
Exclusion Criteria:
- Astronauts not selected to fly on a space mission.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ottawa Hospital Research Institute | Ottawa | Ontario | Canada | K1Y 4E9 |
Sponsors and Collaborators
- Ottawa Hospital Research Institute
Investigators
- Principal Investigator: Guy Trudel, Ottawa Hospital Research Institute
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 0220470-01H