Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis
Study Details
Study Description
Brief Summary
The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 4 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: laparoscopic operation on rocuronium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
Drug: rocuronium
Rocuronium 0.6 mg.kg-1 was administered within 5 s as an intravenous bolus
|
| Experimental: laparoscopic operation on cisatracurium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
Drug: cisatracurium
cisatracurium 0.15mg.kg-1 was administered within 5 s as an intravenous bolus
|
| Experimental: conventional open surgery on rocuronium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
Drug: rocuronium
Rocuronium 0.6 mg.kg-1 was administered within 5 s as an intravenous bolus
|
| Experimental: conventional open surgery on cisatracurium according different surgical type, all patients were divided into 2 groups: the laparoscopic surgery group and open surgery group.Each group were randomly assigned to the rocuronium group and cisatracurium group. |
Drug: cisatracurium
cisatracurium 0.15mg.kg-1 was administered within 5 s as an intravenous bolus
|
Outcome Measures
Primary Outcome Measures
- the blood flow in the right and middle hepatic veins [up to 9 months]
Measurements of the blood flow in the right and middle hepatic veins were performed at baseline and 1,5, 10, 20, 30min after insufflation of carbon dioxide or incise the skin as well as 1 and 5 min after deflation or close the wound.
Secondary Outcome Measures
- the plasma Concentration of rocuronium and cisatracurium [up to 9 months]
Venous blood samples (3 ml) were taken 2 min prior to and at 5,30, 60 min following administration of rocuronium/cisatracurium.The aim of the present was to study the blood concentration of rocuronium/cisatracurium in laparoscopic surgery compared with conventional open gynaecological surgery
Other Outcome Measures
- pharmacodynamic comparison of rocuronium and cisatracurium [up to 9 months]
This study was undertaken to investigate the duration of action of 0.9 mg.kg-1 rocuronium or cisatracurium 0.15 mg.kg-1 administered during laparoscopic surgery compared with conventional open gynaecological surgery.Adductor pollicis train-of-four responses following ulnar nerve stimulation were monitored with mechanomyography.We recorded the time from the end of injection of rocuronium or cisatracurium to time to recovery of T1, and to recovery to 5% and 25% of baseline height
Eligibility Criteria
Criteria
Inclusion Criteria:
-
American Society of Anesthesiology 1-2
-
BMI 18-30 kg.m-2
-
elective gynaecological operations under general anaesthesia
Exclusion Criteria:
-
cirrhosis
-
hepatitis
-
hepatoma
-
heart failure
-
arrhythmia
-
renal dysfunction
-
electrolyte disturbances
-
acid-base imbalances
-
neuromuscular disorders
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Fudan University
Investigators
- Principal Investigator: Shaoqiang Huang, doctor, Obstetrics and Gynecology,Fudan University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- TingtingWang