Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Sponsor

Radboud University Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT00441753

Collaborator

(none)

Enrollment

Location

Study Details

Study Description

Brief Summary

Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Condition or Disease	Intervention/Treatment	Phase
Cardiac Arrest Post-Anoxic Encephalopathy

Study Design

Study Type:

Observational

Anticipated Enrollment :

10 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Study Start Date :

Sep 1, 2006

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 95 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

adult patients
GCS after return of circulation < 7
Induced mild hypothermia for 24 hours
primary rhythm ventricular fibrillation

Exclusion Criteria:

Thrombolysis
Cardiogenic shock with expected survival < 24 hrs
Pregnancy
No informed consent

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Radboud University Nijmegen Medical Centre	Nijmegen		Netherlands	6500 HB

Sponsors and Collaborators

Radboud University Medical Center

Investigators

Principal Investigator: Cornelia Hoedemaekers, MD PhD, Radboud University Medical Center
Study Director: Johannes van der Hoeven, MD PhD, Radboud University Medical Center