Evaluation of Cerebral Venous Return With Internal Jugular Vein Blood Flow in Gynecological Laparoscopic Surgery

Sponsor

Selcuk University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT04922060

Collaborator

(none)

Enrollment

Anticipated Duration (Days)

Study Details

Study Description

Brief Summary

The steep Trendelenburg position (STP) provides an advantage in laparoscopic procedures as it optimizes the surgical image. In laparoscopic operations, the need for CO2 pneumoperitoneum (PP), together with this non-physiological position, raises concerns about the patient's physiological homeostasis. Although most patients seem to tolerate the combination of STP and PP, this method carries risks of ICP (intracranial pressure) and brain perfusion. The head-down position increases arterial pressure as well as CVP, thereby disrupting cerebral venous drainage and increasing hydrostatic pressures in the cerebral vascular system. This increases cerebrovascular resistance and decreases cerebral blood flow by increasing ICP and cerebral edema. Systemic CO2 absorption from pneumoperitoneum causes hypercarbia. Hypercarbia can increase cerebral blood flow through cerebral vasodilation.

Seventy-four percent to 95% of cerebral venous drainage in the supine position is provided by IJVs. Studies have shown that IJVs, which are responsible for most cerebral venous drainage, exhibit changes in diameter and blood flow due to TP. These studies were generally conducted on moderate TP and on healthy volunteers. In this study, we aim to evaluate the effects of a steep Trendelenburg position (25°) and pneumoperitoneum on IJV blood flow in patients undergoing operation under general anesthesia

Condition or Disease	Intervention/Treatment	Phase
Internal Jugular Vein (IJV) Blood Flow in Gynecological Laparoscopic Surgery

Study Design

Study Type:

Observational

Anticipated Enrollment :

20 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Evaluation of Cerebral Venous Return With Internal Jugular Vein Blood Flow in Gynecological Laparoscopic Surgery

Anticipated Study Start Date :

Jun 8, 2021

Anticipated Primary Completion Date :

Jun 24, 2021

Anticipated Study Completion Date :

Jun 30, 2021

Outcome Measures

Primary Outcome Measures

Change in internal jugular vein blood flow in laparoscopic gynecological cases [90 minute]
to evaluate the effects of the pneumoperitoneum (PP) and steep Trendelenburg position (STP) on cerebral venous return with internal jugular vein (IJV) blood flow in gynecological laparoscopic surgery

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Inclusion Criteria:

ASA I-II physical status age between 18 and 65 years planned gynecological laparoscopic surgery. -

Exclusion Criteria:

history of head and neck surgery history of cerebrovascular disease ASA III-IV physical status

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

Selcuk University

Investigators

Principal Investigator: emine ASLANLAR, selcuk univercity medical faculty

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

EMİNE ASLANLAR, Assistant professor, Selcuk University

ClinicalTrials.gov Identifier:

NCT04922060

Other Study ID Numbers:

EASLANLAR

First Posted:

Jun 10, 2021

Last Update Posted:

Jun 15, 2021

Last Verified:

Jun 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by EMİNE ASLANLAR, Assistant professor, Selcuk University

Laparoscopic surgery

cerebral venous drainage

internal jugular vein

Study Results

No Results Posted as of Jun 15, 2021