Sex-specific Effect of Restricted Sleep on Brain Health

Sponsor

University of Missouri-Columbia (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05920759

Collaborator

(none)

Enrollment

Arms

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

Transcranial Doppler (TCD) is a non-invasive diagnostic tool used to estimate cerebral blood flow velocity (CBFV), cerebral autoregulation, cerebrovascular reactivity (CVR), intracranial pressure, cerebral perfusion pressure as well as other indicators of cerebral hemodynamics and autoregulation. Whereas TCD has been widely used in research, clinical, and outpatient settings, studies specifically designed to examine the effect of limited sleep on brain health and potential impact of sex are sparse. This is problematic for a number of reasons outlined above. Thus, the present study will investigate sex-specific differences in cerebral blood flow under conditions of normal and restricted sleep. We will conduct measures of CBFV and CVR on two separate days under tightly controlled experimental conditions. We hypothesize greater morning cerebral blood flow velocity following a night of normal sleep compared to restricted sleep. We further hypothesize the effect of sleep restriction on CBFV and CVR will be greater in males compared to females. Results from the present study will provide important data necessary to develop future, well-controlled studies examining the impact of long-term modifications in exercise and/or sleep on cerebral hemodynamics and, by extension, risk for cerebrovascular events (i.e. stroke).

Condition or Disease	Intervention/Treatment	Phase
Cerebrovascular Circulation	Diagnostic Test: Cerebral blood flow	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

20 participants

Allocation:

Randomized

Intervention Model:

Single Group Assignment

Masking:

Single (Participant)

Primary Purpose:

Basic Science

Official Title:

Sex-specific Effect of Restricted Sleep on Brain Health

Anticipated Study Start Date :

Jul 1, 2023

Anticipated Primary Completion Date :

Sep 1, 2023

Anticipated Study Completion Date :

Sep 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Normal sleep	Diagnostic Test: Cerebral blood flow Transcranial Doppler (TCD) is a non-invasive diagnostic tool used to estimate cerebral blood flow velocity (CBFV), cerebral autoregulation, cerebrovascular reactivity (CVR), intracranial pressure, cerebral perfusion pressure as well as other indicators of cerebral hemodynamics and autoregulation.
Experimental: Restricted sleep	Diagnostic Test: Cerebral blood flow Transcranial Doppler (TCD) is a non-invasive diagnostic tool used to estimate cerebral blood flow velocity (CBFV), cerebral autoregulation, cerebrovascular reactivity (CVR), intracranial pressure, cerebral perfusion pressure as well as other indicators of cerebral hemodynamics and autoregulation.

Arm

Intervention/Treatment

Experimental: Normal sleep

Diagnostic Test: Cerebral blood flow

Experimental: Restricted sleep

Diagnostic Test: Cerebral blood flow

Outcome Measures

Primary Outcome Measures

Cerebral blood flow velocity [Two days]
Greater morning cerebral blood flow velocity following a night of normal sleep compared to restricted sleep

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 45 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy adult men and women, 18-45 years of age, BMI 18-30 kg/m2, non-pregnant, non-breastfeeding, and non-nicotine users

Exclusion Criteria:

any medications known to affect sleep, autonomic, metabolic, or cardiovascular health, have a self-reported history of hepatic, renal, pulmonary, cardiovascular, or neurological disease, stroke or neurovascular disease, bleeding/clotting disorders, sleep apnea or other sleep disorders, diabetes, history of alcoholism or substance abuse, major cardiovascular event or surgical procedure within the past three months, or hypertension

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

University of Missouri-Columbia

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Jill Kanaley, Interim Chair & Associate Professor, University of Missouri-Columbia

ClinicalTrials.gov Identifier:

NCT05920759

Other Study ID Numbers:

2097207

First Posted:

Jun 27, 2023

Last Update Posted:

Jun 27, 2023

Last Verified:

Jun 1, 2023

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Product Manufactured in and Exported from the U.S.:

Yes

Study Results

No Results Posted as of Jun 27, 2023