Clincosm LogoSign in Get a demo

AGNORIENT: Orientation Agnosia: Clinical and Anatomical Study

Sponsor
University Hospital, Rouen (Other)
Overall Status
Completed
CT.gov ID
NCT01304576
Collaborator
(none)
34
Enrollment
1
Location
2
Arms
39
Duration (Months)
0.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Neuropsychological testing
  • Other: MRI
 N/A

Detailed Description

Idem

Study Design

Study Type:
Interventional
Actual Enrollment :
34 participants
Allocation:
Non-Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Screening
Official Title:
Orientation Agnosia: Neuropsychological Evaluation, Associated Symptoms, Clinical and Anatomical Correlations
Study Start Date :
Sep 1, 2010
Actual Primary Completion Date :
Dec 1, 2013
Actual Study Completion Date :
Dec 1, 2013

Arms and Interventions

Arm Intervention/Treatment
Experimental: patient with right parietal lesions

Behavioral: Neuropsychological testing
Experimental test about orientation agnosia and standard neuropsychological tests.

Other: MRI
Cerebral MRI
Active Comparator: patient with left parietal lesions

Behavioral: Neuropsychological testing
Experimental test about orientation agnosia and standard neuropsychological tests.

Other: MRI
Cerebral MRI

Outcome Measures

Primary Outcome Measures

  1. orientation agnosia evaluation [1 week to 6 months (average)]

    orientation agnosia test

Secondary Outcome Measures

  1. associated clinical symptoms especially apraxia [1 week to 6 months (average)]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • age between 18 and 80 years

  • french language

  • right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion

  • informed consent

Exclusion Criteria:

  • previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years

  • previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment

  • drug or alcohol abuse

  • severe cranial traumatism

  • other severe chronic pathology

  • psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month

  • visual impairment

  • motor or sensory deficit sufficient to render impossible neuropsychological tests

  • patient without judicial or administrative liberty

  • measure of legal protection or no capable to express their consent

  • pregnancy or breastfeeding

Contacts and Locations

Locations

Site City State Country Postal Code
1 CHU de Rouen - Hôpitaux de Rouen Rouen Haute-Normandie France 76031

Sponsors and Collaborators

  • University Hospital, Rouen

Investigators

  • Principal Investigator: Olivier MARTINAUD, Doctor, Service de neurologie et centre mémoire de ressources et recherche

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
University Hospital, Rouen
ClinicalTrials.gov Identifier:
NCT01304576
Other Study ID Numbers:
  • 2009/126/HP
  • number ID RCB 2009-A01005-52
First Posted:
Feb 25, 2011
Last Update Posted:
Sep 3, 2014
Last Verified:
Sep 1, 2014
Keywords provided by University Hospital, Rouen
stroke
parietal lesions
Additional relevant MeSH terms:
Cerebrovascular Disorders
Agnosia

Study Results

No Results Posted as of Sep 3, 2014