Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
Study Details
Study Description
Brief Summary
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow. Interventions that can restore cerebral metabolism and enhance cerebral blood flow may protect against conversion to dementia. Exogenous ketone supplements have been shown rapidly improves brain network function in young adults. Further, infusion studies demonstrate that ketone bodies enhance cerebral blood flow in cognitively normal adults. Whether acute ketone monoester supplementation can improve brain function in adults with subjective memory complaints is currently unknown.
This study will investigate the effects of a single ketone monoester dose on resting-state functional connectivity in the default mode network and resting cerebral blood flow in adults with subjective memory complaints.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Placebo Comparator: Placebo Single dose of a taste-matched calorie-free placebo |
Other: Placebo
Ingestion of a taste-matched calorie-free placebo drink followed by 90 minutes of rest.
|
| Experimental: β-OHB Single dose of a ketone monoester ([R]-3-hydroxybutyl [R]-3-hydroxybutyrate; 0.6 g β-OHB/kg body weight) |
Dietary Supplement: β-OHB
Ingestion of a high dose [R]-3-hydroxybutyl [R]-3-hydroxybutyrate (0.6 g β-OHB/kg body weight) followed by 90 minutes of rest.
|
Outcome Measures
Primary Outcome Measures
- Brain network connectivity [90 minutes]
Functional connectivity of the default mode network (DMN) is measured via functional MRI. Changes in BOLD signal in each region are determined by independent component analysis and then functional connectivity is measured as a Pearson correlation (r) between the neural regions comprising the DMN and transformed into a z score.
- Cerebral blood flow [90 minutes]
Sum of blood flow in the internal carotid and vertebral arteries via phase contrast MRI in ml/min.
Secondary Outcome Measures
- Working memory [90 minutes]
Computer battery to assess working memory (n-back test) based on N2 reaction time
- Executive function [90 minutes]
Computer battery to assess executive function (Stroop test) based on Stroop Cost (reaction times to incongruent stimuli minus congruent stimuli).
- Attention and working memory [90 minutes]
Computer battery to assess working memory (digit symbol substitution task) based on the number of correct responses in 120 seconds.
Other Outcome Measures
- Mean arterial pressure [90 minutes]
Automated blood pressure cuff measurement of brachial artery pressure in mmHg.
- Plasma beta-hydroxybutyrate [90 minutes]
Measured via finger capillary samples in mM
Eligibility Criteria
Criteria
Inclusion Criteria:
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between the ages of 55 and 70
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presence of subjective memory complaints as determined by the Prospective- Retrospective Memory Questionnaire
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cognitively normal, e.g. score ≥26 on the Montreal Cognitive Assessment
Exclusion Criteria:
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Presence of obesity (body mass index > 30 kg/m^2)
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Presence of known cardiovascular disease
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Presence of type 2 diabetes
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History of cardiovascular events requiring hospitalization (e.g., heart attack, stroke)
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History of concussion(s) with persistent symptoms
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Currently following a ketogenic diet and/or taking ketone body supplements
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Diagnosis of any form of Alzheimer's disease or dementia
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- McMaster University
- Alzheimer's Society of Brant, Haldimand Norfolk, Hamilton Halton
Investigators
- Principal Investigator: Jeremy Walsh, PhD, McMaster University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- rs-KME