Change of Circulating Tumor Cells Quantity in the Central Vein During Laparoscopic or Transanal Endoscopic Surgery for Rectal Cancer.
Study Details
Study Description
Brief Summary
The primary purpose of this study is to compare the changes of circulating tumor cells (CTCs) at different time points in rectal cancer patients undergoing laparoscopic or transanal endoscopic radical resection. Our secondary purpose is to explore the effects of perioperative circulating tumor cells on tumor recurrence and metastasis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Mid-low rectal cancer is one of the common malignant tumors and the incidence has increased significantly in recent years. At present, surgery is still the most important and effective method for the treatment of mid-low rectal cancer. Traditional laparoscopic surgery and emerging transanal total mesorectal excision (TaTME) are the main methods. More than one-third of rectal cancer patients will eventually local recurrence and distant metastasis, which are the most important factors affecting prognosis. Circulating tumor cells may lead to distant metastasis, so the detection of CTCs in blood has important clinical significance in predicting recurrence and metastasis of rectal cancer and monitoring treatment response. Due to the different degrees of contact between distinct surgical methods, this may lead to an increase in the quantity of CTCs in the blood, which may affect the prognosis of patients. Therefore, the investigators conducted a randomized controlled study to compare the changes in the quantity of CTCs in the central vein before, during and after operation in rectal cancer patients undergoing transanal endoscopic or laparoscopic radical resection. To explore the effect of two surgical methods on the risk of micrometastasis, and to provide new ideas for the selection and improvement of rectal cancer treatment.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| laparoscopic surgery
|
Procedure: Surgical approach
Different surgical methods for rectal cancer resection
|
| Transanal endoscopic surgery
|
Procedure: Surgical approach
Different surgical methods for rectal cancer resection
|
Outcome Measures
Primary Outcome Measures
- Change of circulating tumor cells during laparoscopic or transanal endoscopic surgery [1 years]
Determine the changes of circulating tumor cells at different time points in patients undergoing laparoscopic or transanal endoscopic radical resection of rectal cancer
Secondary Outcome Measures
- Disease free survival [3 years]
Determine relationship of CTC numbers and local recurrence and distant metastasis
Eligibility Criteria
Criteria
Inclusion Criteria:
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Mid-low rectal cancer.
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Single lesion.
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No metastasis.
Exclusion Criteria:
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History of malignant tumors.
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Acute bowel obstruction, bleeding or perforation.
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Tumor over 6cm in diameter or in severe adhesion with surrounded tissues.
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Severe other contradictions of surgery.
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Pregnant women will be excluded.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Department of colorectal surgery, the Sixth Affiliated Hospital, Sun Yat-Sen University | Guangzhou | Guangdong | China | 510655 |
Sponsors and Collaborators
- Sun Yat-sen University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GIHSYSU-20