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Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

Sponsor
Centre Hospitalier La Chartreuse (Other)
Overall Status
Completed
CT.gov ID
NCT03817008
Collaborator
JAZAYERI Aline (Other), BOUCHOT Olivier (Other), JAZAYERI Saed (Other), MALAPERT Ghislain (Other), PETROSYAN Andreanik (Other)
19
Enrollment
52.5
Actual Duration (Months)

Study Details

Study Description

Brief Summary

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.

Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Ascending aorta replacement with graft

Detailed Description

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention.

The pre and postoperative cardiac MRI are planned in standard of care.

Study Design

Study Type:
Observational
Actual Enrollment :
19 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging
Actual Study Start Date :
Sep 1, 2014
Actual Primary Completion Date :
Jan 17, 2019
Actual Study Completion Date :
Jan 17, 2019

Outcome Measures

Primary Outcome Measures

  1. Aortic compliance of descending aorta (mm2/mmHg) [post-operative cardiac MRI performing between 12 and 24 months]

    Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI. Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Secondary Outcome Measures

  1. Aortic compliance of ascending aorta (mm2/mmHg) [post-operative cardiac MRI performing between 12 and 24 months]

    Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI. Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 99 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  • 18 years

  • Elective patient

  • Ascending aorta replacement with graft

Exclusion Criteria:

  • Prior cardiac surgery

  • Contraindication to performing cardiac MRI

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Centre Hospitalier La Chartreuse
  • JAZAYERI Aline
  • BOUCHOT Olivier
  • JAZAYERI Saed
  • MALAPERT Ghislain
  • PETROSYAN Andreanik

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
MORGANT Marie-Catherine, PI, Centre Hospitalier La Chartreuse
ClinicalTrials.gov Identifier:
NCT03817008
Other Study ID Numbers:
  • MORGANT 2019
First Posted:
Jan 25, 2019
Last Update Posted:
Jan 25, 2019
Last Verified:
Jan 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No

Study Results

No Results Posted as of Jan 25, 2019