ADIPENIGME: Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle

• Sponsor: Centre Hospitalier Universitaire de Nice (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT05955976
• Collaborator: (none)
• Enrollment: 20
• Location: 1
• Anticipated Duration (Months): 8
• Patients Per Site Per Month: 2.5

Study Details

Study Description

Brief Summary

Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics. In particular, weakness of the quadriceps muscle would be a key determinant of KOA. However the mechanisms underpinning the influence of skeletal muscle in the pathophysiology of ostheoarthritis (OA) are poorly understood.

Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA.

The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis.

This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.

Condition or Disease	Intervention/Treatment	Phase
Osteo Arthritis Knee	Other: BIOPSY

Study Design

• Study Type: Observational
• Anticipated Enrollment: 20 participants
• Observational Model: Case-Only
• Time Perspective: Prospective
• Official Title: Study to Compare the Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle
• Actual Study Start Date: Jul 20, 2023
• Anticipated Primary Completion Date: Sep 20, 2023
• Anticipated Study Completion Date: Mar 20, 2024

Arms and Interventions

Arm	Intervention/Treatment
Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.	Other: BIOPSY; biopsy

Outcome Measures

Primary Outcome Measures

1. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): adipose tissue size differences [4 months]

   size mesured in mm

2. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): lipid levels [4 months]

   level mesured in %

3. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps):fibrotic tissue [4 months]

   rate mesured in %

Eligibility Criteria

Criteria

• Ages Eligible for Study: 40 Years to 85 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Adult patient, aged between 40 and 85 years

• Patient having a confirmed diagnosis of knee ostheoarthritis

• Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis

Exclusion Criteria:

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Nice University Hospital	Nice		France	06000

Sponsors and Collaborators

• Centre Hospitalier Universitaire de Nice

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Centre Hospitalier Universitaire de Nice
• ClinicalTrials.gov Identifier: NCT05955976
• Other Study ID Numbers: 23Rhumato02
• First Posted: Jul 21, 2023
• Last Update Posted: Jul 25, 2023
• Last Verified: Jul 1, 2023

• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Osteoarthritis; Osteoarthritis, Knee

Study Results

No Results Posted as of Jul 25, 2023