HPGAIT: Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Sponsor

Henri Mondor University Hospital (Other)

Overall Status

Active, not recruiting

CT.gov ID

NCT05998473

Collaborator

(none)

150

Enrollment

Location

Anticipated Duration (Months)

21.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Condition or Disease	Intervention/Treatment	Phase
Hydrocephalus Parkinson Disease Walking, Difficulty Movement Disorders Gait Ataxia Diagnoses Disease	Diagnostic Test: Dynamic stability measurement

Detailed Description

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Study Design

Study Type:

Observational

Anticipated Enrollment :

150 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Actual Study Start Date :

Jun 1, 2023

Anticipated Primary Completion Date :

Sep 30, 2023

Anticipated Study Completion Date :

Dec 31, 2023

Arms and Interventions

Arm	Intervention/Treatment
Normal pressure hydrocephalus Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories	Diagnostic Test: Dynamic stability measurement The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.
Parkinson's disease Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories	Diagnostic Test: Dynamic stability measurement The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Arm

Intervention/Treatment

Normal pressure hydrocephalus

Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories

Diagnostic Test: Dynamic stability measurement

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Parkinson's disease

Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories

Diagnostic Test: Dynamic stability measurement

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Outcome Measures

Primary Outcome Measures

Coefficient of variation in step length [30 seconds]
Coefficient of variation in step length during 8-meter comfortable walking test

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 100 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Age >18 years
Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement
Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion Criteria:

Levodopa drugs administrated during a delay of 12 hours before walking test
Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.