GLYNO: Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery
Study Details
Study Description
Brief Summary
The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important. In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. The analysis of glycocalyx in routine care is important to guide volume expansion. Indeed, the literature provides evidence about the poor prognosis of excess water and its impact on organ. This analysis challenge is to justify filling solution of choice according to the characteristic of this capillary leakage.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Extra corporeal circulation and aortic clamp induce ischemia-reperfusion damages.
Vascular damages are represented by first glycocalyx, a layer of endovascular vessel proteoglycans, responsible for fluid permeability and secondly by nitro oxygen liberation responsible for vascular tonus.
The investigators suppose that both functions are impaired after cardiac surgery.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| presence of a vascular dysfunction plasma |
Biological: plasma
assesment of glycocalyx protein
|
| absence of vascular dysfunction plasma |
Biological: plasma
assesment of glycocalyx protein
|
Outcome Measures
Primary Outcome Measures
- glycocalyx proteins 1 [48 hours]
proteoglycan in patient plasma is assayed.
Eligibility Criteria
Criteria
Inclusion Criteria:
- cardiac surgery
Exclusion Criteria:
-
auricular fibrillation
-
endocarditis
-
aortic dissection
-
end stage chronic renal disease
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | CHU Amiens Picardie | Amiens | France | 80054 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire, Amiens
Investigators
- Principal Investigator: Osama ABOU ARAB, MD, CHU Amiens
- Study Director: Emmanuel LORNE, MD-PhD, CHU Amiens
- Principal Investigator: Pierre-Gregoire GUINOT, MD, CHU Amiens
Study Documents (Full-Text)
None provided.More Information
Publications
- Becker BF, Jacob M, Leipert S, Salmon AH, Chappell D. Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases. Br J Clin Pharmacol. 2015 Sep;80(3):389-402. doi: 10.1111/bcp.12629. Epub 2015 May 22. Review.
- Chawla LS, Ince C, Chappell D, Gan TJ, Kellum JA, Mythen M, Shaw AD; ADQI XII Fluids Workgroup. Vascular content, tone, integrity, and haemodynamics for guiding fluid therapy: a conceptual approach. Br J Anaesth. 2014 Nov;113(5):748-55. doi: 10.1093/bja/aeu298. Epub 2014 Sep 17.
- Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R; International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002 Jan 16;39(2):257-65. Erratum in: J Am Coll Cardiol 2002 Mar 20;39(6):1082.
- PI2015_843_0027