Chest Dysphoria in Transmasculine Spectrum Adolescents

Sponsor
Northwestern University (Other)
Overall Status
Completed
CT.gov ID
NCT04195659
Collaborator
Ann and Robert H. Lurie Children's Hospital of Chicago (Other), University of Illinois at Chicago (Other)
81
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26.1
27
1

Study Details

Study Description

Brief Summary

The investigators hypothesize that masculinizing top surgery (e.g., mastectomy and chest masculinization) leads to an improvement in self-report chest dysphoria, gender dysphoria, and gender congruence in assigned-female-at-birth, transgender and non-binary youth and young adults. This is a prospective, observational study that will enroll assigned-female-at-birth, transmasculine spectrum individuals age 13 to 25 years old who are or are not undergoing top surgery. Participants will complete a set of standard of care questionnaires regarding their chest dysphoria (e.g., distress about the chest), gender dysphoria (e.g., distress about a gender identity that does not match assigned sex), and gender congruence (e.g., degree to which an individual feels they are living in their authentic appearance and gender identity). They will complete this same set of questionnaires either three months after their top surgery or three months after the initial set of surveys.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Mastectomy and chest masculinization

Study Design

Study Type:
Observational
Actual Enrollment :
81 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
The Effect of Top Surgery on Chest Dysphoria in Assigned-Female-At-Birth, Transmasculine Spectrum Youth and Young Adults
Actual Study Start Date :
Oct 29, 2019
Actual Primary Completion Date :
Dec 31, 2021
Actual Study Completion Date :
Dec 31, 2021

Arms and Interventions

Arm Intervention/Treatment
Top Surgery

Individuals assigned the female sex at birth, who identify as a gender other than female, are between the ages of 13 and 25 years, and who are undergoing mastectomy and chest masculinization in one of three plastic surgery practices in Chicago.

Procedure: Mastectomy and chest masculinization
A surgical procedure in which the breasts are removed and the chest is given a masculine contour.

Control

Individuals assigned the female sex at birth, who identify as a gender other than female, are between the ages of 13 and 25 years, were seen in a gender development clinic in Chicago, and who are not planning to undergo top surgery. Controls will be matched with top surgery patients on age and number of months of testosterone.

Outcome Measures

Primary Outcome Measures

  1. Chest Dysphoria [Three month]

    The disruption of individual comfort, physical functioning, and interpersonal relationships from a chest with breasts, as measured by the Chest Dysphoria Measure (Score 0-51, Higher number means greater chest dysphoria)

Secondary Outcome Measures

  1. Gender Dysphoria [Three month]

    Distress about a gender identity that differs from assigned sex, measured by the Utrecht Gender Dysphoria Scale (Score 12-60, Higher number means greater gender dysphoria)

  2. Gender Congruence [Three month]

    Feelings of living in an authentic gender identity and appearance, as measured by the Kozee Transgender Congruence Scale (Score 12-60, Higher number means greater gender congruence)

Eligibility Criteria

Criteria

Ages Eligible for Study:
13 Years to 25 Years
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Assigned the female sex at birth

  • Affirmed gender identity of male, non-binary, or gender other than female

  • English-speaking

  • Undergoing top surgery or matches a top surgery participant on age and number of months on testosterone

Exclusion Criteria:
  • Non English speaking

  • Unable to complete self-report questionnaires

Contacts and Locations

Locations

Site City State Country Postal Code
1 Ann and Robert H Lurie Children's Hospital of Chicago Chicago Illinois United States 60611
2 Northwestern University Chicago Illinois United States 60611
3 University of Illinois Chicago Chicago Illinois United States 60612

Sponsors and Collaborators

  • Northwestern University
  • Ann and Robert H. Lurie Children's Hospital of Chicago
  • University of Illinois at Chicago

Investigators

  • Principal Investigator: Sumanas W Jordan, MD PhD, Northwestern University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Sumanas Jordan, Assistant Professor, Northwestern University
ClinicalTrials.gov Identifier:
NCT04195659
Other Study ID Numbers:
  • SP0052757
First Posted:
Dec 12, 2019
Last Update Posted:
Jun 10, 2022
Last Verified:
Jun 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jun 10, 2022