Clincosm LogoSign in Get a demo

Skeletal Muscle Dysfunction in Heart Failure

Sponsor
Ullevaal University Hospital (Other)
Overall Status
Unknown status
CT.gov ID
NCT00156234
Collaborator
Norwegian Health Association (Other), Norwegian School of Sport Sciences (Other), The Research Council of Norway (Other), University of Oslo (Other)
45
Enrollment
2
Locations
22.5
Patients Per Site

Study Details

Study Description

Brief Summary

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: One-knee extension ergometer
 N/A

Study Design

Study Type:
Interventional
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single
Primary Purpose:
Educational/Counseling/Training
Official Title:
Training and Congestive Heart Failure
Study Start Date :
Mar 1, 2005

Outcome Measures

Primary Outcome Measures

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    40 Years to 78 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Coronary Heart Failure

    • Ejection fraction <35%

    • NYHA 2-3

    • Spirometry FEV1 > 80%

    Exclusion Criteria:

    • Cardiomyopathy

    • Transplantation candidate

    • Active malignancy

    • Restraining skeletal-muscular disease

    • Claudication in legs

    • Hospitalized last 30 days due to acute ischemic episode

    • Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion

    • AMI last 8 weeks prior to inclusion

    • Organized training last 4 months

    • Smoking on daily basis last 4 months

    • Creatinin < 150microliters/liter

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Institute for Experimental Medical Research Oslo Norway 0407
    2 Norwegian School of Sport Sciences Oslo Norway 0806

    Sponsors and Collaborators

    • Ullevaal University Hospital
    • Norwegian Health Association
    • Norwegian School of Sport Sciences
    • The Research Council of Norway
    • University of Oslo

    Investigators

    • Study Chair: Ole M Sejersted, Professor, Institute for Experimental Medical Research, Ullevaal University Hospital
    • Study Director: Per Kristian B Lunde, Post Doc, Institute for Experimental Medical Research, Ullevaal University Hospital
    • Study Director: Ivar Sjaastad, Post Doc, Institute for Experimental Medical Research, Ullevaal University Hospital
    • Study Chair: Jostein Hallen, Professor, Norwegian School of Sport Sciences
    • Principal Investigator: Morten Munkvik, Ph.D student, Institute for Experimental Medical Research, Ullevaal University Hospital
    • Principal Investigator: Tommy A Rehn, Vit.ass., Institute for Experimental Medical Research, Ullevaal University Hospital
    • Principal Investigator: Gunnar S Petersen, Ph.D student, Norwegian School of Sport Sciences

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00156234
    Other Study ID Numbers:
    • TRUST-001
    • Helse Øst
    • Helse og rehabilitering
    First Posted:
    Sep 12, 2005
    Last Update Posted:
    Sep 12, 2005
    Last Verified:
    Sep 1, 2005
    Additional relevant MeSH terms:
    Heart Failure

    Study Results

    No Results Posted as of Sep 12, 2005