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Childhood Body Composition and Brain Structure and Function

Sponsor
Arkansas Children's Hospital Research Institute (Other)
Overall Status
Completed
CT.gov ID
NCT01822054
Collaborator
(none)
27
Enrollment
1
Location
31
Duration (Months)
0.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The specific aim of this research project is to use MRI methods to evaluate and compare brain structure and function in normal weight and obese children age 8-10 years.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    27 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Childhood Body Composition and Brain Structure and Function
    Study Start Date :
    Jan 1, 2012
    Actual Primary Completion Date :
    Aug 1, 2013
    Actual Study Completion Date :
    Aug 1, 2014

    Arms and Interventions

    Arm Intervention/Treatment
    Normal weight
    Obese

    Outcome Measures

    Primary Outcome Measures

    1. Brain structure [8 - 10 years of age]

      We will use high resolution volumetric MRI and DTIto measure the brain structure of these children

    Secondary Outcome Measures

    1. Brain Function [8-10 years of age]

      We will use high resolution fMRI to measure the brain function under different cognitive paradigms

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    8 Years to 10 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Healthy normal weight or obese children

    • Parental report of full-term gestation

    • Parental report of birth weight between 5th-95th percentiles

    • Parental report of breastfeeding or cow's milk formula fed during infancy

    • Right hand dominance

    Exclusion Criteria:

    • Maternal diabetes

    • Maternal alcohol, tobacco or drug use during pregnancy

    • Chronic sleep disorder

    • History of psychological or psychiatric diagnosis

    • History of neurological impairment or injury

    • Surgical implant or other foreign object in the body which may be a MRI safety concern

    • Dental work which may cause artifacts in MRI

    • Claustrophobia

    • High likelihood of inability to tolerate loud noise from the MRI scanner

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Arkansas Children's Nutrition Center Little Rock Arkansas United States 72203

    Sponsors and Collaborators

    • Arkansas Children's Hospital Research Institute

    Investigators

    • Principal Investigator: Xiawei Ou, PhD, Arkansas Children's Nutrition Center

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Arkansas Children's Hospital Research Institute
    ClinicalTrials.gov Identifier:
    NCT01822054
    Other Study ID Numbers:
    • 133540
    First Posted:
    Apr 2, 2013
    Last Update Posted:
    Aug 5, 2022
    Last Verified:
    Aug 1, 2022

    Study Results

    No Results Posted as of Aug 5, 2022