Exercise and Diet Restriction on Cardiovascular Function in Obese Children and Adolescents
Study Details
Study Description
Brief Summary
Prevalence rates of childhood obesity have reached alarming levels. As childhood obesity may already be associated with serious comorbidities, obese adolescents are at significantly higher risk for obesity and increased morbidity and mortality during adulthood. Combined lifestyle interventions, which include regular physical activity and dietary restriction, have been shown to result in most significant improvements in cardiovascular function and their associated factors in the pediatric and adolescent population with obesity. The aim of this study is to investigate the effects of a combined exercise and diet intervention on cardiovascular function and their associated factors in obese children.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Sixty obese children and adolescents will complete a 6-week program of exercise and diet intervention. Thirty normal-weight children and adolescents will be recruited as control group. Clinical characteristics, body composition, blood biochemistry, and circulating irisin levels of the subjects will be measured before and after 6-week intervention. Endothelial function will be assessed by a flow-mediated dilation test. Circulating exosome-derived miRNAs, exercise-induced epigenetic modifications, circulating irisin levels irisin concentration in plasma and arterial stiffness as well as cardiac autonomic function will be investigated before and after the 6-week intervention. Fecal samples were collected before and after the 6-week intervention for analysis of the compositional and functional changes in the human gut microbiota.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Obese intervention group Obese children were received exercise and diet intervention for 6 weeks. |
Behavioral: Exercise
Subjects were provided with energy-restricted diets of 1300-2200 kcal/day based on weight. The energy percentages provided by protein, fat and carbohydrate were 20%, 20% and 60%, respectively, while energy distributions at breakfast, lunch and dinner were 30%, 40% and 30%, respectively. Subjects performed a series of endurance exercise such as bicycling, walking, running, dancing and ball games for 5 hour/day, supplemented with resistance exercise. Training interventions were performed 5-6 day/week for 6 weeks. The exercise program was designed to result in an energy expenditure of 1500-2500 kcal/day.
Other Names:
|
| No Intervention: Normal weight control group Normal weight children were recruited as a control group without any intervention. |
Outcome Measures
Primary Outcome Measures
- Change from flow-mediated dilation (FMD) at 6 weeks [before and after the 6-week intervention]
for brachial endothelial function assessment
Secondary Outcome Measures
- Change from circulating exosome-derived miRNAs at 6 weeks [before and after the 6-week intervention]
exosome-secreted miRNA levels in plasma
- Change from circulating irisin levels at 6 weeks [before and after the 6-week intervention]
irisin concentration in plasma
- Change from pulse wave velocity at 6 weeks [before and after the 6-week intervention]
for arterial stiffness assessment
- Change from heart rate variability at 6 weeks [before and after the 6-week intervention]
for cardiac autonomic function assessment
Other Outcome Measures
- Change from the composition of gut microbiota at 6 weeks [before and after the 6-week intervention]
the composition of gut microbiota in fecal samples
- Change from short chain fatty acids (SCFAs) concentractions at 6 weeks [before and after the 6-week intervention]
short chain fatty acids (SCFAs) concentractions in fecal samples
Eligibility Criteria
Criteria
Inclusion Criteria:
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Participants aged 7-17 years
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Participants satisfied the obesity diagnosis criteria is based on "Body mass index reference standards for the screening of overweight and obesity in Chinese children and adolescents" released in 2004, with cut-off points of p(95) for obesity
Exclusion Criteria:
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Metabolic disease
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Gastrointestinal disease
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Cardiac disease
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Taking medications which affected energy expenditure
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Losing weight in the past three months whether by diet, taking weight-loss medication or more physical exercise than normal
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Guangzhou Sport University | Guangzhou | Guangdong | China | 510000 |
Sponsors and Collaborators
- Guangzhou Sport University
Investigators
- Principal Investigator: Min Hu, PhD, Guangzhou Sport University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Trial2017.1